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Curriculum Vitae

Name : Mehmet KAYA

Date and Place of Birth: July 01, 1958; Erzincan; Turkey

Citizenship : Turkish

Home Address : ---------

Workplace Address : Koç University School of Medicine, Physiology

Rumelifeneri Yolu, Sarıyer, 34450-Istanbul, Turkey

Work Telephone : (+90) 212 338 1177

E-mail : mehmetkaya@ku.edu.tr; mkaya942@gmail.com

Web : http//medicine.ku.edu.tr/

Present Position : Professor of Physiology, Koç University School of Medicine.

Education

Undergraduate : Erzincan High school; 1975

Graduate : Department of Biology, Faculty of Science, Istanbul University; 1980.

Postgraduate : Master and PhD in Medical Physiology in Istanbul Faculty of

Medicine, Institute of Health Sciences, Istanbul University, 1989.

Positions : Assoc. Prof; Department of Physiology, Istanbul Faculty of Medicine,

1991.

Promotion to Full Professor; Department of Physiology, Istanbul Faculty

of Medicine, Istanbul University, 1998.

Professional Activities and History

1981–1986 : Laboratory assistantship, Electron Microscopy Facility, Department of

Pathology, Istanbul Faculty of Medicine, Istanbul University.

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1985–1991 : Laboratory assistantship, Department of Physiology, Istanbul Faculty of

Medicine, Istanbul University.

1991–1998 : Assoc Prof. in Department of Physiology, Istanbul Faculty of Medicine,

Istanbul University.

1994 January –1996 July: Visiting scientist, Laboratory of Neurobiology, NINDS, NIH, Bethesda,

USA.

1998 –2015 : Prof. Dr. in Department of Physiology, Istanbul Faculty of Medicine,

Istanbul University.

September 2015- : Professor of Physiology, Koç University School of Medicine.

Awards

1993 : Award of “Sedat Simavi Health Sciences” for study of “The effects of

Epilepsy and Hypertension on blood-brain barrier permeability”.

2008 : Award of the best experimental study to titled “Morphological and

functional changes of blood-brain barrier in kindled rats with cortical

dysplasia” by Turkish Epilepsy Foundation.

2010 : Award of the experimental study to titled “Effects of levetiracetam on

blood-brain barrier disturbances following hyperthermia-induced seizures

in rats with cortical dysplasia” by Turkish Epilepsy Foundation.

2011 : Award of the experimental study to titled “Effects of vagal nerve

stimulation on cortical dysplasia in rats” by 27. Turkish National Clinic

Neurophysiology EEG-EMG Meeting, April 27–May 1, 2011 Sarıgerme,

Muğla Turkey.

2012 : Award of the experimental study to titled “Effects of acute seizures

blood-brain barrier integrity in septic rats” by 28. Turkish National Clinic

Neurophysiology EEG-EMG Meeting, 25–29 April, 2012 Belek,

Antalya, Turkey.

2013 : Award of the experimental study to titled “Long term video-EEG

monitoring in a rat model of temporal lobe epilepsy induced by kainic

acid” by 29. Turkish National Clinic Neurophysiology EEG-EMG

Meeting, 3–7 April, 2013, Antalya, Turkey.

2014 : Award of the experimental study to titled “Selective vulnerability for

transcellular pathway of blood-brain barrier in acute and chronic phase of

the kainate model of temporal lobe epilepsy in rat” by Turkish Epilepsy

Foundation.

Administrative Duties

2005- 2009 : The Director of Institute of Experimental Medicine, Istanbul University

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2005- 2009 : Head of Department of Neuroscience, The Institute of Experimental

Medicine, Istanbul University

2006- 2009 : The Founder Chairman of Animal Ethics Committee, Istanbul University

2007- 2009 : Director of Research Fund of Istanbul University

2007- 2009 : Member of Academic Evaluation and Innovation Committee of Istanbul

University

2007-2009 : Member of Strategic Planning Committee of Istanbul University

2009 -2015 : Member of Board for Epilepsy Clinical and Research Center for Epilepsy,

Istanbul University

2011- : The Chairman of “14 The Symposium on Signal Transduction in the

Blood-Brain Barriers” September 7-9, 2011, Istanbul-Turkey

2013- : Member of Animal Ethics Committee, Boğaziçi University

2014- : The Chairman of "First Symposium on Experimental Design and Pre-

statistics” September 29-30, 2014, Istanbul

2015- : The Chairman of "Second Symposium on Experimental Design and Pre-

statistics” October 5-6, 2015, Istanbul

2015- : The Assessment Committee Member of Koç University School of

Medicine

2015- : Student Research Committee Member of Koç University School of

Medicine

2015- : Curriculum Development Coordination Committee Member of Koç

University School of Medicine.

