ÚSTAV EXPERIMENTÁLNEJ ONKOLÓGIE UEO SAV 2006.pdf · 2007. 10. 23. · cenu SAV získal nominant...

UacuteSTAV EXPERIMENTAacuteLNEJ ONKOLOacuteGIE

Slovenskej akadeacutemie vied

Spraacuteva o činnosti za rok 2006

Bratislavajanuaacuter 2007

Obsah osnovy Spraacutevy o činnosti organizaacutecie SAV za rok 2006

I Zaacutekladneacute uacutedaje o organizaacutecii 3

II Vedeckaacute činnosť 6

III Vedeckaacute vyacutechova a pedagogickaacute činnosť 15

IV Medzinaacuterodnaacute vedeckaacute spolupraacuteca 18

V Spolupraacuteca s vysokyacutemi školami inyacutemi domaacutecimi vyacuteskumnyacutemi

inštituacuteciami a s hospodaacuterskou sfeacuterou pri riešeniacute vyacuteskumnyacutech uacuteloh

28

VI Aktivity pre Naacuterodnuacute radu SR vlaacutedu SR uacutestredneacute orgaacuteny štaacutetnej

spraacutevy SR a ineacute subjekty

30

VII Vedecko-organizačneacute a popularizačneacute aktivity ceny a

vyznamenania

30

VIII Činnosť knižnično-informačneacuteho pracoviska 46

IX Aktivity v orgaacutenoch SAV 47

X Hospodaacuterenie organizaacutecie 48

XI Nadaacutecie a fondy pri organizaacutecii 49

XII Ineacute vyacuteznamneacute činnosti 50

XIII Vyznamenania ocenenia a ceny udeleneacute pracovniacutekom organizaacutecie

v roku 2006 (mimo SAV)

50

XIV Poskytovanie informaacuteciiacute v suacutelade so zaacutekonom o slobode informaacuteciiacute 51

XV Probleacutemy a podnety pre činnosť SAV 51

PRIacuteLOHY1 Mennyacute zoznam zamestnancov k 31 12 2006 52

2 Projekty riešeneacute na pracovisku 55

3 Vedeckyacute vyacutestup ndash bibliografickeacute uacutedaje vyacutestupov 95

4 Uacutedaje o pedagogickej činnosti organizaacutecie 162

5 Uacutedaje o medzinaacuterodnej vedeckej spolupraacuteci 165

2

I Zaacutekladneacute uacutedaje o organizaacutecii 1 Kontaktneacute uacutedaje

Naacutezov Uacutestav experimentaacutelnej onkoloacutegie SAV Riaditeľ Doc Ing Čestmiacuter Altaner DrSc Zaacutestupca riaditeľa RNDr Jaacuten Sedlaacutek CSc Vedeckyacute tajomniacutek RNDr Zdena Bartošovaacute CSc Predseda vedeckej rady Ing Katariacutena Luciakovaacute DrSc Adresa siacutedla Vlaacuterska 7 833 91 Bratislava

tel 59327 255fax 59327 250e-mail exonueosavbask

wwwexonsavbask

Naacutezvy a adresy detašovanyacutech pracoviacutesk

Uacutestav nemaacute detašovaneacute pracoviskaacute

Typ organizaacutecie rozpočtovaacute organizaacutecia od r 1951

2 Počet a štruktuacutera zamestnancov

ŠTRUKTUacuteRA ZAMESTNANCOV

K

K do 35 rokov

Kved prac

M Ž M Ž

F P

Celkovyacute počet zamestnancov 129 17 41 18 16 115 1218

Vedeckiacute pracovniacuteci 59 9 17 18 15 46 562

Odborniacute pracovniacuteci VŠ 17 4 12 16 162

Odborniacute pracovniacuteci UacuteS 23 3 23 225

Ostatniacute pracovniacuteci 20 2 1 20 145

Doktorandi v dennej forme doktorandskeacuteho štuacutedia

10 2 8 10 10

Vysvetlivky

K ndash kmeňovyacute stav zamestnancov v pracovnom pomere k 31 12 2006 (uvaacutedzaniacute suacute zamestnanci v pracovnom pomere vraacutetane riadnej materskej dovolenky zamestnanci pocircsobiaci v zahraničiacute)F ndash fyzickyacute stav zamestnancov k 31 12 2006 (bez riadnej materskej dovolenky zamestnancov pocircsobiacich v zahraničiacute v štaacutetnych funkciaacutech zamestnancov pocircsobiacich v zastupiteľskyacutech zboroch a na zaacutekladnej vojenskej službe) P ndash celoročnyacute priemernyacute prepočiacutetanyacute počet zamestnancov

3

M Ž ndash muži ženy

3 Štruktuacutera vedeckyacutech pracovniacutekov (kmeňovyacute stav k 3l l2 2006)

Rodovaacute

skladba

Pracovniacuteci s hodnosťou Vedeckiacute pracovniacuteci

v stupňoch

DrSc CSc

PhD

prof doc I IIa IIb

Muži 5 20 1 2 5 16 6

Ženy 5 29 6 10 16

4 Štruktuacutera pracovniacutekov zo stĺpca F v bode 2 zaradenyacutech do riešenia projektov (domaacutecich alebo medzinaacuterodnyacutech)

Vekovaacute štruktuacutera(roky)

lt 30 30-35 35-40 40-45 45-50 50-55 55-60 60-65 gt65

Muži 9 8 1 3 5 6 3 3 8Ženy 26 15 3 6 7 11 5 2 8

Priemernyacute vek riešiteľov projektov podľa vyššie uvedenej tabuľkyMuži 500Ženy 503

Priemernyacute vek všetkyacutech kmeňovyacutech zamestnancov k 31 12 2006 436Priemernyacute vek kmeňovyacutech vedeckyacutech pracovniacutekov k 31 12 2006 411

5 Ineacute docircležiteacute informaacutecie k zaacutekladnyacutem uacutedajom o organizaacutecii a zmeny za posledneacute obdobie (v zameraniacute v organizačnej štruktuacutere a pod)

Uacutestav je organizovanyacute do 6 hlavnyacutech laboratoacuteriiacute

Laboratoacuterium molekulovej onkoloacutegieLaboratoacuterium imunoloacutegie naacutedorovLaboratoacuterium genetiky naacutedorovyacutech ochoreniacuteLaboratoacuterium molekulaacuternej bioloacutegieLaboratoacuterium mutageneacutezy a karcinogeneacutezyLaboratoacuterium molekulaacuternej genetiky

V raacutemci každeacuteho laboratoacuteria a medzi laboratoacuteriami spravidla existujuacute ďalšie podskupiny ktoreacute sa formujuacute podľa riešenia aktuaacutelnych grantov V roku 2006 sa riešilo 23 VEGA grantov 5 APVV grantov 1 grant Centra excelentnosti a 2 projekty finančne podporovaneacute Ligou proti rakovine Naďalej pokračuje vzdelaacutevaciacute projekt financovanyacute z Euroacutepskeho sociaacutelneho fondu Začali sa riešiť dva projekty 6 Raacutemcoveacuteho programu EUacute a jeden bilateraacutelny zahraničnyacute projekt Pokračuje riešenie dvoch multilateraacutelnych projektov a jeden projekt financovanyacute zo zahraničia bol uacutespešne uzavretyacute

4

Na uacutestave sa realizuje zaacutekladnyacute a aplikovanyacute onkologickyacute vyacuteskum Hlavnyacutem zameraniacutem projektov suacute

bull vyacuteskum dospelyacutech kmeňovyacutech buniek pre použitie v nasmerovanej terapii naacutedorov

bull priacuteprava vektorov a experimentaacutelnych modelov pre geacutenovuacute terapiu

bull testovanie karcinogenity chemickyacutech laacutetok

bull hlbšie štuacutedium signaacutelnych draacuteh po aplikaacutecii priacuterodnyacutech laacutetok s potenciaacutelnym anti-karcinogeacutennym a terapeutickyacutem uacutečinkom

bull genetika a epigenetika naacutedorovyacutech ochoreniacute

bull detekcia poškodenia DNA a štuacutedium procesov opravy DNA

bull štuacutedium procesov apoptoacutezy nekroacutezy a nemoacutezy

bull štuacutedium transkripčnej a translačnej regulaacutecie geacutenov v normaacutelnych a naacutedorovyacutech bunkaacutech

bull determinaacutecia povrchovyacutech znakov naacutedorovyacutech buniek imunofenotypizaacuteciou Vyacuteznamnou mierou k realizaacutecii vyacuteskumnyacutech projektov prispievajuacute aj medzinaacuterodneacute

oficiaacutelne a neoficiaacutelne spolupraacutece finančneacute prostriedky z mimorozpočtovyacutech zdrojov ziacuteskanyacutech najmauml z Nadaacutecie Vyacuteskum rakoviny a z Ligy proti rakovine SR V tomto roku vďaka podpore Nadaacutecie vyacuteskum rakoviny uacutestav ziacuteskal ďalšiacute drahyacute priacutestroj tzv Wave systeacutem na ryacutechly skriacutening genetickyacutech zmien

V roku 2006 uacutestav slaacutevil 60 vyacuteročie svojho vzniku Pri priacuteležitosti tohto vyacuteročia usporiadal celosvetovuacute medzinaacuterodnuacute konferenciu v CC Academia v Starej Lesnej slaacutevnostneacute spoločenskeacute stretnutie troch onkologickyacutech inštituacuteciiacute v Bratislave (Naacuterodnyacute onkologickyacute uacutestav Onkologickyacute uacutestav Sv Alžbety a UacuteEO SAV) a Deň otvorenyacutech dveriacute Všetky podujatia sa uskutočnili na vysokej vedeckej a spoločenskej uacuterovni aj vďaka finančnej a organizačnej podpore nadaacutecie Vyacuteskum rakoviny Uacutestav ziacuteskal medailu od Dekana PriF UK za dlhoročnuacute spolupraacutecu pri vyacutechove študentov a vedeckuacute spolupraacutecu Viaceriacute pracovniacuteci uacutestavu ziacuteskali v r 2006 vyacuteznamneacute ocenenia napr ocenenia za zaacutesluhy v rozvoji vedy a technoloacutegii v akcii Vedec roka SR 2005 RNDr Jana Jakubiacutekovaacute PhD ziacuteskala cenu Mladyacute vedec roka RNDr Jozef Biacutezik DrSc MUDr Oľga Babušiacutekovaacute DrSc a RNDr Darina Slameňovaacute DrSc ziacuteskali čestneacute uznania Ing Jela Brozmanovaacute DrSc ziacuteskala cenu Vyacuteznamnaacute osobnosť SAV a RNDr Ivan Chalupa CSc Striebornuacute medailu za zaacutesluhy pre Slovenskuacute lekaacutersku spoločnosť Držiteľom prestiacutežnej ceny od Euroacutepskej spoločnosti pre lekaacutersku onkoloacutegiu ESMO Best Exam Award sa stal externyacute doktorand uacutestavu MUDr Michal Mego PhD Aj medzinaacuterodnuacute cenu SAV ziacuteskal nominant UacuteEO SAV Prof Josef Jiricny zo Švajčiarska Uacutestav zaznamenal v roku 2006 rekordnyacute počet ohlasov v meacutediach 115

Uacutestav prešiel požiarnou kontrolou a dvomi auditmi (SAV a ESF) Neboli zisteneacute žiadne zaacutevažneacute nedostatky Naopak v niektoryacutech aspektoch bolo konštatovaneacute že uacutestav mocircže sluacutežiť ako vzor pre ineacute inštituacutecie Ďalšie organizačneacute poznaacutemky 1 Uacutestav je registrovanyacute pre praacutecu s geneticky modifikovanyacutemi organizmami v rizikovej triede 1 a 2 2 Veterinaacuterny dozor vo zverinci UacuteEO SAV začal vykonaacutevať MVDr J Liška CSc 3 Zodpovednyacutem pracovniacutekom pre Komisiu pre bezpečnosť a ochranu zdravia pri praacuteci bol určenyacute RNDr Peter Rauko CSc 4 Dozor nad nebezpečnyacutemi chemikaacuteliami a jedmi bol určenyacute Ing Karolovi Kleiblovi CSc 5 RNDr J Prachař CSc bol poverenyacute mať na starosti odpadoveacute hospodaacuterstvo uacutestavu

5

II Vedeckaacute činnosť

1 Domaacutece projekty

ŠTRUKUacuteRA PROJEKTOV Počet projektov Prideleneacute financie na

rok 2006 v tis

A

organizaacutecia je nositeľom projektu

B

organizaacutecia sa zmluvne

podieľa na riešeniacute

projektu

A B

1 Vedeckeacute projekty ktoreacute boli v r 2006 financovaneacute VEGA 22 1 3 030 0

2 Vedeckeacute projekty ktoreacute boli roku 2006 financovaneacute APVT (APVV)

3 2 3 017 270

3 Uacutečasť na novyacutech vyacutezvach APVV r 2006 6 - - -

4 Projekty riešeneacute v raacutemci ŠPVV a ŠO - - - -

5 Projekty centier excelentnosti SAV - 1 - 293

6 Vedecko-technickeacute projekty ktoreacute boli v roku 2006 financovaneacute

- - - -

7 Projekty podporovaneacute Euroacutepskym sociaacutelnym fondom 1 - 1 522 -

8 Ineacute projekty (uacutestavneacute na objednaacutevku rezortov a pod)

3 - 600 -

Pracovisko veduacuteceho projektu zodpovedneacuteho riešiteľa zhotoviteľa veduacuteceho centra alebo manažeacutera projektu

Medzinaacuterodneacute projekty suacute uvedeneacute v kapitole IV

Bližšie vysvetlenie projektov a rozbor probleacutemov zapojenie a využitie projektu do sfeacutery VŠ do aplikačnej sfeacutery a pre verejnosť k bodu 7 (ESF) je v Priacutelohe č 2

6

2 Najvyacuteznamnejšie vyacutesledky vedeckej praacutecea) zaacutekladneacuteho vyacuteskumu

Stresom indukovanaacute inaktivaacutecia c-Myb onkoproteiacutenu (VEGA - 2405726 Autori Bies J Šramko M Markus J v spolupraacuteci s Wolff L z USA)

Proteiacuten c-Myb je jednyacutem z kľuacutečovyacutech bunkovyacutech faktorov ktoreacute suacute zodpovedneacute za spraacutevny priebeh krvotvorby Tento transkripčnyacute faktor maacute nezastuacutepiteľnuacute uacutelohu v regulaacutecii geacutenov priamo riadiacich rast maturaacuteciu a programovanuacute smrť krvnyacutech buniek Funkcia tohoto proteiacutenu musiacute byť priacutesne kontrolovanaacute pretože už malaacute odchyacutelka v jeho aktivite vedie k narušeniu rovnovaacutehy regulačnyacutech procesov naacutesledkom ktoreacuteho je nekontrolovanyacute rast prekurzorovyacutech buniek charakteristickyacute pre rakovinoveacute ochorenie krvi leukeacutemiu V našom laboratoacuteriu sme ako prviacute popiacutesali regulaacuteciu aktivity c-Myb onkoproteiacutenu kovalentnyacutem pripojeniacutem proteiacutenov rodiny SUMO Dokaacutezali sme že v podmienkach optimaacutelneho rastu je aktivita c-Myb-u modulovanaacute vyacutehradne SUMO-1 proteiacutenom zatiaľ čo v podmienkach metabolickeacuteho a genotoxickeacuteho stresu dochaacutedza k jeho okamžitej inaktivaacutecii pripojeniacutem SUMO-2-3 proteiacutenov Odhalenie mechanizmov regulujuacutecich c-Myb otvaacutera noveacute možnosti pre vyacutevoj cielenej terapie zameranej na liečbu naacutedorovyacutech ochoreniacute u ktoryacutech je dokaacutezanaacute zvyacutešenaacute aktivita tohto onkoproteiacutenu (Angl Stress-induced inactivation of the c-Myb oncoprotein) ŠRAMKO M - MARKUS J - KABAacuteT J - WOLFF L - BIES J Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-23 proteins In Journal of Biological Chemistry Vol 281(52) 40065-40075 (2006) (5854-IF2005)

Noveacute environmentaacutelne vhodneacute využitie ligniacutenovyacutech biopolymeacuterov z odpadu chemickeacuteho spracovania dreva pre chemoprevenciu naacutedorovyacutech a genetickyacutech ochoreniacute (APVT 51-032602 Autori Slameňovaacute D Šramkovaacute M Laacutebaj J Košiacutekovaacute B)

Na bunkaacutech izolovanyacutech z myšaciacutech alebo potkaniacutech testes ako aj na ľudskyacutech pečeňovyacutech a črevnyacutech bunkaacutech sme skuacutemali vplyv netoxickej koncentraacutecie biopolymeacuteru ligniacutenu na odolnosť bunkovej DNA voči poškodeniam DNA vyvolanyacutem rocircznymi genotoxiacutenmi Použili sme peroxid vodiacuteka ktoryacute indukuje priame zlomy DNA a oxiduje baacutezy DNA viditeľneacute svetlo ktoreacute v kombinaacutecii s metyleacutenovou modrou oxiduje baacutezy DNA ako aj dve ďalšie laacutetky ktoreacute vyvolaacutevajuacute v DNA najmauml leacutezie labilneacute v alkalickom prostrediacute a to pesticiacuted 12-dibroacutemo-3-chloacuteropropaacuten a liečivo pocircsobiace proti viacuterusu HIV - 3`-azido-3`-dideoxytymidiacuten Komeacutetovyacutem testom sme dokaacutezali že vo vode rozpustnyacute ligniacutenovyacute preparaacutet ziacuteskanyacute frakcionaacuteciou hydrolyzaacutetu dreva chraacuteni DNA tyacutechto buniek voči poruchaacutem DNA vyvolanyacutem uvedenyacutemi agentami Tento jav pozorovanyacute aj po aplikaacutecii ligniacutenu na krvneacute a pečeňoveacute bunky potkanov alebo po jeho podaniacute zvierataacutem z ktoryacutech boli bunky izolovaneacute potvrdzuje ochranneacute protinaacutedoroveacute uacutečinky ligniacutenu (Angl New environmental friendly use of lignin biopolymers from wastes of chemical wood treatment for chemoprevention of cancer and genetic diseases)SLAMEŇOVAacute D - HORVAacuteTHOVAacute E - BARTKOVAacute M Nature of DNA lesions induced in human hepatoma cells human colonic cells and human embryonic lung fibroblasts by the antiretroviral drug 3`- azido-3`deoxythymidine In Mutation Research Fund and Mol Mechanisms of Mutagenesis Vol 593 no 1-2 (2006) p 97-107 ( 3340ndash IF2005)

KOŠIacuteKOVAacute B - LAacuteBAJ J - SLAMEŇOVAacute D - SLAacuteVIKOVAacute E - GREGOROVAacute A Novel environmentally friendly use of lignin biomass component In Biomass and Bioenergy New Research Brenes MD (editor) Nova Science Publishers Inc Hauppauge NY 2006 ISBN 1-59454-865-X p169-200

7

b) aplikačneacuteho typu Detekcia genetickej predispoziacutecie k naacutedorom prsniacuteka a vaječniacutekov na uacuterovni DNA (VEGA - 2621726 Autori Čiernikovaacute S Tomka M Kovaacuteč M Števurkovaacute V Zajac V)Na odporuacutečanie klinickyacutech genetikov sme doteraz analyzovali 130 rodiacuten s podozreniacutem na dedičnuacute formu rakoviny prsniacutekov a vaječniacutekov K odhaleniu zmien v geacutenoch BRCA12 veduacutecich k indukcii ochorenia boli využiteacute naacuteročneacute molekulovo-genetickeacute metoacutedy ako aj vysokocitlivyacute analyzaacutetor DNA zmienndashWAVE System Analyacutezou bolo detekovanyacutech 20 rodiacuten s mutaacuteciou v geacutene BRCA1 a 3 rodiny s mutaacuteciou v geacutene BRCA2 V uvedenom suacutebore sa najčastejšie vyskytovala patogeacutenna varianta c5266dupC ktoraacute je charakteristickaacute pre Aškenaacutezi židovskuacute populaacuteciu Okrem mutaacuteciiacute v geacutenoch BRCA12 sme sledovali aj zmeny v geacutene CHEK2 ktoreacute tiež veduacute k zvyacutešeneacutemu riziku karcinoacutemu prsniacuteka Analyacuteza 115 pacientiek nepotvrdila priacutetomnosť najfrekventovaejšej alteraacutecie (1100delC) avšak identifikovali sme novuacute mutaacuteciu ktoraacute vedie k strate 9 a 10 exoacutenu geacutenu CHEK2 Na zaacuteklade medzinaacuterodnej spolupraacutece sa ukazuje že nami zistenaacute varianta CHEK2 je priacutetomnaacute približne u 2 pacientiek z regioacutenu Čiech a Slovenska Detekcia genetickyacutech zmien v uvedenyacutech geacutenoch umožniacute včasneacute odhalenie predispoziacutecie a naacuteslednyacutem terapeutickyacutem zaacutekrokom prediacutesť vzniku naacutedoru (Angl Detection of genetic predisposition to breast and ovarian cancer on DNA level) WALSH T ndash CASADEI S ndash COATS K ndash SWISHER E - STRAY S ndash HIGGINS J ndash ROACH K ndash MANDELL J ndash LEE M ndash ČIERNIKOVAacute S ndash FORETOVA L ndash SOUCEK P ndash KING M Spectrum of mutations in BRCA1 BRCA2 CHEK2 and TP53 in families at high risk of breast cancer In Journal of American Medical Association Vol295 no12 (2006) p 1379-1388 (23332 ndash IF2005)

ČIERNIKOVAacute S ndash TOMKA M ndash KOVAacuteČ M ndash ŠTEVURKOVAacute V - ZAJAC V Ashkenazi founder BRCA1BRCA2 mutations in Slovak hereditary breast andor ovarian cancer families In Neoplasma Vol53 no2 (2006) p 97-102 (0 731 ndash IF2005)

Mutaacutecie RET proto-onkogeacutenu - ich vyacuteznam v suacutevislosti s vyacuteskytom naacutedorov štiacutetnej žľazy v diagnostike a prevencii naacutedorov štiacutetnej žľazy (VEGA- 2507726 Autori Poturnajova M Altanerovaacute V Altaner Č)

Mnohopočetnaacute endokrinnaacute neoplaacutezia typu 2 (MEN 2) je dedičneacute naacutedoroveacute ochorenie spojeneacute so 100-ne zvyacutešenyacutem vyacuteskytom rakoviny štiacutetnej žľazy Zodpovednyacutem genetickyacutem faktorom suacute mutaacutecie v RET geacutene Rodina s predispoziacuteciou bola vyšetrenaacute na vyacuteskyt mutaacuteciiacute v RET geacutenu Molekulovaacute- genetickaacute analyacuteza odhalila priacutetomnosť dvoch bodovyacutech mutaacuteciiacute Jednu už znaacutemu v kodoacutene 634 a druhu doteraz neznaacutemu v kodoacutene 641 v transmembraacutenovej domeacutene RET geacutenu Novaacute mutaacutecia je unikatnaacute svojiacutem vyacuteskytom aj lokalizaacuteciou Obe mutaacutecie pochaacutedzajuacute od jedneacuteho rodiča a suacute dedičneacute Mutaacutecie neboli naacutejdeneacute u zdravyacutech členov rodiny a u negatiacutevnych kontrol čo je docirckazom toho že novoobjavenaacute zaacutemena v kodoacutene 641 nie je polymorfizmus ale mutaacutecia spojenaacute s MEN 2A syndroacutemom Jedinečnyacute model dvoch mutaacutecii umožňuje sledovať zmeny na molekulovej uacuterovni v naacutedorovyacutech bunkaacutech a tyacutem prispieť k objasneniu mechanizmu vzniku naacutedoru Mutaacutecie v RET geacutene umožňuje skoruacute diagnostiku choroby a uacutespešneacute liečenie pacientov v začiatočnom štaacutediu ochorenia (Angl Mutation of RET proto-oncogene - its implication in connection of thyreoid tumor incidence in diagnostic and prevention of thyreoid gland tumors)POTURNAJOVA M - ALTANEROVA V - KOSTALOVA L - BREZA J - ALTANER C Novel germline mutation in the transmembrane region of RET gene close to Cys634Ser mutation associated with MEN 2A syndrome Journal of Molecular Medicine Vol 83 no 4 (2005) p287-295 (4256 ndash IF2004)

8

c) medzinaacuterodnyacutech vedeckyacutech projektov

Incidencia naacutedorov štiacutetnej žľazy u detiacute a adolescentov a ich prežiacutevanie v Euroacutepe v rokoch 1978-1997 (Medzinaacuterodnyacute projekt ACCIS Programme-Automated Chilldhood Cancer Information System Autor zo SR Pleško I)

Cieľom projektu bolo zistiť incidenciu naacutedorov štiacutetnej žľazy u detiacute a porovnať ich prežiacutevanie medzi jednotlivyacutemi euroacutepskymi krajinami Dĺžka prežiacutevania je indikaacutetorom kvality poskytovanej liečby Incidencia je pomerne niacutezka oproti inyacutem typom naacutedorovyacutech ochoreniacute a prežiacutevanie je pomerne dobreacute avšak variacuteruje medzi jednotlivyacutemi krajinami Prežiacutevanie pacientov s tyacutemto ochoreniacutem na Slovensku dosahuje euroacutepsky štandard Vyacuteskum poukaacutezal aj na to že iodizaacutecia soli pozitiacutevne ovplyvňuje patogeneacutezu ochorenia tyacutem že sa meniacute pomer naacutedorov nediferencovaneacuteho typu ktoreacute majuacute horšiu prognoacutezu a naacutedorov diferencovanyacutech ktoreacute majuacute lepšiu prognoacutezu (Angl Thyroid cancer incidence and survival among European children and adolescents in period of 1978-1997)

1 STELIAROVA-FOUCHER E - STILLER CA - PUKKALA E - LACOUR B - PLESKO I - PARKIN DM Thyroid cancer incidence and survival among European children and adolescents (1978-1997) report from the Automated Childhood Cancer Information System project In European Journal of Cancer Vol 42 no 13 (2006) p 2150-2169 (3706-IF2005)

9

3 Vedeckyacute vyacutestup (bibliografickeacute uacutedaje vyacutestupov suacute v Priacutelohe č 3)

PUBLIKAČNAacute PREDNAacuteŠKOVAacute A EDIČNAacute ČINNOSŤ Počet v r 2006 a doplnky z r 2005

1 Vedeckeacute monografie vydaneacute doma 0

2 Vedeckeacute monografie vydaneacute v zahraničiacute 0

3 Knižneacute odborneacute publikaacutecie vydaneacute doma 04 Knižneacute odborneacute publikaacutecie vydaneacute v zahraničiacute 0

5 Kapitoly v publikaacuteciaacutech ad 1 v monografiaacutech vydanyacutech doma 1

6 Kapitoly v publikaacuteciaacutech ad 2 v monografiaacutech vydanyacutech v zahraničiacute 17 Kapitoly v publikaacuteciaacutech ad 3 v knižnyacutech odbornyacutech publikaacuteciaacutech v zahraničiacute 2

8 Kapitoly v publikaacuteciaacutech ad 4 0

9 Vedeckeacute praacutece v časopisoch evidovanyacutech

a v Current Contents

b v inyacutech medzinaacuterodnyacutech databaacutezach

54

110 Vedeckeacute praacutece v ostatnyacutech časopisoch 14

11 Vedeckeacute praacutece v zborniacutekoch (konferenčnyacutech aj nekonferenčnyacutech vydanyacutech tlačou alebo na CD)

a recenzovanyacutech

b nerecenzovanyacutech

0

12 Vedeckeacute praacutece v zborniacutekoch rozšiacuterenyacutech abstraktov 5

13 Recenzie vedeckyacutech praacutec vo vedeckyacutech časopisoch 1 (doplnok z 2005)

14 Prednaacutešky a vyacutevesky na vedeckyacutech podujatiach s min 30 zahraničnou uacutečasťou

104

15 Ostatneacute prednaacutešky a vyacutevesky 50

16 Vydaacutevaneacute periodikaacute evidovaneacute v Current Contents 1

17 Ostatneacute vydaacutevaneacute periodikaacute 0

18 Vydaneacute alebo editovaneacute zborniacuteky z vedeckyacutech podujatiacute 2

19 Vysokoškolskeacute učebnice a učebneacute texty 0

20 Vedeckeacute praacutece uverejneneacute na internete

a v cudzom jazyku

b v slovenčine

0

21 Preklady vedeckyacutech a odbornyacutech textov 0

Publikaacutecia prinaacuteša noveacute vedeckeacute poznatky alebo sa opiera o vedeckeacute praacutece

10

4 Vedeckeacute recenzie oponentuacutery

Vyžiadaneacute recenzie rukopisov monografiiacute a vedeckyacutech praacutec v zahraničnyacutech časopisoch priacutespevkov na konferencie s medzinaacuterodnou uacutečasťou oponovanie grantovyacutech projektov

Počet v r 2006 a doplnok z r 2005

60

5 Ohlasy

CITAacuteCIE Počet v r 2005 Doplnok za r 2004

Citaacutecie vo WOS 427 -

Citaacutecie podľa inyacutech indexov a baacutez napr SCOPUS

s uvedeniacutem prameňa15 -

Citaacutecie v monografiaacutech učebniciach a inyacutech publikaacuteciaacutech 4 -

Pozn Suacute uvedeneacute len tie praacutece ktoryacutech aspoň jeden autor je spolu s adresou pracoviska uvedenyacute v autorskom kolektiacuteve (tyacuteka sa aj autorov uvedenyacutech pod čiarou ndash on leave etc) Neuvaacutedzajuacute sa autocitaacutecie

Zoznam pozvanyacutech priacutespevkov na medzinaacuterodnyacutech konferenciaacutech

1 ALTANER C Normal and cancer stem cells Potential implication for cancer therapy In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 16 (R)

2 BARTOSOVA Z - FRIDRICHOVA I Advances in molecular diagnostics of hereditary non-polyposis colorectal cancer in Slovakia In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 10 (R)

3 BIES J - SRAMKO M - MARKUS J WOLFF L Leukemogenesis and c-myb Story of a tightly regulated transcriptional regulator (prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 3 (R)

4 BIZIK J - BABUSIKOVA O - KANKURI E Nemosis - prospective cell based therapy In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 12-13 (R)

11

5 BODO J - CHOVANCOVA J - SULIKOVA M - JAKUBIKOVA J - SEDLAK J Isothiocyanate E-4IB induced MAPK activation delayed transition through cell cycle and G2M-linked apoptosis (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 22 (R)

6 BUJALKOVA M - WOLF B - KRIVULCIK T - DE WIND N - JIRICNY J - BARTOSOVA Z Development of SNP based method for directed HNPCC mutation screening (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 23

7 CIERNIKOVA S - TOMKA M - KOVAC M - STEVURKOVA V - BELLA V - KLEIBL Z - ZAJAC V Mutation screening of BRCA1 BRCA2 and CHEK2 in Slovak HBOC families (pozvanaacute prednaacuteška) Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 p 24 (R)

8 DUDASOVA Z - WARD T A ndash MC HUGH P J - CHOVANEC M The yeast Snm1Pso2 protein and its possible interactions (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 12-13 (R)

9 GURSKY J - RYBANSKA I - HALL H - SALAZAR EP - NICODEMOU A - KIMLICKOVA E - KLEIBLK - THOMPSON LH - PIRSEL M Repair of oxidative DNA damage in the helicase mutants (prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 5-6 (R)

10 JAKUBIKOVA J - CHOLUJOVA D - SEDLAK J Modulation of human monocyte-derived dendritic cell maturation by BioBran (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 28 (R)

11 KOVAC M - TOMKA M - CIERNIKOVA S - STEVURKOVA V - ZAJAC V APC gene mutations may clinically mimic Lynch syndrome (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 31 (R)

12 KUCEROVA L - MATUSKOVA M - ALTANEROVA V - TYCIAKOVA S - ALTANER C Retrovirus Transduced Mesenchymal Stem Cells Exert Strong Antitumor Effect (prenaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 17 (R)

12

13 LETAVAYOVA L - MARKOVA E - VLASAKOVA D - VLCKOVA V - HERMANSKA K - BROZMANOVA J - CHOVANEC M Cellular response to oxidative DNA damage in Saccharomyces cerevisiae In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 12-13 (R)

14 SEDLAK J - BODO J - JAKUBIKOVA J A possible role of dietary chemopreventive compounds in tumor therapy In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 15 (R)

15 SRAMKO M - MARKUS J - KABAT J - WOLFF L - BIES J Stress-induced inactivation of transcription factor c-Myb through conjugation of SUMO-23 proteins (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 34 (R)

16 VAN HOUTEN B - CROTEAU DL - WANG H - DELLAVECCHIA MJ - BIENSTOCK R - KISKER C - SKORVAGA M In search of damage structure - function studies of nucleotide excision repair proteins In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 4 (R)

17 ZAJAC V - MEGO M - KOVAC M - CIERNIKOVA S - STEVURKOVA V - MARTINICKYacute D FAP and HBOC Two players in one playground n Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 9 (R)

18 GURSKAacute S ndash FARKAŠOVAacute T ndash GAacuteBELOVAacute A Vplyv polymorfizmu v geacutene hOGG1 na opravu oxidačnyacutech poškodeniacute DNA (vyžiadanaacute prednaacuteška) 29 pracovniacute dny Českeacute a Slovenskeacute společnosti pro mutagenezu zevniacutem prostřediacutem Československeacute biologickeacute společnosti 2 ndash 4maacutej 2006 Brno Českaacute Republika Zborniacutek ISBN 80-7013-438-0 p 25

19 MARKOVA E - ALTANEROVA V - HILLERT L - MALMGREEN L ndash PERSON B - BELYAEV I ldquoAdverse effects of microwaves from GSMUMTS mobile phones on human primary lymphocytes fibroblast and stem cellsrdquo European Social Forum Seminar on Mobile telephony and Public Health Athens Greece May 5-8 2006 publikovaneacute na webovej straacutenke European Social forum httpmedia2bioluoagreuropean-social-forumhtm

20 PLEŠKO I First results of Pilot study ndash EUROCHIP project in Slovakia Workshop EUROCHIP projectldquo ndash Milano Italia 14-1592006 Taliansko 2006

21 PLEŠKO I EUROCHIP project in Slovakia ndash problems and results Workshop EUROCHIP pilot studies Amalfi Italia 14-1662006 Taliansko 2006

22 PLEŠKO I Collection and analysis of cancer mortality data in Slovakia Plenary meeting of contributiors to bdquoAtlas of Cancer Mortality in Europe Lyon France 9-1252006 Francuacutezsko 2006

13

Zoznam inyacutech vyacuteznamnyacutech ohlasov

BARTOŠOVAacute Z Vyžiadanaacute recenzia vedeckeacuteho člaacutenku pre redakciu časopisu Human Molecular Genetics (IF2005 ndash 7764)

6 Patentovaacute a licenčnaacute činnosť

Uacutestav nemal takuacuteto činnosť

7 Komentaacutere k vedeckeacutemu vyacutestupu a ineacute docircležiteacute informaacutecie k vedeckyacutem aktivitaacutem pracoviska

Traja terajšiacute pracovniacuteci uacutestavu (Slameňovaacute D Chovanec M Dudaacutešovaacute Z) sa stali spoluautormi kapitol v knižnyacutech publikaacuteciaacutech vydanyacutech v USA Spolu vyšlo 54 vedeckyacutech praacutec evidovanyacutech v Current Contents čo je o 7 praacutec viac ako v minulom roku Z toho 39 praacutec bolo publikovanyacutech v zahraničnyacutech karentovanyacutech časopisoch Najvyššiacute dosiahnutyacute impakt faktor časopisu bol 23494 (JAMA-Journal of American Medical Association) v ktorom publikovala mladaacute vedeckaacute pracovniacutečka S Čiernikovaacute

Tri praacutece boli publikovaneacute v novyacutech zahraničnyacutech časopisoch ktoreacute zatiaľ nie suacute karentovaneacute ale suacute vyacuteznamnyacutem zdrojom vedeckyacutech informaacuteciiacute Ďalšiacutech 12 praacutec bolo publikovanyacutech v domaacutecich (resp česko-slovenskyacutech) nekarentovanyacutech časopisoch lekaacuterskeho charakteru (napr Klinickaacute onkologie Lekaacuterske listy Onkoloacutegia Internaacute mediciacutena) Tieto publikaacutecie suacute vyacuteznamneacute z hľadiska udržiavania a ďalšieho rozvoja spolupraacutece s klinickyacutemi pracoviskami ako aj z hľadiska prenosu poznatkov zo zaacutekladneacuteho vyacuteskumu do povedomia lekaacuterskej komunity

Na vedeckyacutech podujatiach s medzinaacuterodnou uacutečasťou bolo odprezentovanyacutech 104 priacutespevkov vo forme prednaacutešok alebo posterov čo je o 22 priacutespevkov viac ako v minulom roku Tento naacuterast bol podmienenyacute aj vysokou uacutečasťou pracovniacutekov uacutestavu na medzinaacuterodnej konferencii bdquoCancer2006 From molecular biology processes to tumor-tailored therapyldquo ktoruacute uacutestav organizoval v tomto roku Zvyacutešil sa aj počet ostatnyacutech prednaacutešok a vyacutevesiek až o 33

Potešiteľnyacute je aj aspoň mierny naacuterast citaacuteciiacute praacutec z 411 v roku 2004 na 447 v roku 2005 Uacutestav vydal dva zborniacuteky z vedeckyacutech podujatiacute a pokračuje vo vydaacutevaniacute periodika Neoplasma evidovaneacuteho v Current Contents

Okrem publikačnyacutech vyacutestupov maacute uacutestav aj klinickeacute vyacutestupy vo forme naacuteročnyacutech diagnostickyacutech vyšetreniacute ktoreacute často nie suacute publikovateľneacute v karentovanyacutech časopisoch resp vysoko-impaktovyacutech časopisoch Takyacutechto vyacutestupov bolo v roku 2006 celkom 863

Posilňujuacuteca orientaacutecia na translačnyacute vyacuteskum ktoraacute je v suacutelade s celosvetovyacutem trendom vyžaduje čas na zavaacutedzanie novyacutech metodiacutek a prehlbovanie spolupraacutece s klinickyacutemi pracoviskami čo sa neprejavuje bezprostredne publikačnyacutemi vyacutestupmi ale je docircležiteacute pre ďalšie pokroky v prevencii diagnostike a liečbe naacutedorovyacutech ochoreniacute

14

II Vedeckaacute vyacutechova a pedagogickaacute činnosť

Uacutedaje o doktorandskom štuacutediu

Forma Počet k 31122006 Počet ukončenyacutech doktorantuacuter v r 2006

Doktorandi Ukončenie z docircvodov

celkovyacute počet

z toho novoprijatiacute

uacutespešnou obhajobou

M Ž M Ž M Ž

uplynutiacutem času určeneacuteho na štuacutedium

neobhaacutejeniacutem dizertačnej praacutece alebo neudeleniacutem vedeckej hodnosti

rodinnyacutech zdravotnyacutech a inyacutech resp bez udania docircvodu

nevykonania odbornej skuacutešky

Dennaacute 2 8 0 5 2 5 3 0 2 a 1 prerušila

0

Externaacute 1 0 0 0 1 3 0 0 0 0

Prehľad uacutedajov o doktorandoch ktoriacute ukončili doktorandskeacute štuacutedium uacutespešnou obhajobouMeno doktoranda Forma

DŠMesiac rok naacutestupu na DŠ

Mesiac rok obhajoby

Čiacuteslo a naacutezov vedneacuteho odboru

Meno a organizaacutecia školiteľa

Fakulta udeľujuacuteca vedeckuacute hodnosť

Mgr Gabriela Kirschnerovaacute

externaacute 062001 12006 15-14-9onkoloacutegia

Babušiacutekovaacute O MUDr DrScUacuteEO SAV

LF UK Bratislava

MUDr MichalMego


Zajac V RNDrCScUacuteEO SAV

LF UK Bratislava

Ing Juraj Boďo dennaacute 102002 62006 15-14-9 onkoloacutegia

Sedlaacutek J RNDr CSc UacuteEO SAV

LF UK Bratislava

RNDr Andrea Pastoraacutekovaacute

dennaacute 122000 102006 15-14-9 onkoloacutegia

Altaner Č Doc Ing DrSc UacuteEO SAV

LF UK Bratislava

RNDr Zdenka Krajčovičovaacute


Gaacutebelovaacute A RNDr CScUacuteEO SAV

LF UK Bratislava

MUDr Slaacutevka Lukaacutečovaacute

externaacute 062001 102006 15-14-9 onkoloacutegia

Ujhaacutezy V MUDr DrSc UacuteEO SAV

LF UK Bratislava

RNDr Soňa Čiernikovaacute

dennaacute 102002 12006 15-03-9 genetika


PriF UK Bratislava

Mgr DanielaKošťanovaacute-Poliakovaacute


Šabovaacute Ľ RNDr CSc UacuteEO SAV

PriF UK Bratislava

Mgr Michal Kovaacuteč dennaacute 092001 92006 15-03-9 genetika


PriF UK Bratislava

RNDr Monika Šramkovaacute


Slameňovaacute D RNDr DrSc UacuteEO SAV

PriF UK Bratislava

RNDr Martina Ondrušovaacute

externaacute 092001 12006 51-06-9 epidemioloacutegia

Pleško I MUDr DrScUacuteEO SAV

LF UK Bratislava

15

Uacutedaje o pedagogickej činnosti

PEDAGOGICKAacute Prednaacutešky Cvičenia

ČINNOSŤ doma v zahraničiacute doma v zahraničiacute

Počet prednaacutešateľov alebo veduacutecich cvičeniacute

8 1 14 0

Celkovyacute počet hodiacuten v r 2006 57 1 80685 0

ndash vraacutetane seminaacuterov vedenyacutech alebo konzultovanyacutech bakalaacuterskychdiplomovyacutech praacutec a dizertačnyacutech praacutec doktorandov prijatyacutech podľa noveacuteho vysokoškolskeacuteho zaacutekona ktoriacute suacute tyacutemto študentmi Univerzity Komenskeacuteho

ndash nie suacute uvaacutedzaniacute pracovniacuteci ktoriacute suacute na dlhodobyacutech staacutežach na univerzitaacutech

Prehľad prednaacutešateľov predmetov a veduacutecich cvičeniacute s uvedeniacutem naacutezvu predmetu uacutevaumlzku katedry a vysokej školy je uvedenyacute v Priacutelohe č 4

1 Počet pracovniacutekov ktoriacute pocircsobili ako veduacuteci alebo konzultanti diplomovyacutech praacutec 12

2 Počet vedenyacutech alebo konzultovanyacutech diplomovyacutech praacutec 15

3 Počet pracovniacutekov ktoriacute pocircsobili ako školitelia doktorandov (PhD) 12

4 Počet oponovanyacutech dizertačnyacutech a habilitačnyacutech praacutec 6

5 Počet pracovniacutekov ktoriacute oponovali dizertačneacute a habilitačneacute praacutece 5

6 Počet pracovniacutekov ktoriacute pocircsobili ako členovia komisiiacute pre obhajoby doktorandskyacutech dizertačnyacutech praacutec 6

7 Počet pracovniacutekov ktoriacute pocircsobili ako členovia komisiiacute pre obhajoby doktorskyacutech dizertačnyacutech praacutec 4

8Počet pracovniacutekov ktoriacute pocircsobili ako členovia komisiiacute resp oponenti v inauguračnom alebo habilitačnom konaniacute na vysokyacutech školaacutech

1

16

Mennyacute prehľad pracovniacutekov ktoriacute boli menovaniacute do spoločnyacutech odborovyacutech komisiiacute pre doktorandskeacute štuacutedium

Mennyacute prehľad pracovniacutekov ktoriacute pocircsobili ako členovia vedeckyacutech raacuted fakuacutelt a vysokyacutech škocircl

Mennyacute prehľad pracovniacutekov ktoriacute ziacuteskali vyššiu vedeckuacute pedagogickuacute hodnosť alebo vyššiacute kvalifikačnyacute stupeň (s uvedeniacutem hodnostistupňa)

1 Babušiacutekovaacute O (LF UK)Novotnyacute L (predseda Faculty Council Faculty of Pharmacy Kuwait University)

Čipaacutek L (IIA)

2 Gaacutebelovaacute A (PriF UK) Novotnyacute L (člen University Council Kuwait University) Boďo J (PhD)

3 Luciakovaacute K (PriF UK) Čiernikovaacute S (PhD)

4 Piršel M (PriF UK UPJŠ) Kirschnerovaacute G (PhD)

5 Pleško I (LF UK) Košťanovaacute-Poliakovaacute D (PhD)

6 Zajac V (PriF UK) Kovaacuteč M (PhD)

Krajčovičovaacute Z (PhD)

Pastoraacutekovaacute A (PhD)

Šramkovaacute M (PhD)

Ineacute docircležiteacute informaacutecie k pedagogickej činnostiZrušenie vyhlaacutešky MŠ SR č 1311997 Zz o doktorandskom štuacutediu a absencia novej

vyhlaacutešky MŠ SR o doktorandskom štuacutediu ktoraacute by nadvaumlzovala na novyacute zaacutekon č 1312002 Zz o vysokyacutech školaacutech spocircsobuje naďalej chaos v organizovaniacute doktorandskeacuteho štuacutedia a to predovšetkyacutem na akreditovanyacutech externyacutech vzdelaacutevaciacutech inštituacuteciaacutech Presun celej administratiacutevy na vysokeacute školy spocircsobuje duplicitneacute vedenie agendy na školaacutech a externyacutech vzdelaacutevaciacutech inštituacuteciaacutech Doktorandi ako tomu bolo aj v predošlyacutech rokoch zostali administratiacutevne a legislatiacutevne nedoriešeniacute Skutočnosť že každaacute vysokaacute škola maacute svoje vlastneacute kriteacuteriaacute kreditoveacuteho hodnotenia doktorandov a každaacute externaacute vzdelaacutevacia inštituacutecia maacute s nimi uzavreteacute ineacute individuaacutelne dohody vedie k ťažko vzaacutejomne porovnateľnyacutem hodnoteniam doktorandov dokonca aj v tom istom vednom odbore

Za pozitiacutevum možno hodnotiť skutočnosť že sa doplnkovyacutem akreditačnyacutem konaniacutem zjednotila dĺžka doktorandskeacuteho štuacutedia v odbore Onkoloacutegia a odbore Genetika na priacuteslušnyacutech vysokyacutech školaacutech a UacuteEO SAV na 4 roky a to so spaumltnou platnosťou od školskeacuteho roku 20052006 Rovnako došlo ku kompromisnej dohode medzi VŠ (PRIF UK) a externyacutemi vzdelaacutevaciacutemi inštituacuteciami v kreditovom hodnoteniacute doktorandov Oceňujeme uacutestretovosť a tolerantnosť VŠ pri riešeniacute administratiacutevnych probleacutemov Hodnotenie študentov III stupňa vysokoškolskeacuteho vzdelaacutevania kreditovyacutem systeacutemom považujeme za nevhodneacute

17

III Medzinaacuterodnaacute vedeckaacute spolupraacuteca

1 Medzinaacuterodneacute projekty

DRUH PROJEKTU Počet projektov Prideleneacute financie na

rok 2006

(prepočiacutetaneacute na Sk)

A


B

organizaacutecia sa podieľa na

riešeniacute projektu

A B

1 Projekty 5 raacutemcoveacuteho programu EUacute (iba projekty riešeneacute v roku 2006 neuvaacutedzať projekty ktoreacute suacute už ukončeneacute)

- - - -

2 Projekty 6 raacutemcoveacuteho programu EUacute (neuvaacutedzať projekty ukončeneacute pred r 2006)

- 2 - 0

3 Multilateraacutelne projekty v raacutemci vedeckyacutech programov COST INTAS EUREKA ESPIRIT PHARE NATO UNESCO CERN IAEA ESF (European Science Foundation) a ineacute

- 2 - 20 000

4 Projekty v raacutemci medzivlaacutednych dohocircd o vedecko-technickej spolupraacuteci (Greacutecko ČR Nemecko a ineacute)

- - - -

5 Ineacute projekty financovaneacute zo zahraničnyacutech zdrojov 1 - 1 295 358 -

6 Bilateraacutelne projekty 1 - 617 849 - Koordinaacutetor alebo analogicky ako pri tabuľke II 1

Uacutespešnosť v ziacuteskavaniacute projektov 6 RP EUacute počet akceptovanyacutech resp financovanyacutech projektovpočet podanyacutech naacutevrhov akceptovaneacute 2 z piatich podanyacutech

Uacutedaje k projektom suacute v Priacutelohe č 2

18

2 Najvyacuteznamnejšie priacutenosy MVTS uacutestavu vyplyacutevajuacutece z uskutočnenej mobility a riešenia medzinaacuterodnyacutech projektov

a najvyacuteznamnejšie priacutenosy MVTS vyplyacutevajuacutece z uskutočnenej mobility

1) Prof L Novotnyacute je na dlhodobom pobyte na Department of Pharmaceutical Chemistry Faculty of Pharmacy Kuwait University Kuwait Spolupracuje naďalej s uacutestavom najmauml s Dr P Raukom v oblasti uacutečinku triterpenoidov na bunky a potenciaacutecie uacutečinku niektoryacutech chemoterapeutickyacutech laacutetok inhibiacutetorom ribonukleotid reduktaacutezy trimidoxomSpoločneacute publikaacutecie 2 Pracovnyacute pobyt 365 dniacute (Novotnyacute L)

2) Dr J Hlavatyacute je na dlhodobom pobyte na Research Institute of Virology and Biomedicine University of Veterinary Medicine A-1210 Viedeň Rakuacutesko Zaoberaacute sa priacutepravou retroviacuterusovyacutech vektorov pre geacutenovuacute terapiuPracovnyacute pobyt 365 dniacute (Hlavatyacute J)

3) Dr V Frecer je na dlhodobom pobyte v International Centre for Science and High Technology UNIDO Terst Taliansko Zaoberaacute sa otaacutezkami teoretickeacuteho dizajnu synteacutezy a testovania biologickej uacutečinnosti antiviraacutelnych antimikrobiaacutelnych a antikancerogeacutennych laacutetok - inhibiacutetorov aspartickyacutech proteaacutez metalloproteaacutez a onkoproteiacutenu MycPublikaacutecie 2 Prednaacutešky a vyacutevesky2Pracovnyacute pobyt 365 dniacute (Frecer V)