2016- : Member of Animal Ethics Committee, Koç University

Memberships

The International Blood-Brain Barrier Organization “Founding member”

European Neuroscience Association

International Union of Physiological Science

Federation of European Physiological Societies

Turkish Epilepsy Society

Major Fields of Research

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Blood-brain barrier (BBB) integrity.

Nanoparticles for drug delivery to the brain through the BBB.

Pericyte – Endothelium interrelations.

Astroglia – Endothelium interrelations.

Epilepsy – BBB interrelations.

Hypertension – BBB interrelations.

Cortical dysplasia – Epileptogenesis – BBB interrelations.

Sepsis – BBB interrelations.

Hyperbaric oxygen – BBB interrelations.

I have been working on the morphology, physiology and pathology of the rat brain microvessels in

experimental animal models since 1984. Starting from the beginning of the 1990’s, I have focused my

studies on the BBB reactions to various experimental pathological conditions, especially epilepsy. In

one of my articles published in “Experimental Neurology” journal in 1996, I have demonstrated the

conversion of a normal barrier type brain capillary into fenestrated type in an experimental setting. My

research topics between 2000 and 2014 concentrated on the reactions of BBB to a number of

experimental conditions including sepsis, hypertension and epilepsy. The main goal of my previous

and future research is to determine putative mechanisms which may enable the treatment drugs 98% of

which are unable to pass into the brain tissue owing to a functioning BBB, to permeate into the brain

by physiological manipulations for opening the BBB for a desired period and subsequently closing the

barrier.

Invited International Projects

1. “The blood-brain barrier integrity in claudin3 knock-out mice”. Leibniz-Institut für Molekulare

Pharmakologie, Berlin, Germany, 2012-2015.

2. “To characterize the blood-brain barrier in pericyte-deficient Imatinib treated mice using electron

microscopy”. Department of Immunology, Genetics and Pathology, Cancer and Vascular Biology;

Uppsala University, Sweden, 2013-2015.

3. “Localisation of coated gold-nanoparticles in the CNS in vivo”. The Open University and Midatech

Co., London., UK, 2014-2015.

4. “Localisation of coated gold-nanoparticles in the CNS in vivo”. The Open University and Midatech

Co., London., UK, 2017 -

Thesis project consultants:

1. PhD. Student; Rivaze Bulut Kalaycı, title of project; “Functional and Structural Changes in Blood-

Brain Barrier in a Rat Model of Hypercholesterolemia and Hypertension”. 2005.

2. Medicine Resident; Sezen Milli Avtan, MD, title of project; “The effects of hyperbaric oxygen

therapy on blood-brain barrier permeability in septic conditions”. 2010.

3. MsC. Student; Metin Bahçeci, title of project; “The effects of pentylenetetrazole-induced seizures

during sepsis on blood-brain barrier integrity”. 2012.

4. PhD. Student; Nurcan Orhan, title of project; “The effects of β-hydroxybutyrate on the blood-brain

barrier disruption induced by traumatic brain injury in rats”. 2013.

5. MsC. Student; Canan Uğur Yılmaz, title of project; Blood-brain barrier changes following kainic

acid-induced seizures, 2013.

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6. Canan Uğur Yılmaz, PhD student (in the dissertation stage).

7. Nilüfer Ulaş Aytürk, PhD student (in the dissertation stage).

8. Müge Atış, PhD student (in the dissertation stage).

9. Arzu Temizyürek, PhD student (in the dissertation stage).

10. Ugur Akcan, PhD student (in the dissertation stage).

Student Lectureres

1. Transport of substances through cell membranes for medical students; 1991 – 1994.

2. Medical Physiology for Physio-Therapy and Rehabilitation Students; 1996 – 2015.

3. Endocrine Physiology for medical students; 2005 – 2015.

4. How to write and publish a scientific paper for PhD students; 2005 – 2015.

5. Experimental animal models for medical students; 2005 – 2015.

6. The special senses and behavioral and motivational mechanisms in the brain; 2015 – 2016.

7. Animal models in neuroscience research for PhD students; 2016 – 2017.

8. Endocrine physiology for PhD students; 2016 – 2017.

9. MEDI201 " Transport of substances through cell membranes for medical students; 2016 – 2017.

10. NUTI "Gastrointestinal system for medical students"; 2016 – 2017.

11. ERUS "The introduction of the male and female reproductive organs (2 h); 2016 – 2017.

12. Brain and Behaviour "8 h"; 2016 – 2017.

Journal Editorial Board

1. Henry Journal of Cytology & Histology; The member of Editorial Board.

Invited speaker in International Conferences

1. "Blood-Brain Barrier Changes in Long-Term Nitric Oxide Deficiency" in Palermo University,

Italy, 2005.

2. "Blood-brain barrier, epileptogenesis and treatment strategies in cortical dysplasia" in Ben Gurion

University of the Negev in Israel, 2012.

3. "The blood-brain barrier integrity and epileptogenesis in genetic absence epilepsy of WAG/Rij rats

with cortical dysplasia" in ILAE/IBE International Epilepsy Congress in Istanbul, 2015.

Marital Status: Married, two children.

Hobby: Play a musical instrument (Divan Saz) and understand the daily life in the ancient civilizations

in Anatolia such as Hittites, Luwians, Kathars and the people of Çatalhöyük.

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BIBLIOGRAPHY

1. Öztaş B., Bayındır Ç., Kaya M. Hipoglisemi komasında açılan kan beyin bariyerinin

ultrastrüktürel düzeyde incelenmesi. Diabet ve Endokrinoloji Yıllığı 1987.

2. Kaya M. Kronik elektroşokun kan beyin bariyeri permeabilitesine etkisinin ultrastrüktürel

düzeyde incelenmesi. Istanbul Tıp Fakültesi Mecmuası 50, 419-428, 1987.

3. Kaya M. Dişi ve erkek sıçanda kan beyin bariyeri permeabilite değişikliğinin ultrastrüktürel

düzeyde incelenmesi. Istanbul Tıp Fakültesi Mecmuası 52, 225-232, 1989.

4. Kaya M. Kan beyin bariyeri ve EEG. Türk Tıp Derneği Dergisi 56, 294-299, 1990.

5. Oztaş B, Kaya M, Çamurcu S. Age-related changes in the effect of electro convulsive shock on

the blood-brain barrier permeability in rats Mech. Ageing Dev. 51, 149-155, 1990.

6. Çamurcu S., Kaya M. Kan beyin bariyerinin osmotik açılmasının EEG üzerindeki

etkileri.İstanbul Üniversitesi İstanbul Tıp Fakültesi 11. Kurultayı 1991.

7. Kaya M. Gamma ışınlarının kan beyin bariyeri permeabilitesi üzerine etkisi. Istanbul Tıp

Fakültesi Mecmuası 54, 537-542, 1991.

8. Oztaş B and Kaya M. The effect of acute hypertension on the blood-brain barrier permeability

to albumin during experimentally induced epileptic seizures. Pharmacol. Res. 23 (1), 41-46,

1991.

9. Oztaş B, Kaya M. Blood-brain barrier permeability during acute and chronic electroconvulsive

seizures. Pol. J. Pharmacol Pharm. 43, 259-263, 1991.

10. Oztaş B, Kaya M, Çamurcu S. Blood-brain barrier permeability in experimental induced

seizure: Variations during the estrous cycle. Horm. Metab. Res. 23 (8), 401-403, 1991.

11. Kaya M. Hipoterminin organ sistemlerine ve kan beyin bariyeri permeabilitesine etkisi. Tıp

Fakültesi Mecmuası 55,489-494, 1992.

12. Oztaş B, Kaya M, Camurcu S. Influence of profound hypothermia on the blood-brain barrier

permeability during acute arterial hypertension. Pharmacol. Res. 26 (1), 75-84, 1992.