4) Dr J Bies je na dlhodobom pracovnom pobyte u Prof L Wolff z Laboratory of Cellular Oncology National Cancer Institute Bethesda USA Zaoberaacute sa štuacutediaom uacutelohy post-translačnyacutech modifikaacutecii transkripčneacuteho faktora c-Myb pri regulaacutecii jeho proteolytickej stability Spolupraacuteca vyacuteznamne prispieva k riešeniu VEGA grantu bdquoŠtuacutedium post-translačnej modifikaacutecie onkoproteiacutenu c-Myb kovalentnou SUMO-23 proteiacutenovldquoSpoločneacute publikaacutecie 1Spoločneacute prednaacutešky a vyacutevesky 4Pracovneacute pobyty 365 dniacute

5) Dr J Markus je na postdoktorandskom pobyte u Prof L Wolff z Laboratory of Cellular Oncology National Cancer Institute Bethesda USA Zaoberaacute sa štuacutediaom uacutelohy post-translačnyacutech modifikaacutecii transkripčneacuteho faktora c-Myb pri regulaacutecii jeho proteolytickej stability Spolupraacuteca vyacuteznamne prispieva k riešeniu VEGA grantu bdquoŠtuacutedium post-translačnej modifikaacutecie onkoproteiacutenu c-Myb kovalentnou SUMO-23 proteiacutenovldquoSpoločneacute publikaacutecie 1Spoločneacute prednaacutešky a vyacutevesky 4Štuacutedijnyacute pobyt 365 dniacute

6) Dr P Kuacutedela je na postdoktorandskom pobyte na University of Pittsburgh Cancer Institute Department of Medicine Division of HematologyOncology Pittsburgh USA Charakterizujuacute sa dendritoveacute bunky a prezentaacutecia naacutedorovo asociovanyacutech antigeacutenovŠtuacutedijnyacute pobyt 365 Publikaacutecie 1

19

7) Dr M Tomka bol na postdoktorandskom pobyte na Department of Biochemistry and Molecular Genetics university of Virginia Charlottsville Virginia USA Riešila sa novaacute problematika regulaacutecie chromozomaacutelnej replikaacutecie DNA a genetickej instability v naacutedoroch na cicavčom systeacuteme Pracovnyacute pobyt 230 dniacute

8) Spolupraacuteca Dr J Biziacuteka s Dr E Kankuri z Department of Virology University of Helsinki Fiacutensko sa tyacuteka štuacutedia molekulaacuternych mechanizmov nekroacutezy a jeho patofyziologic-kyacutech aspektov Vyacuteznamne prispieva k riešeniu VEGA grantu bdquoBiologickeacute a molekulaacuterne aspekty v progresii ľudskyacutech melanoacutemov Sledovanie vplyvu nesteroidnyacutech protizaacutepalovyacutech laacutetok na invaziacutevnosť naacutedorovyacutech buniek pomocou trojrozmerneacuteho organotypickeacuteho kultivačneacuteho systeacutemuldquoSpoločneacute publikaacutecie 1 Spoločneacute prednaacutešky1Pracovnyacute pobyt 61 dniacute

9) Spolupraacuteca Dr E Markovej s Dr I Belyaevom z Department of Genetics Microbiology and Toxicology Stockholm University Stockholm Šveacutedsko rieši sa projekt bdquoBiochemical markers in lymphocytes for evaluation of individual sensitivity to radiationsldquo Taacuteto spolupraacuteca vyacuteznamne prispieva k riešeniu VEGA grantu bdquoUplatnenie citlivyacutech metoacuted na predikciu citlivosti k radiaacutecii v terapii rakoviny naacutedorov prsniacutekaldquo (zodpovednaacute riešiteľka Markovaacute E)Spoločneacute publikaacutecie 1 prijataacuteSpoločneacute prednaacutešky a vyacutevesky 4Pracovnyacute pobyt 30 dniacute

10) Mgr Z Dudaacutešovaacute bola na štuacutedijnom pobyte u Dr PJ McHugha The Weatherall Institute of Molecular Medicine University of Oxford vo Veľkej Britaacutenii Riešila sa charakterizaacutecia kvasinkovyacutech SNM1PSO2 proteiacutenov a ich potenciaacutelne interakcieSpoločneacute prednaacutešky a vyacutevesky 1Pracovnyacute pobyt 28 dniacute

11) Doc I Pleško spolupracuje s Dr Andrea Michelim z Naacuterodnyacute onkologickyacute uacutestav pre vyacuteskum a liečbu zhubnyacutech naacutedorov v Milaacutene ndash (Istituto Nazionale per lo Studio e la Cura dei Tumori Milano Italy) ktoryacute je koordinaacutetorom spoločneacuteho projektu v 6 Raacutemcovom programe EUacute Riešenie medzinaacuterodnyacutech projektov zvyacuteraznilo existenciu a vysokuacute uacuteroveň uacutedajov o evidencii diagnostike a liečbe onkologickyacutech ochoreniacute v SRPrednaacutešky 2Pracovnaacute porada 7 dniacute

12) Ing K Luciakovaacute spolupracuje s Dr B Nelsonom z Department of Biochemistry and Biophysics Arrhenius Laboratories University of Stockholm Šveacutedsko Spolupraacuteca sa tyacuteka najmauml využitia hmotnostneacuteho spektrometra na sekvenovanie bielkoviacutenSpoločneacute publikaacutecie v priacutepravePracovnyacute pobyt 7 dniacute

13) Dr P Baraacuteth spolupracuje s Equipe Information et Programmation Cellulaire Universite de Rennes I Francuacutezsko Spolupraacuteca je zameranaacute na purifikaacuteciu in vitro exprimovanyacutech bielkoviacuten z veľkeacuteho množstva za uacutečelom priacutepravy protilaacutetok Spoločnyacute projekt 6RP

20

Pracovnaacute porada 3 dni

14) Doc I Pleško spolupracuje s Dr Evou Kramaacuterovou-Foucher z Medzinaacuterodnej agentuacutery pre vyacuteskum rakoviny v Lyone (WHO) Riešenie medzinaacuterodnyacutech projektov zvyacuteraznilo existenciu a vysokuacute uacuteroveň uacutedajov o evidencii diagnostike a liečbe onkologickyacutech ochoreniacute v SRSpoločnyacute projekt Automatickyacute systeacutem registraacutecie zhubnyacutech naacutedorov v detskom veku Spoločneacute publikaacutecie 1Pracovnaacute porada 3 dni

3 Členstvo a funkcie v medzinaacuterodnyacutech vedeckyacutech spoločnostiach uacuteniaacutech a naacuterodnyacutech komiteacutetoch SR

UacuteEO SAV Staacutele členstvo v Organizaacutecia Euroacutepskych onkologickyacutech uacutestavov (OECI) staacutele členstvo v bdquoNCI Information Associates Programldquo zahŕňa suacutečasne poplatok za časopis Journal of the National Cancer Institute realizaacutetor ndash National Institute of Health National Cancer Institute Bethesda Maryland

Altaner Č člen bdquoWorld Committee of International Association for Comparative Research on Leukemia and Related Diseasesldquozaacutestupca Slovenskeacuteho onkologickeacuteho centra v OECI (Organizaacutecia Euroacutepskych onkologickyacutech uacutestavov)člen Vedeckej rady Euroacutepskej onkologickej školy (ESO)expert pre vyacuteskumneacute zaacutemery v onkoloacutegii MZ a MŠ ČR

Biacutezik J Councillor naacuterodnej vetvy EACRčlen Union Internationale contre le Cancer (UICC)

Gaacutebelovaacute A pokladniacutečka slovenskej sekcie EACRčlenka Vyacuteboru Českej a Slovenskej spoločnosti pre mutageneacutezu vonkajšiacutem prostrediacutemCouncillor naacuterodnej vetvy EEMS (do maacuteja 2006)členka European Society of Toxicology (Eurotox)

Ujhaacutezy V člen naacuterodneacuteho komiteacutetu SRčlen Euroacutepskej Akadeacutemie Vied a Umeniacute Salzburgčestnyacute člen Union Internationale contre le Cancer (UICC)

Pleško I člen Medzinaacuterodnej asociaacutecie onkologickyacutech registrov (IACR)člen European National Cancer Registries (ENCR)člen European Institute of Ecology and Cancer člen World Institute of Ecology and Cancer California USASenior research associate of European Institute of Oncology Milano Taliansko člen Research Board of Advisors of the American Biographical Institute (USA)

21

auditor pre posudzovanie uacuterovne populačnyacutech onkologickyacutech registrov ndashv Euroacutepe v raacutemci ENCR

Polaacutekovaacute K členka European Science Foundation Standing Commitee European Medical Research Council (EMRC)

Novotnyacute L člen Kuwait Pharmaceutical Association

čestnyacute člen Pharmaceutical Society of Egypt

Slameňovaacute D členka European Society of Toxicology (Eurotox)

Bartošovaacute Z International Society for Gastrointestinal Hereditary Tumours

Sirackyacute J International Academy of Cytology (USA)

Sedlaacutek J International Society of Analytical Cytology

Luciakovaacute K American Society for Biochemistry and Molecular Biology

Čipaacutek Ľ The American Association for the Advancement of Science

FEBS členovia

Kleibl K Piršel M Gurskyacute J Škorvaga M Gurskaacute S Laacutebaj J Čipaacutek Ľ

European Environmental Mutagen Society (EEMS) členovia

Farkašovaacute T Gurskaacute S Gaacutebelovaacute A Horvaacutethovaacute E Slameňovaacute D

European Association for Cancer Research (EACR) členovia

Altaner Č Babušiacutekovaacute O Biacutezik J Duraj J Frecer V Fridrichovaacute I Gaacutebelovaacute A Hlavatyacute J Horvaacutethovaacute E Hunaacutekovaacute Ľ Jakubiacutekovaacute J Kuacutedela P Novotnyacute L Pleško I Sedlaacutek J Slameňovaacute D Ujhaacutezy V Zajac V

4 Členstvo v redakčnyacutech radaacutech časopisov v zahraničiacute

Altaner Č Viral Immunology USAJournal of Experimental and Clinical Cancer Research TalianskoExperimental Pathology and Parasitology Bulharskaacute akadeacutemia viedFolia Biologica Praha ČRNowotwory Poľsko

Babušiacutekovaacute O Klinickaacute onkologie Brno ČR

22

Novotnyacute L Medical Principles and Practice Kuvajt

Pleško I Klinickaacute onkologie Brno ČRMedicine Biology and Environment Taliansko

Sirackyacute J Acta Cytologica USAKlinickaacute onkologie Brno ČR

Ujhaacutezy V Klinickaacute onkologie Brno ČR

5 Medzinaacuterodneacute vedeckeacute podujatia ktoreacute uacutestav organizoval alebo sa na ich organizaacutecii podieľal s vyhodnoteniacutem vedeckeacuteho a spoločenskeacuteho priacutenosu podujatia Do tejto kategoacuterii patria podujatia s aspoň 30 zahraničnyacutech uacutečastniacutekov

1) Uacutestav organizoval medzinaacuterodnuacute konferenciu bdquoCancer2006 From molecular biology processes to tumor - tailored therapyrdquo pri priacuteležitosti 60-teho vyacuteročia svojho vzniku Konferencia sa konala 20-24 augusta v kongresovom centre ACADEMIA vo Vysokyacutech Tatraacutech v Starej Lesnej Na podujatiacute sa zuacutečastnilo celkom 89 uacutečastniacutekov z 13 štaacutetov celeacuteho sveta (43 zahraničnyacutech uacutečastniacutekov)

Vedeckyacute priacutenos širšiacute zaacuteber konferencie odraacutežal komplexnosť molekulaacuterno-biologickyacutech procesov zahrnutyacutech v maliacutegnej transformaacutecii normaacutelnej bunky na naacutedorovuacute Kľuacutečovou otaacutezkou bolo ako tieto poznatky využiť v liečbe ktoraacute musiacute byť šitaacute na mieru pacienta a naacutedoru Preto konferencia siacutece mala komplexnyacute charakter ale s presne špecifikovanyacutem zameraniacutem do spoločenskej praxe Pozvaniacute prednaacutešatelia v jednotlivyacutech sekciaacutech predstavovali špičky v danej problematike čo sa prejavilo na aktuaacutelnosti informaacuteciiacute v schopnosti zaujať posluchaacutečov a v diskusiaacutech Uskutočnili sa 3 kľuacutečoveacute prednaacutešky a 32 pozvanyacutech prednaacutešok a prihlaacutesenyacutech prednaacutešok Mladiacute vedeckiacute pracovniacuteci vynikli najmauml v sekcii Young scientists present v ktorej odznelo 11 prednaacutešok a pri posterovyacutech prezentaacuteciach Posterovaacute sekcia umožnila hlbšie prediskutovať vyacutesledky a navzaacutejom si vymeniť informaacutecie v jednotlivyacutech problematikaacutech Ako každaacute konferencia aj taacuteto prispela k rozšiacutereniu obzorov priniesla noveacute informaacutecie prehĺbila jestvujuacutece spolupraacutece a bola pocircdou pre vznik novyacutech kontaktov a spolupraacutec Niektoriacute mladiacute vedeckiacute pracovniacuteci z uacutestavu sa zuacutečastnia zahraničnyacutech pobytov na pracoviskaacutech na ktoreacute ziacuteskali kontakty na tejto konferencii Priacutespevky z podujatia boli vydaneacute v recenzovanom Zborniacuteku abstraktov s ISBN

Spoločenskyacute priacutenos Okrem akademickyacutech a vyacuteskumnyacutech pracovniacutekov sa konferencie zuacutečastnili aj lekaacuteri čo prispieva k zlepšeniu podmienok na translačnyacute vyacuteskum a aplikaacuteciu vedeckyacutech poznatkov do klinickej praxe Konferencia sa tešila pozornosti vyacuteznamnyacutech osobnostiacute Nad podujatiacutem prevzal zaacuteštitu prezident SR Ivan Gašparovič a predseda SAV Štefan Luby Na otvaacuteracom ceremoniaacutely sa suacutečastnil zaacutestupca z prezidentskej kancelaacuterie paacuten Saboacute podpredseda SAV Ivan Zaacutehradniacutek a veľvyslanec USA Rodolphe Valee Uacutečastniacuteci ocenili lokalitu - naacutedherneacute prostredie Vysokyacutech Tatier v ktorej sa konferencia uskutočila Vo voľnom dni kedy boli organizovaneacute dve spoločenskeacute podujatia jedno zameraneacute na obdivovanie priacuterody (vyacutelet na Lomnickyacute štiacutet) a druheacute na historickeacute pamiatky (Spišskyacute hrad Levoča Kežmarok) mohli prebiehať ďalej neformaacutelne vedeckeacute diskusie v uvolnenom prostrediacute Konferencia tyacutemto však prispela aj k propagaacutecii kraacutes a kultuacutery Slovenska Rekreačneacute možnosti v tomto regioacutene preskuacutemali najmauml rodinniacute priacuteslušniacuteci uacutečastniacutekov konferencie Mnohiacute uacutečastniacuteci sa plaacutenujuacute na Slovensko vraacutetiť či už pre kraacutesy Slovenska alebo noveacute vzniknuteacute ldquovedeckeacute kamaraacutetstvardquo Takyacuteto priacutepad už aj nastal

23

Organizovanie podujatia ďalej vyacuteznamne prispelo k propagaacutecii vedy onkologickeacuteho vyacuteskumu a SAV V suacutevislosti s podujatiacutem odznelo vyše 20 spraacutev v rocircznych meacutediach

2) Uacutestav organizoval tzv Jesenneacute pracovneacute dni bdquoGenetickaacute toxikoloacutegia a prevencia rakovinyldquo v dňoch 23 ndash 25102006 v prednaacuteškovej saacutele UacuteEO SAV

Pravidelneacute spoločneacute stretnutia vedeckyacutech a odbornyacutech pracovniacutekov umožňujuacute vyacutemenu informaacuteciiacute a diskusiu vlastnyacutech vyacutesledkov Suacute zaacutekladom na budovanie buduacutecich spolupraacutec pri riešeniacute priacutebuznyacutech probleacutemov Odbornyacutem garantom podujatia je Spoločnosť pre mutageneacutezu vonkajšiacutem prostrediacutem pri Československej biologickej spoločnosti a Sekcia Pracovniacutekov s tkanivovyacutemi kultuacuterami pri Onkologickej spoločnosti SLS Podujatie sluacuteži zaacuteroveň ako forma ďalšieho vzdelaacutevania pre pracovniacutekov v zdravotniacutectve Priacutespevky z podujatia boli vydaneacute v Zborniacuteku abstraktov s ISBN

6 Medzinaacuterodneacute vedeckeacute podujatia ktoreacute usporiada uacutestav v r 2006 (anglickyacute a slovenskyacute naacutezov podujatia miesto a termiacuten konania meno telefoacutenne čiacuteslo a e-mail zodpovedneacuteho pracovniacuteka)

Uacutestav plaacutenuje usporiadať ďalšiacute ročniacutek Jesennyacutech pracovnyacutech dniacute bdquoGenetickaacute toxikoloacutegia a prevencia rakovinyldquo - Autumn Workshop Genetic Toxicology and Cancer Prevention v termiacutene 22 ndash 24102007 v prednaacuteškovej saacutele UacuteEO SAV Zodpovednyacute pracovniacutek RNDr Alena Gaacutebelovaacute CSc tel 59327 512 e-mail alenagabelovasavbask

Uacutestav plaacutenuje usporiadať medzinaacuterodnuacute konferenciu bdquoBiomodulating activity of natural and synthetic compaunds (Biomodulačnaacute aktivita priacuterodnyacutech a syntetickyacutech laacutetokldquo v termiacutene 28-3032007 v prednaacuteškovej saacutele UacuteEO SAV Zodpovednyacute pracovniacutek RNDr Darina Slameňovaacute DrSc tel 59327 203 e-mail darinaslamenovasavbask

V spolupraacuteci s British Council Slovakia uacutestav usporiada bdquoWorkshop on Genomics and Proteomics of Cancer (Pracovnyacute miacuteting o Genomike a Proteomike rakoviny)ldquo v dňoch 282 - 23 2007 v Smoleniciach Zodpovednyacute pracovniacutek Ing Katariacutena Luciakovaacute DrSc tel 59327 110 e-mail katarinaluciakovasavbask

7 Počet pracovniacutekov v programovyacutech a organizačnyacutech vyacuteboroch medzinaacuterodnyacutech konferenciiacute

1) Počet pracovniacutekov v Programovom vyacutebore konferencie bdquoCancer2006 From molecular biology processes to tumor - tailored therapyrdquo ktoraacute sa konala 20-2482006 3

Prezident konferencie Altaner ČPredseda programoveacuteho vyacuteboru Bartošovaacute ZČlen programoveacuteho vyacuteboru Bujalkovaacute M

Predsedovia sekciiacute Altaner Č Sedlaacutek J Bartošovaacute Z Piršel M Biziacutek J

24

2) Počet pracovniacutekov v Organizačnom vyacutebore konferencie bdquoCancer 2006 From molecular biology processes to tumor - tailored therapyrdquo ktoraacute sa konala 20-2482006 8

Predseda organizačneacuteho vyacuteboru Bartošovaacute Z

Členovia organizačneacuteho vyacuteboru Krivulčiacutek TBujalkovaacute MKovaacuteč MChudějovaacute EFridrichovaacute IJakubiacutekovaacute JDudaacutešovaacute Z

3) Počet pracovniacutekov v Programovom a organizačnom vyacutebore konferencie bdquoAutumn Workshop Genetic Toxicology and Cancer Preventionldquo ktoraacute sa konala 23-25102006 9

Predseda programoveacuteho a organizačneacuteho vyacuteboru Gaacutebelovaacute A

Členovia programoveacuteho a organizačneacuteho vyacuteboru Farkašovaacute T Gurskaacute SHorvaacutethovaacute E Chalupa ISlameňovaacute D Šramkovaacute-Lazarovaacute M

Valovičovaacute Z

E Horvaacutethovaacute bola členkou organizačneacuteho vyacuteboru 11 medziodborovej slovensko- českej toxikologickej konferencie v Trenčianskych Tepliciach ktoraacute sa konala v juacuteni 2006

8 Uacutečasť expertov na hodnoteniacute projektov RP ESF priacutepadne inyacutech

Altaner Č expert INTAS expert ESF v European Survey on Bio-medical Research Infrastructures Bio-med RI za SRčlen European Cancer Research Managers Forum (ECRM) v raacutemci 6RP ndash expert za SR

recenzent projektov Ministerstva školstviacute a sportu ČR ČR

25

9 Medzinaacuterodneacute ocenenia a ineacute informaacutecie k medzinaacuterodnej vedeckej spolupraacuteci

a medzinaacuterodneacute ocenenia 1) Dudaacutešovaacute Z udelenie cestovneacuteho štipendia od organizaacutetorov konferencie

FEBS Advanced Lecture Course ndash Free Radical Summer School 2006 Biomarkers of Oxidative Stress amp Responses v Greacutecku

2) Maršaacutelkovaacute L udelenie cestovneacuteho štipendia od organizaacutetorov konferencie FEBS Advanced Lecture Course ndash Free Radical Summer School 2006 Biomarkers of Oxidative Stress amp Responses v Greacutecku

3) Železniacutekovaacute T udelenie štipendia z European Commissionrsquos Marie Curie Actions Scholarship na uacutečasť na workshope bdquoESH-EHA third annual diagnostic work-up of hematological malignanciesldquo v Riacuteme

4) Mego M (extd) udelenie prestiacutežnej ceny od Euroacutepskej spoločnosti pre lekaacutersku onkoloacutegiu ESMO Best Exam Award

b ineacute informaacutecie k medzinaacuterodnej vedeckej spolupraacuteci

1) Nominant uacutestavu Prof Josef Jiricny z Institute for Molecular Cancer Research Zuumlrich ziacuteskal Medzinaacuterodnuacute cenu SAV Stručneacute zdokumentovanie spolupraacutece Prof Jiricneho s UacuteEO SAV

1 Pod odbornyacutem vedeniacutem Prof Jiricneho bola v roku 1998 identifikovanaacute prvaacute zaacuterodočnaacute mutaacutecia v slovenskej rodine s dedičnou formou rakoviny hrubeacuteho čreva - HNPCC Tento vyacutesledok mal zaacutesadnyacute vyacuteznam pre vznik noveacuteho smeru molekulaacuternej diagnostiky genetickyacutech predispoziacuteciiacute na Slovensku Okrem umožnenia pracovneacuteho pobytu pracovniacutečke Uacutestavu experimentaacutelnej onkoloacutegie SAV (viď dokumenty v priacutelohe) počas ktorej došlo k objavu spomiacutenanej mutaacutecie venoval UacuteEO SAV draheacute priemery kity a chemikaacutelie v hodnote cca 250 000- Sk ktoreacute umožnili začať mutačnyacute skriacutening choryacutech rodiacuten s HNPCC na Slovensku

2 Snaha ešte vyacuteraznejšie finančne pomocirccť vede na Slovensku vyuacutestila do priacutepravy projektu v 5 Raacutemcovom programe EUacute do konzorcia ktoreacuteho bolo pozvaneacute aj Slovensko Prof Jiricny bol hlavnyacutem koordinaacutetorom tohto projektu Slovensko v ňom ziacuteskalo vyacuteznamneacute finančneacute prostriedky vo vyacuteške cca 45 milioacutena koruacuten (11000000 Eur viď v priacutelohe) Prof Jiricny presvedčil zaacutestupcov Euroacutepskej komisie povoliť Slovensku financovať z grantu draheacute priacutestroje Ziacuteskanie automatickeacuteho kapilaacuterneho Genetickeacuteho analyzaacutetora ABI 310 (DNA sekvenaacutetor) vyacuteznamne posunulo možnosti zaacutekladneacuteho a aplikovaneacuteho onkologickeacuteho vyacuteskumu na Slovensku Za vyacutesledky dosiahnuteacute počas riešenia projektu bolo v r 2002 udeleneacute ocenenie bdquoZa vyacutesledky v raacutemcovom programe EUacuteldquo v šiestom ročniacuteku akcie bdquoVedec roka SRldquo RNdr Zdene Bartošovej CSc z UacuteEO SAV

3 Prof Jiricny vyacuteznamne pomaacuteha propagovať slovenskuacute vedu a zvyšovať prestiacutež Uacutestavu experimentaacutelnej onkoloacutegie SAV Nakoľko je liacutedrom vo vyacuteskume mechanizmov vzniku

26

naacutedorovyacutech ochoreniacute najmauml defektov v reparačnej draacutehe (bdquoMMR Repairldquo) veduacutecich k naacutedorom hrubeacuteho čreva nezriedka je pozyacutevanyacutem prednaacutešateľom na pracoviskaacute a prestiacutežne konferencie V roku 2002 navštiacutevil a poskytol prednaacutešku UacuteEO SAV Vyacuteznamnou propagaacuteciou slovenskej vedy pred celyacutem svetom bolo jeho členstvo vo vedeckom a organizačnom vyacutebore konferencie v Starej Lesnej v auguste 2006 Vyacuteznamne pomaacutehal pri priacuteprave vedeckeacuteho programu konferencie a pri zabezpečeniacute kvalitnyacutech prednaacutešateľov

4 Prof Jiricny pomaacuteha slovenskej vede aj v publikačnej a prezentačnej aktivite Podieľal sa na najvyacuteznamnejšiacutech vyacutesledkoch vedeckej praacutece UacuteEO SAV v medzinaacuterodnyacutech vedeckyacutech projektoch (Spraacuteva o činnosti UacuteEO SAV za rok 2003)

5 O neobyčajnom vedeckom priacutenose Prof Jiricneho vo vzťahu k SR svedčiacute aj fakt že o jeho pomoci slovenskej vede sa zmieňovali aj viacereacute slovenskeacute meacutediaacute Pomohol etablovať molekulaacuternu diagnostiku ktoraacute v SR zachraňuje životy ľuďom s HNPCC ochoreniacutem

2) Voľneacute medzinaacuterodneacute spolupraacutece v suacutečasnosti bez oficiaacutelnych medzinaacuterodnyacutech projektov alebo uskutočnenej mobility

Clinical Institute of Medical and Chemical Laboratory Diagnostics General Hospital of Vienna Vienna University Viedeň Rakuacutesko V spolupraacuteci sa testuje bio-modulačnyacute potenciaacutel novyacutech preparaacutetov v kombinovanej chemoterapii (Rauko P)

Institute of Organic Chemistry University of Tubingen Nemecko Spolupraacuteca je zameranaacute na monitorovanie antineoplastickeacuteho potenciaacutelu novosyntetizovanyacutech dimeacuterov araC a cis-Pt (Rauko P)

Institute of Inorganic Chemistry University of Vienna Rakuacutesko Spolupraacuteca je zameranaacute na testovanie toxicity a terapeutickej efektiacutevnosti novosyntetizovanyacutech Pt-komplexov v experimentaacutelnych in vivo modeloch Vyacutesledkom spolupraacutece je screening laacutetok s vysokyacutem terapeutickyacutem indexom (Rauko P)

Institute of Molecular Cancer Research Zuumlrich Švajčiarsko Spolupraacuteca sa tyacuteka biochemickej charakterizaacutecie zaacuterodočnyacutech mutaacuteciiacute v opravnyacutech geacutenoch a vyacutevoja noveacuteho diagnostickeacuteho testu na selekciu mutovaneacuteho geacutenu (Bartošovaacute Z)Spoločneacute publikaacutecie 1Spoločneacute prezentaacutecie na konferenciaacutech 2

NIEHS NIH Research Triangle Park NC 27709 USA Spolupraacuteca je zameranaacute na štuacutedium mechanizmov nukleotidovej exciacuteznej opravy (Škorvaga M)Spoločneacute publikaacutecie 2Spoločneacute prezentaacutecie na konferenciaacutech 1

Institute of Food Research Norwich UK Spolupraacuteca je zameranaacute na štuacutedium protektiacutevnych uacutečinkov priacuterodnyacutech laacutetok rastlinneacuteho pocircvodu (Sedlaacutek J)Spoločneacute publikaacutecie 1

27

Prehľad uacutedajov o medzinaacuterodnej vedeckej spolupraacuteci je uvedenyacute v Priacutelohe č 5

V Spolupraacuteca s vysokyacutemi školami inyacutemi domaacutecimi vyacuteskumnyacutemi inštituacuteciami a s hospodaacuterskou sfeacuterou pri riešeniacute vyacuteskumnyacutech uacuteloh

1 Prehľad spolupracujuacutecich vysokyacutech škocircl (fakuacutelt) a vyacutesledky spolupraacutece

Priacuterodovedeckaacute fakulta UK Bratislava Katedra genetiky spolupraacuteca sa tyacuteka štuacutedia opravy dvojvlaacuteknovyacutech zlomov DNA v kvasinkaacutech S cerevisiae Štuacutedium tejto problematiky je teacutemou diplomovyacutech praacutec ktoreacute sa realizujuacute v laboratoacuteriu alebo vyacutesledky suacute predmetom konzultaacuteciiacute Ďalšia spolupraacuteca sa tyacuteka oboru genotoxikoloacutegia a taktiež sa realizuje vedeniacutem dipolomovyacutech praacutec študentov spoločnyacutech publikaacuteciiacute vo vedeckyacutech časopisoch a prezentaacuteciiacute na vedeckyacutech konferenciaacutech

Slovenskaacute technickaacute univerzita Fakulta chemickej a potravinaacuterskej technoloacutegie Katedra biocheacutemie a mikrobioloacutegie Spolupraacuteca sa tyacuteka vedenia dipolomovyacutech praacutec študentov v odboroch genotoxikoloacutegia a vplyv priacuterodnyacutech laacutetok na signaacutelne bunkovaacute draacutehy Vyacutesledkom suacute spoločneacute publikaacutecie vo vedeckyacutech časopisoch a prezentaacutecie na vedeckyacutech konferenciaacutech

Lekaacuterska fakulta UK Bratislava spolupraacuteca sa tyacuteka priacutepravy druheacuteho doplneneacuteho vydania učebnice epidemioloacutegie pre časť venovanuacute epidemioloacutegii zhubnyacutech naacutedorov

Lekaacuterska fakulta UK Bratislava Katedra patologickej anatoacutemie a Katedra bioloacutegie spolupraacuteca spočiacuteva vo vedeckej vyacutechove študentov ktoriacute majuacute zaacuteujem o molekulaacuternu bioloacutegiu a klinickuacute genetiku Študenti sa pravidelne zuacutečastnujuacute ŠVOČ RNDr V Zajac CSc prednaacuteša na Katedre patologickej anatoacutemie a maacute certifikaacutet z dekanaacutetu LFUK ktoryacute ho opraacutevňuje k vedeniu ŠVOČ a tiež aj diplomovyacutech praacutec ktoreacute sa už stali povinnyacutem predmetom na LFUK

Slovenskaacute zdravotniacutecka univerzita Referenčneacute centrum HIVAIDS spolupraacuteca spočiacuteva v analyacuteze bakteacuteriiacute od HIVAIDS pacientov Vyacutesledkom spolupraacutece je zistenie že bakteacuterie tyacutechto pacientov majuacute mimoriadnu schopnosť internalizovať ľudskeacute bunkoveacute liacutenie HL-60 a HeLa ako aj normaacutelne ľudskeacute lymfocyty Sleduje sa ďalšia uacuteloha tyacutechto bakteacuteriiacute v procese ochorenia AIDS

Chemickyacute uacutestav SAV v Bratislave Spolupracovalo sa na vhodnom uplatneniacute glukaacutenov v protinaacutedorovej terapii Vyacutesledkom spolupraacutece je spoločnyacute Vega grant spoločneacute publikaacutecie vo vedeckyacutech časopisoch a prezentaacutecie na vedeckyacutech konferenciaacutech

Endokrinologickyacute uacutestav SAV v Bratislave Spolupracovalo sa na synteacuteze a biologickom testovaniacute cytotoxicky uacutečinnyacutech laacutetok s antineoplastickyacutem potenciaacutelom

28

2 Vyacuteznamneacute aplikaacutecie vyacutesledkov vyacuteskumu v spoločenskej praxi

V raacutemci spolupraacutece s Naacuterodnyacutem onkologickyacutem uacutestavom Detskyacutem onkologickyacutem oddeleniacutem Slovenskej zdravotniacuteckej Univerzity Onkologickyacutem uacutestavom sv Alžbety a inyacutemi onkologickyacutemi a hematologickyacutemi pracoviskami (v priacutepade nejasnej diagnoacutezy) sa uskutočňoval imunologickyacute vyacuteskum buniek krvotvorneacuteho tkaniva (kostnaacute dreň perifeacuterna krv časť lymfatickej uzliny vyacutepotkov a mozgovo-miešneho moku) ktoryacute sa realizoval pomocou imununofenotypizaacutecie prietokovyacutem cytometrom (detiacute a dospelyacutech pacientov) s cieľom

a) potvrdenie a spresnenie diagnoacutezy a zaradenie pacientov do jednotlivyacutech prognostickyacutech skupiacuten leukeacutemiiacute a lymfoacutemov

b) docirckaz včasneacuteho naacutevratu choroby (vznik relapsu)

c) monitorovanie (sledovanie) priebehu liečby

V roku 2006 sa celkom vykonalo vyšetrenie 843 vzoriek (z toho pacientov v diagnoacuteze a pri transplantaacutecii kmeňovyacutech buniek 512 a kontrolnyacutech vyšetreniacute pri monitorovaniacute liečby 331)

V spolupraacuteci s Naacuterodnyacutem onkologickyacutem uacutestavom Raacutediologickyacutem oddeleniacutem bol vypracovanyacute spoločnyacute projekt zameranyacute na sledovanie citlivosti k radiaacutecii u pacientok s naacutedormi prsniacuteka ktoreacute podstuacutepili terapiu ožarovaniacutem Dr Lackovaacute a Dr Pobijakovaacute zabezpečovali vyacuteber vhodnyacutech pacientok a odbery krvi Vyacutesledkom spolupraacutece je 10 zanalyzovanyacutech vzoriek z celkovo plaacutenovanyacutech 20 Spomedzi všetkyacutech pacientok sa doteraz nepodarilo zachytit žiadnu so zvyacutešenou citlivosťou k radiaacutecii

Pracovnaacute skupina epidemioloacutegie naacutedorov Uacutestavu experimentaacutelnej onkoloacutegie SAV sa podieľala na tvorbe a analyacuteze uacutedajov v Naacuterodnom onkologickom registri ktoreacuteho hlavneacute pracovisko bolo presunuteacute do Naacuterodneacuteho strediska mediciacutenskych informaacuteciiacute (spadaacute pod Ministerstvo zdravotniacutectva SR) Tyacutem sa vyacutesledky zo Slovenska dostaacutevali do rocircznych štatistickyacutech a epidemiologickyacutech prehľadov Svetovej zdravotniacuteckej organizaacutecie (WHO) Medzinaacuterodnej agentuacutery pre vyacuteskum rakoviny (IARC) a Euroacutepskej siete onkologickyacutech registrov (ENCR)

Laboratoacuterium genetiky naacutedorovyacutech ochoreniacute uskutočňovalo skriacutening mutaacuteciiacute u pacientov so suspektnou dedičnou predispoziacuteciou k naacutedorom hrubeacuteho čreva (HNPCC) Vyšetrilo sa 20 rizikovyacutech osocircb a identifikovalo sa 8 jedincov s takouto predispoziacuteciou Tyacutemto jedincom bude poskytnutaacute pravidelnaacute lekaacuterska kontrola ktorej zmyslom je odhalenie priacutepadnyacutech novotvarov vo včasnom štaacutediu kedy suacute klinicky ľahko zvlaacutednuteľneacute Hlavnyacutemi použiacutevateľmi tyacutechto vyacutesledkov suacute Oddelenie onkogenetiky Naacuterodnyacute onkologickyacute uacutestav Bratislava Centrum lekaacuterskej genetiky FN Bratislava Regionaacutelne oddelenia genetiky v zdravotnyacutech zariadeniach na Slovensku

29

VI Aktivity pre vlaacutedu SR Naacuterodnuacute radu SR uacutestredneacute orgaacuteny štaacutetnej spraacutevy SR a ineacute organizaacutecie

Pracovniacuteci naacutedorovej epidemioloacutegie vykonaacutevali Expertiacuteznu činnosť pre štaacutetnu spraacutevu pri

tvorbe uacutedajov a zabezpečenia funkciiacute Naacuterodneacuteho onkologickeacuteho registra pri vydaacutevaniacute

ročeniek ndash momentaacutelne je v tlači ročenka za rok 2003 ndash o vyacuteskyte zhubnyacutech naacutedorov v SR

a podklady pre tvorbu a orientaacuteciu Naacuterodneacuteho programu boja proti rakovine v SR

VII Vedecko-organizačneacute a popularizačneacute aktivity ceny a vyznamenania

Popularizaacutecia v televiacutezii 13

1 JANA JAKUBIacuteKOVAacute - MLADYacute VYacuteSKUMNIacuteK SR 2005 (15032006 Televiacutezna stanica TA 3 Spraacutevy 1645 4 min) Rozhovor s ocenenou vedeckou pracovniacutečkou z UacuteEO SAV

2 BROKOLICA KEL ŠPENAacuteT A KAPUSTA OBSAHUJUacute LAacuteTKY KTOREacute ZNIŽUJUacute RIZIKO NAacuteDOROVYacuteCH OCHORENIacute (21032006 Televiacutezna stanica STV 1 Spraacutevy STV 1930 2 min GULOVAacute Z) I JANDA moderaacutetor Jana JAKUBIacuteKOVAacute zo Slovenskej akadeacutemie vied ziacuteskala za praacutece v tejto oblasti cenu Mladyacute vyacuteskumniacutek roka ndash hovoriacute J JAKUBIacuteKOVAacute a JAacuteN SEDLAacuteK Uacutestav experimentaacutelnej onkoloacutegie SAV

3 OCEŇOVALI NAJUacuteSPEŠNEJŠIacuteCH SLOVENSKYacuteCH VEDCOV 2005 (21032006 Televiacutezna stanica STV 2 Spraacutevy a komentaacutere 2130 15 min Z GULOVAacute redaktorka O akcii Vedec roka ndash Mladyacute vyacuteskumniacutek roka ndash JANA JAKUBIacuteKOVAacute z UacuteEO SAV pokračuje v praacuteci profesorky HORAacuteKOVEJ a dr BROBINCU Aj JAacuteN SEDLAacuteK Uacutestav experimentaacutelnej onkoloacutegie SAV

4 O PODMIENKACH NA PRAacuteCU SLOVENSKYacuteCH VEDCOV V ROZHOVORE

S OCENENOU J JAKUBIacuteKOVOU Z UacuteSTAVU EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV A Ľ LENOCHOM Z KLUBU VEDECKO-TECHNICKYacuteCH ŽURNALISTOV SSN (21032006 Televiacutezna stanica STV 2 Spraacutevy a komentaacutere 2130 6 min beseda GUBKOVAacute Nora)

5 JANA JAKUBIacuteKOVAacute ZO SAV SA STALA MLADYacuteM VYacuteSKUMNIacuteKOM ROKA ndash TV Markiacuteza Teleraacuteno 21 32006 o 7 30 h Rozhovor s J JAKUBIacuteKOVOU

6 STV1 ndash večerneacute spraacutevy STV1 2292006 ndash spraacutevy o zaacutevere IVročniacuteka kampane bdquoNa kolesaacutech proti rakovineldquo a vyacutesledku finančnej zbierky na priacutestroj Wave System pre

30

UacuteEO SAV s vysvetleniacutem ako pomocircže tento priacutestroj ľuďom s podozreniacutem na naacutedoroveacute ochorenie - M KLOBUŠICKAacute

7 TV JOJ - Noviny JOJ 2292006 - spraacutevy o zaacutevere IVročniacuteka kampane bdquoNa kolesaacutech proti rakovineldquo a vyacutesledku finančnej zbierky na priacutestroj Wave System pre UacuteEO SAV s vysvetleniacutem ako pomocircže tento priacutestroj ľuďom s podozreniacutem na naacutedoroveacute ochorenie ndashM KLOBUŠICKAacute

8 TA3 - Spraacutevy TA3 2292006 - spraacutevy o zaacutevere IVročniacuteka kampane bdquoNa kolesaacutech proti rakovineldquo a vyacutesledku finančnej zbierky na priacutestroj Wave System pre UacuteEO SAV s vysvetleniacutem ako pomocircže tento priacutestroj ľuďom s podozreniacutem na naacutedoroveacute ochorenie -M KLOBUŠICKAacute

-

9 Beseda o udeleniacute Nobelovyacutech cien za rok 2006 (12 10 2006 Televiacutezna stanica STV 2 Pod lampou 2145 180 min HRIacuteB Štefan) Diskutovali vedci zo SAV J ORAVEC M MOJŽIŠ a P ŠEVERA P ZAJAC S PASTOREKOVAacute a P BARAacuteTH Konštatovali Slovaacutek mocircže tiež dostať Nobelovu cenu ak bude pracovať v USA M MOJŽIŠ tiež pripomenul že na vyacutechovu kvalitnyacutech špičkovyacutech vedcov je potrebneacute zreformovať aj systeacutem školstva a vzdelaacutevania

10 Priacutestroj odhaliacute rakovinu aj 20 rokov vopred (21112006 Televiacutezna stanica TA 3 Hlavneacute spraacutevy + 1900 15 min NAGYOVAacute Linda) Aj slovenskiacute lekaacuteri už dokaacutežu odhaliť riziko rakoviny dvadsať rokov vopred Uacutestav experimentaacutelnej onkoloacutegie SAV vďaka kampani Na kolesaacutech proti rakovine ziacuteskal priacutestroj ktoryacute dokaacuteže presne odhaliť predispoziacuteciu na ochorenie dlho predtyacutem ako by mohlo vzniknuacuteť Vyjadruje sa VLADIMIacuteR ZAJAC Božidara TURZONOVOVA a ZDENA BARTOŠOVAacute

11 Euroacutepsky tyacuteždeň vedy (21 11 2006 Televiacutezna stanica STV 1 Spraacutevy STV 1930 2 min JANČKAacuteROVAacute Marta) O špičkovyacutech vyacutesledkoch svojho pracoviska ale aj o finančnyacutech probleacutemoch hovorili LUCIA KUČEROVAacute a ČESTMIacuteR ALTANER

12 Prehľad domaacutecich spraacutev (21 11 2006 Televiacutezna stanica JOJ Noviny 1930 2 min KMOTRIacuteKOVAacute Adriana) Po štyroch rokoch verejnej zbierky pre kampaň Na kolesaacutech proti rakovine odovzdali bratislavskeacutemu UacuteSTAVU EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV priacutestroj Wave system Pomocircže včas objaviť začiacutenajuacuteci naacutedorovyacute proces čiacutem sa zvyšuje šanca na vyliečenie

13 Proti rakovine (28112006 Markiacuteza č 482006 s 27 -) Wave System je naacutezov priacutestroja ktoryacute pomocircže včas odhaľovať začiacutenajuacuteci naacutedorovyacute proces Minulyacute tyacuteždeň ho slaacutevnostne odovzdali UacuteSTAVU EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV v Bratislave

Popularizaacutecia v rozhlase 23

1 V primaciaacutelnom palaacuteci sa včera uskutočnil novoročnyacute koncert nadaacutecie vyacuteskum rakoviny (18012006 Rozhlasovaacute stanica Regina Spraacutevy 1000 1 min MRAacuteZIKOVAacute Miroslava) V nadvaumlznosti na spraacutevu o novoročnom koncerte Nadaacutecie Vyacuteskum rakoviny a Uacutestavu experimentaacutelnej onkoloacutegie SAV bol stručne predstavenyacute UacuteEO SAV

31

2 SLOVENSKAacute AKADEacuteMIA VIED A JOURNALIST STUDY OCEŇOVALI NAJLEPŠIacuteCH SLOVENSKYacuteCH VEDCOV (15032006 Rozhlasovaacute stanica Slovensko Raacutediožurnaacutel 1200 3 min OTTOVAacute Katariacutena) Reportaacutež z akcie Vedec roka ndash spomiacutena sa Dvurečenskij JAKUBIacuteKOVAacute Balaacutež Čižmaacuterik Gaduš

3 OCENENIE MLADYacute VYacuteSKUMNIacuteK SR V ROKU 2005 ZIacuteSKALA JANA JAKUBIacuteKOVAacute Z UacuteSTAVU EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV (17032006 Rozhlasovaacute stanica Twist Predpoludňajšie vysielanie 1120 2 min Martin Mikuacutešek)

4 V BRATISLAVE DNES ODOVZDAacuteVALI OCENENIA VEDEC ROKA SLOVENSKA 2005 (17032006 Raacutedio OKEY Popoludňajšie vysielanie 35 min Reportaacutež z odovzdaacutevania oceneniacute Vedec roka Rozhovory s ocenenou J JAKUBIacuteKOVOU

5 Predstavujeme Mladeacuteho vyacuteskumniacuteka roka ndash RNDr JANU JAKUBIacuteKOVUacute (17 03 2006 Raacutedio HEY red Dana Šejirmanovaacute ndash 330 min)

6 Novyacute spocircsob liečby rakoviny hrubeacuteho čreva (29 7 2006 Rozhlasovaacute stanica Slovensko Raacutediožurnaacutel 1800 25 min ČIŽMAacuteRIKOVAacute Zuzana) O novej metoacutede liečby rakoviny hrubeacuteho čreva ktoraacute je v štaacutediu klinickeacuteho vyacuteskumu a spočiacuteva v cielenej terapii zasahujuacutecej priamo choruacute bunku hovoriacute aj riaditeľ Uacutestavu experimentaacutelnej onkoloacutegie SAV ČESTMIacuteR ALTANER ako o pokroku liečby

7 Vedci v boji proti rakovine (Slovenskyacute rozhlas Raacutedio Slovensko 25 8 2006 1435 350 min Ivana Ratkovskaacute) Zvukovaacute informaacutecia o Medzinaacuterodnom sympoacuteziu organizovanom Uacutestavom experimentaacutelnej onkoloacutegie SAV v Starej Lesnej bdquoRAKOVINA 2006ldquo

8 Vedci v boji proti rakovine (Slovenskyacute rozhlas Raacutedio Slovensko 14 8 2006 857 30 sec) Zvukovaacute informaacutecia o Medzinaacuterodnom sympoacuteziu organizovanom Uacutestavom experimentaacutelnej onkoloacutegie SAV v Starej Lesnej bdquoRAKOVINA 2006ldquo

9 Vedci v boji proti rakovine (Slovenskyacute rozhlas Raacutedio Slovensko 15 8 2006 1057 a 1458 30 sec) Zvukovaacute informaacutecia o Medzinaacuterodnom sympoacuteziu organizovanom Uacutestavom experimentaacutelnej onkoloacutegie SAV v Starej Lesnej bdquoRAKOVINA 2006ldquo





14 Vedci v boji proti rakovine (Slovenskyacute rozhlas Raacutedio Slovensko 22 8 2006

32

1257 30 sec) Zvukovaacute informaacutecia o Medzinaacuterodnom sympoacuteziu organizovanom Uacutestavom experimentaacutelnej onkoloacutegie SAV v Starej Lesnej bdquoRAKOVINA 2006ldquo

15 MEDZINAacuteRODNAacute KONFERENCIA ONKOLOacuteGIE V STAREJ LESNEJ (25 8 2006 Rozhlasovaacute stanica Slovensko Predpoludňajšie vysielanie 1040 4 min RADKOVSKAacute Ivana) Rozhovor s českyacutem rodaacutekom prof Josefom JIŘIČNYacuteM z Onkologickeacuteho uacutestavu v Zuumlrichu ktoryacute dostal Zlatuacute medailu SAV za zavaacutedzanie diagnostiky rakoviny hrubeacuteho čreva pomocou molekulaacuternej diagnostiky Vyjadruje sa aj doc ČESTMIacuteR ALTANER riaditeľ Onkologickeacuteho uacutestavu SAV

16 Rozhovor s riaditeľom Uacutestavu experimentaacutelnej onkoloacutegie SAV Čestmiacuterom Altanerom o novyacutech poznatkoch v liečbe rakoviny (18 8 2006 Rozhlasovaacute stanica Slovensko Raacutediožurnaacutel 1200 25 min MICHALICOVAacute Alena) Riaditeľ Uacutestavu experimentaacutelnej onkoloacutegie SAV ČESTMIacuteR ALTANER pripomiacutena 60 vyacuteročie vzniku uacutestavu ktoreacute oslaacutevi aj prestiacutežnym medzinaacuterodnyacutem podujatiacutem CANCER 2006 ktoreacute bude vo Vysokyacutech Tatraacutech kde sa bude hovoriť najmauml o spocircsoboch liečby ktoraacute je tzv šitaacute na mieru

17 Dni otvorenyacutech dveriacute na pracoviskaacutech SAV v raacutemci Euroacutepskeho tyacuteždňa vedy a techniky (20 11 2006 Rozhlasovaacute stanica Slovensko Dobryacute deň Slovensko 0830 45 min KASALA Ľuboš) SPOMIacuteNA SA DEŇ OTVORENYacuteCH DVERIacute NA UacuteSTAVE EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV v Bratislave

18 Pozvaacutenka na deň otvorenyacutech dveriacute v Uacutestave experimentaacutelnej onkoloacutegie SAV (21112006 Rozhlasovaacute stanica Slovensko Dobryacute deň Slovensko 0810 3 min) O Dni otvorenyacutech dveriacute v raacutemci Euroacutepskeho tyacuteždňa vedy v UacuteSTAVE EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV hovoril inžinier Jaacuten JURAacuteŠ

19 V SR pribudne ročne 23-tisiacutec novyacutech onkologickyacutech pacientov (21 11 2006 Rozhlasovaacute stanica Slovensko Raacutediožurnaacutel 1800 3 min ČIŽMAacuteRIKOVAacute Zuzana) O najnovšiacutech možnostiach liečby ale aj diagnostiky onkologickyacutech ochoreniacute hovoril riaditeľ Uacutestavu experimentaacutelnej onkoloacutegie SAV ČESTMIacuteR ALTANER

20 Priacutestroj na odhaľovanie začiacutenajuacutecich naacutedorovyacutech procesov slaacutevnostne odovzdali do užiacutevania v Bratislave (21 11 2006 Rozhlasovaacute stanica Regina Spraacutevy 1400 05 min ŠRAacuteMEK Pavol) Priacutestroj ktoryacute pomocircže včas odhaľovať začiacutenajuacuteci naacutedorovyacute proces dnes slaacutevnostne odovzdali do užiacutevania v UacuteSTAVE EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV v Bratislave pri priacuteležitosti Dňa otvorenyacutech dveriacute v uacutestave v raacutemci Euroacutepskeho tyacuteždňa vedy a techniky na Slovensku