13. Oztaş B, Camurcu S, Kaya M. Influence of sex on the blood-brain barrier permeability during

bicuculline-induced seizures. J. Intern. Neurosci. 65, 131-139, 1992.

14. Oztaş B, Kaya M, and Camurcu S. Influence of pregnancy on blood-brain barrier integrity

during seizures in rats. Pharmacol. Res. 28(4), 317-323, 1993.

15. Oztaş B, Kaya M. The effect of profound hypothermia on the blood-brain barrier permeability

during pentylenetetrazol-induced seizures. Epilepsy Res. 19, 221-227, 1994.

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16. Kaya M. İskemi/perfüzyonda kan beyin bariyeri yıkımı ve serbest radikallerin rolü. Türk Tıp

Derneği Dergisi 60, 62-68, 1994.

17. Kaya M. Derin hipotermi ve hipotansiyonun kan-beyin bariyeri permeabilitesine etkisi.

İstanbul Tıp Fakültesi Mecmuası 57, 3, 1994.

18. Kaya M. Deneysel subaraknoidal kanamanın kan-beyin bariyeri permeabilitesine etkisi.

İstanbul Tıp Fakültesi Mecmuası 59, 1, 1996.

19. Kaya M, Chang L, Truong A, Brightman M. Chemical induction of fenestrae in vessels of the

blood-brain barrier. Exp. Neurol. 142, 6-13, 1996.

20. Kaya M, Chang L, Truong A, Brightman M. Reversible induction of fenestrae in vessels of the

blood-brain barrier. J. FASEB 10 (3), 3383-3383, 1996.

21. Öztaş B, Kaya M. Influence of orchidectomy and ovariectomy on the blood-brain barrier

permeability during bicuculline-induced seizures. Horm. Metab. Res. 30, 1-4, 1998.

22. Kaya M, Küçük M., Kılıç Ş., Erkin E., Kavunoğlu G., Şimşek G. Alkolik sıçanlarda

hiperterminin kan-beyin bariyeri permeabilitesine etkisi. İstanbul Tıp Fakültesi Mecmuası 61,

2, 1998.

23. Kaya M, Küçük M, Bilir A, Bulut R, Çevik A. Aluminyum toksisitesi ve pentilentetrazol ile

oluşturulan epileptik nöbetlerin kan-beyin bariyer permeabilitesine etkileri. İstanbul Tıp

Fakültesi Mecmuası 62, 1, 1999.

24. Kaya M, Küçük M, Bulut RK, Palandüz Ş. Acute hyperglycemia augments blood-brain barrier

damage in experimental status epilepticus. Neurosci. Res. Commun. 25(2), 111-119, 1999.

25. Brightman MW, Kaya M. Permeable endothelium and interstitial space of brain. Cellular and

Molecular Neurobiology, 20(2), 109-128, 2000.

26. Kalaycı R, Kaya M, Küçük M, Elmas İ, Kozanoğlu O, Tufekçi M.A, Çevik A. Selenium

supplementation reduces blood-brain barrier permeability induced by epileptic seizures in acute

hyperglycemic rats. Endothelium, 8(4), 294, 2001.

27. Elmas İ, Baslo B, Ertaş M, Kaya M. Analysis of gastrocnemius compound muscle action

potential in rat after death. Forensic Science International, 116, 125-132, 2001.

28. Elmas I, Küçük M, Kalaycı RB, Elmas İ, Çevik A, Kaya M. Effects of severe hypothermia on

the blood-brain barrier permeability in acute and chronically ethanol treated rats. Forensic

Science International, 119, 212-216, 2001.

29. Kaya M, Kucuk M, Bulut RK, Gurses C, Kozanoglu D, Tüfekçi MA, Çevik A. Magnesium

sulfate attenuates increased blood-brain barrier permeability during insulin-induced

hypoglycemia and hypothermia in rats. European Journal of Neuroscience, 12, 357, 2000.

30. Küçük M, Kalaycı R, Elmas İ, Kaya M. Effect of aluminum on the blood-brain barrier

permeability in acute and chronically hyperglycemic rats. Biological Trace Elem Res. 80(2),

181-192, 2001.