21 V Uacutestave experimentaacutelnej onkoloacutegie v Bratislave majuacute priacutestroj na včasneacute diagnostikovanie naacutedorovyacutech ochoreniacute (21 11 2006 Rozhlasovaacute stanica Regina Ozveny dňa 1700 3 min GAPČOVAacute Martina) V UacuteSTAVE EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV odovzdali systeacutem na včasneacute diagnostikovanie naacutedorovyacutech ochoreniacute Predchaacutedzala tomu takmer štvorročnaacute finančnaacute zbierka ktoruacute organizoval Slovenskyacute paralympijskyacute vyacutebor Na kolesaacutech proti rakovine

22 Bratislavskyacute Uacutestav experimentaacutelnej onkoloacutegie SAV maacute novyacute priacutestroj na včasneacute odhalenie rakoviny (21112006 Rozhlasovaacute stanica Okey Spraacutevy 1800 05 min MICHALIacuteKOVAacute Iveta) UacuteSTAV EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV maacute

33

novyacute priacutestroj Wave system Ten včas odhaliacute začiacutenajuacutecu rakovinu hrubeacuteho čreva štiacutetnej žľazy vaječniacutekov prsniacutekov či prostaty Odovzdali ho pri priacuteležitosti Tyacuteždňa vedy v SR

23 Uacutestav experimentaacutelnej onkoloacutegie v Bratislave ziacuteskal novyacute priacutestroj na diagnostiku rakoviny (21112006 Rozhlasovaacute stanica Expres Infoexpres 1500 05 min KAŠIAROVAacute Maacuteria) UacuteSTAV EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV v Bratislave ziacuteskal novyacute priacutestroj ktoryacute uryacutechli diagnostiku dedičnyacutech foriem rakoviny Odovzdali ho pri priacuteležitosti Tyacuteždňa vedy v SR

Popularizaacutecia v tlači 40

1 Bratislavčania suacute uvaacutežliviacute darcovia (20 1 2006 Pravda priacuteloha Bratislava s I II Kopřivovaacute Alena) Po novoročnom koncerte nadaacutecie Vyacuteskum rakoviny a UacuteEO SAV hovoriacute riaditeľ Uacutestavu experimentaacutelnej onkoloacutegie SAV ČESTMIacuteR ALTANER o vyacuteskume rakoviny na pocircde SAV

2 Cena za vyacuteskum naacutedorovyacutech buniek (16032006 Hospodaacuterske noviny s 1) Ocenenie Mladyacute vyacuteskumniacutek SR si včera v Bratislave prevzala vedeckaacute pracovniacutečka Uacutestavu experimentaacutelnej onkoloacutegie SAV JANA JAKUBIacuteKOVAacute + foto na 1 str

3 Veda je kraacutesna je to dobrodružstvo (20032006 Hospodaacuterske noviny priacuteloha Biznis s 21 Gossaacutenyi Vojtech) Napriek podfinancovaniu vedy maacute Slovensko uacutespešnyacutech vedcov A akyacute je recept aby človek na tomto poli uspel Prof Anatolij Dvurečenskij (MUacute SAV) JANA JAKUBIacuteKOVAacute (UacuteEO SAV) a Jaacuten Balaacutež z košickeacuteho UacuteEF SAV a ich vyacuteskumy Po Akcii Vedec roka 2005)

4 Vedci nie suacute mediaacutelne hviezdy Slovensko maacute inyacute zaacuteujem (20032006 Hospodaacuterske noviny priacuteloha Biznis s 26 Gossaacutenyi Vojtech) O postaveniacute vedy a vyacuteskumu na Slovensku ich financovaniacute a o vedeckej a vyacuteskumnej činnosti hovoria oceneniacute vedeckiacute pracovniacuteci na akcii vedec roka 2005 - medzi nimi aj Mladyacute vyacuteskumniacutek roka - vedeckaacute pracovniacutečka Uacutestavu experimentaacutelnej onkoloacutegie SAV JANA JAKUBIacuteKOVAacute - odborniacutečka v oblasti experimentaacutelna onkoloacutegia

5 Slovenskyacutem vedcom roka sa stal matematik (16032006 Pravda s 20) o podujatiacute vedec roka ndash JANA JAKUBIacuteKOVAacute

6 Ak sa vyacuteskum nedariacute rakovina mu daacute zmysel (25032006 Pravda priacuteloha Sobota s 1 9 Vajs Miroslav Porubskyacute Juraj) Slovenskaacute vedkyňa JANA JAKUBIacuteKOVAacute (29 ndash UacuteEO SAV) maacute doktoraacutet z onkoloacutegie i biocheacutemie Za vyacutesledky boja proti naacutedorovyacutem bunkaacutem ziacuteskala ocenenie Mladyacute vedec roka 2005 (profilovyacute rozhovor)

7 Ocenenyacute vedec roka Kľuacutečom k rozvoju sveta bude matematika (18032006 Sme s 4 dro) BRATISLAVA - Paumlť slovenskyacutech vedcov ziacuteskalo najprestiacutežnejšie ocenenie Vedec roka 2005 Hovoriacute Ľubomiacuter Lenoch (vyhlasovateľ) Zdocircrazňujuacute sa praacutece prof Dvurečenskeacuteho ndash vedca roka z MUacute SAV Jaacutena Balaacuteža ndash technoloacutega roka z UacuteEF SAV JANY JAKUBIacuteKOVEJ ndash mladyacute vyacuteskumniacutek roka z UacuteEO SAV a ďalšiacutech ocenenyacutech

8 Celebrity o ktoryacutech vie maacutelokto (16032006 Večerniacutek s 6) Na Zvaumlze

34

slovenskyacutech vedecko-technickyacutech spoločnosti z iniciatiacutevy Klubu vedecko-technickyacutech žurnalistov vyhlaacutesili Vedca roka 2005 - Mladyacutem vyacuteskumniacutekom roka - onkologička JANA JAKUBIacuteKOVAacute

9 Novyacute priacutestroj v onkologickej diagnostike v SR (23032006 Zdravotniacutecke noviny č 122006 s 5 ) Analyzaacutetor umožňuje zistiť chybu na geacutenoch a presne určiť jej lokalizaacuteciu a charakter Doc Ing ČESTMIacuteR ALTANER DrSc riaditeľ Uacutestavu experimentaacutelnej onkoloacutegie SAV doplnil že na Slovensku sa už zaviedla diagnostika dedične podmieneneacuteho karcinoacutemu hrubeacuteho čreva

10 Mladyacute vyacuteskumniacutek roka 2005 je z Uacutestavu experimentaacutelnej onkoloacutegie SAV (23032006 Zdravotniacutecke noviny č 122006 s 5 mi) SAV spolu so ZVTS a KVTŽ SSN usporiadali 9 ročniacutek oceňovania osobnostiacute ktoreacute sa zasluacutežili o rozvoj vedy a technoloacutegiiacute -Vedec roka SR 2005 V kategoacuterii Mladyacute vyacuteskumniacutek roka SR 2005 ziacuteskala cenu RNDr JANA JAKUBIacuteKOVAacute PhD) z Uacutestavu experimentaacutelnej onkoloacutegie SAV spomiacutenajuacute sa aj 3 čestneacute uznania ktoreacute dostali RNDr JOZEF BIZIacuteK DrSc MUDr OĽGA BABUŠIacuteKOVAacute DrSc a RNDr DARINA SLAMEŇOVAacute DrSc všetci traja z Uacutestavu experimentaacutelnej onkoloacutegie SAV

11 Vyhlaacutesili vedca roka 2005 TASR 1532006 Informaacutecia o vedcoch (aj zo SAV) ocenenyacutech v raacutemci akcie bdquoVedec roka 2005ldquo ndash technoloacuteg roka Ing Jaacuten Balaacutež PhD Mladyacute vyacuteskumniacutek roka RNDr JANA JAKUBIacuteKOVAacute PhD

12 V Košiciach odštartovali kolesaacute proti rakovine (4 5 2006 Košickyacute korzaacuter s 2 sam) Niekoľkonaacutesobnyacute držiteľ Guinnessovyacutech rekordov Juraj Barbarič odštartoval včera ťahaniacutem Škody Fabia 4 ročniacutek celoslovenskej kampane Na kolesaacutech proti rakovine Ide o zariadenie WAVE System a malo by byť po kuacutepe nainštalovaneacute v UacuteSTAVE EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SLOVENSKEJ AKADEacuteMIE VIED BRATISLAVA

13 Slovensko roztočiacute kolesaacute proti rakovine Pokračovanie v ušľachtilej myšlienke paralympijskeacuteho viacuteťaza R Kaufmana (11 52006 Zdravotniacutecke noviny č 192006 s 3 mž) Od maacuteja do oktoacutebra tohto roku sa uskutočni štvrtyacute ročniacutek celoslovenskej kampane Na kolesaacutech proti rakovine ktoruacute organizuje Slovenskyacute paralympijskyacute vyacutebor a Nadaacutecia Vyacuteskum rakoviny v spolupraacuteci s Uacuteniou miest Slovenska a Ministerstvom školstva SR Wave Systeacutem ktoryacute sa zakupuje pre UacuteSTAV EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV

14 Suacuteperiacute s ťažkyacutem protivniacutekom (4 5 2006 Slovenka č 192006 s 61 Staszovaacute Miroslava) Mladaacute priacuteťažlivaacute žena maacute naacuteročneacute povolanie v laboratoacuteriu suacuteperiacute s ťažkyacutem protivniacutekom - rakovinou Študuje zaacutekladneacute pochody v naacutedorovyacutech bunkaacutech aj možnosti ako ich ovplyvniť testuje protinaacutedoroveacute uacutečinky liečiv ale aj prirodzenyacutech laacutetok ktoreacute sa vyskytujuacute v potravinaacutech Maacute uacutespech doma - stala sa nositeľkou ocenenia Mladyacute vyacuteskumniacutek SR roka 2005 - aj v zahraničiacute Profilovyacute rozhovor s RNDr JANOU JAKUBIacuteKOVOU PhD

15 HODINKA S Profilovyacute rozhovor (celeacute dve strany Tele Plus 262006) Eleny Ťapajovej s RNDr JANOU JAKUBIacuteKOVOU PhD z Uacutestavu experimentaacutelnej onkologie SAV ktoraacute ziacuteskala ocenenie a titul Mladyacute vedec roka 2005

16 BOJOVNIacuteCI SUacute UacuteSPEŠNEJŠIacute (5 6 2006 Zdravie č 062006 s 66ndash68 Kaššovaacute

35

Jozefiacutena) Rozhovor s prof MUDr Ivanom Kozom DrSc prezidentom Slovenskej onkologickej spoločnosti V suacutevislosti so svojimi začiatkami spomiacutena UacuteSTAV EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV

17 Vyacuteskum rakoviny Slovensko držiacute krok so svetom (25 8 2006 Pravda s 3 Jančura Vladimiacuter) Text sa zaoberaacute vyacutesledkami štvordňovej konferencie CANCER 2006 o najnovšiacutech vyacutesledkoch onkologickeacuteho vyacuteskumu ktoruacute usporiadal Uacutestav experimentaacutelnej onkoloacutegie SAV vo Vysokyacutech Tatraacutech a zuacutečastnili sa na nej vedci z celeacuteho sveta Člaacutenok cituje vyjadrenia riaditeľa uacutestavu ČESTMIacuteRA ALTANERA a upozorňuje na ocenenie švajčiarskeho vedca českeacuteho pocircvodu Josefa Jiricneho riaditeľa Uacutestavu pre molekulaacuterny vyacuteskum rakoviny v Zuumlrichu Medzinaacuterodnou cenou SAV

18 V Tatraacutech o rakovine (17 8 2006 Zdravotniacutecke noviny č 302006 s 1) Spraacuteva informuje o tom že v Starej Lesnej sa 20 až 24 augusta 2006 uskutočniacute pri priacuteležitosti 60 vyacuteročia Uacutestavu experimentaacutelnej onkoloacutegie SAV medzinaacuterodneacute sympoacutezium CANCER 2006 Zaacuteštitu nad niacutem prevzali prezident SR Ivan Gašparovič a prezident SAV Štefan Luby

19 Ocenenie SAV prof J Jiricneacutemu (31 8 2006 Zdravotniacutecke noviny č 312006 s 2) Spraacuteva informuje o odovzdaacutevaniacute Medzinaacuterodnej ceny SAV 2006 za vynikajuacutece dielo v oblasti priacuterodnyacutech vied vyacuteznamnej osobnosti onkologickeacuteho vyacuteskumu v Euroacutepe prof Josefovi Jiricneacutemu (Zuumlrich) prof Štefanom Lubym Spomiacutena sa aj UacuteSTAV EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV

20 Zaacutezračnaacute liečba (25 8 2006 Plus 7 dniacute č 352006 s 68-70 Kubišovaacute Tatiana) K spraacuteve že na trhu sa čoskoro objaviacute prvaacute očkovacia laacutetka proti rakovine sa vyjadruje riaditeľ Uacutestavu experimentaacutelnej onkoloacutegie SAV ČESTMIacuteR ALTANER K člaacutenku je okrem toho pripojenyacute aj rozhovor s niacutem o uacutelohe genetiky a pravdepodobnosti ochorenia na rakovinu a fotografia RNDr KATARIacuteNY ZAacuteVODNEJ pri obsluhe DNA sekvenaacutetora

21 Vzdelanie je veľkou vyacutehodou slovenskyacutech vyacuteskumniacutekov (2 9 2006 Pravda s 1 4 Jancura Vladimiacuter) Celostranovyacute rozhovor s čerstvyacutem nositeľom Medzinaacuterodnej ceny SAV prof Josef Jiricnym (pocircvodom Čech) šeacutefom Uacutestavu pre molekulaacuterny vyacuteskum rakoviny v Zuumlrichu Spomiacutena aj spolupraacutecu s RNDr ZDENOU BARTOŠOVOU CSc z UacuteEO SAV

22 O zaacutepase proti rakovine prsniacuteka v USA (7 9 2006 Zdravotniacutecke noviny č 322006 s 3 mi) Nancy G Brinker zakladateľka Nadaacutecie Susan G Komen na boj s rakovinou prsniacuteka navštiacutevila SR Na stretnutiacute u americkeacuteho veľvyslanca v SR s poprednyacutemi slovenskyacutemi onkoloacutegmi poukaacutezal riaditeľ Uacutestavu experimentaacutelnej onkoloacutegie SAV Ing ČESTMIacuteR ALTANER DrSc na aplikovanyacute vyacuteskum v oblasti testovania na genetickuacute predispoziacuteciu naacutedorovyacutech ochoreniacute

23 Časopis TELEPLUS č 20 (23 9 ndash 6 10 Elena ŤAPAJOVAacute) Rubrika Haloacute ndash Haloacute - haloacute rozhovor s prof Josefom Jiricnym pri priacuteležitosti udelenia Medzinaacuterodnej ceny SAV Spomiacutena UacuteEO SAV a spolupraacutecu s RNDr ZDENOU BARTOŠOVOU CSc

36

24 Quark 1026 Medzinaacuterodnaacute cena SAV prof Josefovi Jiricneacutemu Str 20 Autor Marian Babic spomiacutena sa aj ZDENA BARTOŠOVAacute z UacuteEO SAV

25 Superliek Bude (24112006 Plus 7 dniacute č 482006 s 74-76 Wirghovaacute Ivica) V rozhovore s držiteľom prestiacutežnej ceny od Euroacutepskej spoločnosti pre lekaacutersku onkoloacutegiu ESMO Best Exam Award MUDr MICHALOM MEGOM PhD

26 Verejnaacute zbierka pomohla kuacutepiť zbraň proti chorobe (22 11 2006 Pravda priacuteloha Bratislava s III ) Včera na pocircde Uacutestavu experimentaacutelnej onkoloacutegie SAV predstavili americkyacute priacutestroj za 45 milioacutena koruacuten ktoryacute pomaacuteha odhaľovať včas naacutedorovyacute proces Uviedol to pri priacuteležitosti Tyacuteždňa vedy v SR riaditeľ uacutestavu ČESTMIacuteR ALTANER

27 Odhaľovanie dedičnyacutech foriem rakoviny sa zryacutechli (30112006 Zdravotniacutecke noviny č 442006 s 2 mž) V UacuteSTAVE EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV pribudol novyacute diagnostickyacute priacutestroj Wave System ktoryacute umožniacute na Slovensku ryacutechlejšiu skoruacute diagnostiku dedičnyacutech foriem rakovinovyacutech ochoreniacute Do prevaacutedzky ho uviedli počas dňa otvorenyacutech dveriacute v Tyacuteždni vedy v SR

28 Tyacuteždeň vedy aj v mediciacutene (30112006 Zdravotniacutecke noviny č 442006 s 3 mž) V spraacuteve sa hovori o dňoch otvorenyacutech dveriacute v raacutemci Euroacutepskeho tyacuteždňa vedy aj v troch uacutestavoch SAV Medzi nimi sa spomiacutena UacuteSTAV EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV

29 Experimentaacutelna onkoloacutegia (10 11 2006 Župneacute noviny č 102006 s 2 upr) V utorok 21 novembra sa o 10 h otvoria dvere UacuteSTAVU EXPERIMENTAacuteLNEJ ONKOLOacuteGIE SAV na Vlaacuterskej ulici 7 v Bratislave Toto podujatie sa konaacute pri priacuteležitosti Tyacuteždňa vedy EUacute Suacutečasťou Dňa otvorenyacutech dveriacute bude aj prehliadka vybranyacutech pracoviacutesk UacuteEO SAV so sprievodcom besedy s vyacuteskumnyacutemi pracovniacutekmi a doktorandmi

30 Deň otvorenyacutech dveriacute plaacutenuje uacutestav experimentaacutelnej onkoloacutegie SAV (19112006 Cupalovaacute TASR) V raacutemci ETVT sa uskutočniacute Deň otvorenyacutech dveriacute a do činnosti sa spustiacute novyacute priacutestroj Wawe System O vyacutezname priacutestroja hovoriacute prezidentka NVR M KLOBUŠICKAacute Spraacuteva informuje o programe počas DOD i 60 vyacuteročiacute vzniku UacuteEO SAV ktoryacute si počas tohto dňa pripomenie toto vyacuteznamneacute jubileum Z Tlač konf

31 Odovzdali priacutestroj Wave System na včasnuacute diagnostiku naacutedorov (21112006 C Cupalovaacute TASR) Stalo sa tak pri priacuteležitosti Dňa otvorenyacutech dveriacute v uacutestave v Raacutemci ETVThellip Včasnyacutem zachyteniacutem tohto procesu sa šanca na vyliečenie najmauml naacutedorov hrubeacuteho čreva štiacutetnej žľazy vaječniacutekov prsniacutekov či prostaty O priacutestroji informoval riaditeľ UacuteEO SAV Č ALTANER a ďalšiacute odborniacuteci uacutestavu Peniaze na zakuacutepenie priacutestroja - 39 milioacutena Sk sa podarilo ziacuteskať v spolupraacuteci s Nadaacuteciou SPP a Slovenskyacutem paralympijskyacutem vyacuteborom vďaka verejnej zbierke ktoraacute sa realizovala ako suacutečasť štyroch doterajšiacutech ročniacutekov celoslovenskej kampane Na kolesaacutech proti rakovine

32 Novyacute priacutestroj uryacutechli diagnostiku dedičnyacutech foriem rakoviny (21 november SITA) Novyacute diagnostickyacute priacutestroj s naacutezvom Wave-system umožniacute včasnuacute diagnostiku dedičnyacutech foriem rakovinovyacutech ochoreniacute hrubeacuteho čreva štiacutetnej žľazy prsniacuteka a vaječniacutekov Spraacuteva predstavuje novyacute priacutestroj slovami VLADIMIacuteRA ZAJACA

37

(UacuteEO) ktoryacute jeho činnosť vysvetlil novinaacuterom počas tlačovej konferencii v raacutemci Dňa otvorenyacutech dveriacute v UacuteEO i pozadie jeho ziacuteskania (zbierky nadaacutecie) z Tlačovej konferencie a DOD v UacuteEO SAV

33 Jedna otaacutezka (20 5 2006 Pravda s 2) Zuacutečastniacutete sa na parlamentnyacutech voľbaacutech ndash pre JANU JAKUBIacuteKOVUacute vyacuteskumniacutečku z Uacutestavu experimentaacutelnej onkoloacutegie SAV

34 Tyacuteždenniacutek bdquoTyacuteždeňldquo č 51 2006 ndash člaacutenok z rozhovoru s P BARAacuteTHOM na teacutemu Nobelova cena za mRNA

35 Spraacutevy SAV č 092006 - celostranovyacute člaacutenok na str 6 bdquoOsobnosť onkologickeacuteho vyacuteskumuldquo o odovzdaacutevaniacute medzinaacuterodnej ceny SAV prof J Jiricnemu a jeho spolupraacuteci s UacuteEO SAV Spomiacutena sa aj ZDENA BARTOŠOVAacute z UacuteEO SAV

36 Spraacutevy SAV č 092006 - celostranovyacute člaacutenok bdquoTerapia šitaacute na mieruldquo o medzinaacuterodnej konferencie bdquoCANCER 2006ldquo usporiadanej UacuteEO SAV Autor ZDENA BARTOŠOVAacute z UacuteEO SAV

37 Časopis DIMENZIE juacutel ndash august 2006 člaacutenok z rozhovoru s tajomniacutečkou uacutestavu Z BARTOŠOVOU o medzinaacuterodnej konferencii bdquoCANCER 2006ldquo usporiadanej uacutestavom Člaacutenok vyšiel pod naacutezvom bdquoNa Slovensku proti rakovineldquo

38 Časopis DIMENZIE č 112006 - celaacute strana (č16) bola venovanaacute propagaacutecii Dňa otvorenyacutech dveriacute na UacuteEO SAV Člaacutenok vyšiel pod naacutezvom bdquoCancer Research Foundation and Cancer Research Institute of Slovak Academy of Sciences organize Doors Open Dayldquo Podklady pripravili pracovniacuteci uacutestavu Čiernikovaacute S Bujalkovaacute M Krivulčiacutek T

39 CANCER 2006 (16 11 2006 Zdravotniacutecke noviny č 422006 priacuteloha Lekaacuterske listy str 16) Člaacutenok informuje o tom že v Starej Lesnej sa 20 až 24 augusta 2006 uskutočnila pri priacuteležitosti 60 vyacuteročia Uacutestavu experimentaacutelnej onkoloacutegie SAV medzinaacuterodnaacute konferencia CANCER 2006 Člaacutenok prinaacuteša abstrakt jednej z kľuacutečovyacutech prednaacutešok konferencie Dr A Futreala

40 TWIN CITY JOURNAL č 122006 str 31-33- člaacutenok venovanyacute 60vyacuteročiu slovenskej onkoloacutegie a benefičnyacutem podujatiam pre Nadaacuteciu Vyacuteskum rakoviny pod naacutezvom bdquoBenefičneacute podujatia pre Nadaacuteciu Vyacuteskum rakovinyldquo na zaacuteklade rozhovoru s riaditeľom uacutestavu Č ALTANEROM a prezidentkou nadaacutecie Vyacuteskum rakoviny M KLOBUŠICKOU

Tlačoveacute besedy 3

1 Tlačovaacute beseda 2932006 uacutečasť riaditeľa uacutestavu Č Altanera na tlačovej besede v hoteli Danube usporiadanej Ligou proti rakovine SR pri priacuteležitosti Dňa narcisov

2 Tlačovaacute beseda 932006 uacutečasť riaditeľa uacutestavu Č Altanera na tlačovej besede na Naacuterodnom onkologickom uacutestave v Bratislave pri priacuteležitosti zakuacutepenia priacutestroja pre NOUacute

38

3 Tlačovaacute beseda 21112006 na UacuteEO SAV organizovanaacute uacutestavom a Nadaacuteciou Vyacuteskum rakoviny z priacuteležitosti Dňa otvorenyacutech dveriacute UacuteEO SAV a uvedenia diagnostickeacuteho priacutestroja Wave System do prevaacutedzky

Popularizaacutecia na internete 39

1 Vyhlaacutesili vedca roka 2005 TASR 1532006 161255 Informaacutecia o vedcoch (aj zo SAV) ocenenyacutech v raacutemci akcie bdquoVedec roka 2005ldquo ndash technoloacuteg roka Ing Jaacuten Balaacutež PhD Mladyacute vyacuteskumniacutek roka RNDr JANA JAKUBIacuteKOVAacute PhD vedec roka prof Anatolij Dvurečenskij - wwwpravdaskspravy

2 Vyhlaacutesili vedca roka 2005 TASR wwwcassoviask3 Vyhlaacutesili vedca roka 2005 TASR wwwspacesaskesk4 Vyhlaacutesili vedca roka 2005 TASR wwwdennesk5 SAV už po deviaty raz ocenila najlepšiacutech vedcov 1532006 Webnoviny ndash

wwwwebnovinysk SITA6 SAV už po deviaty raz ocenila najlepšiacutech vedcov 1532006 WNSITA

www24hodsk7 SAV už po deviaty raz ocenila najlepšiacutech vedcov 1532006 SITA wwwfaktysk8 Už po deviaty raz ocenili najlepšiacutech vedcov ndash člaacutenok na DENNEsk

wwwdenneskpamatsmesk SITA9 SAV už po deviaty raz ocenila najlepšiacutech vedcov 1532006 SITAx

wwwhnonlinesk HN online10 Deň otvorenyacutech dveriacute na Uacutestave experimentaacutelnej onkoloacutegie SAV bude 21 11

(Spraacuteva TASR 1911 2006 Prevzal httpwwwzzzsk 2011200611 Novyacute priacutestroj uryacutechli diagnostiku dedičnyacutech foriem rakoviny (21 november

SITA) Novyacute diagnostickyacute priacutestroj s naacutezvom Wave-system umožniacute včasnuacute diagnostiku dedičnyacutech foriem rakovinovyacutech ochoreniacute hrubeacuteho čreva štiacutetnej žľazy prsniacuteka a vaječniacutekov Spraacuteva predstavuje novyacute priacutestroj slovami Vladimiacutera Zajaca (UacuteEO) ktoryacute jeho činnosť vysvetlil novinaacuterom počas tlačovej konferencii v raacutemci Dňa otvorenyacutech dveriacute v UacuteEO i pozadie jeho ziacuteskania (zbierky nadaacutecie) Spraacutevu prevzali WEBNOVINYsk - wwwwebnovinysk 21112006 1342 (Patria agentuacutere SITA)

12 Novyacute priacutestroj uryacutechli diagnostiku SMEsk - wwwsmesk13 Novyacute priacutestroj uryacutechli diagnostiku wwwbleskovkysk14 Novyacute priacutestroj uryacutechli diagnostiku 24 hodinsk - www24hodinsk 15 Novyacute priacutestroj uryacutechli diagnostiku CHELLOsk - wwwchellosk16 Novyacute priacutestroj uryacutechli diagnostiku wwwnovinyvsetkocom17 Novyacute priacutestroj uryacutechli diagnostiku Velka epocha wwwvelkaepochask18 Novyacute priacutestroj uryacutechli diagnostiku FIT SERVER - wwwfitserverssk19 Novyacute priacutestroj uryacutechli diagnostiku AKTUALITYsk - httpwwwaktualitysk20 Novyacute priacutestroj uryacutechli diagnostiku wwwwapmaniaskspravy21 Novyacute priacutestroj uryacutechli diagnostiku ICTNEWS - httpwwwictnewssk22 Novyacute priacutestroj uryacutechli diagnostiku ITKARIERA ndash Portal for IR Professionals

wwwitkarierask23 Novyacute priacutestroj uryacutechli diagnostiku httpwwwhladamskarchiv

39

24 Novyacute priacutestroj uryacutechli diagnostiku Bratislava online - httpwwwbaonsk25 Novyacute priacutestroj uryacutechli diagnostiku Košice na Dennesk -

wwwdenneskdomovkosice26 Novyacute priacutestroj uryacutechli diagnostiku PC SERVER - pcserverssk27 Novyacute priacutestroj uryacutechli diagnostiku Gamily G ndash wwwfamilygsk 28 Novyacute priacutestroj uryacutechli diagnostiku Centrumcz - searchcentrumcz29 Odovzdali priacutestroj Wave System na včasnuacute diagnostiku naacutedorov (2111 TASR)

Priacutestroj Wave System ktoryacute pomocircže včas odhaľovať začiacutenajuacuteci naacutedorovyacute proces dnes slaacutevnostne odovzdali do užiacutevania v Uacutestave experimentaacutelnej onkoloacutegie SAV v Bratislave Prevzali ATLASsk ndash httpdnesatlassk

30 Odovzdali priacutestroj Wave System ORANGE portal - wwworangeportalskdnes

31 Odovzdali priacutestroj Wave System wwwspvskaktuality32 Odovzdali priacutestroj Wave System wwwmamatatask33 Odovzdali priacutestroj Wave System wwwzdravcentrask34 Odovzdali priacutestroj Wave System wwwzdraviesk35 Slaacutevnostneacute odovzdanie diagnostickeacuteho priacutestroja Wave System

httpwwwspvskaktualitywsview36 Informačnyacute servis SAV (wwwsavsk)- zo dňa 2012006 - priacutespevky riaditeľa uacutestavu

Č ALTANERA a prezidentky NVR M KLOBUŠICKEJ ktoreacute odzneli na Novoročnom koncerte Nadaacutecie Vyacuteskum rakoviny 1712006 v Zrkadlovej sieni Primaciaacutelneho palaacuteca

37 Informačnyacute servis SAV (wwwsavsk) ndash oznamy SAV ndash Aktuality ndash 2882006 -Vedci proti rakovine ndash informaacutecia o konferencii CANCER 2006 ndash Vložila A Štrpkovaacute - Autor ZDENA BARTOŠOVAacute

38 Informačnyacute servis SAV (wwwsavsk) - oznamy SAV ndash Aktuality ndash 2882006 - Laureaacutetom prof Josef Jiricny ndash Vložil V Šmihula ndash spomiacutena sa UacuteEO SAV a spolupraacuteca s Dr ZDENOU BARTOŠOVOU

39 Informačnyacute servis SAV (wwwsavsk) - oznamy SAV ndash Aktuality o Detekcii dedičnyacutech zmien za 24 hodiacuten (24 11 2006 A Štrpkovaacute) Informaacutecia + fotoreportaacutež z tlačovej konferencie a Dňa otvorenyacutech dveriacute v UacuteSTAVE EXPERIMENTAacuteLNEJ ONKOLOacuteGIE počas ETVT kde spustili do činnosti priacutestroj Wawe Systeacutem na detekciu mutaacutecie DNA zakuacutepenyacute zo zbierok Slovenskeacuteho paralympijskeacuteho vyacuteboru a daru Nadaacutecie Slovenskeacuteho plynaacuterenskeacuteho priemyslu

Popularizačneacute člaacutenky v novinaacutech a časopisoch 6

1 Časopis Quark č 122006 ndash člaacutenok bdquoZaacutezrak zvanyacute kmeňoveacute bunkyldquo autor Č ALTANER

2 Školskyacute časopis Bioloacutegia Ekoloacutegia Cheacutemia č1 9-14 2006 ndash stať bdquoČo je to naacutedoroveacute ochorenie (rakovina) ako vznikaacute a ako sa pred niacutem chraacuteniťldquo autor Č ALTANER

3 Školskyacute časopis Bioloacutegia Ekoloacutegia Cheacutemia č 2 10-16 2006 - stať bdquoJe rakovina

dedičnaacuteldquo autor Č ALTANER

40

4 Školskyacute časopis Bioloacutegia Ekoloacutegia Cheacutemia č 3 16-17 2006 - stať bdquoMolekulovo nasmerovanaacute terapia naacutedorovldquo autor Č ALTANER

5 Školskyacute časopis Bioloacutegia Ekoloacutegia Cheacutemia č 4 00-00 2006 stať bdquoKmeňoveacute bunkyldquo autor Č ALTANER

6 Denniacutek Uacutejszoacute - 872006 ndash člaacutenok v maďarskom jazyku bdquoVyužitie genetiky vo vyacuteskume rakovinyldquo autor A ALEMAYEHU

Vedecko-popularizačneacute prednaacutešky 10

1 273 2006 na Onkologickom uacutestave sv Alžbety Heydukova ul Bratislava - vyžiadanaacute prednaacuteška riaditeľa uacutestavu Č ALTANERA bdquoUacuteloha kmeňovyacutech buniek pri vzniku naacutedoruldquo a bdquoCielenaacute terapialdquo

2 862006 v Kultuacuternom dome Ľ Štuacutera v Modre - vyžiadanaacute prednaacuteška riaditeľa uacutestavu Č ALTANERA bdquoAko sa braacuteniť vzniku rakovinyldquo

3 23112006 na Agroinštituacutete v Nitre - vyžiadanaacute prednaacuteška riaditeľa uacutestavu Č ALTANERA bdquoUacuteloha kmeňovyacutech buniek pri vzniku naacutedoru prevencia a možnosti cielenej terapieldquo

4 23112006 na Agroinštituacutete v Nitre - vyžiadanaacute prednaacuteška riaditeľa uacutestavu Č ALTANERA bdquoVyacuteživa a naacutedoroveacute chorobyldquo

5 2832006 Na Evanjelickom Lyacuteceu - vyžiadanaacute prednaacuteška Z BARTOŠOVEJ Je rakovina dedičnaacute

6 ALTANER Č Normaacutelne a naacutedoroveacute kmeňoveacute bunky potenciaacutelne využitie na terapiu naacutedorov Vyžiadanaacute prednaacuteška pre Spolok slovenskyacutech lekaacuterov NTUacute LFUK Bratislava 30102006

7 ALTANER Č Uacutestav experimentaacutelnej onkoloacutegie SAV ndash 60 rokov existencie Vyžiadanaacute prednaacuteška pre Spolok slovenskyacutech lekaacuterov NTUacute LFUK Bratislava 30102006

8 BARTOŠOVAacute Z Možnosti detekcie dedičnej predispoziacutecie ku vzniku naacutedorov Vyžiadanaacute prednaacuteška pre Spolok slovenskyacutech lekaacuterov NTUacute LFUK Bratislava 30102006

9 SEDLAacuteK J Epigenetickaacute regulaacutecia geacutenovej expresie Prednaacuteška 4 okt 2006 DFNsP Bratislava

10 SEDLAacuteK J Suacute priacuterodneacute chemopreventiacutevne laacutetky využiteľneacute v terapii naacutedorov Vyžiadanaacute prednaacuteška pre Spolok slovenskyacutech lekaacuterov NTUacute LFUK Bratislava 30102006

Vedecko-popularizačneacute člaacutenky na internetovej straacutenke wwwnvrsk 12

1 ZAacuteVODNAacute K Dedičneacute formy rakoviny - určenie predispoziacutecie pomaacuteha prežiť2 ČIERNIKOVAacute S Dedičnaacute rakovina prsniacuteka a vaječniacutekov - molekulaacuterna genetika a

prevencia

41

3 ŽELEZNIacuteKOVAacute T Imunofenotypizaacutecia leukeacutemiiacute- ako zlepšuje diagnostiku a liečbu pacientov

4 KIRSCHNEROVAacute G Cytogenetickaacute a FISH analyacuteza naacutedorov - skryteacute tajomstvaacute chromozoacutemov

5 KUČEROVAacute L Využitie kmeňovyacutech buniek v liečbe naacutedorov - Troacutejsky kocircň v onkoloacutegii

6 PASTORAacuteKOVAacute A Geacutenovaacute terapia naacutedorov - sen sa staacuteva skutočnosťou7 CHOLUJOVAacute D Protinaacutedorovaacute imunita a imunoterapia - molekulaacuterne ministerstvo

obrany8 ŠRAMKOVAacute M Chemickaacute mutageneacuteza a karcinogeneacuteza - ako naacutes chemikaacutelie

menia9 DUDAacuteŠOVAacute Z Poškodenie DNA jej oprava a vznik naacutedorov- neviditeľnyacute ochranca

v akcii10 POLAKOVIČOVAacute E Rakovina kože a oprava DNA - čo naacutes chraacuteni pred

poškodeniacutem UV svetlom11 BOĎO J Signaacutelne draacutehy a rakovina- zmeneneacute kontakty vnuacutetri buniek12 KOŠŤANOVAacute-POLIAKOVAacute D Apoptoacuteza ndash bunkovaacute smrť v službaacutech života

Usporiadanie domaacutecich vedeckyacutech podujatiacute (vraacutetane kurzov a škocircl) s uvedeniacutem naacutezvu podujatia daacutetumu miesta konania a počtu uacutečastniacutekov)

1) Uacutestav usporiadal vo svojich priestoroch Deň otvorenyacutech dveriacute dňa 21112006 Uacutestav navštiacutevilo takmer 250 študentov strednyacutech škocircl a gymnaacuteziiacute Uacutestav navštiacutevila aj verejnosť televiacutezia a novinaacuteri a vyacuteznamneacute osobnosti kultuacuterneho a verejneacuteho života

Uacutestav navštiacutevili žiaci tyacutechto škocirclStrednaacute zdravotniacuteckaGymnaacutezium BiacutelikovaGymnaacutezium Grosslingova Suacutekromna hotelovaacute akadeacutemia HaGMa Gymnaacutezium Sv Vincenta Gymnaacutezium Vazovova Gymnaacutezium Metodova Evanjelickeacute lyacuteceum Gymnaacutezium Sv Uršule Gymnaacutezium Tomaacutešikovaacute Gymnaacutezium Milana Rastislava Štefaacutenika

Program Dňa otvorenyacutech dveriacute bol nasledovnyacute

bull Tlačovaacute beseda so slaacutevnostnyacutem uvedeniacutem priacutestroja Wave system do prevaacutedzky (Jaacuten Riapoš predseda Slovenskeacuteho paralympijskeacuteho vyacuteboru a Miroslav Lapuniacutek generaacutelny riaditeľ Slovenskeacuteho plynaacuterenskeacuteho priemyslu a s)

bull Exkurzia do laboratoacuteriiacute UacuteEO SAV besedy s vyacuteskumnyacutemi pracovniacutekmi a doktorandami

42

bull Prehliadky posterov s vyacutekladombull Vystuacutepenia a rozhovory s priateľmi Nadaacutecie Vyacuteskum rakoviny (Posol NVR Božidara

Turzonovovaacute jazzovyacute klavirista Pavol Bodnaacuter spievajuacuteci paralympionik ndash vozičkaacuter Pavol Elgyutt juniorskyacute viacuteťaz French Open 2006 - Roland Gaross Martin Kližan kuacutezelniacutek Peter Šestaacutek tanečnyacute suacutebor Latiniko a ďalšiacute)

bull Beseda s lekaacutermi a naacuteslednaacute naacutevšteva laboratoacuteriiacute pre verejnosť

2) Uacutestav sa spolupodieľal na usporiadaniacute XLIII Bratislavskyacutech onkologickyacutech dniacute a XVII konferencie SZP ktoreacute sa uskutočnili dňa 5- 6102006

3) Uacutestav organizoval na svojej pocircde 21 odbornyacutech seminaacuterov Dvanaacutesť prednaacutešok uskutočnili pracovniacuteci uacutestavu (suacute zaradeneacute v priacutelohe 3 v sekcii Ostatneacute prednaacutešky) Prednaacutešky mimouacutestavnyacutech prednaacutešateľov boli nasledovneacute

1 Dr Wolf ndash Dieter Schultz iA Dr Reiner Gangnus PALM-Zeiss ldquoLaser Microdissection Pressure Catapulting as a key technology for modern molecular medicine and biologyrdquo 822006 (počet uacutečastniacutekov 38)

2 Dr Imrich Hikkel Odd onkologickej genetiky NOUacute Bratislava ldquoIdentifikaacutecia genetickeacuteho prediktiacutevneho faktora 18q pre chemoterapiu klinickeacuteho štaacutedia II kolorektaacutelneho karcinoacutemuldquo 1532006 (počet uacutečastniacutekov 39)

3 Prof Jozef Gecz PhD Neurogenetics Laboratory Department of Genetic Medicine Womens and Childrens Hospital Adelaide Australia ldquoMining for GOLD on the X chromosome (GOLD ndash genes Of Learning Disability)ldquo 2232006 (počet uacutečastniacutekov 44)

4 Igor Belyaev PhD Dept of Genetics Microbiology and Toxicology Stockholm University Stockholm Sweden ldquoElectromagnetic fields and cancer genetic or epigenetic mechanismsldquo 2732006 (počet uacutečastniacutekov 23)

5 Dr Frank Koltrowitz Export Manager Miltenyi Biotec GmbH Bergisch-Glandbach ldquoMagnetic Separation of Cells and Biomolecules Basic principlesldquo 2932006 (počet uacutečastniacutekov 29)

6 Prof RNDr Vladimiacuter Bužek DrSc Vyacuteskumneacute centrum pre kvantovuacute informaacuteciu Fyzikaacutelny uacutestav SAV Bratislava ldquoLa gaya scienza ()rdquo 2452006 (počet uacutečastniacutekov 35)

7 MUDr Ing Peter Celec PhD Uacutestav patologickej fyzioloacutegie Oddelenie molekulaacuternej bioloacutegie Univerzita Komenskeacuteho Bratislava ldquoAlternatiacutevna geacutenovaacute terapia - bakteacuterie v geacutenovej terapiirdquo 1462006 (počet uacutečastniacutekov 33)

8 Yongping Bao PhD School of Medicine Health Policy and Practice University of East Anglia Norwich United Kingdom ldquoAnticarcinogenic activity of dietary isothiocyanatesrdquo 31102006 (počet uacutečastniacutekov 21)

9 Prof RNDr Katariacutena Horaacutekovaacute DrSc Uacutestav biotechnoloacutegie a potravinaacuterstva Fakulta chemickej a potravinaacuterskej technoloacutegie Slovenskaacute Technickaacute Univerzita Bratislava ldquoFytochemikaacutelie s protinaacutedorovyacutem uacutečinkom vyskytujuacutece sa v potravinaacutech Cieleneacute stravovanierdquo 14122006 (počet uacutečastniacutekov 33)

43

Členstvo v organizačnyacutech vyacuteboroch domaacutecich vedeckyacutech podujatiacute s uvedeniacutem naacutezvu podujatia daacutetumu a miesta konania

XLIII Bratislavskeacute onkologickeacute dni a XVII konferencia SZP ktoreacute sa uskutočnili dňa 5- 6102006 SUacuteZA MZV SR Drotaacuterska cesta 46 Bratislava a na Naacuterodnom onkologickom uacutestave Klenovaacute 1 Bratislava

Členovia organizačneacuteho vyacuteboru Altaner Č Babušiacutekovaacute O Sedlaacutek J

Členstvo v organizačnyacutech vyacuteboroch dvoch domaacutecich medzinaacuterodnyacutech vedeckyacutech podujatiacute je uvedeneacute v sekcii IV Medzinaacuterodnaacute vedeckaacute spolupraacuteca

Domaacutece vyznamenania a ceny za vedeckuacute a inuacute činnosť a ineacute docircležiteacute informaacutecie k vedecko-organizačnyacutem a popularizačnyacutem aktivitaacutem (uviesť konkreacutetne)

Brozmanovaacute J Vyacuteznamnaacute osobnosť SAV

Jakubiacutekovaacute J Mladyacute Vyacuteskumniacutek roka 2005

Babušiacutekovaacute O Čestneacute uznanie v raacutemci akcie bdquoVedec roka 2005ldquo

Biziacutek J Čestneacute uznanie v raacutemci akcie bdquoVedec roka 2005ldquo

Slameňovaacute D Čestneacute uznanie v raacutemci akcie bdquoVedec roka 2005ldquo

Čiernikovaacute S schvaacutelenie Schwarzovho štipendia

Markovaacute E cestovneacute štipendium z Literaacuterneho fondu

Členstvo v redakčnyacutech radaacutech domaacutecich časopisov

Ujhaacutezy V šeacutefredaktor časopisu NEOPLASMAAltaner Č člen redakčnej rady časopisu NEOPLASMAOndrušovaacute M členka redakčnej rady časopisu UROLOacuteGIA

členka redakčnej rady LEKAacuteRSKYCH LISTOV

Martinickyacute D redaktor v ZDRAVOTNIacuteCKYCH NOVINAacuteCH

Činnosť v domaacutecich resp v česko-slovenskyacutech vedeckyacutech spoločnostiach

Altaner Č člen Slovenskej lekaacuterskej spoločnosti

Babušiacutekovaacute O členka Slovenskej lekaacuterskej spoločnosti

44

Bačovaacute G členka Česko-Slovenskej biologickej spoločnosti ndash Spoločnosti pre mutageneacutezu vonkajšiacutem prostrediacutem

Bartošovaacute Z členka Genetickej spoločnosti Gregora Mendela

Brozmanovaacute J členka Československej společnosti mikrobiologickeacute

Dudaacuteš A člen Genetickej spoločnosti Gregora Mendela

Farkašovaacute T členka Česko-Slovenskej biologickej spoločnosti ndash Spoločnosti pre mutageneacutezu vonkajšiacutem prostrediacutem

Gaacutebelovaacute A členka vyacuteboru Česko-Slovenskej biologickej spoločnosti ndash Spoločnosti pre mutageneacutezu vonkajšiacutem prostrediacutem

členka Slovenskej lekaacuterskej spoločnosti

Gurskaacute S členka Česko-Slovenskej biologickej spoločnosti ndash Spoločnosti pre mutageneacutezu vonkajšiacutem prostrediacutem

Hlubinovaacute K členka Slovenskej lekaacuterskej spoločnosti

členka vyacuteboru Sekcie Pracovniacutekov s tkanivovyacutemi kultuacuterami Onkologickej spoločnosti SLS

Horvaacutethovaacute E členka Slovenskej lekaacuterskej spoločnosti

členka Česko-Slovenskej biologickej spoločnosti ndash Spoločnosti pre mutageneacutezu vonkajšiacutem prostrediacutem

Chalupa I člen Genetickej spoločnosti Gregora Mendela

člen Slovenskej lekaacuterskej spoločnosti

predseda Sekcie Pracovniacutekov s tkanivovyacutemi kultuacuterami Onkologickej spoločnosti SLS

Chovanec M člen Genetickej spoločnosti Gregora Mendela

Klobušickaacute M členka vyacuteboru Slovenskej histo- a cytochemickej spoločnosti SLS

Lazarovaacute M členka Česko-Slovenskej biologickej spoločnosti ndash Spoločnosti pre mutageneacutezu vonkajšiacutem prostrediacutem

Novotnyacute L člen Slovenskej lekaacuterskej spoločnosti

člen Slovenskej farmaceutickej spoločnosti

Ondrušovaacute M členka Slovenskej onkologickej spoločnosti

členka Slovenskej urologickej spoločnosti

Piršel M člen Genetickej spoločnosti Gregora Mendela

Pleško I člen Slovenskej mikrobiologicko-epidemiologickej spoločnosti

člen Slovenskej onkologickej spoločnosti

člen Spoločnosti sociaacutelneho lekaacuterstva

Šramkovaacute M členka Česko-Slovenskej biologickej spoločnosti ndash Spoločnosti pre mutageneacutezu vonkajšiacutem prostrediacutem

45

Sirackyacute J predseda sekcie Klinickaacute cytoloacutegia Spoločnosti patoloacutegov SLS

Slameňovaacute D členka Česko-Slovenskej biologickej spoločnosti ndash Spoločnosti pre mutageneacutezu vonkajšiacutem prostrediacutem


Ujhaacutezy V člen Slovenskej akademickej spoločnosti


člen Spoločnosti pre podporu kritickeacuteho myslenia

Valovičovaacute Z členka Česko-Slovenskej biologickej spoločnosti ndash Spoločnosti pre mutageneacutezu vonkajšiacutem prostrediacutem

Zajac V člen Slovenskej lekaacuterskej spoločnosti

VIII Činnosť knižnično-informačneacuteho pracoviska

1 Uacutestav disponuje knižnicou v ktorej je zamestnanaacute pracovniacutečka na 75 uvaumlzok

2 Knižnica poskytovala v r 2006 nasledovneacute služby

bull vyacutepožičky periodiacutek a monografiiacute pre pracovniacutekov uacutestavu

bull prezenčneacute vyacutepožičky (5 naacutevštevniacutekov)

bull v raacutemci medziknižničnej vyacutepožičnej služby xerokoacutepie separaacutetov (40 ks)

3 Stav knižničnyacutech fondov (počet titulov dochaacutedzajuacutecich periodiacutek počet dizertaacuteciiacute

fotodokumentov a pod)

Stav ku koncu r 2006 5425 knižničnyacutech jednotiek (vyradenyacutech 71)

Periodikaacute sme ziacuteskali vyacutemenou za časopis NEOPLASMA vydaacutevanyacute uacutestavom a darom

Vyacutemena 11 periodiacutek

Dar 9 periodiacutek

Do knižnice pribudlo 6 dizertačnyacutech praacutec

46

IX Aktivity v orgaacutenoch SAV

1 Členstvo vo vedeckyacutech koleacutegiaacutech SAVAltaner Č člen Vedeckeacuteho koleacutegia SAV pre molekulaacuternu bioloacutegiuBabušiacutekovaacute O členka Vedeckeacuteho koleacutegia SAV pre lekaacuterske vedyUjhaacutezy V člen Vedeckeacuteho koleacutegia SAV pre lekaacuterske vedyAltaner Č člen Učenej spoločnosti SAV

2 Členstvo v komisiaacutech Predsedniacutectva SAV

Hlubinovaacute K členka Bytovej komisie SAV

Polaacutekovaacute K členka European Science Foundation

Polaacutekovaacute K členka Standing Committee of European Medical Research Council (EMRC)

3 Členstvo v orgaacutenoch VEGA

Polaacutekovaacute K členka komisie VEGA pre lekaacuterske a farmakologickeacute vedyPiršel M podpredseda komisie VEGA pre molekulovuacute a bunkovuacute

bioloacutegiuPiršel M člen Predsedniacutectva VEGA

47

X Hospodaacuterenie organizaacutecie

Vyacutedavky RO SAVv tis Sk

Kategoacuteria Poslednyacuteupravenyacute

rozpočet r 2006

Čerpaniek 31122006

celkom

z toho

z rozpočtu z mimorozzdrojov

Vyacutedavky celkom 44 545 47 349 44 545 2 804z toho- kapitaacuteloveacute vyacutedavky 427 576 426 150- bežneacute vyacutedavky 44 118 46 773 44 158 2 654 z toho - mzdoveacute vyacutedavky 22 625 22 625 22 625 0

odvody do poisťovniacute a NUacuteP

8 356 8 310 8 310 0

- tovary a ďalšie služby 11 160 13 689 11 160 2 529 z toho

vyacutedavky na projekty (VEGA APVV MVTP ESF )