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31. Oztaş B, Küçük M, Kaya M. Sex-dependent changes in blood-brain barrier permeability in

epileptic rats following acute hyperosmotic exposure. Pharmacol Res. 43 (5), 469-72, 2001.

32. Kaya M, Küçük M, Kalaycı R, Çimen V, Gürses C, Elmas İ, Arıcan N. Magnesium sulfate

attenuates increased blood-brain barrier permeability during insulin-induced hypoglycemia in

rats. Canadian Journal of Physiology and Pharmacology, 79 (9), 793-798, 2001.

33. Kalayci R, Kaya M, Küçük M, Çimen V, Arican N, Gurses C, Elmas I. Catalase and -

tocopherol attenuate blood-brain barrier breakdown in pentylenetetrazole-induced epileptic

seizures in acute hyperglycemic rats. Pharmacol Res, 45(2), 129-133, 2002.

34. Arican N, Kaya M, Kalayci R, Küçük M, Çimen V, Elmas I. Effects of acute cold exposure on

blood-brain barrier permeability in acute and chronic hyperglycemic rats. Forensic Science

International, 125(2-3), 137-141, 2002.

35. Küçük M, Kaya M, Kalayci R, Cimen V, Kudat H, Arican N, Elmas I, Korkut F. Effects of

losartan on the blood-brain barrier permeability in long-term nitric oxide blockade-induced

hypertensive rats. Life Sciences, 71, 937-46, 2002.

36. Elmas İ, Baslo B, Ertaş M, Kaya M. Compound muscle action potential analysis in different

death models: Significance for the estimation of early postmortem interval. Forensic Science

International, 127, 75-81, 2002.

37. Esen F, Erdem T, Aktan D, Kalayci R, Cakar N, Kaya M, Telci L. Effects of magnesium

administration on brain edema and blood-Brain barrier breakdown after experimental traumatic

brain injury in rats. J Neurosurg Anesthesiol 15(2), 119-125, 2003.

38. Kaya M, Kalaycı R, Arıcan N, Küçük M, Elmas I. Effect of aluminum on the blood-brain

barrier permeability during nitric oxide-blockade-induced chronic hypertension in rats.

Biological Trace Element Research, 92(3), 221-230, 2003.

39. Oztaş B, Kaya M, Küçük M, Tuğran N. Influence hypoosmolality on the blood-brain barrier

permeability during epileptic seizures. Progress in Neuro-Psychopharmacology and Biological

Psychiatry, 27, 701-704, 2003.

40. Kaya M, Kalayci R, Küçük M, Arican N, Elmas I, Kudat H, Korkut F. Effect of losartan on the

blood-brain barrier permeability in diabetic hypertensive rats. Life Sciences. 73(25), 3235-44.

2003.

41. Kaya M, Palanduz A, Kalayci R, Kemikler G, Simsek G, Bilgic B, Bulent Ahishali, Nadir

Arican, Zuhal C. Kocyildiz, Imdat Elmas, Mutlu Kucuk, Ahmet Karadeniz. Effects of

lipopolysaccharide on the radiation-induced changes in the blood-brain barrier and the

astrocytes. Brain Research, 1019 (1-2): 105-12, 2004.

42. Kaya M, Gulturk S, Elmas I, Kalayci R, Arican N, Kocyildiz ZC, Kucuk M, Yorulmaz H,

Sivas A. The effects of magnesium sulfate on blood-brain barrier disruption caused by

intracarotid injection of hyperosmolar mannitol in rats. Life Sciences. 76(2): 201-212, 2004.

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43. Esen F, Erdem T, Aktan D, Orhan M, Kaya M, Eraksoy H, Cakar N, Telci L. Effect of

magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal

sepsis: a randomized controlled experimental study. Critical Care, 9(1): R18-23, 2005.

44. Ahishali B, Kaya M, Kalayci R, Uzun H, Bilgiç B, Arican N, Elmas İ, Aydın S, Küçük M.

Effects of lipopolysaccharide on the blood-brain barrier permeability in prolonged nitric oxide

blockade induced hypertensive rats. Intern. J. Neuroscience, 115: 445–457, 2005.

45. Kalayci R, Kaya M, Elmas I, Arican N, Ahishali B, Uzun H, Bilgic B, Kucuk M, Kudat H.

Effects of atorvastatin on blood-brain barrier permeability during L-NAME hypertension

followed by angiotensin-II in rats. Brain Research, 1042(2):184-193, 2005.

46. Kaya M. Blood-Brain Barrier Changes in Long-Term Nitric Oxide Deficiency. Molecular

bases of neurodegeneration, Editors: Italia Di Liegro and Giovanni Savettieri. Research

Signpost, Kerala, India, pp 163-182, 2005.

47. Arıcan N., M. Kaya, C. Yorulmaz, R. Kalayci, H. Ince, M. Kucuk, S. K. Fincanci, I. Elmas.

The effect of hypothermia on the blood-brain barrier permeability following traumatic brain

injury in chronically ethanol-treated rats. Intern. J. Neuroscience, 116(7), 2006.

48. Arican N, Kaya M, Kalayci R, Uzun H, Ahishali B, Bilgic B, Elmas I, Kucuk M, Gurses C,

Uzun M. Effects of lipopolysaccharide on blood-brain barrier permeability during

pentylenetetrazole-induced epileptic seizures in rats. Life Sciences. 79(1):1-7. 2006.

49. Kalayci R, Kaya M, Ahishali B, Arican N, Elmas I, Kucuk M. Long-term L-NAME treatment

potentiates the blood-brain barrier disruption during pentylenetetrazole-induced seizures in rats.

Life Sciences, 79(1):16-20, 2006.

50. Kaya M, Gurses C, Kalayci R, Ekizoglu O, Ahishali B, Orhan N, Oku B, Arican N, Ustek D,

Bilgic B, Elmas I, Kucuk M, Kemikler G. Morphological and functional changes of blood-

brain barrier in kindled rats with cortical dysplasia. Brain Research. 1208:181-91, 2008.

51. Kaya M. Nöronal uyarilabilirliğin kontrolü: Uyarici ve inhibe edici sinaptik geçiş. Editörler;

Bora İ, Yeni SN ve Gürses C. Epilepsi, Nobel Tıp Kitabevi, sayfalar: 15-27, 2008.

52. Gurses C, Ekizoglu O, Orhan N, Ustek D, Arican N, Ahishali B, Elmas I, Kucuk M, Bilgic B,

Kemikler G, Kalayci R, Karadeniz A, Kaya M. Levetiracetam decreases the seizure activity

and blood-brain barrier permeability in pentylenetetrazole-kindled rats with cortical dysplasia.

Brain Res. 1281:71-83, 2009.

53. Toklu HZ, Uysal MK, Kabasakal L, Sirvanci S, Ercan F, Kaya M. The effects of riluzole on

neurological, brain biochemical, and histological changes in early and late term of sepsis in

rats. J Surg Res. 152 (2): 238-48, 2009.

54. Kalayci R, Kaya, M, Uzun, H, Bilgic, B, Ahishali, B, Arican, N, Elmas, I and Küçük, M.

Influence of hypercholesterolemia and hypertension on the integrity of the blood-brain barrier

in rats. Int. J. Neurosci. 119 (10): 1881-1904, 2009.

55. Imer M, Omay B, Uzunkol A, Erdem T, Sabanci P, Karasu A, Albayrak S, Sencer A, Hepgul

K, Kaya M. Effect of magnesium, MK-801 and combination of magnesium and MK-801 on

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blood-brain barrier permeability and brain edema after experimental traumatic diffuse brain

injury. Neurol Res. 31(9): 977-81. 2009.

56. Ahishali B, Kaya M, Orhan N, Arican N, Ekizoglu O, Elmas I, Kucuk M, Kemikler G, Kalayci

R, Gurses C. Effects of levetiracetam on blood-brain barrier disturbances following

hyperthermia-induced seizures in rats with cortical dysplasia. Life Sci. 87(19-22): 609-19,

2010.

57. Karasu A, Aras Y, Sabancı PA, Sağlam G, Izgi N, Biltekin B, Barak T, Hepgül KT, Kaya M,

Bilir A. The effects of protein kinase C activator phorbol dibutyrate on traumatic brain edema

and aquaporin-4 expression. Ulus Travma Acil Cerrahi Derg. 16(5):390-4, 2010.