4684 4 684 4 684 2 305

vyacutedavky na periodickuacute tlač

259 459 259 200

transfery na vedeckuacute vyacutechovu

1 947 1 947 1 947 0

Priacutejmy RO SAVv tis Sk

Kategoacuteria Poslednyacute upravenyacuterozpočet r 2006

Plneniek 31122006

Priacutejmy celkom 3102 2 956z tohorozpočtovaneacute priacutejmy (uacutečet 19) 282 301z toho- priacutejmy za naacutejomneacute 282 282mimorozpočtoveacute priacutejmy (uacutečet 780)

2 820 2 655

48

XI Nadaacutecie a fondy pri pra covisku (s uvedeniacutem naacutezvu zamerania)

1) Spolupraacuteca s Nadaacuteciou Vyacuteskum rakoviny

Nadaacuteciu Vyacuteskum rakoviny (NVR) založili pracovniacuteci UacuteEO SAV Jej hlavnyacutem cieľom je finančne podporovať zaacutekladnyacute a aplikovanyacute onkologickyacute vyacuteskum so zameraniacutem na prevenciu včasnuacute diagnostiku a liečbu rocircznych zhubnyacutech naacutedorov Organizovaniacutem tlačovyacutech konferenciiacute s uacutečasťou rocircznych meacutediiacute a verejnyacutemi vystuacutepeniami v raacutediu televiacutezii a na benefičnyacutech podujatiach sa NVR usiluje propagovať Uacutestav experimentaacutelnej onkoloacutegie SAV a vedeckeacute vyacutesledky jeho pracovniacutekov Aktivity zameriava najmauml na ziacuteskavanie finančnyacutech prostriedkov na doplnenie a zmodernizovanie laboratoacuterneho a diagnostickeacuteho priacutestrojoveacuteho vybavenia uacutestavu V roku 2006 sa zavŕšila kampaň bdquoNa kolesaacutech proti rakovineldquo vyacutesledkom ktorej bol finančnyacute priacutespevok 750 000- Sk na drahyacute priacutestroj Wave systeacutem Nadaacutecia v roku 2006 finančne podporila sumou 250 000- Sk medzinaacuterodnuacute konferenciu bdquoCancer 2006ldquo usporiadanuacute uacutestavom Viaceriacute pracovniacuteci UacuteEO SAV suacute členmi orgaacutenov nadaacutecie

Klobušickaacute M prezidentkaBiacutezik J viceprezidentChudějovaacute E spraacutevkyňa

Brozmanovaacute J členka spraacutevnej radyŠabovaacute Ľ členka spraacutevnej radySedlaacutek J člen spraacutevnej radyZajac V člen spraacutevnej radyBujalkovaacute M členka spraacutevnej radyČiernikovaacute S členka spraacutevnej radyKirschnerovaacute G členka spraacutevnej rady

Bartošovaacute Z členka dozornej radyHlubinovaacute K členka dozornej radyJakubiacutekovaacute M členka dozornej rady

2) Spolupraacuteca s Ligou proti rakovine SR

Liga proti rakovine SR podporovala finančneacute zabezpečenie dvoch projektov v celkovej sume 600 000- Sk a najmauml kuacutepu zahraničnyacutech vedeckyacutech časopisov Dvaja pracovniacuteci UacuteEO SAV suacute členmi orgaacutenov Ligy

Altaner Č člen Vedeckej rady a člen Generaacutelnej radyUjhaacutezy V člen Vedeckej rady

49

XII Ineacute vyacuteznamneacute činn osti pracoviska

1 Uacutestav uacutezko spolupracuje s klinickyacutemi pracoviskami v Bratislave s cieľom zlepšiť podmienky pre translačnyacute vyacuteskum Spolupraacuteca zahŕňa Onkologickyacute uacutestav sv Alžbety Naacuterodnyacute onkologickyacute uacutestav Detskeacute onkologickeacute oddelenie Detskej fakultnej nemocnice s poliklinikou Klinika hematoloacutegie a transfuzioloacutegie Interneacute oddelenie a patologickeacute oddelenie Deacutererovej fakultnej nemocnice s poliklinikou a ďalšie

2 Pracovniacuteci uacutestavu boli zakladateľmi a spoluriešiteľmi projektov Naacuterodneacuteho onkologickeacuteho registra SR ktoreacuteho analyacutezy tvoria podklad pre expertiacutezy rozhodovania v oblasti verejneacuteho zdravotniacutectva

3 Pracovniacuteci uacutestavu pripravujuacute spraacutevy o vyacuteskyte vybranyacutech zhubnyacutech naacutedorov pre Svetovuacute zdravotniacutecku organizaacuteciu (WHO) Medzinaacuterodnuacute uacuteniu pre boj proti rakovine (UICC)) a Medzinaacuterodnuacute agentuacuteru pre vyacuteskum rakoviny (IARC) a rocirczne programy cestou UZIŠ MZdSR a Slovenskej uacuteradovne WHO

4 Uacutestav je akreditovanyacute podieľať sa na uskutočňovaniacute doktorandskeacuteho štuacutedijneacuteho programu v štuacutedijnom odbore onkoloacutegia a genetika

5 Riaditeľ uacutestavu je expertom pre hodnotenie vyacuteskumnyacutech zaacutemerov Ministerstva zdravotniacutectva a Ministerstva školstva Českej republiky expertom pre genomiku INTAS programu EUacute členom European Cancer Research Manager Forum (ECRM) a členom svetoveacuteho vyacuteboru bdquoInternational Association for Comparative Research in Leukemia and Related Diseasesldquo

6 Pracovisko je členom Organizaacutecie euroacutepskych onkologickyacutech uacutestavov kde spolu s Onkologickyacutem uacutestavom sv Alžbety tvoriacute Comprehensive Cancer Center Bratislava

XIII Vyznamenania ocenenia a ceny udeleneacute pracovniacutekom organizaacutecie v roku 200 6 (mimo SAV)

1) Dekan Priacuterodovedeckej fakulty Univerzity Komenskeacuteho v Bratislave Prof RNDr Anton Gaacuteplovskyacute DrSc udelil uacutestavu Medailu

FACULTAS RERUM NATURALIUM CONDITA MCMXLUNIVERSITAS COMENIANA BRATISLAVENSIS

ako ocenenie spolupraacutece a pomoci UacuteEO SAV pri vyacutechove diplomantov a vyacuteučbe študentov ktoraacute trvaacute viac ako 30 rokov V liste dekana sa ďalej uvaacutedza že taacuteto plodnaacute spolupraacuteca vyuacutestila do uplatnenia absolventov predovšetkyacutem katedier genetiky molekulaacuternej bioloacutegie a biocheacutemie na UacuteEO a niektoryacutech aj na NOUacute OUSA

2) RNDr Ivan Chalupa CSc bol ocenenyacute Striebornou medailou za zaacutesluhy o Slovenskuacute lekaacutersku spoločnosť (udelila Slovenskaacute onkologickaacute spoločnosť SLS Bratislava)

50

51

XIV Poskytovanie informaacuteciiacute v suacutelade so zaacutekonom o slobode informaacuteciiacute

Pracovnaacute skupina epidemioloacutegie naacutedorov poskytovala informaacutecie o incidencii a mortalite na naacutedoroveacute ochorenia v suacutelade so zaacutekonom o slobode informaacuteciiacute

XV Zaacutevažneacute probleacutemy pracoviska a podnety pre činnosť SAV Vzhľadom na nedostatok finančnyacutech prostriedkov na reacutežiu uacutestavu vedenie uacutestavu muselo rozhodnuacuteť o odobratiacute 33 finančnyacutech prostriedkov riešiteľom z VEGA grantov Vaumlčšia časť z tyacutechto odobratyacutech prostriedkov sa koncom roka vraacutetila avšak zniacuteženie prostriedkov v druhom polroku malo negatiacutevny dopad na priebeh riešenia priacuteslušnyacutech grantov Uacutestav by priviacutetal keby sa takyacutemto situaacuteciam dalo predchaacutedzať

Uacutestav oceňuje činnosť Tlačoveacuteho odboru Uacuteradu SAV ktoryacute pomaacutehal propagovať UacuteEO SAV v suacutevislosti s jeho 60 vyacuteročiacutem vzniku a v suacutevislosti s organizovaniacutem medzinaacuterodnej konferencie vo Vysokyacutech Tatraacutech a informoval uacutestav o vačšine mediaacutelnych spraacutev ktoreacute aj v tejto suacutevislosti vznikli

Spraacutevu o činnosti organizaacutecie SAV spracoval(i) uviesť meno a telefoacuten

Doc Ing Čestmiacuter Altaner DrSc Tel 0259327 260

(riaditeľ UacuteEO SAV)

RNDr Jaacuten Sedlaacutek CSc Tel 0259327 123

(zaacutestupca riaditeľa UacuteEO SAV)

RNDr Zdena Bartošovaacute CSc Tel 0259327 221

(vedeckyacute sekretaacuter UacuteEO SAV)

Ing Erika Chudějovaacute Tel 0259327 233

(veduacuteci ekonoacutem UacuteEO SAV)

Spraacutevu o činnosti UacuteEO SAV schvaacutelili členovia Vedeckej rady UacuteEO SAV

Ing Katariacutena Luciakovaacute DrSc (predsedkyňa VR)

Členovia VR

RNDr Zdena Bartošovaacute CSc

Mgr Andrej Dudaacuteš PhD

RNDr Miroslav Piršel CSc

RNDr Katariacutena Polaacutekovaacute DrSc

RNDr Ľudmila Šabovaacute CSc

52

RNDr Vladimiacuter Zajac CSc

53

Priacuteloha č 1

Mennyacute zoznam pracovniacutekov k 31122006

K a t e g oacute r i a Priezvisko meno Uacutevaumlzok hod1 ved ved prac DrSc Ia ALTANER Čestmiacuter 1002000 2 BABUŠIacuteKOVAacute Oľga 751500 1 BIZIacuteK Jozef 10020002 BROZMANOVAacute Jela 751500 3 LUCIAKOVAacute Katariacutena 1002000 4 NOVOTNYacute Ladislav NV5 PLEŠKO Ivan 501000 6 POLAacuteKOVAacute Katariacutena 10020007 SLAMEŇOVAacute Darina 7515008 UJHAacuteZY Viliam 701400 9 ved ved prac CSc Ib ALTANEROVAacute Veronika 751500 10 sam ved prac CSc IIa BARTOŠOVAacute Zdena 100200011 BARAacuteTH Peter 100200012 BIES Juraj NV13 ČIPAacuteK Ľuboš 100200014 DUDAacuteŠ Andrej 100200015 DURAJ Jozef 1002000 16 FRECER Vladimiacuter NV 17 FRIDRICHOVAacute Ivana 1002000 18 GAacuteBELOVAacute Alena 1002000 19 HLUBINOVAacute Kristiacutena 1002000 20 HORVAacuteTHOVAacute Eva 100200021 HUNAacuteKOVAacute Ľuba 100200022 CHALUPA Ivan 1002000 23 CHOVANEC Miroslav 100200024 KLEIBL Karol 1002000 25 KLOBUŠICKAacute Margita 751500 26 KUČEROVAacute Lucia 100200027 KUSENDA Jaacuten l002000 28 MARKOVAacute EVA 1002000 29 PIRŠEL Miroslav 1002000 30 PRACHAŘ Jarmil 1002000 31 RAUKO Peter 1002000 32 SEDLAacuteK Jaacuten 1002000 33 ŠABOVAacute Ľudmila 1002000 34 ŠKORVAGA Milan 100200035 ZAJAC Vladimiacuter 1002000 36 ved pracCScPhDIIb IIIc BOĎO Juraj 100200037 ČIERNIKOVAacute Soňa 100200038 GURSKAacute Soňa 100200039 HLAVATYacute Juraj NV40 JAKUBIacuteKOVAacute Jana 100200041 KIRSCHNEROVAacute Gabriela 10200

54

42 KOŠŤAacuteNOVAacute Daniela 100200043 KOVAacuteČ Michal 100200044 KOZICS Katariacutena 100200045 KRAJČOVIČOVAacute Zdenka MD46 KRETOVAacute Miroslava 100200047 KUDELA Pavol NV48 MARKUS Jaacuten NV49 MATUacuteŠKOVAacute Miroslava 100200050 MLČAacuteKOVAacute Andrea MD51 ONDRUŠOVAacute Martina 2448052 PASTORAacuteKOVAacute Andrea 100200053 POTURNAJOVAacute Martina MD54 SOKOLIacuteKOVAacute Barbora MD55 ŠRAacuteMKOVAacute Monika 100200056 TOMKA Miroslav 100200057 TYČIAKOVAacute Silvia MD58 odbprac VŠ ALEMAYEHU Aster MD59 BOHOVIČ Roman 100200060 BUJALKOVAacute Maacuteria 100200061 DUDAacuteŠOVAacute Zuzana 100200062 FARKAŠOVAacute Timea 100200063 GURSKYacute Jaacuten 100200064 HRUŠOVSKAacute Ľubica MD65 CHOLUJOVAacute Danka 100200066 LEHOCZKYacute Peter 100200067 MARŠAacuteLKOVAacute Lenka 100200068 NOVOTNAacute Ľudmila 24480 69 POLAacuteKOVIČOVAacute Erika 100200070 RYBANSKAacute Ivana 100200071 SRANČIacuteKOVAacute Anamaacuteria 100200072 ŠRAMKO Marek 100200073 ZAacuteVODNAacute Katariacutena 100200074 ŽELEZNIacuteKOVAacute Tatiana 100200075 odb prac UacuteSOV CHOVANCOVAacute Jana 1002000 76 DUBROVČAacuteKOVAacute Maacuteria 100200077 FRIacuteVALSKAacute Viera 1002000 78 GAŠAJOVAacute Gabriela 1002000 79 HURBANOVAacute Lenka 100200080 HUacuteSKOVAacute Gertruacuteda 1002000 81 KADNAacuteROVAacute Alena 1002000 82 KOVARIacuteKOVAacute Anna 100200083 MADŽOVAacute Jozefiacutena 751500 84 POKRIVČAacuteKOVAacute Maacuteria l002000 85 ŠEBOVAacute Liacutevia 751500 86 ŠTEVULOVAacute Libuša l002000 87 ŠTEVURKOVAacute Viola l002000 88 ŠULIacuteKOVAacute Margita l002000 89 VLASAacuteKOVAacute Dana l002000

55

90 administratiacuteva BARLIacuteKOVAacute Eva 100200091 CHUDĚJOVAacute Erika l002000 92 JAKUBIacuteKOVAacute Maacuteria l002000 93 JURIOVAacute Jana 100200094 PANYIKOVAacute EVA 1002000 95 PUTEROVAacute Zdenka 100200096 ŽABKOVAacute Jana l002000 97 KRUacutePOVAacute Oľga 75150098 Ostatniacute CIESLER Štefan 100200099 DUDAacuteŠ Milan 1002000

100 GAacuteL Jozef l002000 101 GEacuteCI Vladimiacuter l002000 102 GORČIacuteKOVAacute Slaacutevka 24480 103 HERBERGEROVAacute Zlatica l002000 104 JURICKYacute Aladaacuter 1002000105 KAVICKYacute Ladislav 24480 106 KĽUČKA Ivan 1002000107 KNIEZ Mariaacuten 1002000 108 KRAJČOVIČ Milan 1002000109 MAacuteLEKOVAacute Ľubica 25500110 MASAacuteR Simeon 1002000111 NOVAacuteKOVAacute Eva 1002000112 PROKOPEC Miroslav 1002000113 SLANINOVAacute Viera 1002000 114 ŠTEVURKA Igor 1002000115 TRUBANOVAacute Maacuteria l002000 116 VAŠEK Štefan 1002000117 VOKAacuteLIKOVAacute Alžbeta l002000 118 Doktorandi HADVINOVAacute Lucia 1002000119 KOLLAacuteROVIČ Gabriel 1002000120 KRIVULČIacuteK Tomaacuteš 1002000121 LETAVAYOVAacute Lucia 1002000122 LUKAacuteČIKOVAacute Petra 1002000123 MAacuteTELOVAacute Lenka 1002000124 PATRAacuteŠOVAacute Maacuteria 1002000125 ŠEBOVAacute Katariacutena 1002000126 ŠTRELINGEROVA Jana 1002000127 VALOVIČOVAacute Zuzana 1002000

56

Priacuteloha č 2

Projekty riešeneacute na pracovisku

A Domaacutece projekty

1 Vedeckeacute projekty ktoreacute boli v r 2006 financovaneacute VEGAFinančneacute zabezpečenie projektov Vedeckaacute grantovaacute agentuacutera Ministerstva školstva SR a Slovenskej akadeacutemie vied Štefaacutenikova 49 814 38 Bratislava 1

11 Projekty VEGA na ktoryacutech je uacutestav nositeľom projektu

1) Modulaacutecia biomarkerov karcinogeneacutezy in vitro a in vivo priacuterodnyacutemi cyklickyacutemi triterpeacutenmi s potenciaacutelne chemopreventiacutevnymi uacutečinkami (Modulation of biomarkers related to carcinogenic processes in vitro and in vivo by natural cyclic triterpenes possessing potential chemopreventive properties)

Veduacuteci projektu CHALUPA Ivan RNDr CSc Doba riešenia projektu 012004 - 122006Evidenčneacute čiacuteslo projektu 2400526Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 194 000-Sk

Dosiahnuteacute vyacutesledky

Metoacutedou polarografickej analyacutezy sme stanovili inhibičnuacute aktivitu cyklickyacutech triterpeacutenov (kyselina oleaacutenolovaacute (OA) kys ursolovaacute (UA) taraxasterol (TS) a β-sitosterol (SS)) voči naacutedoroveacutemu promoacutetoru fenobarbitaacutelu V systeacuteme s naacutedorovyacutem promoacutetorom fenobarbitaacutelom vykazovali študovaneacute triterpenoidy vyacuterazneacute inhibičneacute uacutečinky pričom ich schopnosť inhibovať klesala v poradiacute OA gt UA gt SS gt TS Niacutezky toxickyacute potenciaacutel študovanyacutech laacutetok sme potvrdili v situaacutecii in vitro na bunkovyacutech liacuteniach L1210 K562 a HL-60 ako aj in vivo na leukocytoch samcov kmeňa Sprague-Dawley Stanoveneacute boli aj modulačneacute uacutečinky priacuterodnyacutech laacutetok na aktivitu vybranyacutech Metoacutedou jednobunkovej geacutelovej elektroforeacutezy sme stanovili protektiacutevne uacutečinky triterpenoidov voči poškodeniu DNA indukovaneacutemu H2O2 na leukemickyacutech bunkovyacutech liacuteniach Pentacyklickeacute triterpeacutenoveacute kyseliny UA a OA štatisticky vyacuteznamne inhibovali priacutetomnosť jednoreťazcovyacutech zlomov indukovanyacutech H2O2 Ako model pre porovnanie protektiacutevnych uacutečinkov zmesi a samotnej laacutetky doplnili sme ešte skupinu študovanyacutech laacutetok o izolaacutet zo soacuteje Aj v tomto priacutepade sme zaznamenali inhibiacuteciu poškodenia DNA Ziacuteskaneacute vyacutesledky poukaacutezali na možnosť využitia triterpenoidov ako podpornyacutech laacutetok v klinickej liečbe naacutedorovyacutech ochoreniacute na jednej strane a na druhej strane ako možnyacutech biomodulaacutetorov nepriaznivyacutech vedľajšiacutech uacutepčinkov niektoryacutech cytostatiacutek

57

PublikaacutecieKOZICS K - KRAJČOVIČOVAacute Z - VACHAacuteLKOVAacute A Electrochemical behavior and determination of tumor inhibiting or promoting activities of flavonoids In Neoplasma Vol 53 no 4 (2006) p 337-342

OVESNA Z - KOZICS K - BADER Y - SAIKO P - HANDLER N - ERKER T - SZEKERES T Antioxidant activity of resveratrol piceatannol and 33rsquo44rsquo55rsquo-hexahydroxy-trans-stilbene in three leukemia cell lines In Oncology Reports Vol 16 no 3 (2006) p 617-624

OVESNAacute Z - KOZICS K - SLAMEŇOVAacute D Protective effects of ursolic acid and oleanolic acid in leukemic cells In Mutation Research - Fundamental and Molecular Mechanism of Mutagenesis Vol 600 no 1-2 (2006) p 131-137

Prednaacutešky a vyacutevesky KRAJČOVIČOVAacute Z - KOZICS K The use of DC polarography as a pre-screening method for identifying potential chemopreventive compounds 11th Interdisciplinary Slovak-Czech Toxicology Conference Juacuten 2006 Trenčianske Teplice Slovakia p 37

2) Uacutečasť hlodavčej ERCC3XPB DNA helikaacutezy v rozpoznaacutevaniacute poškodenia DNA(Involvement of the hamster ERCC3XPB DNA helicase in DNA damage recognition)

Veduacuteci projektu PIRŠEL Miroslav RNDr CScDoba riešenia projektu 012004 ndash 122006Evidenčneacute čiacuteslo projektu 2400725Počet spoluriešiteľskyacutech inštituacuteciiacute 1 Biofyzikaacutelniacute uacutestav AV ČR Brno Českaacute republikaVyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 160 000- Sk


Identifikovali sme novuacute mutaacuteciu v ERCC3 geacutene Ide o zostrihovuacute mutaacuteciu na hranici posledneacuteho introacutenu a exoacutenu Mutaacutecia spocircsobiacute deleacuteciu 26 nukleotidov posledneacuteho exoacutenu naacuteslednyacute posuv čiacutetacieho raacutemca a vznik noveacuteho STOP kodoacutenu Proteiacuten je celkovo kratšiacute o 37 aminokyseliacuten Zachovanyacutech 7 aminokyseliacuten posledneacuteho exoacutenu je nezmyselnyacutech Mutantneacute bunky suacute veľmi citliveacute k UV-žiareniu majuacute defekt v nukleotidovej exciacuteznej oprave a transkripcii po UV-poškodeniacute nie však po oxidačnom poškodeniacute

PublikaacutecieHALL H - GURSKYacute J - NICODEMOU A - RYBANSKAacute I - KIMLIacuteČKOVAacute E - PIRŠEL M Characterization of ERCC3 mutations in the Chinese hamster ovary 27-1 UV24 and MMC-2 cell lines In Mutation Research Vol 593 (2006) p 177-186

Prednaacutešky a vyacuteveskyGURSKYacute J - RYBANSKAacute I - HALL H - SALAZAR EP - NICODEMOU A - KIMLIacuteČKOVAacute E - KLEIBLK - THOMPSON LH - PIRŠEL M Identification of the new ERCC3 mutations and their DNA repair characteristics (vyacuteveska) Meeting on DNA Repair from Molecular Mechanism to Human Disease Noordwijkerhout 2-7 apriacutela 2006 The Netherlands Book of Abstracts p 142 (R)

58

GURSKYacute J - RYBANSKAacute I - HALL H - SALAZAR EP - NICODEMOU A - KIMLIacuteČKOVAacute E - KLEIBLK - THOMPSON LH - PIRŠEL M Repair of oxidative DNA damage in the helicase mutants (prednaacuteška) Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 p 5-6 (R)

RYBANSKAacute I - PIRŠEL M Involvement of the hamsterERCC3XPB protein in the repair of oxidative DNA damage (vyacuteveska) Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 p 33-34 (R)

POLAKOVIČOVAacute E - GURSKYacute J - RYBANSKAacute I - FAŠKOVAacute M - PIRŠEL M Charakterizaacutecia dvoch škrečiacutech ERCC3XPB mutantnyacutech bunkovyacutech liacuteniiacute (vyacuteveska) Jesenneacute pracovneacute dni Genetickaacute toxikoloacutegia a prevencia rakoviny 23-25 oktoacuteber 2006 Bratislava Zborniacutek p 47-48 (R)

3) Expresia ľudskeacuteho homoloacutegu E coli alkB geacutenu v S cerevisiae podiel poškodeniacute DNA ktoreacute suacute jeho substraacutetom na biologickom efekte alkylačnyacutech laacutetok (The expression of the human homologue of the E coli alkB gene in S cerevisiae the contribution of its substrate DNA lesions to the biological effects of alkylating agents)

Veduacuteci projektu KLEIBL Karol Ing CScDoba riešenia projektu 012004 - 122006Evidenčneacute čiacuteslo projektu 2401826Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 126 000- Sk


Ľudskeacute geacuteny hABH2 a hABH3 klonovaneacute do expresneacuteho vektora pESC-Trp boli exprimovaneacute v kvasinkaacutech S cerevisiae WX 9012 ktoreacute suacute deficientneacute v O6-alkylguaniacuten metyltransferaacuteze Sledovali sme podiel oboch geacutenov v oprave poškodeniacute DNA po uacutečinku MMS stanoveniacutem prežitia buniek Dokaacutezalo sa že hABH2 geacuten vyacuterazne chraacuteni bunky pred toxickyacutem uacutečinkom tejto alkylačnej laacutetky na rozdiel od geacutenu hABH3 Vyacutesledok naznačuje uacutečast produktu hABH2 geacutenu nielen v oprave 1-metyl adeniacutenu a 3-metylcytoziacutenu ale i v oprave takeacuteho typu poškodenia ktoreacute je substraacutetom pre O6-alkylguaniacuten metyltransferaacutezu

Prednaacutešky a vyacutevesky

KLEIBL K - ŠKORVAGA M The in vivo role of hABH2 and hABH3 in repair of methylation damage in DNA (vyacuteveska) Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 p 29 (R)

59

4) Cytofluorometrickaacute analyacuteza acuteempty spacesacute ako zaacuteklad pre diagnoacutezu a sledovanie T- a B-bunkovyacutech akuacutetnych lymfoblastickyacutech leukeacutemiiacute (Cytofluorometric analysis of acuteEmpty Spacesacute as a basis for diagnosis and follow-up of T- and B-cell acute lymphoblastic leukemia)

Veduacuteci projektu BABUŠIacuteKOVAacute Oľga MUDr DrScDoba riešenia projektu 012004 - 122006Evidenčneacute čiacuteslo projektu 2402126Počet spoluriešiteľskyacutech inštituacuteciiacute - Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 213 000- Sk


Vyacuteskum sa zameral na využitie mnohoparametrovej prietokovej cytometrie pri presnom popise membraacutenovyacutech a vnuacutetrobunkovyacutech znakov buniek akuacutetnej lymfoblastovej a myeloblastovej leukeacutemie Ziacuteskali sa podklady pre ich presnuacute diagnostiku nielen podľa kombinaacutecie fenotypovyacutech znakov ale i podľa lokalizaacutecie buniek na bodovyacutech grafoch SSCCD45 definujuacutecich tzv acutepraacutezdne miestaacute Vyacutesledky obohateneacute o podrobnuacute definiacuteciu individuaacutelnych fyziologickyacutech vyacutevojovyacutech faacutez B-lymfocytov (hematogoacutenov) umožňujuacute u leukemickyacutech pacientov počas a po liečbe odliacutešiť obe leukemickeacute bunky a regenerujuacutece B-bunkoveacute subpopulaacutecie počas a po liečbe Tieto poznatky podstatne zlepšia docirckaz zvyškovej leukeacutemie

Publikaacutecie

KIRSCHNEROV Aacute G - TOacuteTHOVAacute A - BABUŠIacuteKOVAacute O Amplification of AML 1 gene in association with karyotype age and diagnosis in acute leukemia patients In Neoplasma Vol 53 no 2 (2006) p 150-154

ŽELEZNIacuteKOVAacute T - BABUŠIacuteKOVAacute O The impact of cell heterogeneity and immunotypic changes on monitoring minimal residual disease in acute myeloid leukemia In Neoplasma Vol 53 no 6 (2006) p 500-506

BABUSIKOVA O - ZELEZNIKOVA T - KIRSCHNEROVA G The leukemia clone in relation to differentiation stages of B-cell precursor subpopulations In preparation for publication in Cancer Treatment Reviews

Prednaacutešky a vyacuteveskyBABUSIKOVA O - ZELEZNIKOVA T - MLCAKOVA A - KUSENDA J - STEVULOVA L - KOVARIKOVA A Hematogoacuteny v detskej populaacutecii (prednaacuteška) X Stretnutie detskyacutech hematoloacutegov a onkoloacutegov 27-28 januaacutera 2006 Bratislava

Ž ELEZNIacuteKOVAacute T - KIRSCHNEROVAacute G - ŠTEVULOVAacute L - KOVARIacuteKOVAacute A - BABUŠIacuteKOVAacute O Fenotypovaacute heterogenita AML a jej zmeny v relapse ovplyvňujuacutece docirckaz MRD (prednaacuteška) II Bratislavskeacute hematologickeacute a transfuziologickeacute dni s medzinaacuterodnou uacutečasťou 26-27 oktoacutebra 2006 Bratislava p 35

KIRSCHNEROVAacute G - ŽELEZNIacuteKOVAacute T - TOacuteTHOVAacute A - KRIŽAN P - BABUŠIacuteKOVAacute O Uacuteskalia prietokovej cytometrie pri posuacutedeniacute prechodnej leukeacutemie kojencov s Downovyacutem syndroacutemom (prednaacuteška) II Bratislavskeacute hematologickeacute a transfuziologickeacute dni s medzinaacuterodnou uacutečasťou 26-27 oktoacutebra 2006 Bratislava p 36

60

BABUSIKOVA O - ZELEZNIKOVA T - KUSENDA J - KIRSCHNEROVA G B- bunkoveacute prekurzoroveacute suspopulaacutecie vo vzťahu k leukemickeacutemu klonumnohoparametrovaacute 4 farebnaacute analyacuteza (prednaacuteška) II Bratislavskeacute hematologickeacute a transfuziologickeacute dni s medzinaacuterodnou uacutečasťou 26-27oktoacutebra 2006 Bratislava p 25

KIRSCHNEROVAacute G - TOacuteTHOVAacute A - ŽELEZNIacuteKOVAacute T - BABUŠIacuteKOVAacute O - KRIŽAN P Bioloacutegia novorodeneckej leukeacutemie pri Downovom syndroacuteme (prednaacuteška) XVII Izakovicov memoriaacutel Bratislava oktoacuteber 2006

ZELEZNIKOVA T - BABUSIKOVA O Multiparameter flow cytometric analysis of heterogeneous populations in AML patients implication for minimal residual disease detection (poster) Cancer 2006 From molecular biology processes to tumor tailored therapy 20-24 August 2006 High Tatras Slovakia Book of Abstracts p 39BABUSIKOVA O - ZELEZNIKOVAacute T - KUSENDA J - KIRSCHNEROVA G Newly-defined differentiation stages of B-cell precursor subpopulations in relation to the leukemia clone 4-color flow cytometry (poster) Cancer 2006 From molecular biology processes to tumor tailored therapy 20-24 August 2006 High Tatras Slovakia Book of Abstracts p 22

5) Uacuteloha oxidaacutecie lipidov a lipidickeacuteho zloženia membraacuten v apoptoacuteze študovanaacute na modeli kvasiniek Kluyveromyces lactis (The role of lipid oxidation and lipid composition of membranes in apoptosis using Kluyveromyces lactis as a model)

Veduacuteci projektu ŠABOVAacute Ľudmila RNDr CScDoba riešenia projektu 012004 - 122006Evidenčneacute čiacuteslo projektu 2405526Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 96 000- Sk


Zisťovali sme či priacutetomnosť mitochondriaacutelnych anionickyacutech fosfolipidov ndash kardiolipiacutenu (CL) a fosfatidylglycerolu (PG) ovplyvniacute toxickyacute uacutečinok pro-apoptotickeacuteho proteiacutenu Bax Ako modelovyacute systeacutem sme použili kvasinku Klactis Pripravili sme kmene s deleacuteciami geacutenov koacutedujuacutecich enzyacutemy zodpovedneacute za synteacutezu kardiolipiacutenu (kardiolipiacuten syntaacuteza KlCLS1) ako aj jeho metabolickeacuteho prekurzora fosfatidylglycerolu (fosfatidylglycerolfosfaacutet syntaacuteza KlPGS1) nakoľko je znaacuteme že PG dokaacuteže vo vaumlčšine funkciiacute zastuacutepiť kardiolipiacuten Expresia Bax proteiacutenu v kmeni s deleacuteciou geacutenu pre kardiolipiacuten syntaacutezu mala nižšiacute toxickyacute uacutečinok v porovaniacute s uacutečinkom Baxu v divom kmeni Podstatneacute zniacuteženie toxicity sme pozorovali v kmeni s deleacuteciou KlPGS Expresia Baxu vyvolala iba zastavenie delenia buniek nie však smrť kvasiniek Momentaacutelne zisťujeme či jeho rezistencia je danaacute jeho zmenenou expresiou Bax proteiacutenu alebo jeho neschopnosťou lokalizovať sa do mitochondriaacutelnej membraacuteny


PATRASOVA M - POLIAKOVA-KOSTANOVA D - SABOVA L The role of cardiolipin and phosphatidylglycerol in BAX mediated cytotoxicity studied in yeast K Lactis (vyacuteveska) Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 p 33 (R)

61

6) Štuacutedium chemopreventiacutevneho a terapeuticko-modulačneacuteho potenciaacutelu bio-aktiacutevnych laacutetok v onkoloacutegii (The study of chemopreventive and chemotherapy modulating activities of the biologically active substances)

Veduacuteci projektu RAUKO Peter RNDr CScDoba riešenia projektu 012004 - 122006Evidenčneacute čiacuteslo projektu 2405626Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 125 000-Sk


Pozornosť bola venovanaacute štuacutediu novosyntetizovanyacutech laacutetok s bio-modulačnyacutem a cytotoxickyacutem potenciaacutelom je jednak zameranaacute na charakterizaacuteciu ich terapeutickeacuteho potenciaacutelu ale najmauml na hľadanie vhodnej strateacutegie ich optimaacutelneho uplatnenia v antineoplastickej terapii S tyacutemto zaacutemerom boli študovaneacute noveacute arabinosylcytoziacutenoveacute konjugaacutety a charakterizoval sa ich cytotoxickyacuteterapeutickyacute potenciaacutel na experimentaacutelnych in vitro a in vivo modeloch Bolo dokladovaneacute komparaacuteciou cytotoxickejterapeutickej aktivity samotneacuteho araC a jeho novyacutech konjugaacutetov že sa u araC-konjugaacutetov vyacuterazne zniacutežila ich inaktivaacutecia počas aplikovanej terapie na zvierataacutech Tento rozdiel v cytotoxickej a terapeutickej aktivite prisudzujeme pomaleacutemu uvoľňovaniu araC z konjugaacutetu a tyacutem predĺženej terapeutickej uacutečinnosti liečiva Tieto vyacutesledky suacute podkladom pre priacutepravu novyacutech araC-analoacutegov so zvyacutešenyacutem protektiacutevnym uacutečinkom pred deaminaacuteciou araC-aminoskupiny a mocircžu sluacutežiť ako depozitnaacute forma pre araC

PublikaacutecieMIADOKOVAacute E - NAĎOVAacute S - TREBATICKAacute M - GROLMUS J - KOPAacuteSKOVAacute M - RAUKO P - MUČAJI P - GRANČAI D Research on biomodulatory effect of natural compounds In Neuroendocrinology Letters Vol 27 (2006) p 53-56 (1005-IF2006)

VLČKOVAacute V - NAĎOVAacute S - DUacuteHOVAacute V - ZAacuteVODNAacute K - MORAacuteŇOVAacute Z - RAUKO P - KOGAN G - MIADOKOVAacute E Natural microbial polysaccharide sulphoethyl glucan as antigenotoxic and cancer preventing agent In Neoplasma Vol 53 no 6 (2006) p 524-529 (0731-IF2006)

ČIPAacuteK Ľ - GRAUSOVA L - MIADOKOVAacute E - NOVOTNYacute L - RAUKO P Dual activity of triterpenoids apoptotic vs antidifferentiation effects In Archives of toxicology Vol 80 no 7 (2006) p 429-435 (1663-IF2006)

NOVOTNYacute L - RAUKO P - LIŠKA J - ELFORD L - SZEKERES T Potentiation of the activity of cisplatin and cyclophosphamide by trimidox a novel ribonucleotide reductase inhibitor in leukemia-bearing mice In Cancer letters Vol 233 (2006) p 178-184 (3049-IF2006)

Prednaacutešky a vyacuteveskyNAĎOVAacute S - VLČKOVAacute V - PRAŽMAacuteRIOVAacute E - ŠPINEROVAacute L - KOGAN G - RAUKO P - MIADOKOVAacute E The evaluation of biomodulatory effects of natural compounds 29 pracovniacute dny Českeacute a Slovenskeacute společnosti pro mutagenezu zevniacutem prostřediacutem 2-4 may 2006 Brno Kniha abstraktov p 51-54

62

NOVOTNYacute L - RAUKO P - MEGO M Antileukemic effects of new dinucleoside conjugates 35th Conference ldquoSynthesis and analysis of drugsrdquo 12-15 sep 2006 Velke Karlovice Czech Republic Book of Abstracts abstract No S-11 p 47

7) Štuacutedium post-translačnej modifikaacutecie onkoproteiacutenu c-Myb kovalentnou SUMO-23 proteiacutenov (Study of posttranslational modification of the c-Myb oncoprotein by the covalent attachment of SUMO-23 proteins)

Veduacuteci projektu BIES Juraj RNDr CScDoba riešenia projektu 012004 - 122006Evidenčneacute čiacuteslo projektu 2405726Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 162 000- Sk


Aktivita transkripčneacuteho faktora c-Myb je vyacuterazne regulovanaacute prostredniacutectvom posttranslačnyacutech modifikaacuteciiacute ako fosforylaacutecia acetylaacutecia ubikvitinaacutecia a SUMOylaacutecia SUMOylaacutecia teda kovalentnaacute konjugaacutecia minimaacutelne dvoch SUMO-1 (Small Ubiquitin Like Modifier) proteiacutenov k negatiacutevne regulujuacutecej domeacutene c-Myb proteiacutenu vedie k vyacuterazneacutemu potlačeniu jeho transaktivačnej kapacity a zaacuteroveň k zvyacutešeniu jeho proteolytickej stability V našich ďalšiacutech experimentoch sme dokaacutezali že c-Myb proteiacuten mocircže byť kovalentne modifikovanyacute aj SUMO-2 a SUMO-3 proteiacutenmi ktoreacute tvoria samostatnuacute podskupinu SUMO proteiacutenov Pomocou mutačnyacutech analyacutez sme zistili že SUMO-23 proteiacuteny rozpoznaacutevajuacute tie isteacute lyziacuteny (K499 a K523) v negatiacutevne regulujuacutecej domeacutene c-Myb proteiacutenu ako SUMO-1 proteiacuten Ukaacutezali sme že v normaacutelnych rastovyacutech podmienkach je c-Myb proteiacuten modifikovanyacute prevažne SUMO-1 proteiacutenom zatiaľ čo v špecifickyacutech stresovyacutech podmienkach dochaacutedza k vyacuterazneacutemu zvyacutešeniu konjugaacutecie SUMO-23 proteiacutenov k c-Myb proteiacutenu Stresom indukovanaacute konjugaacutecia SUMO-23 proteiacutenov je veľmi ryacutechly a reverzibilnyacute proces ktoryacute nie je zaacutevislyacute od aktivaacutecie stresom aktivovanyacutech proteiacuten kinaacutez (p38MAPK a JNK) Kovalentnaacute modifikaacutecia SUMO-23 proteiacutenom podobne ako v priacutepade SUMO-1 proteiacutenu vedie k zniacuteženiu transaktivačnyacutech vlastnostiacute c-Myb proteiacutenu Podarilo sa naacutem identifikovat proteiacuten PIAS-3 ako c-Myb špecifickuacute SUMO E3 ligaacutezu ktoraacute v podmienkach bunkoveacuteho stresu katalyzuje konjugaacuteciu SUMO-23 k c-Myb proteiacutenu

Publikaacutecie

ŠRAMKO M - MARKUS J - KABAacuteT J - WOLFF L - BIES J Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-23 proteins In Journal of biological chemistry Vol 1 no 1 (2006) p 1 (5854-IF2006)

Prednaacutešky a vyacuteveskyBIES J - SRAMKO M - MARKUS J WOLFF L Leukemogenesis and c-myb Story of a tightly regulated transcriptional regulator (prednaacuteška) Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 p 3 (R)

63

SRAMKO M - MARKUS J - KABAT J - WOLFF L - BIES J Stress-induced inactivation of transcription factor c-Myb through conjugation of SUMO-23 proteins (vyacuteveska) Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 p 34 (R)

8) Chemoterapia a mnohonaacutesobnaacute rezistencia (bdquomultidrug resistanceldquo) modulaacutecia rezistencie a jej vzťah k regulaacutecii bunkovej programovanej smrti (apoptoacutezy) u ľudskyacutech naacutedorovyacutech buniek (Chemotherapy and multidrug resistance (MDR) modulation of resistance and relationship to the regulation of apoptosis in human cancer cells)

Veduacuteci projektu DURAJ Jozef RNDr CScDoba riešenia projektu 012004 - 122006Evidenčneacute čiacuteslo projektu 2406925Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 176 000- Sk


Skuacutemali sme schopnosť priacuterodnej laacutetky flavonoidu resveratrolu schopnosť zvyacutešiť citlivosť buniek ľudskej promyelocytaacuternej leukeacutemie (HL-60) a jej resistentnej varianty (HL-60VCR) na protinaacutedoroveacute laacutetky pre pre indukciu apoptoacutezy Vyacutesledky ukaacutezali že resveratrol zastavil u oboch typov buniek bunkovyacute cyklus v S-faacuteze Cytofluorometrickeacute experimenty naviac ukaacutezali rozdielne activity resveratrolu v kombinaacuteciaacutech s protinaacutedorovyacutemi laacutetkami ako suacute doxorubicin cykloheximid busulfan gemcitabiacuten a taxol v indukcii apoptoacutezy (subG1 populaacutevia buniek) preferenčne na uacutekor buniek akumulovanyacutech v S-faacuteze bunkoveacuteho cyklu Tieto vyacutesledky tak ukaacutezali že resveratrol by mohol v spolupraacuteci s niektoryacutemi vybranyacutemi protinaacutedorovyacutemi laacutetkami zvyacutešiť efektivitu protinaacutedorovej terapie u rocircznych typov naacutedorovyacutech buniek včetne leukeacutemiiacute

Publikaacutecie

DURAJ J - BOĎO J - ŠULIacuteKOVAacute M - RAUKO P - SEDLAacuteK J Diverse resveratrol sensitization to apoptosis induced by anticancer drugs in sensitive and resistant leukemia cells In Neoplasma Vol 53 no 5 (2006) p 384-392

9) Izolaacutecia ľudskyacutech mezenchyacutemovyacutech kmeňovyacutech buniek a ich použitie v regeneračnej a geacutenovej liečbe (Isolation of human mesenchymal stem cells and their use in regenerative and gene therapy)

Veduacuteci projektu ALTANER Čestmiacuter Doc Ing DrScDoba riešenia projektu 012005 - 122007Evidenčneacute čiacuteslo projektu 2502826Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 203 000- Sk

64


Retroviacuterusovyacute vektor nesuacuteci fuacutezny kvasinkovyacute geacuten cytoziacutendeaminaacuteza-fosforybozyltransferaacutezu sme transfekovali do obaľovaciacutech bunkovyacutech liacuteniiacute a pomocou takto pripraveneacuteho replikačne defektneacuteho terapeutickeacuteho viacuterusu sme infikovali ľudskeacute mezenchyacutemoveacute kmeňoveacute bunky izolovaneacute z podkožneacuteho tukoveacuteho tkaniva ziacuteskaneacuteho liposukciou (AT-MSC) Bunky majuacute imunofenotyp (CD14- CD29+ CD34- CD44+ CD45- CD90+ CD105+) a schopnosť diferencovať na adipocyty a osteoblasty AT-MSC izolovaneacute z podkožneacuteho tukoveacuteho tkaniva sa javia ako vhodnyacute zdroj kmeňovyacutech buniek pre terapiu bdquošituacute na mieruldquo pacienta z hľadiska lepšej dostupnosti a neinvaziacutevnosti odberu V pokusoch in vitro sme transdukovaneacute AT-MSC bunky kokultivovali s bunkami derivovanyacutemi z karcinoacutemu hrubeacuteho čreva v priacutetomnosti 5-fluorocytoziacutenu AT-MSC konvertovali 5-fluorocytoziacuten na 5-fluorouracil V uvedenom systeacuteme došlo k smrti ľudskyacutech naacutedorovyacutech buniek V pokusoch in vivo sme dokaacutezali že kmeňoveacute bunky exprimujuacutece cytoziacutendeaminaacutezu suacute schopneacute putovať k naacutedoru a majuacute cytostatickyacute efekt Pokusy pokračujuacute v testovaniacute podmienok pre optimaacutelny terapeutickyacute efekt

Publikaacutecie

KUCEROVA L - ALTANEROVA V - MATUSKOVA M - TYCIAKOVA S - ALTANER C Adipose Tissue Derived Human Mesenchymal Stem Cells Mediated Prodrug Cancer Gene Therapy Zaslaneacute na publikovanie do Cancer Research

Prednaacutešky a vyacuteveskyKUCEROVA L - MATUSKOVA M - ALTANEROVA V - TYCIAKOVA S - ALTANER C Retrovirus Transduced Mesenchymal Stem Cells Exert Strong Antitumor Effect (prenaacuteška) Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 p 17 (R)

ALTANER C Normal and cancer stem cells Potential implication for cancer therapyCancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0

MATUSKOVA M - KUCEROVA L - ALTANEROVA V - TYCIAKOVA S - JAKUBIKOVA J - ALTANER C Retrovirus Transduced Human Adipose Tissue Derived Mesenchymal Stem Cells as a Vehicle for Suicide Cancer Gene Therapy Cancer 2006 From molecular biology processes to tumor-tailored therapy August 20 ndash 24 2006 Staraacute Lesnaacute Slovensko

10) Mutaacutecie RET proto-onkogeacutenu - ich vyacuteznam v suacutevislosti s vyacuteskytom naacutedorov štiacutetnej žľazy v diagnostike a prevencii naacutedorov štiacutetnej žľazy (Mutation of RET proto-oncogene - its implication in connection of thyreoid tumor incidence in diagnostic and prevention of thyreoid gland tumors)

Veduacuteci projektu ALTANEROVAacute Veronika Ing CScDoba riešenia projektu 012005 - 122007Evidenčneacute čiacuteslo projektu 2507726Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 103 000- Sk

65

Dosiahnuteacute vyacutesledky V spolupraacuteci s klinickyacutemi pracoviskami hlavne s Naacuterodnyacutem endokrinologickyacutem a

diabetologickyacutem uacutestavom v Ľubochni pokračujeme v molekulaacuterne - genetickom vyšetreniacute mutaacutecie RET ndash geacutenu u pacientov s rizikom dedičneacuteho naacutedoroveacuteho ochorenia - mnohopočetnej endokrinnej neoplaacutezie typu 2 (MEN2) Suacute to pacienti s endokrinnyacutem ochoreniacutem typu medulaacuterneacuteho karcinoacutemu štiacutetnej žľazy resp naacutedoru drene nadobličkovej (feochromocytoacutem) Maliacutegnejšia forma ochorenia typu MEN2B bola nami diagnostikovanaacute u 31-ročneacuteho pacienta Je to prvyacute identifikovanyacute slovenskyacute pacient s tyacutemto typom ochorenia Mutaacutecia je de novo tj nebola priacutetomnaacute u šiestich pokrvnyacutech priacutebuznyacutech Priacutepad je zaujiacutemavyacute aj tyacutem že hoci vaumlčšina MEN2B pacientov sa nedožiacuteva reprodukčneacuteho veku pacientovi ako 16-ročneacutemu bol chirurgicky odstraacutenenyacute feochromocytoacutem zrejme už v tom čase s netestovanou diagnoacutezou MEN2B Diskutuje sa možnosť prenataacutelneho testu lebo pacient si plaacutenuje založiť rodinu

Publikaacutecie POTURNAJOVAacute M - ALTANEROVAacute V Molekulaacuterno-biologickeacute aspekty vzniku mnohopočetnej endokrinnej neoplaacutezie typ-2 Rudolf Moravec a kolektiacutev K problematike chorocircb štiacutetnej žľazy Vydavateľstvo Marko Ľubomiacuter 2006 ISBN 80-969542-2-9

11) Štuacutedium novyacutech prognostickyacutech znakov a terapeutickyacutech priacutestupov u gynekologickyacutech maligniacutet faktory a draacutehy ovplyvňujuacutece priebeh ochorenia a protinaacutedorovuacute imunitu (Study of new prognostic markers and therapeutical approaches in gynaecologic malignancies factors and pathways influencing course (progress) of the disease and antitumour immunity)

Veduacuteci projektu HUNAacuteKOVAacute Ľubica RNDr CScDoba riešenia projektu 012005 - 122007Evidenčneacute čiacuteslo projektu 2504225Počet spoluriešiteľskyacutech inštituacuteciiacute 1 Onkologickyacute uacutestav sv Alžbety sroVyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 107 000- Sk


Suacutečasťou agresiacutevneho fenotypu u ľudskyacutech gynekologickyacutech naacutedorov prsniacuteka je zvyacutešenaacute expresia perifeacuterneho benzodiazepiacutenoveacuteho receptoru (PBR) V našom projekte sme overili toto tvrdenie u karcinoacutemov prsniacuteka a rozšiacuterili poznatky tohto typu na ovariaacutelne karcinoacutemy V suacutelade s vytyacutečenyacutemi cieľmi projektu na prvuacute etapu jeho riešenia sme stanovili expresiu PBR pomocou monoklonaacutelnej protilaacutetky (8D7) na in vitro modeli ľudskyacutech bunkovyacutech liacuteniiacute karcinoacutemovyacutech prsniacutekovyacutech (slabo invaziacutevnych s epiteliaacutelnym fenotypom ER-pozitiacutevnych MCF-7 ER-negatiacutevnych BT-20 a silne invaziacutevnych s mezenchymaacutelnym fenotypom MDA-MB-231 ako aj buniek so slabo luminaacutelnym akoby epiteliaacutelnym fenotypom MDA-MB-453 ktoreacute predstavujuacute akyacutesi prechod medzi vyššie uvedenyacutemi typmi) ďalej karcinoacutemovyacutech ovariaacutelnych s rocircznou chemo- a radio-senzitivitou (SKOV3 A2780 A2780cisplatin A2780ADR CH-1)U ovariaacutelnych bunkovyacutech liacuteniiacute sme zistili vačšiu medzibunkovuacute variabilitu expresie PBR než u prsniacutekovyacutech liacuteniiacute Napriek značnyacutem rozdielom v expresii PBR u sledovanyacutech ovariaacutelnych liacuteniiacute MTT testy neukaacutezali vyacuteznamnejšie pocircsobenie inhibiacutetora PK11195 na tieto liacutenie s vyacutenimkou vysokyacutech koncentraacutecii (nad 75uM) U