58. Kaya M, Ahishali B. Assessment of permeability in barrier type of endothelium in brain using

tracers: evans blue, sodium fluorescein, and horseradish peroxidase. Permeability Barrier:

Methods and Protocols. Editor. Turksen K. Chapter, 25, Methods Mol Biol. 763:369-82,

Springer Science+Business Media, LLC. ISBN-10: 1617791903 | ISBN-13: 978-1617791901,

2011.

59. Avtan SM, Kaya M, Orhan N, Arslan A, Arican N, Toklu AS, Gürses C, Elmas I, Kucuk M,

Ahishali B. The effects of hyperbaric oxygen therapy on blood-brain barrier permeability in

septic rats. Brain Res. 1412:63-72, 2011.

60. Kaya M and Ahishali B. Magnesium in edema and blood-brain disruption. Eds: Vink B and

Nechifor M. Magnesium in the Central Nervous System. The University of Adelaide Press,

“ISBN (electronic) 978‐0‐9870730‐5‐1” “ISBN (paperback) 978‐0‐9870730‐6‐8”. 2011.

61. Kaya M and Çevik A. Planning in animal experiments and choosing model. Deneysel Tıp

Araştırma Enstitüsü Dergisi, 1(2): 36-39, 2011.

62. Esen F, Senturk E, Ozcan PE, Ahishali B, Arican N, Orhan N, Ekizoglu O, Kucuk M, Kaya M.

Intravenous immunoglobulins prevent the breakdown of the blood-brain barrier in

experimentally induced sepsis. Crit Care Med. 40(4):1214-20, 2012.

63. Küçük M, Kaya M, Orhan N, Ekizoğlu O, Arslan E, Arıcan N, Gürses C, Elmas İ, Kalaycı R,

Ahıshalı B. The effect of pentylenetetrazole-induced seizures on blood-brain barrier integrity in

a rat model of preeclampsia. Turk. J. Vet. Anim. Sci. 36 (3):311-318. 2012.

64. Kaya M, Becker AJ, Gürses C. Blood–brain barrier, epileptogenesis, and treatment strategies

in cortical dysplasia. Epilepsia, 53 (Suppl. 6):31–36, 2012.

65. Gürses C, Orhan N, Ahishali B, Yilmaz CU, Kemikler G, Elmas I, Cevik A, Kucuk M, Arican

N, Kaya M. Topiramate reduces blood-brain barrier disruption and inhibits seizure activity in

hyperthermia-induced seizures in rats with cortical dysplasia. Brain Res. 1494:91-100, 2013.

66. Kaya M. Kan-beyin bariyeri ve nörolojik hastalıklarda tutulumu. Pages: 641-648. Editör Emre

M. Temel Nöroloji, Güneş Tıp Kitapevleri, 1. Baskı. ISBN: 978-975-277-433-9. 2013.

67. Nerses B, Kaya M. Etyopatojenik, patofizyolojik ve genetic mekanizmalar. Pages: 1043-1046.

Editör Emre M. Temel Nöroloji, Güneş Tıp Kitapevleri, 1. Baskı. ISBN: 978-975-277-433-9.

2013.

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68. Kaya M, Orhan N, Karabacak E, Berkant Bahceci M, Arican N, Ahishali B, Kemikler G, Uslu

A, Cevik A, Ugur Yilmaz C, Kucuk M, Gürses C. Vagus nerve stimulation inhibits seizure

activity and protects blood-brain barrier integrity in kindled rats with cortical dysplasia. Life

Sci. 92(4-5):289-97, 2013.

69. Sozer V, Uzun H, Gelisgen R, Tabak O, Kaya M, Kalaycı R, Arican N, Konukoglu D. The

effects of atorvastatin on oxidative stress in L-NAME-treated rats. Scand J Clin Lab Invest.

73(7):591-7, 2013.

70. Cevik NG, Orhan N, Yilmaz CU, Arican N, Ahishali B, Kucuk M, Kaya M, Savas AT.

Comparison of the effects of hyperbaric air and hyperbaric oxygen on blood-brain barrier

integrity in rats. Brain Res. 1531:113-21, 2013.