66

prsniacutekovyacutech liacuteniiacute sme však zistili rocircznu citlivosť jednotlivyacutech liacuteniiacute na PK 11195 nezaacutevisluacute od expresie PBR alebo ich invazivity Poznatky o suacutevislosti PBR s rezistenciou na liečivaacute (popri potvrdenej schopnosti jeho ligandu PK 11195 modulovať PgP rezistenciu) sme rozvinuli smerom k cisplatinovej rezistencii kde sme nepotvrdili jeho uacutečasť v draacutehach prispievajuacutecich k tomuto typu rezistencie Druhyacutem sledovanyacutem prognostickyacutem znakom bola anhydraacuteza kyseliny uhličitej CAIX novyacute marker naacutedorovej hypoxie ktorej expresiu na sledovanyacutech karcinoacutemovyacutech liacuteniach sme stanovili pomocou protilaacutetky M75 S vyacutenimkou invaziacutevnych prsniacutekovyacutech liacuteniiacute MDA 231 a MDA 453 ako aj rezistentnej A2780ADR ovariaacutelnej liacutenie takmer všetky liacutenie mali niacutezku expresiu tohto znaku indukovatelnuacute v hustejšiacutech kultuacuterach Zvyacutešenaacute expresia u uvedenyacutech 3 liacuteniiacute mocircže byť spojenaacute so selekčnou vyacutehodou v prospech CA IX exprimujucich buniek ale moze znamenat aj poruchu v hypoxickej draacutehe V imunologickej časti projektu sme pomocou prietokovej cytometrie s využitiacutem štyroch fluorochroacutemov (calcein-AM C-AM 5- (and-6)-carboxyfluorescein succinimidyl ester CFSE cationic lipophilic dye dihexyloxocarbocyanine iodide DiO a MitoTracker Green MTG) štandardizovali novuacute technoloacutegiu na stanovenie NK cytotoxickej activityktoraacute by korelovala s v suacutečasnosti použiacutevanou raacutedioaktiacutevnou Cr release assay NK senzitiacutevna K-562 bunkovaacute liacutenia bola naznačenaacute s uvedenyacutemi fluorochroacutemami a kokultivovanaacute v trojhodinovom cytotoxickom teste s neznačenyacutemi perifeacuternymi mononukleaacuternymi bunkami alebo izolovanyacutemi NK bunkami Zo štatickyacutech hodnoteniacute vyplyacuteva že s Cr release technikou štandardne použiacutevanou na stanovenie cytotoxicity najlepšie koreluje fluorescenčnaacute C-AM technika Farbenie cieľovyacutech buniek C-AM je stabilneacute počas kokultivaacutecie nedochaacutedza k farbeniu efektorovyacutech buniek na zaacuteklade čoho je možneacute presneacute rozliacutešenie oboch populaacuteciiacute V cytotoxickom teste pomocou farbenia s C-AM Annexin V-PE a 7-AAD fluorochroacutemami je možneacute v jednej vzorke stanoviť populaacuteciu živyacutech buniek apoptotickyacutech buniek a nekrotickyacutech buniek Stanovenie NK aktivity touto fluorescenčnou technikou je spoľahlivou a bezpečnou alternatiacutevou konvenčne použiacutevanej raacutedioaktiacutevnej Cr release

PublikaacutecieBOĎO J - HUNAacuteKOVAacute Ľ - KVASNIČKA P - JAKUBIacuteKOVAacute J - DURAJ J - KASPARKOVA J - SEDLAacuteK J Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations In British journal of cancer Vol 96 no 10 (2006) p 1348-1353

KAZIMIROVA M - DOVINOVA I - ROLNIKOVA T - TOTHOVA L - HUNAKOVA L Anti-proliferative activity and apoptotic effect of tick salivary gland In Neuroendocrinology Letters Vol 27 (2006) p 48-52

BODO J - CHOVANCOVA J - HUNAKOVA L - SEDLAK J Enhanced sensitivity of human ovarian carcinoma cell lines A2780 and A2780CP to the combination of cisplatin and synthetic isothiocyanate ethyl 4- isothiocyanatobutanoate E-4IB In Neoplasma Vol 52 no 6 (2005) p 510-516

HUNAKOVA L - BODO J - CHOVANCOVA J - SULIKOVA G - SEDLAK J Expression of peripheral-type benzodiazepine receptor and carbonic anhydrase IX in human breast and ovarian carcinoma cell lines Manuskript v priacuteprave

CHOLUJOVAacute D - JAKUBIacuteKOVAacute J - KUBEŠ M - ARENDACKAacute B - IHNATKO R - SAPAacuteK M - SEDLAacuteK J Comparative study of four fluorescent probes for evaluation of natural killer cell cytotoxicity assays Zaslaneacute do Journal of Immunological Methods

67


BODO J - HUNAKOVA L - KVASNICKA P - DURAJ J - SEDLAK J Signalling pathways involved in the synergy of cisplatin and E-4IB treatment EACR-19 Budapest Hungary 1 ndash 472006

12) Analyacuteza genetickyacutech zmien asociovanyacutech s dedičnyacutem kolorektaacutelnym karcinoacutemom bez polypoacutezy (Analysis of genetic alterations associated to non-polyposis colorectal cancer)

Veduacuteci projektu BARTOŠOVAacute Zdena RNDr CScDoba riešenia projektu 012005 - 122007Evidenčneacute čiacuteslo projektu 2513125Počet spoluriešiteľskyacutech inštituacuteciiacute - Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 120 000- Sk

Dosiahnuteacute vyacutesledkyMetoacutedou priameho genomickeacuteho sekvenovania sme detegovali zaacuterodočneacute mutaacutecie u

dvoch ďalšiacutech slovenskyacutech HNPCC pacientov Pacientovi z rodiny s koacutedovyacutem označeniacutem SK-24 bol diagnostikovanyacute kolorektaacutelny karcinoacutem vo veku 42 rokov a je nosičom bodovej mutaacutecie c677GgtT v 8 exoacutene geacutenu hMLH1 Taacuteto zaacutemena nukleotidov by mohla byť klasifikovanaacute ako mutaacutecia meniaca 226 aminokyselinu (pArg226Leu) v koacutedovanom proteiacutene ale vzhľadom na svoju lokalizaacuteciu (poslednyacute nukleotid exoacutenu) je viac pravdepodobneacute že negatiacutevne ovplyvňuje zostrih koacutedovanej mRNA (deleacutecia exoacutenu 8) Zaacutemenu c677GgtT sme už v minulosti identifikovali u inej slovenskej HNPCC rodiny (SK-10) a bola popiacutesanaacute aj autormi v zahraničiacute Mutaacuteciu sme uzavreli ako rekurentnuacute patogeacutennu mutaacuteciu lokalizovanuacute v mutačnom bdquohotspoteldquo U pacientky z SK-26 rodiny s diagnoacutezou karcinoacutemu hrubeacuteho čreva vo veku 36 rokov sme obdobne detegovali rekurentnuacute mutaacuteciu c1210_1211delCT v 12 exoacutene geacutenu hMLH1 ktoruacute sme ako prviacute popiacutesali už v rodine SK-12 Taacuteto deleacutecia dvoch nukleotidov vedie k posunu čiacutetacieho raacutemca a predčasneacutemu skraacuteteniu koacutedovaneacuteho proteiacutenu Vraacutemci sekvenačneacuteho skriacuteningu asymptomatickyacutech priacutebuznyacutech z rocircznych slovenskyacutech HNPCC rodiacuten bolo diagnostikovanyacutech 5 nosičov mutaacutecie ktoriacute boli naacutesledne začleneniacute do preventiacutevneho klinickeacuteho programu

Zaviedli sme originaacutelnu metoacutedu na detekciu straty heterozygotnosti (LOH) s využitiacutem jednobodovyacutech polymorfizmov (SNPs) v geacutenoch hMLH1 a hMSH2 Metoacuteda je založenaacute na genotypovaniacute 14 vysoko informatiacutevnych SNPs v oboch geacutenoch pričom sme ako prviacute zaviedli využitie 6 doteraz neznaacutemych polymorfizmov za tyacutemto uacutečelom Metoacuteda bola adaptovanaacute aj pre praacutecu s degradovanou DNA z formaliacutenom fixovanyacutech tkaniacutev ktoreacute tvoria vaumlčšinu dostupnyacutech naacutedorovyacutech vzoriek Testovanie prvyacutech vzoriek od 30-ich HNPCC pacientov diagnostikovanyacutech v našom laboratoacuteriu ukaacutezalo že metoacuteda je veľmi perspektiacutevna na predskriacutening HNPCC- suspektnyacutech pacientov a zaacuteroveň na štuacutedium mechanizmov ktoryacutemi dedičnaacute predispoziacutecia vedie k vzniku naacutedorov

Publikaacutecie

ZAacuteVODNAacute K - BUJALKOVAacute M - KRIVULČIacuteK T - ALEMAYEHU A - ŠKORVAGA M - MARRA G - FRIDRICHOVAacute I - JIRICNY J - BARTOŠOVAacute Z Novel and recurrent germline alterations in the MLH1 and MSH2 genes identified in hereditary nonpolyposis colorectal cancer patients in Slovakia In Neoplasma Vol 53 (2006) p 269-276

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Prednaacutešky a vyacuteveskyBUJALKOVAacute M - WOLF B - KRIVULČIacuteK T - DE WIND N - JIRICNY J - BARTOŠOVAacute Z Development of SNP based method for directed HNPCC mutation screening Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 Poster No 5 p 23 (R)

ZAVODNA K - BUJALKOVA M - KRIVULCIK T - ALEMAYEHU A - HAIDER R - MARRA G - FRIDRICHOVA I - JIRICNY J - BARTOSOVA Z The spectrum of inherited DNA mismatch repair genes pathogenic alterations in Slovakia Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 Poster No 33 p 38 (R)

BARTOŠOVAacute Z - FRIDRICHOVAacute I Advances in molecular diagnostics of hereditary non-polyposis colorectal cancer in Slovakia Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 Lecture No 19 p 10 (R)

13) Štuacutedium genetickyacutech a epigenetickyacutech faktorov u familiaacuternej adenomatoacuteznej polypoacutezy (FAP) (Study of genetic and epigenetic factors in familial adenomatous polyposis (FAP))

Veduacuteci projektu ZAJAC Vladimiacuter RNDr CScDoba riešenia projektu 012005 - 122007Evidenčneacute čiacuteslo projektu 2502526Počet spoluriešiteľskyacutech inštituacuteciiacute 2 (Naacuterodnyacute onkologickyacute uacutestav Centrum lekaacuterskej genetiky FN)Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 103 000- Sk


V roku 2006 sme sa suacutestredili na rodiny podozriveacute z familiaacuternej adenomatoacuteznej polypoacutezy (FAP) u ktoryacutech v doterajšej analyacuteze nebola identifikovanaacute zaacuterodočnaacute mutaacutecia v geacutenoch APC TP53 a szlig-kateniacuten V molekulovej diagnostike boli využiteacute tieto techniky test na skraacutetenyacute proteiacuten (PTT) heteroduplexnaacute analyacuteza (HDA) jednovlaacuteknovyacute konformačnyacute polymorfizmus (SSCP) a hlavne automatickeacute sekvenovanie Do prevaacutedzky bol uvedenyacute priacutestroj WAVE System ktoryacute až na 95 odhaliacute akeacutekoľvek zmeny v sledovanyacutech uacutesekoch DNA po ich amplifikaacutecii pomocou PCR Tyacutemito postupmi sme identifikovali patogeacutenne alteraacutecie u 9 pacientov zo šiestich rodiacuten Z identifikovanyacutech mutaacuteciiacute 2 zatiaľ nie suacute popiacutesaneacute v mutačnyacutech databaacutezach V niektoryacutech špecifickyacutech priacutepadoch sme identifikovali suspektneacute rodiny u ktoryacutech ide pravdepodobne o takeacute genetickeacute alteraacutecie ktoreacute nie je možneacute detekovať štandardnyacutemi diagnostickyacutemi postupmi Pre vyriešenie tyacutechto priacutepadov bola v našom laboratoacuteriu etablovanaacute novaacute metodika stanovenia dlhyacutech deleacuteciiacute inzerciiacute alebo inyacutech genomickyacutech prestavieb MLPA (Multiplex Ligation-dependent Probe Amplification) Využitiacutem tejto techniky sme identifikovali deleacutecie vaumlčšiacutech častiacute chromozoacutemu 5 v ktorom je lokalizovanyacute APC geacuten zodpovednyacute za indukciu ochorenia Sledovali sme tiež schopnosť niektoryacutech intestinaacutelnych bakteacuteriiacute intracelularizovať sa v bunkaacutech epitelu hrubeacuteho čreva Internalizaacutecia bakteacuteriiacute bola pozorovanaacute predovšetkyacutem u pacientov s polypmi adenoacutemami a karcinoacutemami Predpokladaacute sa že tieto bakteacuterie sa potenciaacutelne mocircžu podieľať na indukcii kolorektaacutelnych naacutedorov U zdravyacutech osocircb sa takeacuteto bakteacuterie vyskytujuacute len zriedkavo

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Vzhľadom na ich predpokladanyacute patogeacutenny vplyv sme sa ich snažili eradikovať probiotickyacutem kmeňom Enterococcus faecium M-74 s organickyacutem seleacutenom U dvoch pacientov sme dosiahli uacuteplnu likvidaacuteciu intracelulaacuternych bakteacuteriiacute u jedneacuteho pacienta sa ich počet vyacuterazne zredukoval Pozitiacutevny uacutečinok probiotickyacutech bakteacuteriiacute M-74 sa prejavil aj v prevencii febrilnej neutropeacutenie u leukemickyacutech pacientov Ešte vyacuteraznejšia schopnosť bakteacuteriiacute izolovanyacutech z GITu pacientov s kolorektaacutelnymi probleacutemami internalizovať bunky liacuteniiacute HeLa HL-60 a normaacutelne ľudskeacute lymfocyty bola zistenaacute u bakteacuteriiacute izolovanyacutech z intestinaacutelneho traktu HIVAIDS pacientov Zistenyacute fenomeacuten mocircže svedčiť o tom že aj u tohto ochorenia hrajuacute intestinaacutelne bakteacuterie veľmi docircležituacute uacutelohu Preto je jeho štuacutedium veľmi aktuaacutelne

PublikaacutecieKOVAacuteČ M - TOMKA M - ČIERNIKOVAacute S - ŠTEVURKOVAacute V - VALACHOVAacute A - ZAJAC V Multiple gynecologic tumors as rare asociated phenotypes of FAPGardner syndrome in a family with the novel germline mutation in the APC gene In Clinical Genetics Vol 69 (2006) p 183-186

MEGO M - ZAJAC V Probiotikaacute v onkoloacutegii - aacuteno či nie In Klinickaacute onkologie Vol 19 no 3 (2006) p 167-170

ZAJAC V - MEGO M - MARTINICKYacute D - ŠTEVURKOVAacute V - ČIERNIKOVAacute S -UJHAacuteZY E - GAJDOŠIacuteK A - GAJDOŠIacuteKOVAacute A Testing of bacteria isolated from HIVAIDS patients in experimental models In Neuroendocrinology Letters Supplement Vol 27 no 2 (2006) p 61-64

Prednaacutešky a vyacutevesky ZAJAC V - KOVAacuteČ M - ČIERNIKOVAacute S - MEGO M - ŠTEVURKOVAacute V - LIŠKOVAacute A - KRČMEacuteRY V Detection of HIV sequences in respiratory tract bacteria of Cambodia and Kenya AIDS-positive patients Clinical microbiology and infection Supp 4 (2006) 12 p 53

ZAJAC V - KOVAC M - CIERNIKOVA S - MEGO M - STEVURKOVA V - LISKOVA A - KRCMERY V Detection of HIV sequences in respiratory tract bacteria of Cambodian and Kena AIDS positive patients 16th European Congress of Clinical Microbiology and Infectious Diseases 1-4 Apriacutela 2006 Nice Francuacutezsko

ZAJAC V - MEGO M - KOVAacuteČ M - ČIERNIKOVAacute S - ŠTEVURKOVAacute V - MARTINICKYacute D FAP and HBOC Two players in one playground Cancer 2006 From molecular biology processes to tumor-tailored therapy 20-24 Augusta 2006 Staraacute Lesnaacute Slovensko (prednaacuteška)

KOVAacuteČ M - TOMKA M - ČIERNIKOVAacute S - ŠTEVURKOVAacute V - ZAJAC V APC gene mutations may clinically mimic Lynch syndrome Cancer 2006 From molecular biology processes to tumor-tailored therapy 20-24 Augusta 2006 Staraacute Lesnaacute Slovensko (prednaacuteška aj poster)

14) Uplatnenie citlivyacutech metoacuted na predikciu citlivosti k radiaacutecii v terapii rakoviny naacutedorov prsniacuteka (The utilization of sensitive assays for prediction of sensitivity to radiation therapy of breast cancer)

Veduacuteci projektu MARKOVAacute Eva RNDr CScDoba riešenia projektu 012005 - 122007Evidenčneacute čiacuteslo projektu 2502725Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 30 000- Sk

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V raacutemci spolupraacutece s Raacutedioterapeutickyacutem oddeleniacutem NOUacute na Klenovej bolo zahaacutejeneacute štuacutedium reziduaacutelnych 53BP1 fokusov na sledovanie raacutediosenzitivity v lymfocytoch izolovanyacutech z perifeacuternej krvi pacientok podstupujuacutecich liečbu naacutedoroveacuteho ochorenie prsniacuteka raacutedioterapiou po predchaacutedzajuacutecej mastektoacutemii resp prsniacutek zachovaacutevajuacutecom operačnom zaacutekroku Na zaacuteklade predchaacutedzajuacuteceho in vitro štuacutedia reziduaacutelnych fokusov bola vypracovanaacute scheacutema odberu vzoriek od pacientok Momentaacutelne sa analyzujuacute vzorky z 9 pacientok čo predstavuje cca 50 z celkoveacuteho plaacutenovaneacuteho počtu do konca trvania grantu tj decembra 2007

PublikaacutecieMARKOVAacute E - SCHULTZ N - BELYAEV I Dynamics and dose response for DSB colocalizing residual 53BP1 gamma H2AX foci localization in nuclear matrix relation to slow repair and radiosensitivity In International Journal of Radiation Biology 2006 Accepted

Prednaacutešky a vyacutevesky BELYAEV I - MARKOVAacute E - SHULTZ N Radiation-induced 53BP1γH2AX foci dynamic clustering and colocalisation usage for radiosensitivity and biological dosimetry Vth Russian Congress on Radiation Research Research (Radiobiology Radioecology and Radiation Protection) Moscow Russia Russian Academy of Science 2006 vol I p 18 (R)

MARKOVAacute E - ALTANEROVA V - HILLERT L - MALMGREN L - PERSSON B - BELYAEV I Adverse effects of microwaves from GSMUMTS mobile phones on human primary lymphocytes and stem cells depend on carrier frequency and type of signal V th Russian Congress on Radiation Research (Radiobiology Radioecology and Radiation Protection) Moscow Russia Russian Academy of Science 2006 vol III p 95 (R)

SARIMOV R - MARKOVAacute E - JOHANSSON F - JENSSEN D - BELYAEV I Exposure to ELF magnetic field tuned to Zn inhibits growth of cancer cells Vth Russian Congress on Radiation Research (Radiobiology Radioecology and Radiation Protection) Moscow Russia Russian Academy of Science 2006 vol III p 94 (R)

15) Modulaacutecia expresie HLA-G a HLA-E antigeacutenov (The modulation of expression of HLA-G and HLA-E antigens)

Veduacuteci projektu POLAacuteKOVAacute Katariacutena RNDr DrScDoba riešenia projektu 012005 - 122007Evidenčneacute čiacuteslo projektu 2502025Počet spoluriešiteľskyacutech inštituacuteciiacute 2 (Virologickyacute uacutestav SAV Bratislava Slovenskaacute zdravotniacutecka

univerzita Bratislava) Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 128 000- Sk


V prvej etape našej praacutece sme sledovali vplyv proteazoacutemovyacutech inhibiacutetorov (zLLL laktacystiacutenu alebo epoximicinu) na konštitutiacutevnu expresiu mebraacutenovyacutech HLA-G antigeacutenov V choriokarcinoacutemovyacutech JEG-3 bunkaacutech sa primaacuterny HLA-G transkript alternatiacutevne štiepi na takeacute RNA molekuly ktoreacute by mohli koacutedovať štyri membraacutenoveacute antigeacuteny HLA-G1 -G2 -G3

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a -G4 Na bunkovom povrchu sa však detegujuacute len HLA-G1 antigeacuteny a kratšie proteiacutenoveacute izoformy (HLA-G2 -G3 a -G4) sa zatiaľ nepodarilo dokaacutezať Tieto kratšie proteiacutenoveacute izoformy postraacutedajuacute stabilnuacute štruktuacuteru a tak mocircžu podliehať ryacutechlej proteazoacutemovej degradaacutecii Preto sme v našej praacuteci sledovali vplyv proteazoacutemovyacutech inhibiacutetorov (zLLL laktacystiacutenu alebo epoximicinu) na expresiu HLA-G antigeacutenov U JEG-3 buniek sa naacutem ani po použitiacute proteazoacutemovyacutech inhibiacutetorov nepodarilo detegovať kratšie membraacutenoveacute HLA-G izoformy Avšak u stabilnyacutech HLA-G1 a -G2 transfektantoch (K562-G1 a K562-G2) sme pozorovali vyacuterazneacute zvyacutešenie priacuteslušnyacutech HLA-G1 a -G2 proteiacutenov V ďalšej etape riešenia sa pokuacutesime navodiť de novo expresiu HLA-G proteiacutenov v rocircznych typoch buniek a to predovšetkyacutem prostredniacutectvom niektoryacutech demetylačnyacutech agens Vyhodnoteniacutem RT-PCR vyacutesledkov vyberieme najefektiacutevnejšiacute postup indukcie HLA-G geacutenov a využijeme ho na indukciu de novo synteacutezy HLA-G antigeacutenov v leukemickyacutech bunkovyacutech liacuteniaacutech a v leukemickyacutech bunkaacutech ziacuteskanyacutech priamo od pacientov

Publikaacutecie POLAacuteKOVAacute K - BANDZUCHOVAacute E - BYSTRICKAacute M - PANČUCHAacuteROVAacute H - RUSS G Effect of proteasome inhibitors on expression of HLA-G isoforms In Neoplasma Vol 53 no 6 (2006) p 471-477

Prednaacutešky a vyacuteveskyPOLAacuteKOVAacute K- BANDŽUCHOVAacute E- BYSTRICKAacute M- PANČUCHAacuteROVAacute H- RUSS G Expression of truncated HLA-G isoforms in cells exposed to proteasome inhibitors (prednaacuteška) 4th International Conference on HLA-G 10-12 July 2006 Paris FranceAbstract book p17 Tissue Antigens Vol68 no4 (2006) p351

POLAacuteKOVAacute K- BANDŽUCHOVAacute E- BYSTRICKAacute M- PANČUCHAacuteROVAacute H- RUSS G Effect of proteasome inhibitors on expression of HLA-G isoforms 7th EFIS Tatra Immunology Conference 24-28 June 2006 High Tatra Slovakia

16) Uacuteloha aktivovanyacutech stromaacutelnych fibroblastov v regulaacutecii progresie ľudskyacutech hematopoetickyacutech maligniacutet (The role of activated stromal fibroblasts in the control of progression in human hematopoietic malignancies)

Veduacuteci projektu BIacuteZIK Jozef RNDr DrScDoba riešenia projektu 12006 - 122008Evidenčneacute čiacuteslo projektu 2601726Počet spoluriešiteľskyacutech inštituacuteciiacute - Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 198 000- Sk


Progresia naacutedorovyacutech buniek je komplexnyacute proces do regulaacutecie ktoreacuteho aktiacutevne vstupujuacute stromaacutelne bunky Tieto sa často vyznačujuacute hyperplaacuteziou a naacuteslednou silnou zaacutepalovou reakciou Podarilo sa naacutem dosiahnuť originaacutelne vyacutesledky tyacutekajuacutece sa biologickeacuteho procesu prebiehajuacuteceho v ľudskyacutech stromaacutelnych fibroblastoch pri ich kultivaacutecii v špecifickyacutech in vitro podmienkach Tento proces ktoryacute sme nazvali bdquonemoacutezaldquo je v prvom

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rade manifestovanyacute aktivaacuteciou špecifickeacuteho suacuteboru geacutenov a naacuteslednou programovanou bunkovou smrťou

Sledovali sme vplyv nemoacutezy na panel ľudskyacutech leukemickyacutech bunkovyacutech liacuteniiacute a zistili sme že bunky ktoreacute neexprimovali receptor pre hepatocytaacuterny rastovyacute faktor (c-Met) prestali sa deliť a začali diferencovať pričom ziacuteskali fenotyp dendritovyacutech buniek Predpokladaacuteme že tento efekt bol spocircsobenyacute suacuteborom cytokiacutenov ako suacute interleukiacuten ndash1 -6 -8 LIF a GM-CSF produkovanyacutech aktivovanyacutemi fibroblastami Tieto vyacutesledky poukazujuacute na docircležituacute uacutelohu ktoruacute plnia stromaacutelne fibroblasty pri kontrole progresie hematologickyacutech maligniacutet


BIZIK J - BABUSIKOVA O - KANKURI E Nemosis - prospective cell based therapy Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 ISBN 80-969541-8-0 p 12-13 (R)

17) Analyacuteza alteraacuteciiacute v geacutenoch na vzniku dedičnej formy rakoviny prsniacutekov a vaječniacutekov (The analysis of genetic alterations in hereditary forms of breast and ovarian cancers)

Veduacuteci projektu TOMKA Miroslav RNDr PhD Doba riešenia projektu 012006 - 122008Evidenčneacute čiacuteslo projektu 2621726Počet spoluriešiteľskyacutech inštituacuteciiacute 2 (Naacuterodnyacute onkologickyacute uacutestav Centrum lekaacuterskej genetiky FN)Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 101 000- Sk


V roku 2006 boli naše molekuloveacute analyacutezy upriameneacute na odhalenie mutaacuteciiacute v exoacutenoch geacutenu BRCA1 a BRCA2 u ďalšiacutech rodiacuten s predpokladanou dedičnou formou karcinoacutemu prsniacuteka a vaječniacutekov Doteraz bola dokončenaacute analyacuteza 72 rodiacuten a rozpracovanyacutech je ďalšiacutech 24 rizikovyacutech rodiacuten Na skriacutening boli použiteacute dobre etablovaneacute molekulovo-genetickeacute metoacutedy - SSCP HDA V priebehu roka sa dal do prevaacutedzky vysokocitlivyacute a plne automatizovanyacute detekčnyacute priacutestroj WAVE System čo umožnilo prakticky až 100-nuacute detekciu genetickyacutech zmien u analyzovanyacutech rodiacuten Naacuteslednyacutem automatickyacutem sekvenovaniacutem sme u jednej rodiacuteny identifikovali mutaacuteciu c5266dupC (znaacutemu ako 5382insC) a u troch rodiacuten mutaacuteciu c181TgtG (znaacutemu ako C61G) v geacutene BRCA1 U rodiacuten s mutaacuteciou c181TgtG sa v rodinnej anamneacuteze vyskytovala kombinaacutecia mamaacuterneho a ovariaacutelneho karcinoacutemu

Vyacutesledky štuacutediiacute z posledneacuteho obdobia poukazujuacute na suacutevislosť medzi mutaacuteciami v geacutene CHEK2 a zvyacutešenyacutem rizikom vyacutevoja karcinoacutemu prsniacuteka Aby sme potvrdili resp vyvraacutetili uvedenuacute asociaacuteciu pokračovali sme v analyacuteze ďalšiacutech 65 DNA pacientiek na priacutetomnosť najčastejšej patogeacutennej varianty 1100delC Analyacuteza nepotvrdila priacutetomnosť tejto mutaacutecie ani u jednej vzorky avšak identifikovali sme novuacute deleacuteciu až 5567 bp ktoraacute vedie k strate 9 a 10 exoacutenu geacutenu CHEK2 Deleacutecia bola zistenaacute u rodiny s priacutetomnosťou jednak karcinoacutemu prsniacuteka ako aj kolorektaacutelneho karcinoacutemu Na zaacuteklade medzinaacuterodnej spolupraacutece v tejto problematike sa ukazuje že varianta CHEK2del5567 je priacutetomnaacute približne u 2 pacientiek z regioacutenu Čiech a Slovenska

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Pre lepšiu charakterizaacuteciu slovenskyacutech rodiacuten s hereditaacuternou formou karcinoacutemu prsniacuteka a ovaacuteriiacute sme svoju pozornosť upriamili na stanovenie vekovej a geografickej distribuacutecie suacuteboru 130 suspektnyacutech rodiacuten Zistili sme že najčastejšiacute vek naacutestupu karcinoacutemu prsniacuteka u probandiek v našom suacutebore bol v rozmedziacute 40ndash49 roku života zatiaľ čo uacutedaje NOR (Naacuterodneacuteho onkologickeacuteho registra) informujuacute minimaacutelne o 10-ročnom oneskoreniacute diagnoacutezy u neselektovanyacutech viac-menej sporadickyacutech priacutepadoch Rodiny s viacnaacutesobnou priacutetomnosťou karcinoacutemu prsniacuteka a ovaacuteriiacute ako aj rodiny s detekovanou mutaacuteciou BRCA12 suacute približne rovnomerne rozmiestneneacute v raacutemci uacutezemia celeacuteho Slovenska

PublikaacutecieWALSH T - CASADEI S - COATS K - SWISHER E - STRAY S - HIGGINS J - ROACH K - MANDELL J - LEE M - ČIERNIKOVAacute S - FORETOVA L - SOUCEK P - KING M Spectrum of mutations in BRCA1 BRCA2 CHEK2 and TP53 in families at high risk of breast cancer In JAMA - Journal of American Medical Association Vol 295 no 12 (2006) p 1379-1388

ČIERNIKOVAacute S - TOMKA M - KOVAacuteČ M - ŠTEVURKOVAacute V - ZAJAC V Age and geographical distribution in families with BRCA4BRCA2 mutations in the Slovak Republic In Hereditary Cancer in Clinical Practice Vol 4 no 1 (2006) p 7-11

ČIERNIKOVAacute S - TOMKA M - KOVAacuteČ M - ŠTEVURKOVAacute V - ZAJAC V Ashkenazi founder BRCA1BRCA2 mutations in Slovak hereditary breast andor ovarian cancer families In Neoplasma Vol 53 no 2 (2006) p 97-102

Prednaacutešky a vyacuteveskyČIERNIKOVAacute S - TOMKA M - KOVAacuteČ M - ŠTEVURKOVAacute V - BELLA V - KLEIBL Z - ZAJAC V Mutation screening of BRCA1 BRCA2 and CHEK2 in Slovak HBOC families Cancer 2006 From molecular biology processes to tumor-tailored therapy 20-24 Augusta 2006 Staraacute Lesnaacute Slovensko (prednaacuteška aj poster)

HAMEL N- FORETOVA L - NAROD SA - TIHOMIROVA L - ZAJAC V - CIERNIKOVA S - ARMAOU S - YANNOUKAKOS D - GREENWOOD C - FOULKES W Investigating the origins of the BRCA1 mutation c5385dupC The American Society of Human Genetics annual meeting 9-13 Oktoacutebra 2006 New Orleans Louisiana USA (poster)

18) Geacutenovaacute terapia naacutedorov pomocou retroviacuterusovyacutech vektorov Testovanie vektorov s geacutenom faktoru naacutedorovej nekroacutezy a vektorov obsahujuacutecich siRNA expresneacute kazety (Gene therapy for cancer with retrovirus vectors Testing of vectors with tumor necrosis factor and vectors with siRNS expression cassette)

Veduacuteci projektu HLUBINOVAacute Kristiacutena RNDrCSc Doba riešenia projektu 012006 - 122008 Evidenčneacute čiacuteslo projektu 2606126 Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 84 000- Sk


Naše predchaacutedzajuacutece experimenty ukaacutezali že po transfekcii naacutedorovyacutech buniek plazmidovou DNA obsahujuacutecou geacuten pre tumor nekrotizujuacuteci faktor dochaacutedza k jeho

74

naacuteslednej expresii a z toho vyplyacutevajuacuteceho vysokeacuteho percenta apoptickyacutech buniek čo je cieľom geacutenovej terapie naacutedorov V snahe využiť tento poznatok sme pripravili modelovyacute expresnyacute vektor v ktorom je expresia geacutenu pre zelenyacute fluorescenčnyacute proteiacuten (GFP) pod radiačne inducibilnyacutem promoacutetorom EGRI

PublikaacuteciePASTORAacuteKOVAacute A - HLUBINOVAacute K - ALTANER Č Treatment of human tumor cells by combine gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and bacterial cytosine deaminase suicide gene In Neoplasma Vol 53 no 6 (2006) p 478-484

PASTORAacuteKOVAacute A - HLUBINOVAacute K - JAKUBIacuteKOVAacute J - ALTANER Č Combine cancer gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and Herpes simplex thymidine kinase suicide gene In Neoplasma Vol 53 no 5 (2006) p 353-362

Prednaacutešky a vyacutevesky PASTORAacuteKOVAacute A - HLUBINOVAacute K - ALTANER Č Combine cancer gene therapy expression of human tumor necrosis factor alpha simultaneously with suicide gene systems in vitro Cancer 2006 From molecular biology processes to tumor-tailored therapy August 20 ndash 24 2006 Staraacute Lesnaacute Slovensko

PASTORAacuteKOVAacute A Rekombinantneacute DNA techniky a geacutenovaacute terapia Prednaacutešky v Strednej priemyselnej škole Samuela Stankovnianskeacuteho 29 november ndash 1december 2006 Banskaacute Štiavnica Slovensko

19) Podiel homologickej a nehomologickej rekombinaacutecie na oprave dvojvlaacuteknovyacutech zlomov DNA indukovanyacutech oxidačnyacutem stresom v kvasinkaacutech Saccharomyces cerevisiae (Contribution of homologous recombination and non-homologous end-joining to DNA double-strand break repair after oxidative stress in the budding yeast Saccharomyces cerevisiae)

Veduacuteci projektu CHOVANEC Miroslav Mgr PhDDoba riešenia projektu 012006 - 122008Evidenčneacute čiacuteslo projektu 2608226Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 160 000- Sk


Sledovali sme či oxidačnyacute stress vyvolanyacute niektoryacutemi laacutetkami indukuje dvojvlaacuteknoveacute zlomy DNA v kvasinkaacutech Saccharomyces cerevisiae Zistili sme že spomedzi testovanyacutech laacutetok mal takuacuteto schopnosť bleomyciacuten laacutetka rutinne použiacutevanaacute v mediciacutene Oprava dvojvlaacuteknovyacutech zlomov DNA generovanyacutech bleomyciacutenom je plne zaacutevislaacute na funkčnej homologickej rekombinaacutecii a nevyžaduje replikaacuteciu DNA a de novo synteacutezu proteiacutenov Domnievame sa že komplexita a štruktuacutera dvojvlaacuteknovyacutech zlomov DNA indukovanyacutech bleomyciacutenom predstavujuacute probleacutem pre druhuacute draacutehu zodpovednuacute za opravu dvojvlaacuteknovyacutech zlomov DNA v kvasinkaacutech nehomologickeacute spaacutejanie koncov DNA Tento fakt by mohol mať vyacuteznamnyacute vplyv na uacutespešnosť liečby založenej na aplikaacutecii tejto laacutetky

75

PublikaacutecieLETAVAYOVAacute L - MARKOVAacute E - HERMANSKAacute K - VLČKOVAacute V - VLASAacuteKOVAacute D - CHOVANEC M - BROZMANOVAacute J Relative contribution of homologous recombination and non-homologous end-joining to DNA double-strand break repair after oxidative stress in Saccharomyces cerevisiae In DNA repair Vol 5 no 5 (2006) p 602-610

LETAVAYOVAacute L - VLČKOVAacute V - BROZMANOVAacute J Selenium from cancer prevention to DNA damage In Toxicology Vol 227 no 1-2 (2006) p 1-14

Prednaacutešky a vyacutevesky LETAVAYOVAacute L - MARKOVAacute E - VLASAacuteKOVAacute D - VLČKOVAacute V - HERMANSKAacute K - BROZMANOVAacute J - CHOVANEC M Cellular response to oxidative DNA damage in Saccharomyces cerevisiae Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 ISBN 80-969541-8-0 p 12-13 (R)

DUDAacuteŠOVAacute Z - WARD T A - MCHUGH P J - CHOVANEC M The yeast Snm1Pso2 protein and its possible interactions Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 ISBN 80-969541-8-0 p 12-13 (R)

DUDAacuteŠOVAacute Z - WARD T A - MCHUGH P J - CHOVANEC M The possible roles of the yeast Snm1Pso2 and Mgm101 repair factors International Free Radical Summer School 2006 Spetses Island Greacutecko 30 September - 06 Oktoacuteber 2006 p 83-84

LETAVAYOVAacute L - VLČKOVAacute V - VLASAacuteKOVAacute D - CHOVANEC M - BROZMANOVAacute J Selenium DNA damage and repair in Saccharomyces cerevisiae Jesenneacute pracovneacute dni Genetickaacute toxikoloacutegia a prevencia rakoviny UacuteEO SAV Bratislava 23 - 25 Oktoacuteber 2006

20) Uacuteloha genotoxickyacutech a epigenetickyacutech mechanizmov v tkanivovej a orgaacutenovej špecificite chemickyacutech karcinogeacutenov cicavčie bunky kultivovaneacute in vitro ako modelovyacute system (The role of genotoxic and epigenetic mechanisms in tissue and organ specificity of chemical carcinogens mammalian cells cultivated in vitro as a model system)

Veduacuteci projektu GAacuteBELOVAacute Alena RNDr CSc Doba riešenia projektu 012006 - 122008 Evidenčneacute čiacuteslo projektu 2606326 Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 158 000- Sk


Epiteliaacutelne progenitoroveacute bunky WB-F344 izolovaneacute z pečene potkana boli použiteacute na štuacutedium genotoxickyacutech a negenotoxickyacutech uacutečinkov dibenzo[cg]karbazolu (DBC) a jeho dvoch tkanivovo špecifickyacutech derivaacutetov N-metyldibenzo[cg]karbazolu (MeDBC) a 59-dimetyldibenzo[cg]karbazol (diMeDBC) Doterajšie vyacutesledky ukaacutezali že DBC ktoryacute je silnyacute sarkomogeacuten a hepatokarcinogeacuten vyacuterazne inhibuje medzibunkovuacute komunikaacuteciu (gap junctional intercellular communication GJIC) a aktivuje aryl hydrocarbon receptor (AhR) ktoryacute zohraacuteva kľuacutečovuacute uacutelohu pri indukcii biotransformačnyacutech enzyacutemov (cytochroacutemy P450) Striktnyacute hepatokarcinogeacuten diMeDBC je veľmi uacutečinnyacutem induktorom Ah receptora v bunkaacutech

76

WB-F344 čo potvrdilo aj signifikantneacute zvyacutešenie hladiny cytochroacutemov P4501A1 a 1A2 v ovplyvnenyacutech bunkaacutech Na rozdiel od parentalnej molekuly diMeDBC iba mierne inhiboval GJIC rovnako ako tkanivovo špecifickyacute sarkomogeacuten MeDBC MeDBC sa prejavil ako slabyacute aktivaacutetor Ah receptoru Hepatokarcinogeacuteny DBC a diMeDBC na rozdiel od MeDBC signifikantne zvyacutešili fosforylaacuteciu p53 proteiacutenu

Publikaacutecie VONDRAacuteČEK J - ŠVIHAacuteLKOVAacute-ŠINDLEROVAacute L - PĚNČIacuteKOVAacute K - KRČMAacuteŘ P - ANDRYSIacuteK Z - CHRAMOSTOVAacute K - MARVANOVAacute S - VALOVIČOVAacute Z - KOZUBIacuteK A - GAacuteBELOVAacute A - MACHALA M 7H-Dibenzo[cg]carbazole and 59-dimethyldibenzo[cg]carbazole exert multiple toxic events contributing to tumor promotion in rat liver epithelial stem-like cells In Mutation research-Fundamental and molecular mechanisms of mutagenesis Vol 593 (2006) p 43-56

Prednaacutešky a vyacutevesky VALOVIČOVAacute Z - FARKAŠOVAacute T - GURSKAacute S - BINKOVAacute B - GAacuteBELOVAacute A Role of cytochromes P450 in genotoxicity and mutagenity of 7H-dibenzo[cg]carbazole and its tissue specific derivatives Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 P30 p 36 (R)

GAacuteBELOVAacute A - POLAacuteKOVAacute V - POLONCOVAacute K - VALOVIČOVAacute Z - PROCHAZKA G Interactions of aromatic hydrocarbons in their binary mixtures an in vitro study 36th Annual Meeting of the EEMS Prague July 2-6 2006

GAacuteBELOVAacute A - POLAacuteKOVAacute V - POLONCOVAacute K - VALOVIČOVAacute Z - PROCHAZKA G Biologickaacute aktivita binaacuternych zmesiacute aromatickyacutech uhľovodiacutekov in vitro štuacutedia Jesenneacute pracovneacute dni bdquoGenetickaacute toxikoloacutegia a prevencia rakovinyldquo Bratislava 23 ndash 25102006 Zborniacutek ISBN 80-969524-5-5

21) Uacuteloha nukleaacuterneho faktora-1 v rastovo regulovanej expresii ľudskeacuteho ANT-2 geacutenu (Role of nuclear factor-1 in growth regulated expression of the human ANT2 gene)

Veduacuteci projektu BARAacuteTH Peter Mgr PhD Doba riešenia projektu 012006 - 122008 Evidenčneacute čiacuteslo projektu 2606026 Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 156 000- Sk


Cieľom projektu je zistiť ktoreacute transkripčneacute faktory sa zuacutečastňujuacute spolu s NF1 represie transkripcie ANT2 geacutenu pri prechode buniek do kľudovej faacutezy Spolupracujuacutece proteiacuteny chceme zisťovať pomocou hmotnostnej spektrometrie kde by NF1 bol ukotvenyacute na matrixe Nevyhnutnyacutem predpokladom je teda izolaacutecia dostatočneacuteho množstva čisteacuteho transkripčneacuteho faktora NF1 Prvyacutem krokom bola nadexpresia NF1 fuacutezneho proteiacutenu v bakteacuteriaacutech E coli Zostrojili bakteriaacutelny expresnyacute vektor a pri indukcii s IPTG sme exprimovali NF1 fuacutezny proteiacuten v E coli Zistili sme však že NF1 sa v bakteacuteriaacutech produkuje

77

iba v nerozpustnej forme Preto sme sa naklonovali NF1 do expresneacuteho vektora ktoryacute je vhodnyacute pre expresiu proteiacutenov v eukaryotickom organizme v kvasinke Pichia pastoris Doterajšie vyacutesledky ukazujuacute že pre expresiu NF1 fuacutezneho proteiacutenu v rozpustnej forme je docircležitaacute zniacuteženaacute teplota (20degC) počas indukcie Avšak na zaacuteklade elektroforeacutezy v SDS PAGE a naacuteslednej Western blot analyacutezy sme zistili že NF1 fuacutezny proteiacuten je degradovanyacute preto teraz prebieha optimalizaacutecia podmienok na expresiu tohto proteiacutenu v kvasinke P pastoris

22) Klonovanie expresia a purifikaacutecia ľudskyacutech homoloacutegov XPB a XPD z hypertermofilnyacutech Archaea Pyrococcus abyssi (Cloning expression and purification of human homologs XPB and XPD from hyperthermophilic Archaea Pyrococcus abyssi)

Veduacuteci projektu ŠKORVAGA Milan RNDr CSc Doba riešenia projektu 012006 - 122008 Evidenčneacute čiacuteslo projektu 2611026 Počet spoluriešiteľskyacutech inštituacuteciiacute -Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 127 000- Sk


Naklonovali sme ľudskeacute homoloacutegy XPB a XPD diveacuteho typu z hypertermofilnyacutech Archaea Pyrococcus abyssi (Pab) do expresnyacutech vektorov IMPACT systeacutemu pTYB2 pTYB4 a pTXB3 (T7 promoacutetor) vo forme trojčlennej fuacutezie XPBXPD-inteiacuten-CBD Identifikovali sme podmienky pre optimaacutelnu nadprodukciu rozpustneacuteho Pab XPB fuacutezneho proteiacutenu v kmeni Ecoli BL21(DE3)RILpTXB3XPB a to pomocou autoindukcie pri teplote 24degC po dobu 16 hodiacuten Zistili sme že Pab XPD proteiacuten je z IMPACT expresnyacutech vektorov vysoko exprimovanyacute ale nerozpustnyacute Klonovanie XPD geacutenu v kvasinkaacutech Pichia pastoris viedlo k expresii rozpustneacuteho XPD proteiacutenu ale v značne redukovanom množstve v porovnaniacute s bakteraacutelnymi bunkami Autoindukcia buniek EcoliBL21(DE3)RILpET431a(+)XPD pri teplote 20degC po dobu 16-18 hodiacuten rezultovala do vysokej nadprodukcie rozpustneacuteho XPD proteiacutenu fuacutezovaneacuteho s vysokosolubilnyacutem NusA tagom Z uvedeneacuteho vyplyacuteva že sme dosiahli vysokuacute hladinu expresie rozpustnyacutech Pab XPB a XPD proteiacutenov čo naacutem umožniacute jednoduchuacute purifikaacuteciu oboch proteiacutenov pre ďalšie experimenty (kryštalizaacutecia stanovenie helikaacutezovej aktivity)

Publikaacutecie WANG H - DELLAVECCHIA M - ŠKORVAGA M - CROTEAU D - ERIE D - VAN HOUTEN B UvrB domain 4 an autoinhibitory gate for regulation of DNA binding and ATPase activity In Journal of biological chemistry Vol 281 (2006) p 15227-15237

JIANG G - ŠKORVAGA M - CROTEAU D - VAN HOUTEN B - STATES J Robust Incision of Benzo[a]pyrene-78-dihyrodiol-910-epoxide-DNA Adducts by a Recombinant Thermoresistant Interspecies Combination UvrABC Endonuclease System In Biochemistry Vol 45 no 25 (2006) p 7834-7843

Prednaacutešky a vyacutevesky VAN HOUTEN B - CROTEAU DL - WANG H - DELLAVECCHIA MJ - BIENSTOCK R - KISKER C - SKORVAGA M In search of damage structure - function studies of nucleotide

78

excision repair proteins Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 ISBN 80-969541-8-0 p 12-13 (R)

12 Projekty VEGA na ktoryacutech sa uacutestav zmluvne podieľa na riešeniacute projektu

1) Štuacutedium mechanizmov uacutečinku chroacutemu (VI) veduacutecich ku malignej transformaacutecii buniek v dyacutechacom systeacuteme s ohľadom na fajčenie (Study of chromium (VI) caused carcinogenesis in pulmonary system respecting also the risk coming from cigarette smoking)

Veduacuteci projektu HALAŠOVAacute Erika RNDr CSc Doba riešenia projektu 012006 - 122008 Evidenčneacute čiacuteslo projektu 1339706Veduacuteci projektu na UacuteEO SAV ONDRUŠOVAacute Martina RNDr PhDPočet spoluriešiteľskyacutech inštituacuteciiacute 1 (JLF UK Martin)Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR -


Expoziacutecia chroacutemu spocircsobuje indukciu karcinogeneacutezy v respiračnom systeacuteme Mechanizmus uacutečinku chroacutemu nie je jasnyacute Rizikovyacutemi suacute najmauml pracovniacuteci v priemysle kovovyacuteroby Inyacutem rizikovyacutem faktorom je pocircsobenie cigaretoveacuteho dymu najmauml vďaka priacutetomnosti polycyklickyacutech aromatickyacutech uhľovodiacutekov (PAH) Nie je jednoducheacute oddeliť pocircsobenie tyacutechto dvoch hlavnyacutech rizikovyacutech faktorov Začali sme štuacutedie zameraneacute na 1 geneticky definovať rizikovuacute skupinu populaacutecie ktoraacute je senzitiacutevnejšia na pocircsobenie chroacutemu a PAH 2 definovať obsah chroacutemu v tkanive pľuacutecnych naacutedorov a zistiť korelaacuteciu medzi množstvom a priacutetomnosťou erytrocytov a močoviny 3 definovať časovuacute sekvenciu onkogeneacutezy a aktivaacutecie apoptotickyacutech proteiacutenov v in vitro kultivovanyacutech bunkaacutech pľuacutec exponovanyacutech chroacutemu a aktiacutevnym metabolitom PAH

2 Vedeckeacute projekty ktoreacute boli v roku 2006 financovaneacute APVT (APVV)

79

Finančneacute zabezpečenie projektov Agentuacutera pre podporu vedy a techniky (APVT) Hanulova 5B 841 01 Bratislava resp Agentuacutera pre podporu vyacuteskumu a vyacutevoja (APVV) Myacutetna 23 811 07 Bratislava

21 Projekty APVTAPVV na ktoryacutech je uacutestav nositeľom projektu

1) Uacuteloha polymorfizmov opravnyacutech geacutenov hOGG1 a XPD v odpovedi ľudskyacutech buniek na indukovaneacute poškodenie DNA (Role of polymorphisms of DNA repair genes hOGG1 and XPD on DNA damage processing in human cell lines)

Veduacuteci projektu GURSKAacute Soňa Ing PhD Zaacutestupca veduacutecehoprojektu FARKAŠOVAacute Timea IngDoba riešenia projektu 012005 ndash 122007Evidenčneacute čiacuteslo projektu APVT-51-015304Počet spoluriešiteľskyacutech inštituacuteciiacute Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 724 000- Sk