71. Orhan N, Ugur Yilmaz C, Ekizoglu O, Ahishali B, Arican N, Kucuk M, Elmas I, Gürses C,

Kalayci R, Kaya M. The effects of superoxide dismutase mimetic MnTMPyP on the altered

blood-brain barrier integrity in experimental preeclampsia with or without seizures in rats.

Brain Res. 1563:91-102, 2014.

72. Ozcan PE, Senturk E, Esen F, Orhun G, Gumru S, Arican N, Orhan N, Yılmaz CU, Kaya M,

Arıcıoglu F. Effects of intravenous immunoglobulin therapy on behavior deficits and functions

in cecal ligation-puncture induced sepsis model in rats: a randomized, controlled, experimental

study. Ann Intensive Care. 5(1):62, 2015.

73. Orhan N, Ugur Yılmaz C, Ahishali B, Kuçuk M, Arican N, Elmas I, Gürses C, Kaya M.

Effects of beta-hydroxybutyrate on brain vascular permeability in rats with traumatic brain

injury. Brain Research, 1631: 113-126, 2016.

74. Gromnicova R, Yilmaz CU, Orhan N, Kaya M, Davies H, Williams P, Romero IA, Sharrack

B, Male D. Localisation and mobility of glucose-coated gold nanoparticles within the brain.

Nanomedicine (Lond), 11(6):617-25, 2016.

75. Gromnicova R, Kaya M, Romero IA, Williams P, Satchell S, Sharrack B, Male D. Transport of

Gold Nanoparticles by Vascular Endothelium from Different Human Tissues. PLoS One.,

11(8):e0161610, 2016.

76. Esen F, Orhun G, Ozcan PE, Senturk E, Kucukerden M, Giris M, Akcan U, Yilmaz CU, Orhan

N, Arican N, Kaya M, Gazioglu SB, Tuzun E. Neuroprotective effects of intravenous

immunoglobulin are mediated through inhibition of complement activation and apoptosis in a

rat model of sepsis. Intensive Care Med Exp. 5(1):1, 2017.

77. Sahin D, Yilmaz CU, Orhan N, Arican N, Kaya M, Gürses C, Ates N, Ahishali B. Changes in

electroencephalographic characteristics and blood-brain barrier permeability in WAG/Rij rats

with cortical dysplasia. Epilepsy Behav. 67:70-76, 2017.

78. Jozwiak S, Becker A, Cepeda C, Engel J Jr, Gnatkovsky V, Huberfeld G, Kaya M, Kobow K,

Simonato M, Loeb JA. WONOEP appraisal: Development of epilepsy biomarkers-What we

can learn from our patients? Epilepsia. 2017 Apr 7. doi: 10.1111/epi.13728. [Epub ahead of

print]

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79. Tatar S, Orhan N, Yilmaz CU, Arican N, Ahishali B, Kucuk M, Toklu AS, Kaya M. The

effects of hyperbaric oxygen for five days exposure of on blood-brain barrier integrity in rats.

(Accepted), Hyperbaric and Underwater Research, 2017.

80. Kaya M. Excitatory and Inhibitory Properties of Seizures and Mechanisms in Epileptogenesis

Turkiye Klinikleri J Neurol-Special Topic. 10(1):1-5, 2017.

81. Uğur Yılmaz C, Kaya M. Animal Models of Epilepsy. Turkiye Klinikleri J Neurol-Special

Topics. 10(1):30-4. 2017.

82. Nurcan Orhan N, Kaya M. Imaging on Animal Models of Epilepsy. Turkiye Klinikleri J

Neurol-Special Topics. 10(1):41-4. 2017.

83. Kaya M. Nöronal uyarılabilirliğin kontrolü: Uyarıcı ve inhibe edici sinaptik geçiş. Epilepsi

Kitabı; Editorler: Bora İ, Yeni N, Gürses C, 2017. (Baskıda).

84. Kaya M., Uğur Yılmaz C, Epilepside kan-beyin bariyeri ve önemi. Kitabı; Editorler: Bora İ,

Yeni N, Gürses C, 2017. (Baskıda).