Dosiahnuteacute vyacutesledkyV roku 2006 bol projekt zameranyacute na sledovanie vplyvu polymorfizmu v geacutene

hOGG1 (Ser326Cys) a XPD (Lys751Gln) na uacuterovni proteiacutenov Po indukcii špecifickeacuteho poškodenia fotosenzibilizaacutetorom metyleacutenovou modrou a viditeľnyacutem svetlom sme pozorovali zvyacutešenuacute expresiu proteiacutenu hOGG1 len v bunkovej liacutenii HeLa ktoraacute je homozygotnaacute pre seriacuten tj wt Keď sme na indukciu expresie proteiacutenu hOGG1 využili MMS naacuterast expresie tohto proteiacutenu bol sledovanyacute vo všetkyacutech bunkovyacutech liacuteniaacutech Avšak v porovnaniacute s HeLa bunkami v bunkaacutech s variantnou alelou SiHa (SerCys) a C-33A (CysCys) bola zvyacutešenaacute expresia proteiacutenu hOGG1 zaznamenanaacute len pri najvyššej použitej koncentraacutecii MMS (200 μM) a pri najdlhšej expoziacutecii (48 h) Uvedeneacute vyacutesledky poukazujuacute na možnyacute pozitiacutevny vplyv seriacutenu v polohe 326 v proteiacutene hOGG1 Polymorfizmus v geacutene XPD (Lys751Gln) nespocircsobil v expresii proteiacutenu XPD po indukcii špecifickeacuteho poškodenia UV žiareniacutem vyacuterazneacute rozdiely medzi bunkovyacutemi liacuteniami homozygotnyacutemi pre lyziacuten (HeLa bunky) a glutamiacuten (C-33A bunky) Veľmi mierny naacuterast expresie proteiacutenu XPD bol zaznamenanyacute len v bunkaacutech HeLa po 1 h až 6 h od ovplyvnenia


GURSKAacute S - FARKAŠOVAacute T - GAacuteBELOVAacute A Vplyv polymorfizmu v geacutene hOGG1 na opravu oxidačnyacutech poškodeniacute DNA (vyžiadanaacute prednaacuteška) 29 pracovniacute dny Českeacute a Slovenskeacute společnosti pro mutagenezu zevniacutem prostřediacutem Československeacute biologickeacute společnosti 2 - 4maacutej 2006 Brno Českaacute Republika Zborniacutek ISBN 80-7013-438-0 p 25

GURSKAacute S - FARKAŠOVAacute T - GAacuteBELOVAacute A Effect of polymorphism in the DNA repair gene hOGG1 (Ser326Cys) on phenotype (poster) 36th Annual Meeting of the European Environmental Mutagen Society 2 - 6 juacutel 2006 Praha Českaacute Republika Book of abstracts p 198 (R)

80

GURSKAacute S - FARKAŠOVAacute T - GAacuteBELOVAacute A Polymorfizmus v DNA opravnom geacutene hOGG1 (Ser326Cys) a jeho vplyv na fenotyp (poster) Jesenneacute pracovneacute dni Genetickaacute toxikoloacutegia a prevencia rakoviny 23 - 25 oktoacuteber 2006 Bratislava Zborniacutek ISBN 80-969524-5-5 p 49

2) Ďalšia in vivo charakterizaacutecia mutantnyacutech a polymorfnyacutech DNA ligaacutez IV identifikovanyacutech v LIG4 pacientoch (Further in vivo characterization of the mutant and polymorphic DNA ligase IV proteins found in LIG4 patients)

Veduacuteci projektu CHOVANEC Miroslav Mgr PhD Doba riešenia projektu 052006 ndash 42009Evidenčneacute čiacuteslo projektu APVV-51-042705Počet spoluriešiteľskyacutech inštituacuteciiacute Vyacuteška finančneacuteho priacutespevku zo štaacutetneho rozpočtu SR 1 007 000- Sk

Dosiahnuteacute vyacutesledkyV prvej etape riešenia tohto projektu sme sa venovali konštrukcii kvasinkoveacuteho

kmeňa ktoryacute bude exprimovať ľudskyacute DNA ligaacuteza IVXRCC4 (LX) komplex diveacuteho typu zahrnutyacute v oprave dvojvlaacuteknovyacutech zlomov DNA mechanizmom nehomologickeacuteho spaacutejania koncov DNA (NHEJ) Ľudskyacute LX komplex vnaacutešame do kmeňa S cerevisiae JKM 139 Najskocircr sme v JKM 139 kmeni vyradili koacutedujuacutecu oblasť LIF1 kvasinkoveacuteho geacutenu (homoloacuteg XRCC4 geacutenu) URA3 selekčnyacutem markerom čiacutem sme vytvorili lif1Δ0URA3 derivaacutet tohto kmeňa Fenotypicky sme vyradenie LIF1 geacutenu v lif1Δ0URA3 derivaacutete overili stanoveniacutem jeho schopnosti cirkularizovať linearizovanyacute plazmid lif1Δ0URA3 derivaacutet bol defektnyacute v cirkularizaacutecii plazmidovej DNA čo svedčiacute o jeho defekte v NHEJ v docircsledku disrupcie LIF1 geacutenu Naacutesledne sme do lif1Δ0URA3 derivaacutetu vniesli XRCC4 cDNA Vytvorili sme tak lif1Δ0XRCC4 derivaacutet kmeňa JKM 139 Momentaacutelne pracujeme na charakterizaacutecii tohto kmeňa

3) Epitelovo-mezenchymaacutelny prestup v in vitro modeli naacutedorovyacutech kmeňovyacutech buniek karcinoacutemu mliečnej žľazy (Epithelial-mesenchymal transition in the model of breast carcinoma stem cells in vitro)

Veduacuteci projektu SEDLAacuteK Jaacuten RNDr CSc Doba riešenia projektu 032006 - 022009 Evidenčneacute čiacuteslo projektu APVV-51-017505 Počet spoluriešiteľskyacutech inštituacuteciiacute Virologickyacute uacutestav SAV Onkologickyacute uacutestav sv AlžbetyVyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 1 286 000- Sk


Riešili sa dve etapy projektu a to bdquoIzolaacutecia kmeňovyacutech naacutedorovyacutech buniek z permanentnyacutech bunkovyacutech liacuteniiacute a charakterizaacutecia fenotypovej staacutelosti v zaacutevislosti od kultivačnyacutech podmienokldquo a bdquoAnalyacuteza archiacutevnych vzoriek naacutedorov mliečnej žľazyldquo V tejto faacuteze sa optimalizovali kultivačneacute podmienky pre zvyacutešenie podielu buniek s charakteristikami kmeňovyacutech naacutedorovyacutech buniek postupy separaacutecie pomocou prietokoveacuteho

81

cytometra a magnetickyacutech guličiek a technika analyacutezy metylaacutecie promoacutetorov niektoryacutech geacutenov ktoreacute podliehajuacute epigenetickej regulaacutecii v naacutedoroch mliečnej žľazy Boli pripraveneacute vzorky a testovaneacute monoklonoveacute protilaacutetky na archiacutevnych preparaacutetoch naacutedorov mliečnej žľazy Pre štuacutedium metylaacutecie promotorov RASSF1A a CDH1 geacutenov sme navrhli sadu ocircsmych paacuterov primerov pre metoacutedu metylačne špecifickej PCR (MSP) a pre genomickeacute sekvenovanie bisulfitom soacutednym modifikovanej DNA Na nemetylovanyacutech a metylovanyacutech referenčnyacutech vzorkaacutech DNA sme vytitrovali podmienky pre MSP (oba DNA substraacutety) a pre sekvenačneacute PCR pri oboch študovanyacutech geacutenoch v dvoch prekryacutevajuacutecich sa DNA fragmentoch promotorovyacutech sekvenciiacute Otestovali sme kultivaacutecie na agare a v hydrogeacutelom opracovanyacutech miskaacutech Bola vykonanaacute analyacuteza inkorporaacutecie fluorescenčnej sondy R123 a sortovaneacute bunky s niacutezkou akumulaacuteciou tohto farbiva Na takto separovanej frakcii bola stanovenaacute expresia ABCG2 proteiacutenu ktoreacuteho vyacuteskyt je zvyacutešenyacute na kmeňovyacutech bunkaacutech rocircznych tkaniacutev

22 Projekty APVT na ktoryacutech sa uacutestav zmluvne podieľa na riešeniacute projektu

1) Noveacute environmentaacutelne vhodneacute využitie ligniacutenovyacutech biopolymeacuterov z odpadu chemickeacuteho spracovania dreva pre chemoprevenciu naacutedorovyacutech a genetickyacutech ochoreniacute (New environmental friendly use of lignin biopolymers from wastes of chemical wood treatment for chemoprevention of cancer and genetic diseases)

Veduacuteci projektu KOŠIacuteKOVAacute Božena Prof Ing DrSc Nositeľ projektu Chemickyacute uacutestav SAVVeduacuteci za spoluriešiteľskeacutepracovisko SLAMEŇOVAacute Darina RNDr DrSc (UacuteEO SAV)Doba riešenia projektu 012004 - 122006Evidenčneacute čiacuteslo projektu 51-032602Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR Chemickyacute uacutestav poskytol materiaacutel v hodnote

230 000- Sk na UacuteEO SAV


Tretiacute rok riešenia projektu bol zameranyacute na hodnotenie a overovanie vyacutesledkov ziacuteskanyacutech v predchaacutedzajuacutecom obdobiacute a na potvrdenie skutočnosti že ligniacutenovyacute hydrolyzaacutet pocircsobiacute v podmienkach ex vivo aj in vitro ako ochrannyacute faktor a redukuje hladinu poškodeniacute DNA indukovanyacutech rocircznymi genotoxickyacutemi faktormi Zamerali sme sa najmauml na pokusy s myšaciacutemi testikulaacuternymi bunkami Ligniacuten bol aplikovanyacute buď v strave pokusnyacutech zvierat ktoreacute sluacutežili ako zdroj testikulaacuternych buniek alebo boli tieto bunky ovplyvneneacute ligniacutenom až po izolaacutecii tj v podmienkach in vitro Poškodenie DNA bolo vyvolaneacute peroxidom vodiacuteka (H2O2) viditeľnyacutem svetlo v kombinaacutecii s metyleacutenovou modrou pesticiacutedom 12-dibroacutemo-3-chloacuteropropaacutenom (DBCP) alebo anti-HIV laacutetkou 3`-azido-3`-dideoxytymidiacutenom (AZT) Hladina poškodenia DNA bola zisťovnaacute pomocou klasickej a modifikovanej jednobunkovej geacutelovej elektroforeacutezy (SCGE) Peroxid vodiacuteka indukuje prevaacutežne priame zlomy DNA a oxiduje baacutezy DNA vplyvom middotOH radikaacutelov viditeľneacute svetlo za priacutetomnosti fotosenzitizaacutetora oxiduje baacutezy DNA prostredniacutectvom singletoveacuteho kysliacuteka (1O2) a metabolizovanyacute DBCP a AZT indukuje hlavne jednoreťazcoveacute zlomy DNA Dokaacutezali sme že vo vode rozpustnyacute ligniacutenovyacute preparaacutet ziacuteskanyacute frakcionaacuteciou hydrolyzaacutetu dreva pocircsobiacute ako ochrannyacute faktor voči

82

poškodeniam DNA aj v myšaciacutech testikulaacuternych bunkaacutech poškodenyacutech uvedenyacutemi agentami v podmienkach ex vivo aj in vitro

PublikaacutecieSLAMEŇOVAacute D - HORVAacuteTHOVAacute E - BARTKOVAacute M Nature of DNA lesions induced in human hepatoma cells human colonic cells and human embryonic lung fibroblasts by the antiretroviral drug 3`- azido-3`deoxythymidine In Mutation Research Fund and Mol Mechanisms of Mutagenesis Vol 593 no 1-2 (2006) p 97-107

SLAMEŇOVAacuteD - HORVAacuteTHOVAacute E- BARTKOVAacute M- KRAJČOVIČOVAacute Z-MAŠTEROVAacute I Reduction of DNA-damaging effects of anti-HIV drug 3`-azido-3`-dideoxythymidine on human cells by ursolic acid and lignin biopolymer In Neoplasma Vol 53 no 6 (2006) p 485-491

LAZAROVAacute M ndash LAacuteBAJ J ndash ECKL P- SLAMEŇOVAacute D Comparative evaluation of DNA damage by genotoxicants in primary rat cells applying the comet assay In Toxicol Lett Vol 164 no 1 (2006) p 54-62

LAacuteBAJ J ndash SLAMEŇOVAacute D- LAZAROVAacute M- KOŠIacuteKOVAacute B Induction of DNA lesions in freshly isolated rat hepatocytes by different genotoxins and their reduction by lignin given either as a dietary component or in in vitro conditions Nutrition and Cancer (in press)

KOŠIacuteKOVAacute B - LAacuteBAJ J - SLAMEŇOVAacute D - SLAacuteVIKOVAacute E - GREGOROVAacute A Novel environmentally friendly use of lignin biomass component In Biomass and Bioenergy New Research Brenes MD (editor) Nova Science Publishers Inc Hauppauge NY 2006ISBN 1-59454-865-X p 169-200

KOŠIacuteKOVAacute B- SLAacuteVIKOVAacute E - LAacuteBAJ J- SLAMEŇOVAacute D Biological conversion of lignin waste products from chemical wood treatment into anticarcinogenic preparations In Wood Research Vol 51 no 2 (2006) p 41-48

Prednaacutešky a vyacutevesky KOŠIacuteKOVAacute B - LAacuteBAJ J - SLAMEŇOVAacute D Noveacute antikarcinogeacutenne zluacutečeniny z biomasy Medzinaacuterodnaacute konferencia In Technika ochrany prostredia TOP 2006 (Prednaacuteška) Zborniacutek ISBN 8O-227-2436-X p 233-238

KOŠIacuteKOVAacute B - LAacuteBAJ J - GREGOROVAacute A - SLAMEŇOVAacute D Reduction of genotoxic effect of carcinogens and oxidative damage of polyolefins by lignin preparations In 9th European Workshop on Lignocellulosics and Pulp 2006 Vienna (Poster) Book of Abstracts Austria p 319-322

KOŠIacuteKOVAacute B - LAacuteBAJ J - SLAMEŇOVAacute D - SLAacuteVIKOVAacute E Protection of living organisms by natural antigenotoxic agents from lignin waste products of chemical wood treatment In The International Conference and Exhibition on Drug Discovery MipTec 2006 (Poster) Book of Abstracts Basel Switzerland p 104

2) Rastlinneacute extrakty - protizaacutepaloveacute imunomodulačneacute a antimutageacutenne uacutečinky na zvierataacute (Plant extracts - anti-inflammatory cytotoxic ans antimutagenic effects in animals)

Veduacuteci projektu KOPPEL Juraj MVDr DrScNositeľ projektu Uacutestav fyzioloacutegie hospodaacuterskych zvierat SAVVeduacuteci za spoluriešiteľskeacutepracovisko SLAMEŇOVAacute Darina RNDr DrSc (UacuteEO SAV)Doba riešenia projektu 012005 - 122007Evidenčneacute čiacuteslo projektu 51-015404

83

Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 270 000- Sk


V druhom roku riešenia projektu sme zisťovali toxickeacute a protektiacutevne uacutečinky piatich rastlinnyacutech eacuteterickyacutech olejov karvakrolu tymolu eugenolu borneolu a eukalyptolu na ľudskeacute a škrečacie bunky kultivovaneacute in vitro a porovnaacutevali sme ich s toxickyacutem a protektiacutevnym uacutečinkom inyacutech rastlinnyacutech laacutetok (kyselina ursolovaacute kyselina oleanolovaacute glukaacuteny) Eacuteterickeacute oleje sa vyskytujuacute v početnyacutech rastlinaacutech ovociacute a koreninaacutech Na zaacuteklade farbenie ovplyvnenyacutech buniek trypaacutenovou modrou sme v ľudskyacutech pečeňovyacutech a črevnyacutech bunkaacutech zistili odstupňovanuacute toxicitu skuacutemanyacutech laacutetok (karvakrol ge tymol gt eugenol gt borneol gt eukalyptol) Metoacutedou jednobunkovej geacutelovej elektroforeacutezy sme dokaacutezali že tymol a karvakrol aplikovaneacute v koncentraacuteciaacutech nižšiacutech ako IC20-30 nevyvolaacutevajuacute poškodenie DNA ale naopak pocircsobia protektiacutevne voči poškodeniam DNA indukovanyacutem v ľudskyacutech a škrečaciacutech bunkaacutech peroxidom vodiacuteka Nižšiacute protektiacutevny efekt prejavoval aj borneol avšak u eugenolu a eukalyptolu sme takyacuteto efekt nezistili

PublikaacutecieOVESNAacute Z - KOZICS K - SLAMEŇOVAacute D Protective effects of ursolic acid and oleanolic acid in leukemic cells In Mutation Research Fund and Mol Mechanisms of Mutagenesis Vol 600 no 1-2 (2006) p131-137

LAZAROVAacute M - LAacuteBAJ J ndash KOGAN G-SLAMEŇOVAacute D Carboxymethyl chitin-glucan enriched diet exhibits protective effects against oxidative DNA damage induced in isolated rat cells In Neoplasma Vol 53 no 5 (2006) p434-439

LAZAROVAacute M - LAacuteBAJ J ndash ECKL P- KOGAN G - SLAMEŇOVAacute D Effects of dietary intake of a fungal β -d-glucan derivative on the level of DNA damage induced in primary rat hepatocytes by various carcinogens In Nutrition and Cancer Vol 56 no 1 (2006) p 113-122

HORVAacuteTHOVAacute E - ŠRAMKOVAacute M - LAacuteBAJ J- SLAMEŇOVAacute D Study of cytotoxic genotoxic and DNA-protective effects of selected plant essential oils on human cells cultured in vitro In Neuro Endocrinol Lett Suppl 2 (2006) p44-47

SLAMEŇOVAacute D ndash HORVAacuteTHOVAacute E - ŠRAMKOVAacute M ndash MARŠAacuteLKOVAacute L DNA-protective effects of two components of essential plant oils carvacrol and thymol on mammalian cells cultured in vitro In Neoplasma (in press)

Prednaacutešky a vyacutevesky ŠRAMKOVAacute M - LAacuteBAJ J - KOGAN G - SLAMEŇOVAacute D Evaluation of the protective potential of dietary β -D-glucan derivative supplementation in primary rat hepatocytes Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 ISBN 80-969541-8-0 No 27 p 35 (R)

HORVAacuteTHOVAacute E- ŠRAMKOVAacute M- MARŠAacuteLKOVAacute L ndash SLAMEŇOVAacute D Cytotoxic genotoxic and DNA-protective effects of carvacrol and thymol on human cells cultured in vitro Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 ISBN 80-969541-8-0 No 12 p 27 (R)

HORVAacuteTHOVAacute E - SLAMEŇOVAacute D ndash LAZAROVAacute M - LAacuteBAJ J Study of cytotoxic genotoxic and DNA-protective effects of selected plant essential oils on human cells cultured in vitro In 11th Interdisciplinary Slovak-Czech Toxicological Conference Trenčianske Teplice Slovakia June 5 ndash 7 2006 Book of Abstracts

84

HORVAacuteTHOVAacute E- ŠRAMKOVAacute M - LAacuteBAJ J- SLAMEŇOVAacute D Study of DNA-protective effects of selected components of essential plant oils on mammalian cells cultured in vitro Molecular and physiologiacal effects of bioactive food compounds Vienna Austria October 11 ndash 14 2006 Book of Abstracts

MARŠAacuteLKOVAacute L- HORVAacuteTHOVAacute E - SLAMEŇOVAacute D Investigation of protective effects of thymol an essential oil component on H2O2-induced gene mutations in V 79 Chinese hamster cells cultured in vitro In International free radical summer school 2006 Biomarkers of oxidative stress and responses Speets Island Greece September 30-October 6 2006 Book of Abstracts

KOGAN G ndash MIADOKOVAacute E ndash SLAMEŇOVAacute D VLČKOVAacute V- BABINCOVAacute M RAUKO P Antioxidant antigenotoxic and immunomodulating properties of yeast cell wall polysaccharides XX Biochemickyacute zjazd Piešťany 12-16 septembra 2006 ISBN 80-969532-6-5 p 25

KOGAN G - SLAMEŇOVAacute D- RAUKO P ndash STAŠKO A ndash BABINCOVAacute M ndash KOROLENKO TA Could fungal polysaccharides fight cancer In 2nd Baltic Meeting on Microbial Carbohydrates Rostock Germany October 4-8 2006 Book of Abstracts p 57

SLAMEŇOVAacute D- ŠRAMKOVAacute M- HORVAacuteTHOVAacute E - LAacuteBAJ J Porovnanie toxickyacutech a protektiacutevnych uacutečinkov rastlinnyacutech prchavyacutech laacutetok karvakrolu a eukalyptolu na cicavčie bunky kultivovaneacute in vitro In Jesenneacute pracovneacute dni ldquoGenetickaacute toxikoloacutegia a prevencia rakovinyrdquo Bratislava 23-25 oktoacutebra 2006 Zborniacutek ISBN 80-969524-5-5 p 27

HORVAacuteTHOVAacute E ndash SLAMEŇOVAacute D Toxickeacute genotoxickeacute a ochranneacute pocircsobenie dvoch zložiek rastlinnyacutech eacuteterickyacutech olejov (tymolu a borneolu) na cicavčie bunky kultivovaneacute v podmienkach in vitro In Jesenneacute pracovneacute dni ldquoGenetickaacute toxikoloacutegia a prevencia rakovinyrdquo Bratislava 23-25 oktoacutebra 2006 Zborniacutek ISBN 80-969524-5-5 p 71-72

3 Uacutečasť na novyacutech vyacutezvach APVV r 2006

1 Ľudskeacute mezenchyacutemoveacute kmeňoveacute bunky a naacutedoroveacute kmeňoveacute bunky (Predkladateľ Altaner Č)

2 Hľadanie optimaacutelnych terapeutickyacutech režimov pre antineoplastikaacute s bdquoterčovyacutemldquo a konvenčnyacutem cytotoxickyacutem uacutečinkom predklinickaacute štuacutedia (Predkladateľ Rauko P)

3 Uacuteloha bakteacuteriiacute v etioloacutegii kolorektaacutelneho karcinoacutemu a syndroacutemu ziacuteskanej imunodeficiencie (Predkladateľ Zajac V)

4 Vplyv metylaacutecie WNT geacutenov na naacutedorovyacute proces pilotnaacute analyacuteza (Predkladateľ Tomka M)

5 Inovačnaacute metodoloacutegia priacutepravy protinaacutedorovyacutech vakciacuten ex vivo využitiacutem dendritovyacutech buniek (Predkladateľ Biacutezik J)

6 Molekulaacuterne mechanizmy regulujuacutece rast a smrť bunky (Predkladateľ Luciakovaacute K)

7 XPBXPD DNA helikaacutezy štruktuacuterno-funkčneacute analyacutezy a uacuteloha v apoptoacuteze (Predkladateľ Piršel M)

4 Projekty riešeneacute v raacutemci ŠPVV a ŠO

V roku 2006 sa takeacuteto projekty na UacuteEO SAV neriešili

85

5 Projekty centier excelentnosti SAV

Centrum molekulaacuternej mediciacuteny SAV (MOLMED)(Centre of Molecular Medicine of the Slovak Academy of Sciences)

UacuteEO SAV sa zmluvne podieľa na riešeniacute projektu

Veduacuteci projektu PASTOREK Jaroslav prof RNDr DrScVeduacuteci čiastkovyacutech uacuteloh ALTANER Čestmiacuter doc Ing DrSc

BIES Juraj RNDr CScLUCIAKOVAacute Katariacutena Ing DrScSEDLAacuteK Jaacuten RNDr CSc

Doba riešenia projektu 2003 ndash 2006Evidenčneacute čiacuteslo Zmluva č II12003Partnerskeacute pracoviskaacute 2 (Virologickyacute uacutestav SAV

Uacutestav molekulaacuternej bioloacutegie SAV)Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 293 000- Sk

Dosiahnuteacute vyacutesledkyJednyacutem z hlavnyacutech cieľov riešenia projektu bola snaha o užšiu spolupraacutecu s

klinickyacutemi pracoviskami zameranyacutemi na onkoloacutegiu na prepojenie zaacutekladneacuteho a aplikovaneacuteho vyacuteskumu ktoryacute by viedol k ziacuteskaniu poznatkov využiteľnyacutech v relatiacutevne kraacutetkom časovom horizonte Pretože mnohopočetnaacute liekovaacute rezistencia a metastaacutezovanie suacute pretrvaacutevajuacutecimi komplikaacuteciami v liečbe onkologickyacutech pacientov vedeckeacute ciele boli nasmerovaneacute na štuacutedium možnostiacute presnejšej analyacutezy perzistujuacutecich rezistentnyacutech buniek spocircsoby jej ovplyvnenia v in vitro modeli a analyacutezu cirkulujuacutecich naacutedorovyacutech buniek v perifeacuternej krvi Vyacutesledkom riešenia suacute postupy pre presnejšiu charakterizaacuteciu rezistentnyacutech buniek v priacutetomnosti buniek normaacutelnej hemopoeacutezy a postup pre priacutepravu a analyacutezu cirkulujuacutecich naacutedorovyacutech buniek Prveacute využiacuteva vyacutehodu prietokovej cytometrie analyzovať vnuacutetrobunkovuacute koncentraacuteciu fluorescenčnyacutech sond ktoreacute suacute substraacutetmi proteiacutenov zodpovednyacutech za rezistenciu druheacute využiacuteva membraacutenovuacute filtraacuteciu buniek s definovanou veľkosťou poacuterov a naacuteslednuacute analyacutezu filtrov pomocou skenovacieho cytometra na priacutetomnosť špecifickyacutech znakov hematopoetickyacutech a epitelovyacutech buniek

Zistili sme že zjednodušenyacute genoacutem komplexnejšieho retroviacuterusu mocircže sluacutežiť ako vakciacutena v podobe DNA na prevenciu zaacutevažnyacutech ochoreniacute spocircsobenyacutech komplexnejšiacutemi retroviacuterusmi Pripravili sme konštrukty retroviacuterusovyacutech vektorov ktoreacute okrem samovražedneacuteho geacutenu obsahujuacute aj kazetu pre indukciu proapoptickeacuteho geacutenu a v počiatočnej faacuteze je priacuteprava vektorov pre geacutenovuacute terapiu s toxickyacutemi geacutenmi s radiačne indukovanou expresiou

Etablovali sme techniky ktoreacute umožňujuacute praacutecu s dospelyacutemi kmeňovyacutemi bunkami Zaviedli sme metoacutedu izolaacutecie ľudskyacutech mezenchyacutemovyacutech kmeňovyacutech buniek z kostnej drene a z tukoveacuteho tkanivaacute Pre charakterizaacuteciu tyacutechto kmeňovyacutech buniek sme etablovali techniky in vitro osteogennej a lipoidnej diferenciaacutecie a detekciu povrchovyacutech znakov prietokovou imunocytometriou Pokuacutešame sa izolovať a charakterizovať naacutedoroveacute kmeňoveacute bunky priacutetomneacute v naacutedorovyacutech bunkovyacutech liacuteniaacutech

86


BODO J - DURAJ J - JAKUBIKOVA J - SEDLAK J Isothiocyanate E-4IB induces MAPK activation delayed cell cycle transition and apoptosis Cell Proliferation revidovanyacute rukopis v druhom recenznom konaniacute

ALTANEROVA V - HOLICOVA D - KUCEROVA L - ALTANER C Long-term infection with bovine leukemia virus structural gene vector provides protection against BLV disease in rabbits Zaslaneacute do Journal of Virology

SANISLO L- KULIFFAY P - GALBAVYacute Š - SEDLAacuteK J - KAUŠITZ J (2005) Advanced detection and measurement of cells on membrane (ADAMCOM) from peripheral blood by laser scanning cytometry (LSC) in early stage breast cancer patients Zaslaneacute do Anticancer Research

KUCEROVA L - ALTANEROVA V - MATUSKOVA M - TYCIAKOVA S - ALTANER C Adipose Tissue Derived Human Mesenchymal Stem Cells Mediated Prodrug Cancer Gene Therapy Zaslaneacute do Cancer Research



87

7 Projekty podporovaneacute Euroacutepskym sociaacutelnym fondom

Finančneacute zabezpečenie projektu Euroacutepsky sociaacutelny fond - Euroacutepska Uacutenia (50) Ministerstvo zdravotniacutectva SR ndash štaacutetny rozpočet (50) adresa MŠ SR Stromovaacute 1 813 30 Bratislava

Inovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskume (Innovative education programe of young creative experts in cancer research)

Manažeacuter projektu BARTOŠOVAacute Zdena RNDr CScDoba riešenia projektu 102005 - 92008Evidenčneacute čiacuteslo projektu Koacuted projektu 13120200038 reg č JPD3 20044-011Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 761 000- SkVyacuteška finančneacuteho priacutespevkuz Euroacutepskej Uacutenie 761 000- Sk


Z prostriedkov projektu sa realizovala 12-mesačnaacute finančnaacute podpora (štipendium) šiestim a 4-mesačnaacute (september-december) podpora trom ukončenyacutem doktorandom ktoryacutem sa ukončilo doktorandskeacute štuacutedium uplynutiacutem času určeneacuteho na štuacutedium Cieľom tejto podpory bolo poskytnuacuteť čas potrebnyacute na dokončenie vyacutesledkov s konečnou obhajobou dizertačnyacutech praacutec Vďaka podpore z projektu traja frekventanti uacutespešne obhaacutejili dizertačnuacute praacutecu (RNDr S Čiernikovaacute Ing J Boďo RNDr M Šramkovaacute-Lazarovaacute) Ostatniacute pokračujuacute v jej dokončovaniacute Boli publikovaneacute tri odborneacute člaacutenky v karentovanyacutech časopisoch s uvedeniacutem podpory z daneacuteho projektu Uskutočnilo sa 40 metodickyacutech cvičeniacute formou kurzov na šiestich oddeleniach UacuteEO SAV Uskutočnila sa prednaacuteška v raacutemci aktivity bdquoPodnikateľskaacute sfeacuteraldquo V raacutemci projektu bolo publikovanyacutech 6 vedecko-popularizačnyacutech priacutespevkov na internete (viď sekcia VII vedecko-organizačneacute a popularizačneacute aktivity) Na medzinaacuterodnej konferencii ktoruacute uacutestav poriadal sa uskutočnili prednaacutešky šiestich zahraničnyacutech lektorov a sekcia venovanaacute ESF projektu pod naacutezvom bdquoEuropean Social Fund Project Discussion Session frekventantov a zahraničnyacutech lektorovldquo Frekventanti sa zuacutečastnili domaacutecich aalebo zahraničnyacutech konferenciiacute s priacutespevkom z ESF projektu Uskutočnilo sa 18 prednaacutešok v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia v anglickej verziildquo

Frekventanti 112006-31122006 Čiernikovaacute S Boďo J Dudaacutešovaacute Z Šramkovaacute-Lazarovaacute M Cholujovaacute D Kimličkovaacute-Polakovičovaacute E

Frekventanti 192006-31122006 Čiernikovaacute S Boďo J Dudaacutešovaacute Z Šramkovaacute-Lazarovaacute M Cholujovaacute D Kimličkovaacute-Polakovičovaacute E Lehoczkyacute P Zaacutevodnaacute K Železniacutekovaacute T

Prednaacuteška v raacutemci aktivity bdquoPodnikateľskaacute sfeacuteraldquo VLKOVAacute B (Geneton sro) Možnosti aplikaacutecie molekulaacuternej bioloacutegie v podnikateľskej praxi na Slovensku

88

Prednaacutešky zahraničnyacutech lektorov LAWRIE B (USA) New insights into translational regulation of growth control genes lessons derived from study of retroviruses

WOLFF L (USA) Cyclin-dependent kinase inhibitor p15INK4B in leukemia and normal hematopoiesis

MULLENDERS L (Holandsko) From initial DNA damage to cancer lessons from mouse models

LUKAS J (Daacutensko) Cellular response to DNA damage Molecular mechanisms and spatio-temporal organization in living mammalian cells

NYSTROM M (Fiacutensko) Functional significance and clinical phenotype of non-truncating inherited mismatch repair gene variants

OacuteDRISCOLL M (Veľkaacute Britaacutenia) DNA double strand break repair and cancer predisposition lessons from human syndromes

Vedecko-popularizačneacute člaacutenky 12 (viď sekcia VII zaacuteverečnej spraacutevy)

Prednaacutešky v raacutemci kurzu Molekulovaacute onkoloacutegia (anglickaacute verzia ) 20 (viď priacuteloha 3)Probleacutemy s financovaniacutem ESF projektu

Probleacutemy s financovaniacutem ESF projektu vyplyacutevajuacute z toho že Ministerstvo školstva SR neuvoľňuje prostriedky podľa plaacutenovaneacuteho rozpočtu a harmonogramu Prostriedky prichaacutedzajuacute spravidla koncom roka a v nedostatočnej vyacuteške Rozdelenie podľa ekonomickyacutech klasifikaacutetorov neumožňuje prostriedky použiť podľa toho na čo suacute praacuteve potrebneacute Maacuteme kombinovanyacute spocircsob financovania tj zaacutelohoveacute a priebežneacute platby Každyacute mesiac sme posielali žiadosti o zuacutečtovanie zaacutelohovyacutech platieb a štvrťročne monitorovacie spraacutevy Poslali sme aj žiadosť o refundaacutecie a jednu žiadosť o zmeny v rozpočte Všetko bez odozvy z MŠ SR Podpora frekventantov bola v priebehu roka hradenaacute z prostriedkov uacutestavu ktoreacute bolo možneacute refundovať až koncom roka Lektorom obslužneacutemu personaacutelu a manažmentu projektu nebolo možneacute vyplatiť odmeny za celoročnuacute praacutecu Nebolo z čoho zakuacutepiť plaacutenovaneacute počiacutetače Spocircsob riadenia a financovania ESF projektov je veľmi ťažkopaacutedny nedocircstojnyacute nemoraacutelny stresujuacuteci a paralyzuje realizaacuteciu projektov

89


Projekty podporovaneacute Ligou proti rakovine adresa Liga proti rakovine Slovenskej republiky Špitaacutelska 21 812 32 Bratislava

1) Projekt VEGA 2502826 Izolaacutecia ľudskyacutech mezenchyacutemovyacutech kmeňovyacutech buniek a ich použitie v regeneračnej a geacutenovej liečbe (Isolation of human mesenchymal stem cells and their use in regenerative and gene therapy) bol podporenyacute Ligou proti rakovine vo vyacuteške 500 000- Sk

2) Projekt ktoryacute nebol financovanyacute VEGA Hypermetylaacutecia promotoru MLH1 geacutenu vo vzťahu k defektu mismatch opravy v naacutedoroch kolorekta (Hypermethylation of hMLH1 promoter in relation to mismatch repair defect in colorectal cancer) bol podporenyacute Ligou proti rakovine vo vyacuteške 100 000- Sk

Veduacuteci projektu FRIDRICHOVAacute Ivana RNDr CScDoba riešenia projektu 012006 - 122006Evidenčneacute čiacuteslo projektu -Počet spoluriešiteľskyacutech inštituacuteciiacute 2 (Naacuterodnyacute onkologickyacute uacutestav Bratislava

Centrum lekaacuterskej genetiky FN Bratislava)


Cieľom projektu bolo zistiť či inhibiacutecia expresie hypermetylaacuteciou promoacutetora MLH1 geacutenu zohraacuteva uacutelohu v tumorigeneacuteze naacutedorov kolorekta u pacientov s Lynch syndroacutemom (LS) ako bolo pozorovaneacute s vysokou frekvenciou u sporadickyacutech priacutepadov Celkovo sme vyšetrili MLH1 metylačnyacute profil naacutedoroveacuteho tkaniva 22 LS pacientov s MSI-H (vysokou hladinou mikrosatelitovej instability) a identifikovanou zaacuterodočnou mutaacuteciou jeden sporadickyacute tumor s MSI-H fenotypom a 10 vzoriek perifeacuternej krvi od zdravyacutech kontrol Metylaacuteciu sme analyzovali metoacutedami MSP (metylačne špecifickou PCR) v dvoch regioacutenoch MLH1 promoacutetora a genomickyacutem sekvenovaniacutem bisulfitom soacutednym modifikovanej DNA v štyroch prekryacutevajuacutecich sa fragmentoch (67 CpG dinukleotidov) Hypermetylaacutecia distaacutelneho regioacutenu bola zaznamenanaacute u 18 LS pacientov proximaacutelna oblasť bola metylovanaacute v štyroch priacutepadoch vaumlčšinou v zdravom aj naacutedorovom tkanive a bez ohľadu na priacutetomnosť zaacuterodočnej mutaacutecie v geacutenoch MLH1 a MSH2 alebo na chyacutebajuacutecu expresiu MLH1 proteiacutenu Detailnejšia analyacuteza 67 CpG dinukleotidov potvrdila kompletnuacute metylaacuteciu len v distaacutelnom regioacutene u viac ako polovice vyšetrovanyacutech naacutedorovyacutech vzoriek Vyacutesledky ukaacutezali že identifikovanyacute MLH1 metylačnyacute profil u hereditaacuternych karcinoacutemov nie je zodpovednyacute za expresiu MLH1 geacutenu ale je sprievodnyacutem fenomeacutenom v tumorigeneacuteze kolorekta lebo u zdravyacutech kontrol nebol detekovanyacute Naproti tomu v zhode s literaacuternymi uacutedajmi MLH1 promotor jedneacuteho MSI+ sporadickeacuteho tumoru bol kompletne metylovanyacute čo poukazuje na uplatnenie epigenetickej inaktivaacutecie MLH1 geacutenu s naacuteslednyacutem vyradeniacutem mismatch opravy DNA pri vzniku sporadickyacutech naacutedorov kolorekta Rozdiely v metylačnyacutech profiloch hereditaacuternych a sporadickyacutech naacutedorov pomocircžu zefektiacutevniť molekulaacuternu diagnostiku LS

Vedľajšiacutem produktom našej štuacutedie bolo zistenie že pri testovaniacute priacutetomnosti MSI vykazovali viaceriacute LS pacienti v naacutedorovom tkanive inzerčneacute a delečneacute mutaacutecie v mikrosatelitoch lokalizovanyacutech v exoacutenoch MRE11 a RAD50 geacutenov To znamenaacute že okrem mismatch opravy je vyradenaacute aj rekombinačnaacute oprava DNA čo mocircže ovplyvniť strateacutegiu terapie

90

Publikaacutecie FRIDRICHOVAacute I New aspects in molecular diagnosis of Lynch syndrome (HNPCC) In Cancer Biomarkers Vol 2 no 1-2 (2006) p 37-49 (0-IF2006)

ALEMAYEHU A - TOMKOVA K - ZAVODNA K - VENTUSOVA K - KRIVULCIK T - BUJALKOVA M - BARTOSOVA Z - FRIDRICHOVA I The role of clinical criteria genetic and epigenetic alterations in Lynch-syndrome diagnosis Zaslaneacute do Cancer Detection and Prevention

ALEMAYEHU A - FRIDRICHOVA I Impairment of DNA recombinational in tumours of Lynch-syndrome patients Zaslaneacute do European Journal of Human Genetics

Prednaacutešky a vyacutevesky ALEMAYEHU A- ZAVODNA K - BARTOSOVA Z - FRIDRICHOVA I Global and MLH1 methylation in colorectal cancer patients with microsatellite instability (poster) Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 ISBN 80-969541-8-0 No 1 p 21 (R)

3) Epidemioloacutegia zhubnyacutech naacutedorov kolorekta na Slovensku (The epidemiology of colorectal cancers in Slovakia)

Veduacuteci projektu PLEŠKO Ivan Doc MUDr DrScDoba riešenia projektu 012006 - 122006Evidenčneacute čiacuteslo projektu -Počet spoluriešiteľskyacutech inštituacuteciiacuteVyacuteška finančneacuteho priacutespevku -


Uacuteloha bola riešenaacute na požiadavku Ligy proti rakovine v raacutemci iniciovania a pomoci projektu bdquoSkriacutening zhubnyacutech naacutedorov kolorekta na Slovenskuldquo Projekt ktoryacute čiastočne financovala Liga proti rakovine vznikol z iniciatiacutevy prim MUDr Rudolfa Hrčku CSc V roku 2003 nemohol byť plnenyacute v plaacutenovanom rozsahu bez sľuacutebenej finančnej pomoci Ministerstva zdravotniacutectva SR Spolupracovali sme na projekte opakovanyacutemi prednaacuteškami hlavne na seminaacuteroch doma a raz i v zahraničiacute Člaacutenok pre Neoplasmu bol ukončenyacute v novembri 2006 je pripravenyacute k odoslaniu do tlače čakaacuteme iba na suacutehlas zahraničnyacutech spolupracovniacutekov Projekt podporila Liga proti rakovine v roku 2004 sumou 100 000- Sk (časť sumy bola použitaacute na priacutepravu slovenskeacuteho priacutespevku do monografie bdquoAtlas of Cancer Mortality in Europeldquo (Atlas mortality na zhubneacute naacutedory v Euroacutepe) ktoryacute je v suacutečasnosti v tlači ndash vydaacuteva ho Medzinaacuterodnaacute agentuacutera pre vyacuteskum rakoviny v Lyone (IARC ndash WHO)

91

B Zahraničneacute projekty


Dva projekty boli ukončeneacute v r2004


1) Aplikačne orientovanyacute vyacuteskum regulačnyacutech draacuteh zapojenyacutech do homeostaacutezy tukov a ateroskleroacutezy (Application-oriented studies on regulatory networks involved in lipid homeostasis and atherosclerosis Acronym SOUTH)

Finančneacute zabezpečenie Komisia EUacute Brusel BelgickoUacuteEO SAV je spoluriešiteľom projektu

Call FP6-2005-LIFESCIHEALTH-6 Instrument STREPKoordinaacutetor projektu FrancuacutezskoPočet ďalšiacutech spoluriešiteľskyacutech inštituacuteciiacute 8 (Francuacutezsko-2 Taliansko-3 Greacutecko-1 Švajčiarsko-1

Slovensko-1)Veduacuteci projektu v SR BARAacuteTH Peter Mgr PhDDoba riešenia projektu 102006 ndash 092009Evidenčneacute čiacuteslo projektu LSHM-CT-2006-037498Vyacuteška finančneacuteho priacutespevkuZ EUacute 0-Vyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 0-


Cieľom časti projektu ktoruacute rieši slovenskaacute strana je produkcia cieľovyacutech proteiacutenov ldquohepatocyte nuclear factor4rdquo (HNF4) a histoacutendeacetylaacutezy 7 (HDAC7) za uacutečelom ich štruktuacuternej analyacutezy Pretože je projekt iba vo svojej uacutevodnej faacuteze prebieha najmauml klonovanie expresnyacutech konštruktov pre bakteriaacutelnu a kvasinkovuacute expresiu a testovanie hladiny expresie vo vybranyacutech klonoch Zatiaľ sa naacutem podarilo pripraviť expresneacute vektory pre rocirczne konštrukty ligand viažuacutecich HNF4 domeacuten ktoreacute suacute vhodneacute pre purifikaacuteciu za natiacutevnych aj denaturačnyacutech podmienok Prebieha tiež testovanie vhodnyacutech podmienok pre ich expresiu v kvasinke Pichia pastoris

92

2) EUROCHIP-II - Euroacutepsky projekt indikaacutetorov zdravia zameranyacute na naacutedory ndash faacuteza II (European Cancer Health Indicator Project Phase II)

Finančneacute zabezpečenie Euroacutepska komisia (European Commission Health and Consumer Project Directorate General L 2920 Luxembourg) Schvaacutelenaacute suma pre SR 17 800- Eur (cca 660 000- Sk)

Veduacuteci projektu SR PLEŠKO Ivan Doc MUDr DrScKoordinaacutetor projektu Dr Andrea Micheli TalianskoDoba riešenia projektu 012006 ndash 122008 (predbežne)Evidenčneacute čiacuteslo projektu Public Health OJ 2003C6204Počet spoluriešiteľskyacutechInštituacuteciiacute Inštituacutecie zo 17 euroacutepskych štaacutetovVyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 0-Zo zahraničia 0-


V roku 2006 boli zaslaneacute do koordinačneacuteho strediska v Milaacutene demografickeacute uacutedaje uacutemrtnostneacute tabuľky hodnoty vyacuteskytu jednotlivyacutech naacutedorov uacutedaje o prežiacutevaniacute onkologickyacutech pacientov systeacutem a štruktuacutera služieb poskytovanyacutech onkologickyacutem pacientom uacutedaje o skriacuteningu tyacutechto ochoreniacute Podrobne boli pomocou podrobnyacutech dotazniacutekov spracovaneacute a odoslaneacute do Milaacutena uacutedaje o 100 pacientoch liečenyacutech na zhubneacute naacutedory hrubeacuteho čreva u mužov a žien na Slovensku v ďalšom roku sa buduacute ziacuteskavať uacutedaje pre dotazniacuteky zameraneacute na karcinoacutem prsniacutekov u žien a konečniacuteka u oboch pohlaviacute Ďalšie zameranie projektu je v štaacutediu spracovaacutevania diskusiiacute a schvaľovania

PublikaacutecieBRAY F - RICHIARDI L - EKBOM A - FORMAN D - PUKKALA E - CUNINKOVA M - MOLLER H Do testicular seminoma and nonseminoma share the same etiology Evidence from and age-period-cohort analysis of incidence trends in eight European countries In Cancer Epidemiology Biomarkers amp Prevention Vol 15 no 4 (2006) p652-658(4460-IF2005)

BRAY F - RICHIARDI L - EKBOM A - PUKKALA E - CUNINKOVA M - MOLLER H Trends in testicular cancer incidence and mortality in 22 European countries Continuing increases in incidence and declines in mortality In International Journal of Cancer Vol 118 no 12 (2006) p 3099-3111

PrednaacuteškyPLEŠKO I EUROCHIP project in Slovakia ndash problems and results Workshop EUROCHIP pilot studies Amalfi Italia 14-1662006

PLEŠKO I First results of Pilot study ndash EUROCHIP project in Slovakia Workshop EUROCHIP projectldquo ndash Milano Italia 14-1592006

93

3 Multilateraacutelne projekty v raacutemci vedeckyacutech programov COST INTAS EUREKA ESPIRIT PHARE NATO UNESCO CERN IAEA ESF a ineacute

Uacutestav sa podieľa na riešeniacute projektov

1) Vyacuteskyt rakoviny na piatich kontinentoch (Cancer Incidence in five continents)

Veduacuteci projektu SR PLEŠKO Ivan Doc MUDr DrScDoba riešenia projektu od roku 2006Evidenčneacute čiacuteslo projektu -Koordinaacutetor projektu International Agency for Research on Cancer

(IARC-WHO)Vyacuteška finančneacuteho priacutespevkuZo štaacutetneho rozpočtu SR 0-Zo zahraničia 0-


Projekt koordinuje zbiera a analyzuje uacutedaje z celeacuteho sveta vraacutetane Slovenska o vyacuteskyte rakoviny v 5-ročnyacutech intervaloch Spracovaacutevali sa uacutedaje za roky 1998-2002 Uacutedaje za uvedeneacute roky spolu s komentaacutermi boli zaslaneacute do Medzinaacuterodnej agentuacutery pre vyacuteskum rakoviny (IARC) v Lyone v juacuteni 2006 publikaacutecia je v tlači a vyjde asi v roku 2008 alebo 2009

2) Automatickyacute informačnyacute systeacutem o ochoreniach na zhubneacute naacutedory u detiacute (ACCIS) (ACCIS Programme- Automated Chilldhood Cancer Information System)

Veduacuteci projektu SR PLEŠKO Ivan Doc MUDr DrScKoordinaacutetor projektu IARCDoba riešenia projektu trvale od roku 2000Evidenčneacute čiacuteslo projektu -Počet riešiteľskyacutech inštituacuteciiacute Inštituacutecie z viac ako 40 štaacutetov svetaVyacuteška finančneacuteho priacutespevkuzo štaacutetneho rozpočtu SR 0-zo zahraničia 20 000- Sk


Zistilo sa že v rokoch 1988-1997 bola incidencia tyroidnyacutech naacutedorov u detiacute vo veku 0-14 rokov v rozpaumltiacute 05-12 na milioacuten detiacute a incidencia tyroidnyacutech naacutedorov u adolescentov vo veku 15-19 rokov variacuterovala od 44-11 na milioacuten detiacute Najčastejšie sa vyskytovali papilaacuterne naacutedory štiacutetnej žľazy Nepotvrdila sa asociaacutecia medzi naacutedormi štiacutetnej žľazy a naacuterodnyacutem dietetickyacutem stavom iodizaacutecie v 16 krajinaacutech Incidencia naacutedorov u detiacute a adolescentov v Euroacutepe sa v rokoch 1978-1997 zvyšovala o 3 ročne Prežiacutevanie detiacute a adolescentov bolo vysokeacute vo všetkyacutech regioacutenoch Euroacutepy Viac ako 90 pacientov prežiacutevalo 20 rokov po diagnoacuteze

94

Publikaacutecie STELIAROVA-FOUCHER E - STILLER CA - PUKKALA E - LACOUR B - PLESKO I - PARKIN DM Thyroid cancer incidence and survival among European children and adolescents (1978-1997) report from the Automated Childhood Cancer Information System project In European Journal of Cancer Vol 42 no 13 (2006) p 2150-2169



5 Ineacute projekty financovaneacute zo zahraničnyacutech zdrojov

Monitorovanie imunologickyacutech parametrov pacientov s mnohopočetnyacutem myeloacutemom počas konzumaacutecie Biobranu (Monitoring of immunological parameters of multiple myeloma patients during course of Biobran consumption)

Veduacuteci projektu SEDLAacuteK Jaacuten RNDr CScDoba riešenia projektu 012005-122006Počet spoluriešiteľskyacutech inštituacuteciiacute 1 (Fakultnaacute nemocnica Bratislava pracovisko Petržalka)Vyacuteška finančneacuteho priacutespevkuDaiwa Pharmaceutical Japan 1 295 358- Sk


V spolupraacuteci s Hematologickou klinickou FN Bratislava bola do štuacutedie zaradenaacute prvaacute skupina 25 pacientov Podľa harmonogramu sa začali vykonaacutevať merania fenotypu NK aktivity a expresie cytokiacutenov v plazme počas šiestich po sebe nasledujuacutecich 4-tyacuteždňovyacutech intervaloch pre každeacuteho pacienta Do databaacutezy vyacutesledkov bolo vloženyacutech 5950 nameranyacutech uacutedajov ktoreacute suacute podkladom pre mnohorozmernuacute štatistickuacute analyacutezu

Prednaacutešky a vyacuteveskyCHOLUJOVAacute D - JAKUBIacuteKOVAacute J - KUBES M - ARENDACKA B - SEDLAacuteK J Comparative study with four fluorescent probes for evaluation of natural killer cytotoxicity assays Cancer 2006 From molecular biology processes to tumor-tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 No 13 p 27

JAKUBIacuteKOVAacute J - CHOLUJOVAacute D - SEDLAacuteK J Role of BioBran in human monocyte-derived dendritic cell maturation MASIR 2006 14-1862006 Santorini Greece Technology Biology amp Clinical Application P79 p 166

JAKUBIacuteKOVAacute J - CHOLUJOVAacute D - SEDLAacuteK J Modulation of human monocyte-derived dendritic cell maturation by BioBran Cancer 2006 From molecular biology processes to tumor-

95

tailored therapy Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 No14 p 28 (R)

CHOLUJOVAacute D - JAKUBIacuteKOVAacute J - SEDLAacuteK J Modulaacutecia maturaacutecie ľudskyacutech dendritovyacutech buniek uacutečinkom imunostimulačneacuteho potravinoveacuteho doplnku BioBran In Nutrition and Food for 3rd millenium nutrition and cancer 23-24 nov 2006 Nitra Proceedings Book of 6th international scientific conference No 13

6 Bilateraacutelne projekty

Štuacutedium vplyvu transplantaacutecie kostnej drene na dĺžku života a na fyziologickyacute stav myšiacute (Influence of bone marrow transplantation on the life span of ageing mice)

Veduacuteci projektu ALTANEROVAacute Veronika Ing CScDoba riešenia projektu 012004-122008Počet spoluriešiteľskyacutech inštituacuteciiacute 1 (The Laboratory of Stem Cell Research University of

Aalborg Aarhus Denmark )Vyacuteška finančneacuteho priacutespevkuzo zahraničia 617 849- Sk (z Daacutenskeho pracoviska)

Dosiahnuteacute vyacutesledky Starnutie je proces spojenyacute s ireveverzibilnyacutemi zmenami v tkanivaacutech a v orgaacutenoch v

ľudskom tele ktoreacute suacute priacutečinou zvyacutešeneacuteho počtu chorocircb Regeneratiacutevna mediciacutena je klinickou discipliacutenou ktorej cieľom je obnoviť funkcie poškodeneacuteho tkaniva a omladiť starnutiacutem poškodenyacute organizmus Kmeňoveacute bunky svojou schopnosťou diferencovať sa na organovo špecifickeacute bunky sa ukazujuacute byť vhodnyacutem zdrojom regeneračneacuteho procesu Cieľom naacutešho projektu je sledovať vplyv kmeňovyacutech buniek na proces starnutia u myšiacute Projekt je dlhodobyacute začal v roku 2004 a pravdepodobneacute ukončenie druhej faacutezy pokusu je rok 2008

96

Priacuteloha č3

1 Vedeckeacute monografie vydaneacute doma

2 Vedeckeacute monografie vydaneacute v zahraničiacute

3 Knižneacute odborneacute publikaacutecie vydaneacute doma

4 Knižneacute odborneacute publikaacutecie vydaneacute v zahraničiacute

5 Kapitoly v publikaacuteciaacutech ad 1 v monografiaacutech vydanyacutech doma

1 POTURNAJOVAacute M - ALTANEROVAacute V Molekulaacuterno-biologickeacute aspekty vzniku mnohopočetnej endokrinnej neoplaacutezie typ-2 Rudolf Moravec a kolektiacutev K problematike chorocircb štiacutetnej žľazy Vydavateľstvo Marko Ľubomiacuter 2006 ISBN 80-969542-2-9 str 83-94

6 Kapitoly v publikaacuteciaacutech ad 2 v monografiaacutech vydanyacutech v zahraničiacute

1 ONDRUŠOVAacute M ndash ADAMCIKOVA J Klinickaacute epidemioloacutegia karcinomu prsniacuteka InAbrahaacutemovaacute J(ed) Vybraneacute otaacutezky onkoloacutegie X Praha Galeacuten s78-80

7 Kapitoly v publikaacuteciaacutech ad 3 v knižnyacutech odbornyacutech publikaacuteciaacutech v zahraničiacute

1 CHOVANEC M ndash KYSELA B ndash DUDAacuteŠOVAacute Z ndash DOHERTY A J DNA non-homologous end-joining in unicellular organisms In New Developments in Mutation Research Valon CL (editor) Nova Science Publishers Inc Hauppauge NY 2006 ISBN 1-59454-664-9 p1-40

2 KOŠIacuteKOVAacute B - LAacuteBAJ J - SLAMEŇOVAacute D - SLAacuteVIKOVAacute E - GREGOROVAacute A Novel environmentally friendly use of lignin biomass component In Biomass and Bioenergy New Research Brenes MD (editor) Nova Science Publishers Inc Hauppauge NY 2006 ISBN 1-59454-865-X p169-200

8 Kapitoly v publikaacuteciaacutech ad 4

97



2 BARANČIacuteK M - BOHACOVA V - SEDLAacuteK J - SULOVA Z - BREIER A LY294002 a specific inhibitor of PI3KAkt kinase pathway antagonizes P-glycoprotein-mediated multidrug resistance In European journal of pharmaceutical sciences Vol 29 no 5 (2006) p 426-434 (2347-IF2005)

3 BOĎO J - HUNAacuteKOVAacute Ľ - KVASNIČKA P - JAKUBIacuteKOVAacute J - DURAJ J - KASPARKOVA J - SEDLAacuteK J Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations In British journal of cancer Vol 96 no 10 (2006) p 1348-1353 (4115-IF2005)

4 BOĎO J - JAKUBIacuteKOVAacute J - CHALUPA I - BARTOŠOVAacute Z - HORAacuteKOVAacute K - FLOCH L - SEDLAacuteK J Apoptotic effect of ethyl-4-isothiocyanatobutanoate is associated with DNA damage proteasomal activity and induction of p53 and p21cip1waf1 In Apoptosis Vol 11 no 8 (2006) p 1299-1310 (4497-IF2005)

5 BRAY F - RICHIARDI L - EKBOM A - FORMAN D - PUKKALA E - CUNINKOVA M - MOLLER H Do testicular seminoma and nonseminoma share the same etiology Evidence from and age-period-cohort analysis of incidence trends in eight European countries In Cancer Epidemiology Biomarkers amp Prevention Vol 15 no 4 (2006) p652-658 (4460-IF2005)

6 BRAY F - RICHIARDI L - EKBOM A - PUKKALA E - CUNINKOVA M - MOLLER H Trends in testicular cancer incidence and mortality in 22 European countries Continuing increases in incidence and declines in mortality In International Journal of Cancer Vol 118 no 12 (2006) p 3099-3111 (4700-IF2005)

7 ČIERNIKOVAacute S - TOMKA M - KOVAacuteČ M - ŠTEVURKOVAacute V - ZAJAC V Ashkenazi founder BRCA1BRCA2 mutations in Slovak hereditary breast andor ovarian cancer families In Neoplasma Vol 53 no 2 (2006) p 97-102 (0731-IF2005)

8 ČIPAacuteK Ľ - GRAUSOVA L - MIADOKOVAacute E - NOVOTNYacute L - RAUKO P Dual activity of triterpenoids apoptotic vs antidifferentiation effects In Archives of toxicology Vol 80 no 7 (2006) p 429-435 (1663-IF2005)

9 COJOCEL C - NOVOTNY L - VACHALKOVA A Mutagenic and carcinogenic potential of menadione In Neoplasma Vol 53 no 4 (2006) p 316-23 (0731-IF2005)

10 DURAJ J - BOĎO J - ŠULIacuteKOVAacute M - RAUKO P - SEDLAacuteK J Diverse resveratrol sensitization to apoptosis induced by anticancer drugs in sensitive and resistant leukemia cells In Neoplasma Vol 53 no 5 (2006) p 384-392 (0731-IF2005)

11 FRECER V QSAR analysis of antimicrobial and haemolytic effects of cyclic cationic antimicrobial peptides derived from Protegrin-1 In Bioorganic and Medical Chemistry Vol 14 no 17 (2006) p 6065-6074 (2286-IF2005)

98

12 HORVAacuteTHOVAacute E - LAZAROVAacute M - LAacuteBAJ J - SLAMEŇOVAacute D Study of cytotoxic genotoxic and DNA-protective effects of selected plant essential oils on human cells cultured in vitro In Neuro endocrinology letters Vol 27 Supplement 2 (2006) p 101-104 (1005-IF2005)

13 IHNATKO R - KUBEŠ M - TAKACOVA M - SEDLAacuteKOVAacute O - SEDLAacuteK J - PASTOREK J - KOPAacuteČEK J - PASTOREKOVAacute S Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia In International journal of oncology Vol 29 no 4 (2006) p 1025-1033 (2681-IF2005)

14 JAKUBIacuteKOVAacute J - BAO Y - BOĎO J - SEDLAacuteK J Isothiocyanate iberin modulates phase II enzymes posttranslational modification of histones and inhibits growth of Caco-2 cells by inducing apoptosis In Neoplasma Vol 53 no 6 (2006) p 463-470 (0731-IF2005)

15 JAKUBIacuteKOVAacute J - SEDLAacuteK J - BOĎO J - BAO Y Effect of isothiocyanates on nuclear accumulation of NF-kB Nrf2 and thioredoxin in Caco-2 cells In Journal of agricultural and food chemistry Vol 54 no 5 (2006) p 1656-1662 (2507-IF2005)

16 JAKUBIacuteKOVAacute J - SEDLAacuteK J Garlic-derived organosulfides induce cytotoxicity apoptosis cell cycle arrest and oxidative stress in human colon carcinoma cell lines In Neoplasma Vol 53 no 3 (2006) p 191-199 (0731-IF2005)

17 JANJIC B - ANDRADE P - WANG XF - FOURCADE J - ALMUNIA C - KUDELA P - BRUFSKY A - JACOBS S - FRIEDLAND D - STOLLER R - GILLET D - HERBERMAN RB - KIRKWOOD JM - MAILLERE B - ZAROUR HM Spontaneous CD4+ T cell responses against TRAG-3 in patients with melanoma and breast cancers In Journal of Immunology Vol 177 no 4 (2006) p 2717-27 (6387-IF2005)

18 JANTOVAacute S - LETAŠIOVAacute S - BREZOVAacute V - ČIPAacuteK Ľ - LAacuteBAJ J Photochemical and phototoxic activity of berberine on murine fibroblast NIH-3T3 and ehrlich ascites carcinoma cells In Journal of photochemistry and photobiology B Biology Vol 85 no 3 (2006) p 163-176 (1597-IF2005)

19 JIANG G - ŠKORVAGA M - CROTEAU D - VAN HOUTEN B - STATES J Robust Incision of Benzo[a]pyrene-78-dihyrodiol-910-epoxide-DNA Adducts by a Recombinant Thermoresistant Interspecies Combination UvrABC Endonuclease System In Biochemistry Vol 45 no 25 (2006) p 7834-7843 (3848-IF2005)

20 KAZIMIROVA M - DOVINOVAacute I - ROLNIKOVA T - TOTHOVA L - HUNAacuteKOVAacute Ľ Anti-proliferative activity and apoptotic effect of tick salivary gland In Neuro endocrinology letters Vol 27 no (2006) p 48-52 (1005-IF2005)

21 KIRSCHNEROVA G - TOacuteTHOVAacute A - BABUŠIacuteKOVAacute O Amplification of AML 1 gene in association with karyotype age and diagnosis in acute leukemia patients In Neoplasma Vol 53 no 2 (2006) p 150-154 (0731-IF2005)

99

22 KOŠIacuteKOVAacute B - LAacuteBAJ J - SLAMEŇOVAacute D - SLAacuteVIKOVAacute E Novel environmentally friendly use of lignin biomass component In Biomass and bioenergy Supplement no 1-59454-865-X (2006) p 169-200 (1311-IF2005)

23 KOŠIacuteKOVAacute B - SLAacuteVIKOVAacute E - LAacuteBAJ J - SLAMEŇOVAacute D Biological conversion of lignin waste products from chemical wood treatment into anticarcinogenic preparations In Wood research - Slovakia Vol 51 no 2 (2006) p 41-48 (0125-IF2005)

24 KOVAacuteČ M - TOMKA M - ČIERNIKOVAacute S - ŠTEVURKOVAacute V - VALACHOVAacute A - ZAJAC V Multiple gynecologic tumors as rare asociated phenotypes of FAPGardner syndrome in a family with the novel germline mutation in the APC gene In Clinical Genetics Vol 69 (2006) p 183-186 (3276-IF2005)

25 KOZICS K - KRAJČOVIČOVAacute Z - VACHAacuteLKOVAacute A Electrochemical behavior and determination of tumor inhibiting or promoting activities of flavonoids In Neoplasma Vol 53 no 4 (2006) p 337-342 (0731-IF2005)

26 KUBOVČAacuteKOVAacute L - MIČUTKOVAacute L - BARTOŠOVAacute Z - SABBAN E - KRIŽANOVAacute O - KVETŇANSKYacute R Identification of phenylethanolamine N-methyltransferase gene expression in stellate ganglia and its modulation by stress In Journal of neurochemistry Vol 97 no 5 (2006) p 1419-1430 (4604-IF2005)

27 LAZAROVAacute M - LAacuteBAJ J - ECKL P - KOGAN G - SLAMEŇOVAacute D Effects of dietary intake of a fungal beta-D-glucan derivative on the level of DNA damage induced in primary rat hepatocytes by various carcinogens In Nutrition and cancer - an international journal Vol 56 no 1 (2006) p 113-122 (2426-IF2005)

28 LAZAROVAacute M - LAacuteBAJ J - ECKL P - SLAMEŇOVAacute D Comparative evaluation of DNA damage by genotoxicants in primary rat cells applying the comet assay In Toxicology letters Vol 164 no 1 (2006) p 54-62 (243-IF2005)

29 LAZAROVAacute M - LAacuteBAJ J - KOGAN G - SLAMEŇOVAacute D Carboxymethyl chitin-glucan enriched diet exhibits protective effects against oxidative DNA damage induced in freshly isolated rat cells In Neoplasma Vol 53 no 5 (2006) p 434-439 (0731-IF2005)

30 LETASIOVA S - JANTOVAacute S - ČIPAacuteK Ľ - MUCKOVA M Berberine - antiproliferative activity in vitro and induction of apoptosisnecrosis of the U937 and B16 cells In Cancer letters Vol 239 no 2 (2006) p 254-262 (3049-IF2005)

31 LETAVAYOVAacute L - MARKOVAacute E - HERMANSKAacute K - VLČKOVAacute V - VLASAacuteKOVAacute D - CHOVANEC M - BROZMANOVAacute J Relative contribution of homologous recombination and non-homologous end-joining to DNA double-strand break repair after oxidative stress in Saccharomyces cerevisiae In DNA repair Vol 5 no 5 (2006) p 602-610 (5016-IF2005)

32 LETAVAYOVAacute L - VLČKOVAacute V - BROZMANOVAacute J Selenium from cancer prevention to DNA damage In Toxicology Vol 227 no 1-2 (2006) p 1-14 (2584-IF2005)

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33 MIADOKOVAacute E - NAĎOVAacute S - TREBATICKAacute M - GROLMUS J - KOPAacuteSKOVAacute M - RAUKO P - MUČAJI P - GRANČAI D Research on biomodulatory effect of natural compounds In Neuroendocrinology Letters Vol 27 (2006) p 53-56 (1005-IF2005)

34 MIADOKOVAacute E - SVIDOVAacute S - VLČKOVAacute V - DUacuteHOVAacute V - NAĎOVAacute S - RAUKO P - KOGAN G Diverse biomodulatory effects of glucomannan from Candida utilis In Toxicology in vitro Vol 20 (2006) p 649-657 (1754-IF2005)

35 MIERTUS J - BOROZDIN W - LIEBERS M - FRECER V - AMOROSO A - MIERTUŠ S - KOHLHASE J A SALL4 zinc finger missense mutation predicted to result in increased DNA binding affinity is associated with a combination of Duane anomaly cranial midline defects growth retardation and radical defects In Human Genetics Vol 119 no 1-2 (2006) p 154-161 (4331-IF2005)

36 MRAVEC B - GIDRON Y - KUKANOVA B - BIZIK J - KISS A - HULIN I Neural-endocrine-immune complex in the central modulation of tumorigenesis facts assumptions and hypotheses In Journal of Neuroimmunology Vol 18 no 1-2 (2006) p 104-116 (2824-IF2005)

37 NOVOTNY L - PHILLIPS O - RAUKO P - MIADOKOVA E Antileukemic activity of sulfonamide conjugates of arabinosilcytosine In Experimental oncology Vol 28 no 4 (2006) (0752-IF2005)

38 NOVOTNYacute L - RAUKO P - LIŠKA J - ELFORD L - SZEKERES T Potentiation of the activity of cisplatin and cyclophosphamide by trimidox a novel ribonucleotide reductase inhibitor in leukemia-bearing mice In Cancer letters Vol 233 (2006) p 178-184 (3049-IF2005)

39 OVESNAacute Z - KOZICS K - BADER Y - SAIKO P - HANDLER N - ERKER T - SZEKERES T Antioxidant activity of resveratrol piceatannol and 33rsquo44rsquo55rsquo-hexahydroxy-trans-stilbene in three leukemia cell lines In Oncology reports Vol 16 no 3 (2006) p 617-624 (1572-IF2005)

40 OVESNAacute Z - KOZICS K - SLAMEŇOVAacute D Protective effects of ursolic acid and oleanolic acid in leukemic cells In Mutation research-Fundamental and molecular mechanisms of mutagenesis Vol 600 no 1-2 (2006) p 131-137 (334-IF2005)

41 PASTORAacuteKOVAacute A - HLUBINOVAacute K - ALTANER Č Treatment of human tumor cells by combine gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and bacterial cytosine deaminase suicide gene In Neoplasma Vol 53 no 6 (2006) p 478-484 (0731-IF2005)

42 PASTORAacuteKOVAacute A - HLUBINOVAacute K - JAKUBIacuteKOVAacute J - ALTANER Č Combine cancer gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and Herpes simplex thymidine kinase suicide gene In Neoplasma Vol 53 no 5 (2006) p 353-362 (0731-IF2005)

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43 POLAacuteKOVAacute K - BANDZUCHOVAacute E - BYSTRICKAacute M - PANČUCHAacuteROVAacute H - RUSS G Effect of proteasome inhibitors on expression of HLA-G isoforms In Neoplasma Vol 53 no 6 (2006) p 471-477 (0731-IF2005)

44 SIREN V - SALMENPERA P - KANKURI E - BIZIK J - SORSA T - TERVAHARTIALA T - VAHERI A Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases In Annals of Medicine Vol 28 (2006) p 1-9 (3848-IF2005)

45 SLAMENOVA D - HORVATHOVA E - BARTKOVA M - KRAJCOVICOVA Z - LABAJ J - KOSIKOVA B - MASTEROVA I Reduction of DNA-damaging effects of anti-HIV drug 3`-azido-3`-dideoxythymidine on human cells by ursolic acid and lignin biopolymer In Neoplasma Vol 53 no 6 (2006) p 485-491 (0731-IF2005)

46 SLAMEŇOVAacute D - HORVAacuteTHOVAacute E - BARTKOVAacute M Nature of DNA lesions induced in human hepatoma cells human colonic cells and human embryonic lung fibroblasts by the antiretroviral drug 3-azido-3-deoxythymidine In Mutation research-Fundamental and molecular mechanisms of mutagenesis Vol 593 no 1-2 (2006) p 97-107 (334-IF2005)

47 ŠRAMKO M - MARKUS J - KABAacuteT J - WOLFF L - BIES J Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-23 proteins In Journal of biological chemistry Vol 1 no 1 (2006) p 1-1 (5854-IF2005)


49 VLČKOVAacute V - NAĎOVAacute S - DUacuteHOVAacute V - ZAacuteVODNAacute K - MORAacuteŇOVAacute Z - RAUKO P - KOGAN G - MIADOKOVAacute E Natural microbial polysaccharide sulphoethyl glucan as antigenotoxic and cancer preventing agent In Neoplasma Vol 53 no 6 (2006) p 524-529 (0731-IF2005)

50 VONDRAacuteČEK J - ŠVIHAacuteLKOVAacute-ŠINDLEROVAacute L - PĚNČIacuteKOVAacute K - KRČMAacuteŘ P - ANDRYSIacuteK Z - CHRAMOSTOVAacute K - MARVANOVAacute S - VALOVIČOVAacute Z - KOZUBIacuteK A - GAacuteBELOVAacute A - MACHALA M 7H-Dibenzo[cg]carbazole and 59-dimethyldibenzo[cg]carbazole exert multiple toxic events contributing to tumor promotion in rat liver epithelial stem-like cells In Mutation research-Fundamental and molecular mechanisms of mutagenesis Vol 593 (2006) p 43-56 (334-IF2005)

51 WALSH T - CASADEI S - COATS K - SWISHER E - STRAY S - HIGGINS J - ROACH K - MANDELL J - LEE M - ČIERNIKOVAacute S - FORETOVA L - SOUCEK P - KING M Spectrum of mutations in BRCA1 BRCA2 CHEK2 and TP53 in families at high risk of breast cancer In JAMA - Journal of American Medical Association Vol 295 no 12 (2006) p 1379-1388 (23494-IF2005)

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52 WANG H - DELLAVECCHIA M - ŠKORVAGA M - CROTEAU D - ERIE D - VAN HOUTEN B UvrB domain 4 an autoinhibitory gate for regulation of DNA binding and ATPase activity In Journal of biological chemistry Vol 281 (2006) p 15227-15237 (5854-IF2005)

53 ZAJAC V - MEGO M - KOVAacuteČ M - ŠTEVURKOVAacute V - ČIERNIKOVAacute S - UJHAacuteZY E - GAJDOŠIacuteK A - GAJDOŠIacuteKOVAacute A Testing of bacteria isolated from HIVAIDS patients in experimental models In Neuro endocrinology letters Vol 27 no 2 (2006) p 101-104 (1005-IF2005)

54 ZAacuteVODNAacute K - BUJALKOVAacute M - KRIVULČIacuteK T - ALEMAYEHU A - ŠKORVAGA M - MARRA G - FRIDRICHOVAacute I - JIRICNY J - BARTOŠOVAacute Z Novel and recurrent germline alterations in the MLH1 and MSH2 genes identified in hereditary nonpolyposis colorectal cancer patients in Slovakia In Neoplasma Vol 53 (2006) p 269-276 (0731-IF2005)

55 ŽELEZNIacuteKOVAacute T - BABUŠIacuteKOVAacute O The impact of cell heterogeneity and immunotypic changes on monitoring minimal residual disease in acute myeloid leukemia In Neoplasma Vol 53 no 6 (2006) p 500-506 (0731-IF2005)


Praacuteca evidovanaacute v databaacuteze Thomson Scientific (wwwthomsonscientificcom)

1 FRIDRICHOVAacute I New aspects in molecular diagnosis of Lynch syndrome (HNPCC) In Cancer Biomarkers Vol 2 no 1-2 (2006) p 37-49

10 Vedeckeacute praacutece v ostatnyacutech časopisoch

1 ČIERNIKOVAacute S - TOMKA M - KOVAacuteČ M - ŠTEVURKOVAacute V - ZAJAC V Age and geographical distribution in families with BRCA4BRCA2 mutations in the Slovak Republic In Hereditary Cancer in Clinical Practice Vol 4 no 1 (2006) p 7-11

2 MEGO M - ZAJAC V Probiotikaacute v onkoloacutegii - aacuteno či nie In Klinickaacute onkologie Vol 19 no 3 (2006) s 167-170

3 ONDRUŠ D - ONDRUŠOVA M Uacutespechy v liečbe karcinoacutemu hrubeacuteho čreva a naacutedorov hlavy a krku In Kompedium mediciacuteny Lekaacuterske Listy (priloha ZdrN) No 41 (2006) s 4-8

4 ONDRUŠOVA M Epidemioloacutegia zhubnyacutech naacutedorov prsniacuteka In Lekaacuterske Listy (priacutel ZdrN) No 8 (2006) s 6-7

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5 ONDRUŠOVA M - ONDRUŠ D Naacutedory testis epidemioloacutegia etioloacutegia patoloacutegia a diagnostika In Urologickeacute listy Vol 4 no 3 (2006)

6 ONDRUŠOVA M - PLEŠKO I Epidemiologickeacute charakteristiky zhubnyacutech naacutedorov pľuacutec In Lekaacuterske Listy (priacuteloha ZdrN) No 1 (2006) s 4-5

7 ONDRUŠOVA M - PLEŠKO I Zaacutekladneacute charakteristiky vyacuteskytu zhubnyacutech naacutedorov v SR In Lekaacuterske Listy (priloha ZdrN) No 17 (2006) s 11

8 ONDRUŠOVA M Naacuterodnyacute onkologickyacute register - zaacutekladnyacute zdroj informaacuteciiacute v zdravotniacuteckej politike In Onkoloacutegia Vol 1 no 1 (2006) s 64-65

9 ONDRUŠOVA M Naacuterodnyacute onkologickyacute register SR uacutespechy minulosti veda suacutečasnosti viacutezie buduacutecnosti In Lekaacuterske Listy (priloha ZdrN) No 1 (2006) s21

10 ONDRUŠOVA M Systeacutem zberu a analyacutezy daacutet v NOR SR In Lekaacuterske Listy (priacutel ZdrN) No 17 (2006) s8-9

11 ONDRUŠOVA M Zhubneacute naacutedory kolorekta Epidemioloacutegia In Medical Practice Vol 1 no 2 (2006) s27

12 PAUKNER S - STIEDL T - KUDELA P - BIZIK J - AL LAHAM F - LUBITZ W Bacterial ghosts as a novel advanced targeting system for drug and DNA delivery In Expert Opinion on Drug Delivery Vol 3 no 1 (2006) p 11-22

13 PLESKO I Aktuaacutelne globaacutelne a lokaacutelne poznatky a probleacutemy epidemioloacutegie zhubnyacutech naacutedorov In Onkoloacutegia Vol1 no 1 (2006) s 8-13

14 UŠAacuteK J - KRUŽLIAK T - UŠAacuteKOVAacute V - BARTOŠOVAacute Z - HROMEC J - KOPECKAacute I - VEREŠ P Peutzov - Jeghersov syndroacutem (PJS) - ochorenie geneticky diagnostikovaneacute na prelome 21 storočia In Internaacute Mediciacutena Vol 11 (2006) s 598-601

11 Vedeckeacute praacutece v zborniacutekoch

12 Vedeckeacute praacutece v zborniacutekoch rozšiacuterenyacutech abstraktov

1 KLOBUSICKA M - KUSENDA J - BABUSIKOVA O Variations in the activity of nucleolar organizer regions (AgNORs) in acute leukemias In Book of short communications Potential therapeutic targets in cardiovascular and other diseases A tribute to prof Zdenek Lojda Bratislava 15 December 2006 VEDA Publishing House of the Slovak Academy of Sciences Bratislava 2006 ISBN 13 978-80-224-0942-1 p 77-78 (R)

2 KOŠIacuteKOVAacute B - LAacuteBAJ J - GREGOROVAacute A - SLAMEŇOVAacute D Reduction of genotoxic effect of carcinogens and oxidative damage of polyolefins by lignin preparations 9th European Workshop on Lignocellulosics and Pulp 10-15 Vienna Austria Zborniacutek 2006 p 319-322

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3 KOŠIacuteKOVAacute B - LAacuteBAJ J - SLAMEŇOVAacute D Noveacute antikarcinogeacutenne zluacutečeniny z biomasy Medzinaacuterodnaacute konferencia Technika ochrany prostredia TOP 2006 28-30062006 Uacutečeloveacute zariadenie Kancelaacuterie Naacuterodnej rady SR Častaacute ndash Papiernička 2006 ISBN 80-227-2436-X p 233-238

4 NAĎOVAacute S - VLČKOVAacute V - PRAŽMAacuteRIOVAacute E - ŠPINEROVAacute L - KOGAN G - RAUKO P - MIADOKOVAacute E The evaluation of biomodulatory effects of natural compounds 29 pracovniacute dny Českeacute a Slovenskeacute společnosti pro mutagenezu zevniacutem prostřediacutem 2-4 may 2006 Brno Kniha abstraktov p 51-54

5 KLOBUŠICKAacute M ndash KUSENDA J ndash BABUŠIacuteKOVAacute O Variations in the activity of nucleolar organizer regions (AgNORs) in acute leukemias In Potential therapeutic targets in cardiovascular and other diseases Book of short commmunications A tribute to prof Z Lojda (2006) p 77-79

13 Recenzie vedeckyacutech praacutec vo vedeckyacutech časopisoch

BARTOŠOVAacute Z Recenzia na člaacutenok Chialina SG Fornes C Landi C D de La Vega E Nicolorich MV Dourisboure RJ Solano A Solis EA Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue In BMC Medical Genetics 2006 75 (doi1011861471-2350-7-5) Plneacute znenie recenzie je publikovaneacute on-line na httpwwwbiomedcentralcom1471-235075prepub


1 ALEMAYEHU A - ZAacuteVODNAacute K - BARTOŠOVAacute Z - FRIDRICHOVAacute I Global and MLH1 methylation in colorectal cancer patients with microsatellite instability In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 21 (R)


3 BABUSIKOVA O - ZELEZNIKOVA T - KUSENDA J - KIRSCHNEROVAacute G B- bunkoveacute prekurzoroveacute suspopulaacutecie vo vzťahu k leukemickeacutemu klonumnohoparametrovaacute 4 farebnaacute analyacuteza (prednaacuteška) In II Bratislavskeacute hematologickeacute a transfuziologickeacute dni s medzinaacuterodnou uacutečasťou 26-27oktoacutebra 2006 Bratislava 2006 p25

4 BABUSIKOVA O - ZELEZNIKOVAacute T - KUSENDA J - KIRSCHNEROVA G Newly-defined differentiation stages of B-cell precursor subpopulations in relation to

105

the leukemia clone 4-color flow cytometry (poster) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 22 (R)

5 BAKOŠ E - ONDRUŠOVAacute M Incidencia zhubnyacutech naacutedorov vybranyacutech orgaacutenov GIT-u IV slovenskyacute chirurgickyacute kongres s medzinaacuterodnou uacutečasťo Nitra 6-892006 Slovensko 2006

6 BARANCIK M - BOHACOVA V - SEDLAacuteK J - SULOVA Z - BREIER A LY294002 an inhibitor of PI3KAkt kinase pathway reverses the P-glycoprotein-mediated multidrug resistance in L1210VCR cells In Proceedings from XX Biochemickyacute zjazd XX 12-16 September 2006 Piešťany 2006 l52

7 BARTOŠOVAacute Z - FRIDRICHOVAacute I Advances in molecular diagnostics of hereditary non-polyposis colorectal cancer in Slovakia In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 10 (R)

8 BELYAEV I MARKOVAacute E SHULTZ N Radiation-induced 53BP1γH2AX foci dynamic clustering and colocalisation usage for radiosensitivity and biological dosimetry In Vth Russian Congress on Radiation Research Research (Radiobiology Radioecology and Radiation Protection) Moscow Russia Russian Academy of Science 2006 Vol I p18 (R)



11 HUNAKOVA L - BODO J - SEDLAK J - Enhanced sensitivity of human ovarian carcinoma cell lines A2780 and A2780CP to the combination of cisplatin and synthetic isothiocyanate ethyl 4-isothiocyanatobutanoate E-4IB In ECCO 13 the European Cancer Conference Abstract Book Paris France 3010 - 3112005 France Paris 2006 p 274 (R)

12 BOĎO J - CHOVANCOVAacute J - ŠULIacuteKOVAacute M - JAKUBIacuteKOVAacute J - SEDLAacuteK J Isothiocyanate E-4IB induced MAPK activation delayed transition through cell cycle and G2M-linked apoptosis (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 22 (R)

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13 BOĎO J - CHOVANCOVAacute J - ŠULIacuteKOVAacute M - JAKUBIacuteKOVAacute J - SEDLAacuteK J Isothiocyanate E-4IB induced MAPK activation delayed transition through cell cycle and G2M-linked apoptosis (poster) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 22 (R)

14 BODO J - HUNAKOVA L - KVASNICKA P - DURAJ J - SEDLAK J Signalling pathways involved in the synergy of cisplatin and E-4IB treatment EACR-19 19th Meeting of the European Association for Cancer Research Budapest Hungary 1 - 4 July 2006 Budapest Programme Patria Hall 2006 p 77 (R)

15 BOĎO J - JAKUBIacuteKOVAacute J - SEDLAacuteK J Targets of isothiocyanates a Janus compounds 6th CECHTUMA 2006 Book of Abstracts Prague Czech Republic 305-162006 Praha 2006 p 18

16 BUJALKOVAacute M - WOLF B - KRIVULČIacuteK T - DE WIND N - JIRICNY J - BARTOŠOVAacute Z Development of SNP based method for directed HNPCC mutation screening (poster) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 23

17 BUJALKOVAacute M - WOLF B - KRIVULČIacuteK T - DE WIND N - JIRICNY J - BARTOŠOVAacute Z Development of SNP based method for directed HNPCC mutation screening (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 23

18 COJOCEL C- THOMSON MS- NOVOTNY L Ursolic acid effects on cisplatin nephrotoxicity (poster) The Eleventh Annual HSC Poster Conference 2006 Kuwait 24-26 April 2006 p 207

19 CHOLUJOVAacute D - JAKUBIacuteKOVAacute J - KUBES M - ARENDACKA B - SEDLAacuteK J Comparative study with four fluorescent probes for evaluation of natural killer cytotoxicity assays In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 27 (R)

20 CHOLUJOVAacute D - JAKUBIacuteKOVAacute J - SEDLAacuteK J Modulaacutecia maturaacutecie ľudskyacutech dendritovyacutech buniek uacutečinkom imunostimulačneacuteho potravinoveacuteho doplnku BioBran In Nutrition and Food for 3rd millenium nutrition and cancer Proceedings Book (Abstracts) of 6th international scientific conference Nitra 23-24 nov 2006 Nitra 2006 ISBN 80-8069-776-0 p 13 (R)

21 ČIERNIKOVAacute S - TOMKA M - KOVAacuteČ M - ŠTEVURKOVAacute V - BELLA V - KLEIBL Z - ZAJAC V Mutation screening of BRCA1 BRCA2 and CHEK2 in

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Slovak HBOC families (pozvanaacute prednaacuteška) Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 p 24 (R)

22 ČIERNIKOVAacute S - TOMKA M - KOVAacuteČ M - ŠTEVURKOVAacute V - BELLA V - KLEIBL Z - ZAJAC V Mutation screening of BRCA1 BRCA2 and CHEK2 in Slovak HBOC families (poster) Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute Slovensko 20-24 August 2006 Book of Abstracts ISBN 80-969541-8-0 p 24 (R)

23 DUDAacuteŠOVAacute Z - WARD T A ndash MC HUGH P J - CHOVANEC M The possible roles of the yeast Snm1Pso2 and Mgm101 repair factors International Free Radical Summer School 2006 30 September - 06 Oktoacuteber 2006 Spetses Island Greece 2006 Greacutecko2006 p 83-84

24 DUDAacuteŠOVAacute Z - WARD T A ndash MC HUGH P J - CHOVANEC M The yeast Snm1Pso2 protein and its possible interactions (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 12-13 (R)

25 DUDAacuteŠOVAacute Z - WARD T A ndash MC HUGH P J - CHOVANEC M The yeast Snm1Pso2 protein and its possible interactions (poster) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 12-13 (R)

26 FARKAŠOVAacute T - GURSKAacute S - GAacuteBELOVAacute A Assessment of biomarkers in cervical cancer patients 36th Annual Meeting of the EEMS From Genes to Molecular Epidemiology Prague Congress Centre July 2-6 2006 Praha Prague Congress Centre 2006 p 146

27 FRECER V - MIERTUŠ S Design of peptidomimetic inhibitors of aspartic protease of HIV-1 Including ndashPheΨProndash core and favorable ADME properties 6th European Conference on Computational Chemistry 3-7 sep 2006 Tale Book of Abstracts 2006 Tale 2006 p 73

28 GAacuteBELOVAacute A - POLAacuteKOVAacute V - POLONCOVAacute K - VALOVIČOVAacute Z - PROCHAZKA G Interactions of aromatic hydrocarbons in their binary mixtures an in vitro study 36th Annual Meeting of the EEMS From Genes to Molecular Epidemiology Prague Congress Centre July 2-6 2006 Praha Prague Congress Centre 2006 p 106

29 GAacuteBELOVAacute A - POLAacuteKOVAacute V - POLONCOVAacute K - VALOVIČOVAacute Z - PROCHAZKA G Biologickaacute aktivita binaacuternych zmesiacute aromatickyacutech uhľovodiacutekov in vitro štuacutedia In Jesenneacute pracovneacute dni genetickaacute toxikoloacutegia a prevencia rakoviny 23-

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25 oktoacutebra 2006 UacuteEO SAV Bratislava Bratislava Uacutestav experimentaacutelnej onkoloacutegie SAV 2006 ISBN 80-969524-5-5 p 34

30 GAacuteLOVAacute E - NAĎOVAacute S - VLČKOVAacute V - DUacuteHOVAacute V - PRAŽMAacuteRIOVAacute E - HALAacuteSZOVAacute E - RAUKO P - ČIPAacuteK Ľ - MIADOKOVAacute E Activity of extract from artichoke Cynara cardunculus L on genotoxic effects of mutagenscarcinogens XV Congress of the Federation of European Societies of Plant Biology 17-21 jul 2006 Lyon Francuacutezsko 2006 TEC02 - 002

31 GIBALOVA L - SEDLAacuteK J - BREIER A - BARANCIK M - SULOVA Z Effect of cisplatin on L1210 cells In Proceedings from XX Biochemickyacute zjazd 12-16 sep 2006 Piešťany Slovakia Piešťany 2006 P059

32 GURSKAacute S - FARKAŠOVAacute T - GAacuteBELOVAacute A Effect of polymorphism in the DNA repair gene hOGG1 (Ser326Cys) on phenotype In 36th Annual Meeting of the EEMS From Genes to Molecular Epidemiology Prague Congress Centre July 2-6 2006 Praha Prague Congress Centre 2006 p 198

33 GURSKAacute S - FARKAŠOVAacute T - GAacuteBELOVAacute A Polymorfizmus v DNA opravnom geacutene hOGG1 (Ser326Cys) a jeho vplyv na fenotyp In Jesenneacute pracovneacute dni genetickaacute toxikoloacutegia a prevencia rakoviny 23-25 oktoacutebra 2006 UacuteEO SAV Bratislava Bratislava Uacutestav experimentaacutelnej onkoloacutegie SAV 2006 ISBN 80-969524-5-5 p 49

34 GURSKAacute S - FARKAŠOVAacute T - GAacuteBELOVAacute A Vplyv polymorfizmu v geacutene hOGG1 na opravu oxidačnyacutech poškodeniacute In 29 pracovniacute dny českeacute a slovenskeacute společnosti pro mutagenezu zevniacutem prostrediacutem československeacute biologickeacute společnosti 2-4 may 2006 Brno Czech Republic ČR 2006 p

35GURSKYacute J - RYBANSKAacute I - HALL H - SALAZAR EP - NICODEMOU A - KIMLIacuteČKOVAacute E - KLEIBLK - THOMPSON LH - PIRŠEL M Identification of the new ERCC3 mutations and their DNA repair characteristics (vyacuteveska) In Meeting on DNA Repair from Molecular Mechanism to Human Disease Noordwijkerhout 2-7 april 2006 The Netherlands Book of Abstracts Holandsko 2006 p 142 (R)

36 GURSKYacute J - RYBANSKAacute I - HALL H - SALAZAR EP - NICODEMOU A - KIMLIacuteČKOVAacute E - KLEIBLK - THOMPSON LH - PIRŠEL M Repair of oxidative DNA damage in the helicase mutants (prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 5-6 (R)

37 HAMEL N- FORETOVA L - NAROD SA - TIHOMIROVA L - ZAJAC V - CIERNIKOVA S - ARMAOU S - YANNOUKAKOS D - GREENWOOD C - FOULKES W Investigating the origins of the BRCA1 mutation c5385dupC In The American Society of Human Genetics Annual Meeting 9-13 October 2006 New Orleans Louisiana USA USA 2006 p 203

38 HORVAacuteTHOVAacute E - LAZAROVAacute M - LAacuteBAJ J - SLAMEŇOVAacute D Study of DNA-protective effects of selected components of essential plant oils on mammalian cells cultured in vitro In COST 926927 Conference Molecular and physiological

109

effects of bioactive food compounds Vienna Austria 11-14 October 2006 rakuacutesko 2006 p 130

39 HORVAacuteTHOVAacute E - SLAMEŇOVAacute D - LAZAROVAacute M - LAacuteBAJ J Study of cytotoxic genotoxic and DNA-protective effects of selected plant essential oils on human cells cultured in vitro In 11th Interdisciplinary Slovak-Czech Toxicology Conference Programme amp Abstracts Trenčianske Teplice - Spa Hall 5 - 7 June 2006 Trenčianskeacute Teplice 2006 ISBN 80-969474-1-9 p 30

40 HORVAacuteTHOVAacute E - SLAMEŇOVAacute D - LAZAROVAacute M - MARŠAacuteLKOVAacute L Cytotoxic genotoxic and DNA-protective effects of carvacrol and thymol on human cells cultured in vitro In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 27 (R)

41 HORVAacuteTHOVAacute E - SLAMEŇOVAacute D Toxickeacute genotoxickeacute a ochranneacute pocircsobenie dvoch zložiek rastlinnyacutech eacuteterickyacutech olejov (tymolu a borneolu) na cicavčie bunky kultivovaneacute v podmienkach in vitro In Jesenneacute pracovneacute dni genetickaacute toxikoloacutegia a prevencia rakoviny 23-25 oktoacutebra 2006 UacuteEO SAV Bratislava Bratislava Uacutestav experimentaacutelnej onkoloacutegie SAV 2006 ISBN 80-969524-5-5 p 71

42 JAKUBIacuteKOVAacute J - CHOLUJOVAacute D - SEDLAacuteK J Modulation of human monocyte-derived dendritic cell maturation by BioBran (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 28 (R)

43 JAKUBIacuteKOVAacute J - CHOLUJOVAacute D - SEDLAacuteK J Modulation of human monocyte-derived dendritic cell maturation by BioBran (poster) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 28 (R)

44 JAKUBIacuteKOVAacute J - CHOLUJOVAacute D - SEDLAacuteK J Role of BioBran in human monocyte-derived dendritic cell maturation In MASIR 2006 Measurement of Antigen-Specific Immune Responses Technology Biology amp Clinical Application Santorini Greece 14-1862006 Greacutecko 2006 p 166

45 JAKUBIacuteKOVAacute J - SEDLAacuteK J Quantification of specific ABC transporter genes expression by novel multiplex analysis on Luminex platform In Proceedings from XX Biochemickyacute zjazd 12-16 September 2006 Piešťany Slovakia Piešťany 2006 lecture L16

46 KRAJČOVIČOVAacute Z - KOZICS K The use of DC polarography as a pre-screening method for identifying potential chemopreventive compounds In 11th Interdisciplinary Slovak-Czech Toxicology Conference Programme amp Abstracts Trenčianske Teplice - Spa Hall 5 - 7 June 2006 Trenčianskeacute Teplice 2006 ISBN 80-969474-1-9 p 37

47 KIRSCHNEROVAacute G - ZELEZNIKOVA T - TOacuteTHOVAacute A - KRIŽAN P - BABUSIKOVA O Uacuteskalia prietokovej cytometrie pri posuacutedeniacute prechodnej leukeacutemie

110

kojencov s Downovyacutem syndroacutemom In II Bratislavskeacute hematologickeacute a transfuziologickeacute dni s medzinaacuterodnou uacutečasťou 26-27oktoacutebra 2006 Bratislava Bratislava 2006 p36

48 KLEIBL K - ŠKORVAGA M The in vivo role of hABH2 and hABH3 in repair of methylation damage in DNA In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 29 (R)

49 KOGAN G - MIADOKOVAacute E - SLAMEŇOVAacute D - VLČKOVAacute V - BABINCOVAacute M - RAUKO P Antioxidant antigenotoxic and immunomodulating properties of yeast cell wall polysaccharides Key lecture 95 In Proceedings from XX Biochemickyacute zjazd 12-16 September 2006 Piešťany Slovakia Piešťany 2006 p

50 KOGAN G - SLAMEŇOVAacute D - RAUKO P - STAŠKO A - BABINCOVAacute M - KOROLENKO TA Could fungal polysaccharides fight cancer In 2nd Baltic Meeting on Microbial Carbohydrates October 4-8 20 Rostock Germany Rostock 2006 p 57

51 KOLLAacuteROVIČ G - BARAacuteTH P - LUCIAKOVAacute K The role of NF1 and Smad proteins in growth dependent repression of human ANT2 gene In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p30

52 KOLLAacuteROVIČ G - BARAacuteTH P - LUCIAKOVAacute K Involvement of transcription factor NF1 in Smad-mediated TGF-β signaling pathway In 15th Protein Kinase Meeting ndash bdquoSpatial and Temporal Regulation of Signallingldquo21-24 Sept 2006 Oslo Norway

53 KOŠIacuteKOVAacute B - LAacuteBAJ J - SLAMEŇOVAacute D - SLAacuteVIKOVAacute E Protection of living organisms by natural antigenotoxic agents from lignin waste products of chemical wood treatment In The International Conference and Exhibition on Drug Discovery MipTec 2006 15-20 Basel Switzerland Bazilej 2006 p 104

54 KOVAacuteČ M - TOMKA M - ČIERNIKOVAacute S - ŠTEVURKOVAacute V - ZAJAC V APC gene mutations may clinically mimic Lynch syndrome (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 31 (R)

55 KOVAacuteČ M - TOMKA M - ČIERNIKOVAacute S - ŠTEVURKOVAacute V - ZAJAC V APC gene mutations may clinically mimic Lynch syndrome (poster) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 31 (R)

56 KUCEROVA L - MATUSKOVA M - ALTANEROVA V - TYCIAKOVA S - ALTANER C Retrovirus Transduced Mesenchymal Stem Cells Exert Strong

111

Antitumor Effect (prenaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 17 (R)

57 LACIKOVA L - ZAPLETAL J - ABDEL-HAMID ME - NOVOTNY L - MASTEROVA I - GRANCAI D Triterpenes in four Staphylea L species Determination of ursolic acid by MS-MS method (poster) 5th International Symposium on Chromatography of Natural Products (ISCNP) ndash The Application of Chromatographic Methods in Phytochemical amp Biomedical Analysis Lublin Poland June 19-22 2006 Abstract Book abstract P-89 p 141

58 LAZAROVAacute M - LAacuteBAJ J - KOGAN G - SLAMEŇOVAacute D Evaluation of the protective potential of dietary beta-D-glucan derivative supplementation in primary rat hepatocytes In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 27

59 LETAVAYOVAacute L - MARKOVAacute E - VLASAacuteKOVAacute D - VLČKOVAacute V - HERMANSKAacute K - BROZMANOVAacute J - CHOVANEC M Cellular response to oxidative DNA damage in Saccharomyces cerevisiae In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 12-13 (R)

60 LETAVAYOVAacute L - VLČKOVAacute V - VLASAacuteKOVAacute D - CHOVANEC M - BROZMANOVAacute J Selenium DNA damage and repair in Saccharomyces cerevisiae In Jesenneacute pracovneacute dni genetickaacute toxikoloacutegia a prevencia rakoviny 23-25 oktoacutebra 2006 UacuteEO SAV Bratislava Bratislava Uacutestav experimentaacutelnej onkoloacutegie SAV 2006 ISBN 80-969524-5-5 p 28

61 MARKOVAacute E - ALTANEROVA V - HILLERT L - MALMGREN L - PERSSON B - BELYAEV I Adverse effects of microwaves from GSMUMTS mobile phones on human primary lymphocytes and stem cells depend on carrier frequency and type of signal In V th Russian Congress on Radiation Research (Radiobiology Radioecology and Radiation Protection) Moscow Russia Russian Academy of Science 2006 vol III p 95 (R)

62 MARŠAacuteLKOVAacute L - HORVAacuteTHOVAacute E - SLAMEŇOVAacute D Investigation of protective effects of thymol an essential oil component on H2O2-induced gene mutations in V79 Chinese hamster cells cultured in vitro In International Free Radical Summer School 2006 Biomarkers of oxidative stress and responses Book of Abstracts Ostrov Spetses Greacutecko September 29- October 6 2006 p98

63 MATUSKOVA M - KUCEROVA L - ALTANEROVA V - TYCIAKOVA S - JAKUBIKOVA J - ALTANER C Retrovirus Transduced Human Adipose Tissue Derived Mesenchymal Stem Cells as a Vehicle for Suicide Cancer Gene Therapy In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 32 (R)

112

64 MIADOKOVAacute E - NAĎOVAacute S - VLČKOVAacute V - DUacuteHOVAacute V - PRAŽMAacuteRIOVAacute E - RAUKO P - ČIPAacuteK Ľ - KOGAN G Antigenotoxic aspects of natural compounds actions In COST 926927 Conference Molecular and physiological effects of bioactive food compounds Vienna Austria 11-14 October 2006 Viedeň 2006 p 178

65 MIADOKOVAacute E - NAĎOVAacute S - VLČKOVAacute V - DUacuteHOVAacute V - TREBATICKAacute M - GROLMUS J - PRAŽMAacuteRIOVAacute E - ŠPINEROVAacute L - RAUKO P - MUČAJI P - GRANČAI D Research on biomodulatory effect of natural compounds In 11th Interdisciplinary Slovak-Czech Toxicology Conference Programme amp Abstracts Trenčianske Teplice - Spa Hall 5 - 7 June 2006 Trenčianskeacute Teplice 2006 ISBN 80-969474-1-9 p 44

66 MIADOKOVAacute E - PRAŽMAacuteRIOVAacute E - DUacuteHOVAacute V - VLČKOVAacute V - KOGAN G - RAUKO P The role of natural polysaccharides as agent with antimutagenicanticarcinogenic activity (poster) In 36th Annual Meeting of the European Environmental Mutagen Society From Genes to Molecular Epidemiology July 2-6 2006 Prague Czech Republic P 098

67 MIERTUŠ S - FRECER V Computer Assisted Combinatorial chemistry in drug design and development In 6th European Conference on Computational Chemistry 3-7 sep 2006 Tale Book of Abstracts P11

68 NAĎOVAacute S - MIADOKOVAacute E - VLČKOVAacute V - DUacuteHOVAacute V - TREBATICKAacute M - GROLMUS J - RAUKO P - ČIPAacuteK Ľ - MUČAJI P GRANČAI D Genotoxicological study aimed at antimutagenicanticarcinogenic and biomodulatory effects of extract from artichoke cynara cardunculus L evaluation In 36th Annual Meeting of the European Environmental Society From Genes to Molecular Epidemiology 2-6 July 2006 Prague Czech Republic Praha 2006 p 174

69 NAĎOVAacute S - VLČKOVAacute V - PRAŽMAacuteRIOVAacute E - ŠPINEROVAacute L - KOGAN G - RAUKO P ndash MIADOKOVAacute E The evaluation of biomodulatory effects of natural compounds (vyžiadanaacute prednaacuteška) In 29 pracovniacute dny Českeacute a Slovenskeacute společnosti pro mutagenezu zevniacutem prostřediacutem Československeacute biologickeacute společnosti Brno 2 - 4 5 2006 pp 51-54

70 NAĎOVAacute S - PRAŽMAacuteRIOVAacute E - VLČKOVAacute V- DUacuteHOVAacute V- KOGAN G- RAUKO P MIADOKOVAacute E Carboxymethyl glucan - polysaccharide with antigenotoxic potential (poster) In 29 pracovniacute dny Českeacute a Slovenskeacute společnosti pro mutagenezu zevniacutem prostřediacutem Československeacute biologickeacute společnosti Brno 2 - 4 5 2006 pp 97 - 98

71 NOVOTNYacute L - RAUKO P - MEGO M Antileukemic effects of new dinucleoside conjugates In 35th Conference ldquoSynthesis and analysis of drugsrdquo 12-15 September 2006 Velke Karlovice Czech Republic Velkeacute Karlovice 2006 p 47

72 NOVOTNY L - AL-KHARS A Faculty of Pharmacy at Kuwait University ndash the present and the future Kuwait (poster) In 1st Pharmaceutical Sciences Conference and 10th Conference of Scientific Association of Colleges of Pharmacy in the Arab

113

World Faculty of Pharmacy Kuwait University Kuwait December 11-13 2006 abstract No PE-OS-1 p 25

73 ONDRUŠOVAacute M Klinickaacute epidemioloacutegia karcinoacutemu prsniacuteka 10mammologickeacute sympoacutezium 1122006 Praha ČR Českaacute republika 2006

74 ONDRUŠ D - ŠPAacuteNIKOVAacute B - ONDRUŠOVA M Naacutedory testis a poruchy hormonaacutelneho profilu a kostneacuteho metabolizmu Vyacuteročniacute konference ČUS ČLS JEP 11-13102006Českeacute Budějovice ČR Českaacute republika 2006

75 ONDRUŠOVAacute M Epidemioloacutegia naacutedorov testis v SR a ČR Odbornyacute seminaacuter Kliniky detskej onkoloacutegie FN Brno 2642006 Brno ČR Českaacute republika 2006

76 ONDRUŠ D - GALBAVYacute Š- ONDRUŠOVAacute M - HORŇAacuteK M Histopatologickeacute charakteristiky naacutedorov močoveacuteho mechuacutera vo vzťahu k prežiacutevaniu klinickeacuteho suacuteboru pacientov (1968-2003) XIV Zjazd slovenskyacutech a českyacutech patoloacutegov s medzinaacuterodnou uacutečasťou Mojmiacuterovce 6-892006 Slovensko 2006

77 PASTORAacuteKOVAacute A - HLUBINOVAacute K - ALTANER Č Combine cancer gene therapy expression of human tumor necrosis factor alpha simultaneously with suicide gene systems in vitro In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 33 (R)

78 PATRASOVA M - POLIAKOVA-KOSTANOVA D - SABOVA L The role of cardiolipin and phosphatidylglycerol in BAX mediated cytotoxicity studied in yeast K Lactis In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 33 (R)

79 PAULIKOVAacute H - VAĽKOVAacute Z - KADLEČIacuteKOVAacute E - RAUKO P - HUDECOVAacute D - VALENT A Modulation of the cytotoxic effects of Cu(II) complexes by ascorbic acid In 11th Interdisciplinary Slovak ndash Czech Toxicology Conference Slovak and Czech Toxicology in the European Union 5-7 June 2006 Trencianske Teplice Programme amp Abstracts Trenčianskeacute Teplice 2006 p 49




83 POLAacuteKOVAacute K- BANDŽUCHOVAacute E- BYSTRICKAacute M- PANČUCHAacuteROVAacute H- RUSS G Effect of proteasome inhibitors on expression of HLA-G isoforms In 7th EFIS Tatra Immunology Conference Molecular Determinants of T-cell Immunity June 24-28 2006 Štrbskeacute Pleso Slovakia Štrbskeacute Pleso Hotel Patria 2006 p34

114

84 POLAacuteKOVAacute K - BANDŽUCHOVAacute E - BYSTRICKAacute M - PANČUCHAacuteROVAacute H - RUSS G Expression of truncated HLA-G isoforms in cells exposed to proteasome inhibitors (prednaacuteška) In 4th International Conference on HLA-G 10-12 July 2006 Paris France Abstract book p17 and In Tissue Antigens Vol68 no4 (2006) p351

85 POLAKOVIČOVAacute E - GURSKYacute J - RYBANSKAacute I - FAŠKOVAacute M - PIRŠEL M Charakterizaacutecia dvoch škrečiacutech ERCC3XPB mutantnyacutech bunkovyacutech liacuteniiacute (vyacuteveska) In Jesenneacute pracovneacute dni genetickaacute toxikoloacutegia a prevencia rakoviny 23-25 oktoacutebra 2006 UacuteEO SAV Bratislava Bratislava Uacutestav experimentaacutelnej onkoloacutegie SAV 2006 ISBN 80-969524-5-5 p 47-48 (R)

86RYBANSKAacute I - PIRŠEL M Involvement of the hamsterERCC3XPB protein in the repair of oxidative DNA damage In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0p 33-34 (R)

87 SARIMOV R - MARKOVAacute E - JOHANSSON F - JENSSEN D - BELYAEV I Exposure to ELF magnetic field tuned to Zn inhibits growth of cancer cells Vth

Russian Congress on Radiation Research (Radiobiology Radioecology and Radiation Protection) Moscow Russia Russian Academy of Science 2006 vol III p 94 (R)

88 SEDLAacuteK J - BOĎO J - JAKUBIacuteKOVAacute J A possible role of dietary chemopreventive compounds in tumor therapy In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 15 (R)

89 SLAMEŇOVAacute D -ŠRAMKOVAacute M - HORVAacuteTHOVAacute E - LAacuteBAJ J Porovnanie toxickyacutech a protektiacutevnych uacutečinkov rastlinnyacutech prchavyacutech laacutetok karvakrolu a eukalyptolu na cicavčie bunky kultivovaneacute in vitro In Jesenneacute pracovneacute dni genetickaacute toxikoloacutegia a prevencia rakoviny 23-25 oktoacutebra 2006 UacuteEO SAV Bratislava Bratislava Uacutestav experimentaacutelnej onkoloacutegie SAV 2006 ISBN 80-969524-5-5 p 27


91 SRAMKO M - MARKUS J - KABAT J - WOLFF L - BIES J Stress-induced inactivation of transcription factor c-Myb through conjugation of SUMO-23 proteins (poster) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 34 (R)

115

92 VALOVICOVA Z - FARKASOVA T - GURSKA S - BINKOVA B - GABELOVA A Genotoxic mechanisms involved in tissue specificity of chemical carcinogens In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 30

93 VALOVIČOVAacute Z - FARKAŠOVAacute T - GURSKAacute S - BINKOVAacute B - GAacuteBELOVAacute A Role of cytochromes P450 in genotoxicity and mutagenity of 7H-dibenzo[cg]carbazole and its tissue specific derivatives In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 36 (R)


95 WOLFF L ndash BIES J ndash MARKUS J ndash ROSU-MYLES M Cyclin-dependent kinase inhibitor P15INK4B in leukemia and normal hematopoiesis (pozvanaacute prednaacuteška) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 3 (R)

96 ZAJAC V - KOVAacuteČ M - ČIERNIKOVAacute S - MEGO M - ŠTEVURKOVAacute V - LIŠKOVAacute A - KRČMEacuteRY V Detection of HIV sequences in respiratory tract bacteria of Cambodia and Kenya AIDS-positive patients In Clinical microbiology and infection Supp 4 (2006) Abstracts from 16th European Congress of Clinical Microbiology and Infectious Diseases) Nice Acropolis Congress Centre 2006 ISSN 1470-9465 p 53 (R)

97 ZAJAC V - MEGO M - KOVAacuteČ M - ČIERNIKOVAacute S - ŠTEVURKOVAacute V - MARTINICKYacute D FAP and HBOC Two players in one playground n Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 9 (R)

98 ZAJAC V - MEGO M - KOVAacuteČ M - ŠTEVURKOVAacute V - UJHAacuteZY E - GAJDOŠIacuteK A - GAJDOŠIacuteKOVAacute A - ČIERNIKOVAacute S Testing of bacteria isolated from cancer patients on experimental models XI Medziodborovaacute slovensko-českaacute toxikologickaacute konferencia Slovenskaacute a českaacute toxikoloacutegia v EU 5-7 juacuten 2006 Trenčianskeacute Teplice (prednaacuteška)

99 ZAVODNA K - BUJALKOVA M - KRIVULCIK T - ALEMAYEHU A - HAIDER R - MARRA G - FRIDRICHOVA I - JIRICNY J - BARTOSOVA Z The spectrum of inherited DNA mismatch repair genes pathogenic alterations in

116

Slovakia In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p38

100ZELEZNIKOVA T - BABUSIKOVA O Multiparameter flow cytometric analysis of heterogeneous populations in AML patients implication for minimal residual disease detection (poster) In Cancer 2006 From molecular biology processes to tumor-tailored therapy Book of Abstracts CC Academia Stara Lesna High Tatras Slovakia 20-24 August 2006 Staraacute Lesnaacute CC Academia 2006 ISBN 80-969541-8-0 p 39 (R)

101ZELEZNIKOVA T - KIRSCHNEROVA G - STEVULOVA L - KOVARIacuteKOVAacute A - BABUSIKOVA O Fenotypovaacute heterogenita AML a jej zmeny v relapse ovplyvňujuacutece docirckaz MRD (prednaacuteška) In II Bratislavskeacute hematologickeacute a transfuziologickeacute dni s medzinaacuterodnou uacutečasťou 26-27oktoacutebra 2006 Bratislava Bratislava 2006 p35

102MIADOKOVAacute E - NAĎOVAacute S - VLČKOVAacute V - DUacuteHOVAacute V - TREBATICKAacute M - GROLMUS J - PRAŽMAacuteRIOVAacute E - ŠPINEROVAacute L - RAUKO P - MUČAJI P - GRANČAI D Research on biomodulatory effect of natural compounds (poster) In 11th Interdisciplinary Slovak ndash Czech Toxicology Conference Slovak and Czech Toxicology in the European Union Trenčianske Teplice ndash Spa Hall Slovakia June 5-7 2006 p 44 - 45

103PAULIacuteKOVAacute H - VAĽKOVAacute Z - KADLEČIacuteKOVAacute E - RAUKO P - HUDECOVAacute D - VALENT A Modulation of the cytotoxic effects of Cu(II) complexes by ascorbic acid (poster) In 11th Interdisciplinary Slovak ndash Czech Toxicology Conference Slovak and Czech Toxicology in the European Union Trenčianske Teplice - Spa Hall Slovakia June 5-7 2006 p 49 - 50

104MIADOKOVAacute E - NAĎOVAacute S - KOPAacuteSKOVAacute M - VLČKOVAacute V - DUacuteHOVAacute V - ŠPINEROVAacute L - ČIPAacuteK Ľ - RAUKO P - MUČAJI P - GRANČAI D Antimutagenic and anticarcinogenic effect of extract from Artichoke Cynara cardunculus L (prednaacuteška) In Jesenneacute pracovneacute dni Genetickaacute toxikoloacutegia a prevencia rakoviny 23-25 oktoacutebra 2006 UacuteEO SAV Bratislava P 26

15 Ostatneacute prednaacutešky a vyacutevesky

1 ALEMAYEHU A - Status mikrosatelitovej instability a metylaacutecia DNA u HNPCC suspektnyacutech pacientov Prednaacuteška na UacuteEO SAV 122006

2 ALTANER Č Targeted cancer therapy Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 11122006

3 ALTANER Č The role of viruses in oncogenesis Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program

117

vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 4102006

4 ALTANEROVAacute V Thyroid tumors and hereditary predisposition to multiple endocrine neoplasia type 2 (MEN 2) Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 15112006

5 BABUŠIacuteKOVAacute O - ŽELEZNIacuteKOVAacute T - MLCAKOVA A - KUSENDA J - STEVULOVA L - KOVARIacuteKOVAacute A Hematogoacuteny v detskej populaacutecii (prednaacuteška) X Stretnutie detskyacutech hematoloacutegov a onkoloacutegov 27-28 januaacutera 2006 Bratislava

6 BABUŠIacuteKOVAacute O Multiparameter flow cytometric analysis of acute lymphoblastic leukemia and benign B-cell precursors Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 29112006

7 BARAacuteTH P Histone modifications Implications for transcription and therapy Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 16112006

8 BARTOŠOVAacute Z - Informaacutecie o sympoacuteziu Cancer 2006 From molecular biology processes to tumor-tailored therapy Prednaacuteška na Uacutestave experimentaacutelnej onkoloacutegie SAV 352006

9 BIZIK J Molekulaacuterne aspekty aktivaacutecie stromaacutelnych fibroblastov a ich uacuteloha v naacutedorovej progresii Prednaacuteška na Uacutestave experimentaacutelnej onkoloacutegie SAV 132006

10 BIZIK J Nemosis - prospective cell based therapy Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 5102006

11 BOĎO J - Aktivaacutecia bunkovyacutech signalizačnyacutech draacuteh pocircsobeniacutem izotiokyanaacutetu E-4IB Prednaacuteška na Uacutestave experimentaacutelnej onkoloacutegie SAV 1052006

12 BROacuteZMANOVA J Base excision repair mechanism of DNA repair after oxidative stress Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 19102006

13 CHOVANEC M Recombination and DNA repair of double strand breaks Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 26102006

118

14 DURAJ J Multidrug resistance in human cancer cells and its modulationinhibition for cancer therapy Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 7122006

15 FARKAŠOVAacute T - Sledovanie biomarkerov raacutediosenzitivity pacientok s naacutedorom krčka maternice Prednaacuteška na Uacutestave experimentaacutelnej onkoloacutegie SAV 2862006

16 GAacuteBELOVAacute A Drug metabolizing enzymes Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 6122006

17 KIRSCHNEROVAacute G - TOacuteTHOVAacute A - ZELEZNIKOVA T - BABUSIKOVA O - KRIŽAN P Bioloacutegia novorodeneckej leukeacutemie pri Downovom syndroacuteme (prednaacuteška) XIVII Izakovicov memeoriaacutel Bratislava oktoacuteber 2006

18 KLOBUŠICKAacute M - KUSENDA J ndash BABUŠIacuteKOVAacute O Variaacutecie v aktivite jadierkovyacutech organizačnyacutech oblastiacute (AgNORs) v akuacutetnych leukeacutemiaacutech (prednaacuteška) Memoriaacutel prof Lojdu Bratislava 15december 2006

19 KRAJČOVIČOVAacute Z - Protektiacutevne uacutečinky priacuterodnych laacutetok Prednaacuteška na Uacutestave experimentaacutelnej onkoloacutegie SAV 1942006

20 KRIVULČIacuteK T - Rakovina žaluacutedka ako suacutečasť naacutedoroveacuteho spektra hereditaacuternych syndroacutemov Prednaacuteška na Uacutestave experimentaacutelnej onkoloacutegie SAV 832006

21 KUČEROVAacute L Mesenchymal and cancer stem cells properties implications for tumor therapy Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 22112006

22 LAZAROVAacute M - Protektiacutevne uacutečinky b -D- glukaacutenov Prednaacuteška na Uacutestave experimentaacutelnej onkoloacutegie SAV 2542006

23 LUCIAKOVAacute K The role of mitochondria in my life Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 28112006

24 MATUacuteŠKOVAacute M - Multipotentneacute kmeňoveacute bunky z tukoveacuteho tkaniva - charakterizaacutecia a možneacute využitie v geacutenovej terapii Prednaacuteška na Uacutestave experimentaacutelnej onkoloacutegie SAV 2162006

25 PASTORAacuteKOVAacute A Rekombinantneacute DNA techniky a geacutenovaacute terapia Prednaacutešky v Strednej priemyselnej škole Samuela Stankovnianskeacuteho 29 november ndash 1december 2006 Banskaacute Štiavnica Slovensko (ESF)

119

26 PATRAacuteŠOVAacute M - POLIAKOVAacute-KOŠŤANOVAacute D - ČERTIacuteK M - ŠABOVAacute Ľ The role of cardiolipin and phosphatidylglycerol in Bax mediated cytotoxicity in Klactis In Vyacuteročnaacute schocircdza o kvasinkaacutech 10-12 maacuteja 2006 Smolenice

27 POLIAKOVAacute-KOŠŤANOVAacute D - DUNAJČIacuteKOVAacute P PATRAacuteŠOVAacute M - ŠABOVAacute Ľ A role for cytochrome c in cytotoxic effect of Bax in Klactis creation a mutant strain resistant to Bax In Vyacuteročnaacute schocircdza o kvasinkaacutech 10-12 maacuteja 2006 Smolenice

28 ONDRUŠOVAacute M - PLEŠKO I Epidemioloacutegia urologickyacutech maligniacutet na Slovensku Izimneacute urologickeacute sympoacutezium Novyacute Smokovec 15-2112006

29 ONDRUŠOVAacute M Systeacutem zberu a anlyacutezy daacutet v Naacuterodnom onkologickom registry SR Odbornyacute seminaacuter Rozvoj onkologickeacuteho registra a jeho využitie v praxi MZd SR Bratislava 2432006

30 ONDRUŠ D - ŠPAacuteNIKOVAacute B - ONDRUŠOVAacute M Bilateraacutelne naacutedory testis a poruchy kostneacuteho metabolizmu Vyacuteročnaacute konferencia SAS Martin 7-962006

31 ONDRUŠOVAacute M Systeacutem zberu a analyacuteza daacutet v Naacuterodnom onkologickom registry SR Letnyacute bioptickyacute seminaacuter SD IAP Senec 16-1762006

32 ONDRUŠOVAacute M Epidemioloacutegia urologickyacutech maligniacutet vo svete a na Slovensku XLIII Bratislavskeacute onkologickeacute dni Bratislava 5-6102006

33 ONDRUŠOVAacute M Epidemioloacutegia ndash onkologickeacute registre Kurz špecializačneacuteho štuacutedia v špecializačnom odbore ošetrovateľskaacute starostlivosť v onkoloacutegii SZU Bratislava 20102006

34 ONDRUŠOVAacute M Klinickaacute epidemioloacutegia zhubnyacutech naacutedorov obličky Vedeckaacute konferencia Schering Podbanskeacute 27-29102006

35 ONDRUŠOVAacute M Epidemioloacutegia maliacutegnych naacutedorov v SR X Košickeacute chemopterapeutickeacute dni Košice 2325112006

36 PIRŠEL M Cell response to DNA damage ndash DNA repair mechanism and their relation to cancer Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 12102006

37 PLEŠKO I Epidemioloacutegia zhubnyacutech naacutedorov žlčniacuteka pečene a pankreasu IV Bardejovskeacute onkologickeacute dni Bardejov 21-2362006

38 PLEŠKO I Epidemioloacutegia zhubnyacutech naacutedorov na Slovensku Celoštaacutetny seminaacuter MZd SR Bratislava 2432006

39 POLAacuteKOVAacute K HLA antigens and tumors Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 30112006

120

40 POLIAKOVAacute - KOŠŤANOVAacute D - Kluyveromyces lactis naacutestroj na objasnenie mechanizmov bunkovej smrti Prednaacuteška na Uacutestave experimentaacutelnej onkoloacutegie SAV 1752006

41 PRACHAŘ J Molecular nucleo-cytoplasmic transport mechanism with respect to the malignant transformation of the cell Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 11102006

42 ŠABOVAacute Ľ Mitochondrial membrane dynamics in the control of apoptosis Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 23112006

43 SEDLAacuteK J Cell cycle and cell cycle checkpoints with respect to the neoplastic transformation Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 18102006

44 SEDLAacuteK J Naacutedoroveacute kmeňoveacute bunky Uacutestavnyacute seminaacuter VUacute SAV 7 nov 2006 VU SAV Bratislava

45 ZAJAC V Hereditary form of colon breast and ovarian cancer Prednaacuteška v raacutemci kurzu bdquoMolekulovaacute onkoloacutegia ndash anglickaacute verzialdquo ESF Projekt bdquoInovovanyacute program vyacutechovy mladyacutech tvorivyacutech expertov v onkologickom vyacuteskumeldquo Uacutestav experimentaacutelnej onkoloacutegie SAV 9112006

46 ZAacuteVODNAacute K Mutačnaacute analyacuteza geacutenov asociovanyacutech s hereditaacuternou nepolypoacuteznou rakovinou kolorekta (HNPCC) Prednaacuteška na Uacutestave experimentaacutelnej onkoloacutegie SAV 2222006

47 ZAacuteVODNAacute K ndash KRIVULČIacuteK T ndash BARTOŠOVAacute Z Noveacute genetickeacute aspekty naacutedorov žaluacutedka Vyžiadanaacute prednaacuteška XI Gastrofoacuterum Štrbskeacute Pleso 24-271 2006

48 ŽELEZNIacuteKOVAacute T - Multiparametrovaacute prietokovaacute cytometria v diagnoacuteze a sledovaniacute minimaacutelnej zvyškovej choroby akuacutetnych myeloblastovyacutech leukeacutemiiacute Prednaacuteška na UacuteEO SAV 1522006

49 KOGAN G - MIADOKOVAacute E - RAUKO P - SVIDOVAacute S - VLČKOVAacute V - DUacuteHOVAacute V - NAĎOVAacute S Glucomannan of Candida utilis ndash a versatile biomodulatory polysaccharide (poster) In 34th Annual Conference on Yeasts 10 - 12 May 2006 Smolenice Slovakia p 39

50 KOGAN G - MIADOKOVAacute E - SLAMEŇOVAacute D - VLČKOVAacute V - BABINCOVAacute M - RAUKO P Antioxidant antigenotoxic and immunomodulating properties of yeast cell wall polysaccharides In XX Biochemickyacute zjazd Piešťany 12 - 16 september 2006

121

16 Vydaacutevaneacute periodikaacute evidovaneacute v Current Contents

Uacutestav je vydavateľom medzinaacuterodneacuteho časopisu NEOPLASMA (ISSN 0028-2685) Časopis

publikuje člaacutenky z experimentaacutelnej a klinickej onkoloacutegie a naacutedorovej epidemioloacutegie Časopis

vychaacutedza šesťkraacutet ročne Vydaacuteva ho VEDA Slovenskaacute akadeacutemia vied V roku 2005 dosiahol

impakt faktor 0731

17 Ostatneacute vydaacutevaneacute periodikaacute

18 Vydaneacute alebo editovaneacute zborniacuteky z vedeckyacutech podujatiacute

Vydaneacute zborniacuteky z vedeckyacutech podujatiacute

1 CANCER 2006 From molecular biology processes to tumor-tailored therapy BOOK of ABSTRACTS CC ACADEMIA Stara Lesna High Tatras Slovakia 20-24 August 2006 Autori Z Bartosova T Krivulcik M Bujalkova Recenzenti C Altaner J Sedlak Z Bartosova M Chovanec Bratislava Uacutestav experimentaacutelnej onkoloacutegie SAV 2006 51p ISBN 80-969541-8-0

2 Jesenneacute pracovneacute dni genetickaacute toxikoloacutegia a prevencia rakoviny 23-25 oktoacutebra 2006 UacuteEO SAV Bratislava Recenzenti V Vlčkovaacute J Grolmus Bratislava Uacutestav experimentaacutelnej onkoloacutegie SAV 2006 82p ISBN 80-969524-5-5

19 Vysokoškolskeacute učebnice a učebneacute texty

20 Vedeckeacute praacutece uverejneneacute na internete a v cudzom jazyku b v slovenčine

21 Preklady vedeckyacutech a odbornyacutech textov

122

CITAacuteCIE SPOLU 447

Citaacutecie vo WOS 428

ABDEL-HAMID M - NOVOTNYacute L - HAMZA H Determination of diclofenac sodium flufenamic acid indomethacin and ketoprofen by liquid chromatography ndash atmospheric pressure chemical ionization - mass spectrometry In Journal of pharmaceutical and biomedical analysis Vol 24 no 4 (2001) p 587-594

1 SULTAN M - STECHER G STOGGL WM - BAKRY R - ZABORSKI P - HUCK CW - EL KOUSY NM - BONN GK Current medicinal chemistry 2005 Vol 12 Iss pp 573-588

2 MIKSA IR - CUMMINGS MR - POPPENGA RH Journal of analytical toxicology 2005 Vol 29 Iss pp 95-104

3 JOHNSON DW Clinical biochemistry 2005 Vol 38 Iss pp 351-3614 GILPIN RK ZHOU W Journal of pharmaceutical and biomedical analysis 2005 Vol

37 Iss pp 509-5155 GALMIER MJ - BOUCHON B - MADELMONT JC - MERCIER F - PILOTAZ

F - LARTIGUE C Journal of pharmaceutical and biomedical analysis 2005 Vol 38 Iss pp 790-796

6 AMOR-GARCIA I - BLANCO-LOPEZ MC - LOBO-CASTANON MJ - MIRANDA-ORDIERES AJ - TUNON-BLANCO P Electroanalysis 2005 Vol 17 Iss pp 1555-1562

7 OZLU C - BASAN H - SATANA E - ERTAS N - GOGER NG Journal of pharmaceutical and biomedical analysis 2005 Vol 39 Iss pp 606-611

8 DE SOUZA RL - TUBINO M Journal of the brazilian chemical society 2005 Vol 16 Iss pp 1068-1073

9 TUBINO M - DE SOUZA RL Journal of AOAC international 2005 Vol 88 Iss pp 1684-1687

ABDEL-HAMID M - NOVOTNYacute L - HAMZA H Liquid chromatography ndash mass spectrometric determination of celecoxib in plasma using single ndash ion monitoring and its use in clinical pharmatokinetics In Journal of chromatography B Biomedical applications Vol 753 no 2 (2001) p 401-408

10 HAMAMA AK RAY J DAY RO BRIEN JEJournal of chromatographic science 2005 Vol 43 Iss 7 pp 351-354

11 RAO RN MEENA S RAO ARJournal of pharmaceutical and biomedical analysis 2005 Vol 39 Iss pp 349-363

ABDEL-HAMID M - NOVOTNYacute L - HAMZA H Stability study of selected adenosine nucleosides using LC and LCMS analyses In Journal of pharmaceutical and biomedical analysis Vol 22 no 5 (2000) p 745-755

123

12 BANOUB JH - NEWTON RP - ESMANS E - EWING DF - MACKENZIE G Chemical reviews 2005 Vol 105 Iss 5 pp 1869-1915

AROSIO D - CUI S - ORTEGA C - CHOVANEC M - DI MARCO S - BALDINI G - FALASHI A - VINDIGNI A Studies on the mode of Ku interaction with DNA In Journal of biological chemistry Vol 277 no 12 (2002) p 9741-9748

13 DE ANDRADE EV - FREITAS SM - VENTURA MM - MARANHAO AQ - BRIGIDO MM Biochimica et biophysica acta - General subjects 2005 Vol 1726 Iss 3 pp 293-301

BABINCOVAacute M - ALTANEROVAacute V - ALTANER Č - ČIČMANEC P - BABINEC P In vivo heating of magnetic nanoparticles in alterating magnetic field In Medical Physics Vol 31 no 8 (2004) p 2219-2221

14 BRUSENTSOVA TN - BRUSENTSOV NA - KUZNETSOV VD Journal of magnetism and magnetic materials 2005 Vol 293 Iss 1 pp 298-302

15 BRUSENTSOVA TN - BRUSENTSOV NA - KUZNETSOV VD - NIKIFOROV VN Duplikat 2005 Vol 293 Iss 1 pp 298-302

BABINCOVAacute M - ALTANEROVAacute V - LAMPERT M - ALTANER Č - MACHOVAacute E - ŠRAMKA M - BABINEC PSite-specific in vivo targeting of magnetoliposomes using externally applied magnetic field In Zeitschrift fur naturforschung C - A Journal of biosciences Vol 55 no 3-4 (2000) p 278-281

16 REDDY LH Journal of pharmacy and pharmacology 2005 Vol 57 Iss 10 pp 1231-1242

17 KIRCHNER C - JAVIER AM - SUSHA AS Talanta 2005 Vol 67 Iss 3 pp 486-491

18 KULLBERG M - MANN K - OWENS JL Medical hypotheses 2005 Vol 64 Iss 3 pp 486-470

19 TROUTIER AL - DELAIR T - PICHOT C Langmuir 2005 Vol 21 Iss 4 pp 1305-1313

20 TORCHILIN VP Nature reviews drug discovery 2005 Vol 4 Iss 2 pp 145-160

BABINCOVAacute M - ČIČMANEC P - ALTANEROVAacute V - ALTANER Č - BABINEC P AC-magnetic field controlled drug release from magnetoliposomes design of a method for site-specific chemotherapy In Bioelectrochemistry Vol 55 (2002) p 17-19

21 GONZALES M - KRISHNAN KM Journal of magnetism and magnetic materials 2005 Vol 293 Iss 1 pp 265-270


23 ZHANG JQ - ZHANG ZR - YANG H Pharmaceutical research 2005 Vol 22 Iss 4 pp 573-583


25 JAMES J - KULLBERG M Ethnicity amp disease 2005 Vol 15 Iss 3 pp 113-11526 LU ZH - PROUTY MD - GUO ZH Langmuir 2005 Vol 21 Iss 5 pp 2045-2050

124

BABUŠIacuteKOVAacute O - KONIacuteKOVAacute E - KUSENDA J - KOUBEK K Aberrant markers expression in T-and B-lymphoid and myeloid leukemia cells of different differentation stages In Neoplasma Vol 46 no 5 (1999) p 277-282

27 TORUBAROVA NA - SEMIKINA EL - KOPYLTSOVA EA - FILINA OY - MAZITOVA EN - PARTENADZE AN - TEPAEV RF Gematologiya i transfuziologiya 2005 Vol 50 Iss 5 pp 3-9

BARAacuteTH P - ALBERT-FOURNIER B - LUCIAKOVAacute K - NELSON B Characterization of a silencer element and purification of a silencer protein that negatively regulates the human adenine nucleotide translocator 2 promoter In Journal of biological chemistry Vol 274 (1999) p 3378-999

28 ITOI S - MISAKI R - HIRAYAMA M - NAKANIWA M - LIANG CS - KONDO H - WATABE S Mitochondrion 2005 Vol 5 Iss 3 pp 162-172

29 CHEVROLLIER A - LOISEAU D - CHABI B - RENIER G - DOUAY O - MALTHIERY Y - STEPIEN G Journal of bioenergetics and biomembranes 2005 Vol 37 Iss 5 pp 307-316

BARAacuteTH P - LUCIAKOVAacute K - HODNYacute Z - LI R - NELSON B The growth-dependent expression of the adenine nucleotide translocase-2 (ANT2) gene is regulated at the level of transcription and is a marker of proliferation In Experimental cell research Vol 248 (1999) p 583-588

30 CHEVROLLIER A - LOISEAU D - STEPIEN G M s-medecine sciences 2005 Vol 21 Iss 2 pp 156-161


32 KWEKEL JC - BURGOON LD - BURT JW - HARKEMA JR - ZACHAREWSKI TR Physiological genomics 2005 Vol 23 Iss 3 pp 327-342

BARAacuteTH P - POLIAKOVAacute D - LUCIAKOVAacute K - NELSON B Identification of NF1 as a silencer protein of the human adenine nucleotide translocase-2 gene In European journal of biochemistry Vol 271 (2004) p 1781-1788

33 SUN XL - WANG YX - QING H - CHRISTENSEN MA - LIU YQ - ZHOU WH - TONG YG - XIAO CY - HUANG Y - ZHANG SZ - LIU XH - SONG WH FASEB Journal 2005 Vol 19 Iss 7 pp 739-749

BAČOVAacute G - HUNAacuteKOVAacute Ľ - CHORVAacuteTH M - BOLJEŠIacuteKOVAacute E - CHORVAacuteTH B - SEDLAacuteK J - GAacuteBELOVAacute A Radiation-induced DNA damage and repair evaluated with Comet assay in human ovarian carcinoma cell lines with different radiosensitivities In Neoplasma Vol 47 no 6 (2000) p 367-374

34 HILGER I RAPP A GREULICH KO KAISER WARadiology 2005 Vol 237 Iss 2 pp 500-506

BIES J - HOFFMAN B - AMANULLAH A - GIESE T - WOLFF L B-Myb prevents growth arrest associated with terminal differentiation of monocytic cells In Oncogene Vol 12 no 2 (1996) p 355-363

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35 SANTIN AD - ZHAN FH - BIGNOTTI E - SIEGEL ER - CANE S - BELLONE S - PALMIERI M - ANFOSSI S - THOMAS M - BURNETT A - KAY HH - ROMAN JJ - OBRIEN TJ - TIAN EM - CANNON MJ - SHAUGHNESSY J - PECORELLI S Virology 2005 Vol 331 Iss 2 pp 269-291

36 LANG G - WHITE JR - ARGENT-KATWALA MJG - ALLINSON CG - WESTON K Oncogene 2005 Vol 24 Iss 8 pp 1375-1384

37 SANTILLI G - SCHWAB R - WATSON R - EBERT C - ARONOW BJ - SALA A Journal of biological chemistry 2005 Vol 280 Iss 16 pp 15628-15634

BIES J - MARKUS J - WOLFF L Covalent Attachment of the SUMO-1 Protein to the Negative Regulatory Domain of the c-Myb Transcription Factor Modifies Its Stability and Transactivation Capacity In Journal of biological chemistry Vol 277 no 11 (2002) p 8999-9009

38 SPENGLER ML - KENNETT SB - MOOREFIELD KS - SIMMONS SO - BRATTAIN MG - HOROWITZ JM Cellular signalling 2005 Vol 17 Iss 2 pp 153-166

39 GRESKO E - MOLLER A - ROSCIC A - SCHMITZ ML Biochemical and biophysical research communications 2005 Vol 329 Iss 5 pp 1293-1299

40 LEIGHT ER - GLOSSIP D - KORNFELD K Development 2005 Vol 132 Iss 5 pp 1047-1056

41 CHUPRETA S - HOLMSTROM S SUBRAMANIAN L INIGUEZ-LLUHI JAMolecular and cellular biology 2005 Vol 25 Iss 10 pp 4272-4282

42 LEI WL - LIU F - NESS SA - Blood 2005 Vol 105 Iss 10 pp 3855-386143 DEGERNY C - MONTE D - BEAUDOIN C - JAFFRAY E - PORTOIS L -

HAY RT - DE LAUNOIT Y - BAERT JL Journal of biological chemistry 2005 Vol 280 Iss 26 pp 24330-24338

44 MATSUURA T - SHIMONO Y - KAWAI K - MURAKAMI H - URANO T - NIWA Y - GOTO H - TAKAHASHI M Experimental cell research 2005 Vol 308 Iss 1 pp 65-77

45 NAKAGAWA K - KUZUMAKI N Genes to cells 2005 Vol 10 Iss 8 pp 835-85046 TAKANAKA Y - COUREY AJ Mechanisms of development 2005 Vol 122 Iss 10

pp 1130-113747 COOPER HJ - TATHAM MH - JAFFRAY E - HEATH JK - LAM TT -

MARSHALL AG - HAY RT Analytical chemistry 2005 Vol 77 Iss 19 pp 6310-6319

48 MORITA Y - KANEI-ISHII C - NOMURA T - ISHII S Molecular biology of the cell 2005 Vol 16 Iss 11 pp 5433-5444

49 ULRICH HD Trends in cell biology 2005 Vol 15 Iss 10 pp 525-53250 ZHENG G - YANG YC Journal of biological chemistry 2005 Vol 280 Iss 49 pp

40773-40781

BIES J - MUKHOPADHYAYA R - PIERCE J - WOLFF L Only late nonmitotic stages of granulocytes differentiation in 32DCL3 cells are blocked by ectopic expression of murine c-Myb and its truncated forms In Cell growth amp differentiation Vol 6 no 1 (1995) p 59-68

51 NEMETH MJ - CLINE AP - ANDERSON SM - GARRETT-BEAL LJ - BODINE DM Blood 2005 Vol 105 Iss 2 pp 627-634

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BIES J - NAZAROV V - WOLFF L Identification of protein instability determinants in the carboxy-terminal region of c-myb removed as a result of retroviral integration in murine monocytic leukemias In Journal of virology Vol 73 no 3 (1999) p 2038-2044

53 CORRADINI F - CESI V - BARTELLA V - PANI E - BUSSOLARI R - CANDINI O - CALABRETTA B Journal of biological chemistry 2005 Vol 280 Iss 34 pp 30254-30262

54 KASPAR P - PAJER P - SEDLAK D - TAMAOKI T - DVORAK M Experimental cell research 2005 Vol 309 Iss 2 pp 419-428

BIES J - WOLFF L Oncogenic activation of c-Myb by carboxyl-terminal truncation leads to decreased proteolysis by the ubiquitin-26S proteasome pathway In Oncogene Vol 14 no 2 (1997) p 203-212

55 SHAY KP - WANG ZP - XING PX - MCKENZIE IFC - MAGNUSON NS Molecular cancer research 2005 Vol 3 Iss 3 pp 170-181


BIZIK J - GROacuteFOVAacute M - ŠVEC J Release of an Mr 140000 glycoprotein in the culture media of certain human sarcoma and melanoma cell lines In European journal of cancer amp clinical oncology Vol 21 no 3 (1985) p 317-324

57 LEYON PV - LINI CC - KUTTAN G Life sciences 2005 Vol 76 Iss 12 pp 1339-1349

BOZSAKYOVAacute E - CHALUPA I - ŠEBOVAacute L - SLAMEŇOVAacute D Chromosomal aberrations sister chromatid exchanges and micronuclei induced by pentoxifylline in in vitro cultivated Chinese hamster cells (V79) and human blood lymphocytes In Mutation research - Genetic toxicology and environmental mutagenesis Vol 497 (2001) p 63-70

58 LAURENT C - POUGET JP - VOISIN P Radiation research 2005 Vol 164 Iss 1 pp 63-72

BROZMANOVAacute J - DUDAacuteŠ A - HENRIQUES J Repair of oxidative DNA damage- important factor reducing cancer risk In Neoplasma Vol 48 no 2 (2001) p 85-93

59 CIERESZKO A - WOLFE TD - DABROWSKI K Aquatic toxicology 2005 Vol 73 Iss 2 pp 128-138

60 SAMUELS DC Mechanisms of ageing and development 2005 Vol 126 Iss 10 pp 1123-1129

61 PARKER AR - SIEBER OM - SHI CJ - HUA L - TAKAO M - TOMLINSON IP - ESHLEMAN J R Carcinogenesis 2005 Vol 26 Iss 11 pp 2010-2018

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PLESKO I - KRAMAROVA E - STILLER CA - COEBERGH JW - SANTAQUILAN AM and EUROCARE WORKING GROUP Survival of children with Wilms tumour in Europe In European journal of cancer Vol 37 (2001) p 736

402GRABOIS MF - AZAVEDO G - MENDOUCA S Rev Saude Publica Vol 39 (2005) p 731

157

PLESKO I - MAC-FARLANE GJ - EUSTIGEER TV - KRAMAROVA E - OBSITNIKOVA A Oral and pharyngeal cancer incidence in Slovakia 1968-1989 In International journal of cancer Vol 56 (1994) p 481

403DOBROSSY L Cancer Metastasis Rev Vol 24 (2005) p9

ALEXANDER FE - BOYLE P - CARLI PM - COEBERGH JW - EKBOOM A - LEVI F - McKINNEY PA -McWHIRTER W - MICHAELIS J - PERIS-BONET R - PETRIDOU E - POMPE-KIRN V - PLESKO I - PUKKALA E - RAHU M - STILLER CA - STORM HH - TERRACINI B - VARTEN J - WRAY N Population density and childhood leukaemia results of the EUROCLUS Study In European journal of cancer Vol 35 (1999) p 439

404FELTBOWER RG - MAUDA SOM - GILTHOOPE MS Amer J Epidemiol Vol 161 (2005) p 1180

405DALMASSO P - PASTORE G - ZUCCOLO L Haematologica Hemat J Vol 90 (2005) p 1197

406JI JK - HEMMIUKI K J Occupat Enviroment Med Vol 47 (2005) p 1131

KUBIK A - ZATLOUKAL P - TOMASEK L - PAUK N - PETRUZELKA L - PLESKO I In Neoplasma Vol 48 (2001) p 262

407DOREA J - DACOSTA THM Brit J Nutrition Vol 93 (2005) p 773

KUBIK A - ZATLOUKAL P - TOMASEK L - PAUK N - PETRUZELKA L - PLESKO I Lung cancer risk among nonsmoking women in relation to diet and physical activity In Neoplasma Vol 51 (2001) p 136

408LUO ZJ - SAHA AK - XIANG XO TRENDS PHARMACOL SCIENCES Vol 26 (2005) p 69

409GALLUS S - TALAMINI R - GIACOSA A Annals Oncol Vol 16 (2005) p 1841

PLESKO I - PRESTONMARTIN S - DAY NE - TZOUNOV A - DIMITROVAE - SOMOGYI J Parity and cancer risk in Slovakia In International journal of cancer Vol 36 (1985) p 529

410HATCH EE - LINET MS - ZHANG JY INT J CANCER Vol 114 (2005) p797411NICHOLS HB - TRENTHAM-DIETZ A - HAMPTON JM - NEWCOMB PA

Cancer-Epidem-Biomark-Prevent-Vol 14 (2005) p 1212

KUBIK AK - PARKIN DM - PLESKO I - ZATONSKI W - KRAMAROVA E - MOHNER M - FRIEDL HP - JUHASZ L - TZVETANSKI C - REISIGOVAS J Patterns of cigarette sales and lung cancer mortality in some central and eastern European countries 1960-1989 In Cancer Vol 75 (1995) p 2452

412ARAKI J - KOBAYASHI Y - IWASA M Eur J Cancer Vol 41 (2005) p 2360413PAUK N Lung Cancer Vol 48 (2005) p 1

158

PLESKO I - SEVERI G - OBSITNIKOVA A - KRAMAROVA E - BOYLE P - KUBIK A Lung cancer incidence rates by histologic type an example of trends in Eastern Europe--Slovakia 1978-95 In Neoplasma Vol 48 (2001) p 247

414PIRINA R - OSTERA S - SANTORY L Int J Tuberculosis Lung Diss Vol 9 (2005) p 622

VLASAK V - PLESKO I - DIMITROVA E - HUDAKOVA G Recent trends in uterine cervix cancer in Slovakia 1968-1987 In Neoplasma Vol 38 (1991) p 533

415BRAY F - LOOS AH - MCCARROU P Cancer Epidem Biomark Prevention Vol 14 (2005) p 677

PLESKO I - SEVERI G - OBSITNIKOVA A - BOYLE P Trends in the incidence of non-melanoma skin cancer in Slovakia 1978-1995 In Neoplasma Vol 47 (2000) p 137

416DEMERS AA - NUGENT Z - MIHALCIOIU C J Am Acad Dermatol Vol 53 (2005) p 320

417HALPERN AC - KOPP LJ Int J Dfermatol Vol 44 (2005) p 107

PLESKO I - OBSITNIKOVA A - STEFANAKOVA D - MANAKOVA E - PAJENSKA E - BENESOVA A - KOMPAUEROVA H - HLAVATA B - RAKOCZOVA E - POKRIVCAKOVA M - MADZOVA J - FIALOVA D In Cancer Incidence In Slovakia 1995 (1999) p 176

418HALASOVA E - BASKA T - KUKURA F - MAZUROVA D - BUKOVSKA E - DOBROTA D - POLIACEK I - HALASA M Neoplasma Vol 52 (2005) p 291

PLESKO I - OBSITNIKOVA A - STEFANAKOVA D - KUZMA I - MANAKOVA E - PAJENSKA E - BENESOVA A - KOMPAUEROVA H - HLAVATA B - RAKOCZOVA E - MADZOVA J - POKRIVCAKOVA M - FIALOVA D In Cancer Incidence In Slovakia 1997 (2000) p 201


PLESKO I - OBSITNIKOVA A - STEFANAKOVA D - KUZMA I - MANAKOVA E - PAJENSKA E - BENESOVA A - KOMPAUEROVA H - HLAVATA B - RAKOCZOVA E - MADZOVA J - POKRIVCAKOVA M - PISECNA M In Cancer Incidence In Slovakia 1998 (2001) p 200


PLESKO I - OBSITNIKOVA A - STEFANAKOVA D - KUZMA I - MANAKOVA E - PAJENSKA E - BENESOVA A - KOMPAUEROVA H - HLAVATA B - RAKOCZOVA E - MADZOVA J - POKRIVCAKOVA M - PISECNA M 2002 In Cancer Incidence In Slovakia 1999 (2002) p 198

159


PLESKO I - OBSITNIKOVA A - STEFANAKOVA D - KUZMA I - BENESOVA A - KOMPAUEROVA H - HLAVATA B - RAKOCZOVA E - ONDROVICOVA M - MADZOVA J - POKRIVCAKOVA M - SPANKOVA A In Cancer Incidence In Slovakia 2000 (2003) p 207


PLESKO I - OBSITNIKOVA A - STEFANAKOVA D - CUNINKOVA M - KUZMA I - BENESOVA A - KOMPAUEROVA H - HLAVATA B - RAKOCZOVA E - ONDROVICOVA M - MADZOVA J - POKRIVCAKOVA M - SPANKOVA A In Cancer Incidence In Slovakia 2001 (2004) p 208


PLESKO I - ONDRUSOVA M - STEFANAKOVA D - KUZMA I - HLAVATA B - RAKOCZOVA E - KOMPAUEROVA H - BENESOVA A - MADZOVA J - ONDROVICOVA M - POKRIVCAKOVA M In Cancar Incidence In Slovakia 2002 (2005) p 207

424HALASOVA E - BASKA T - KUKURA F - MAZUROVA D - BUKOVSKA E - DOBROTA D - POLIACEK I - HALASA M Neoplasma Vol 52 (2005)

SEVERI G - PLESKO I - ROBERTSON C - OBSITNIKOVA A - BOYLE P Larynx cancer in Slovakia and the role of anatomical subsites In Oral Oncology Vol 35 (1999) p 564

425BRONKA XDR - TROMP DM - DELEEUX JRJ J Scienc Spec Head Neck Vol 27 (2005) p 289

PLESKO I - OBSITNIKOVA A In Prakt Gynekologia Vol 5 (1998) p 61

426BOZSAKYOVA E - WSOLOVA L - CHALUPA I Int J Rad Biol Vol 81 (2005) p 177

PARKIN DM - CARDIS E - MASUZER E - FRIEDL HP - HANSLUWKA H - BOBEV D - IVANOV E - SINNAEVE J - AUGUSTIN J - PLESKO I - STORM HH - RAHU M - KARJALAINEN S - BEDRNARD JL - CARLI PM - LacuteHUILLIER MC - LUTZ JM - SCHAFFER P - SCHRAUB S - MICHAELIS J - MOHNER M - STANECZEK W - VARGHA M - CROSIGNANI P - MAGNANI C - TERRACINI B - KRIAUCIUNAS R - COEBERGH JW - LANGMARK F - ZATONSKI W - MERABISHVILI V - POMPE-KIRN V - BARLOW L - RAYMOND L - BLACK R - STILLER CA - BENNET BG Childhood leukaemia following the Chernobyl accident the European Childhood Leukaemia-Lymphoma Incidence Study (ECLIS) In European Journal of Cancer Vol 29 (1992) p87

160

427HATCH M - ROU E - BOUVILLE A Epid Reviews Vol 27 (2005) p 56428TOROK S - BORGULYA G - LOBMAYER P Eur J Epidemiol Vol 20 (2005) p

899

Citaacutecie v databaacuteze SCOPUS 15

FRIDRICHOVAacute I - ILENČIacuteKOVAacute D - FRIEDL W - HLAVČAacuteK P - ŠKORVAGA M - KRIŽAN P - PALAJ J - PIRŠEL M - FARKAŠOVAacute E - BARTOŠOVAacute Z Approaches to identification of HNPCC suspected patients in Slovak population In Neoplasma Vol 47 no 4 (2000) p 219-226

1 HLAVATYacute T - LUKAacuteČ L - HUORKA M - BEZAYOVAacute T - ĎURIŠ I Českaacute a slovenskaacute gastroenterologie a hepatologie 2005 Vol 59 Iss 6 pp 285-292


2 VALENTIN J Annals of the ICRP 2005 Vol 35 Iss 4 pp 41-60


3 HURLES M Human genomics 2005 Vol 2 Iss 3 pp 179-1864 STERN MC - SIEGMUND KD - CORRAL R - HAILE RW Epidemiology

biomarkers and prevention 2005 Vol 14 Iss 3 pp 609-6155 BALDWIN EL - OSHEROFF N Current medicinal chemistry - Anticancer

agents 2005 Vol 5 Iss 4 pp 363-372


6 PITCHER RS - WILSON TE - DOHERTY AJ Cell cycle 2005 Vol 4 Iss 5 pp 675-678


7 MONTEIRO E - ARZIM G - SILVA R - DA COSTA B - LOPES C Revue de laryngologie otologie rhinologie 2005 Vol 126 Iss 3 pp 135-140

8 NAPPI G - DE LUCA S - BARONIO L Medicina clinica e termale 2005 Vol 18 Iss 56 pp 8-18

HENRIQUES J - BROZMANOVAacute J - BRENDEL M Role of PSO genes in the repair of photoinduced interstrand cross-links and photooxidative damage in the DNA of the yeast Saccharomyces cerevisiae In Journal of photochemistry and photobiology B Biology Vol 39 no 3 (1997) p 185-196

161

9 LI XR - HEJNA J - MOSES RE DNA repair 2005 Vol 4 Iss 2 pp 163-170

MORAIS M - VICENTE E - BROZMANOVAacute J - SCHENBERG A - HENRIQUES J Further characterization of the pso4 1 mutant interaction with rad51 and rad52 mutants after photoinduced lesions In Current genetics Vol 29 no 3 (1996) p 211-218

10 GRILLARI J - AJUH P - STADLER G - LOSCHER M - VOGLAUER R - ERNST W - CHUSAINOW J - EISENHABER F - POKAR M - FORTSCHEGGER K - GREY M - LAMOND AI - KATINGER H Nucleic acids research 2005 Vol 33 Iss 21 pp 6868-6883

SIGLER K - CHALOUPKA J - BROZMANOVAacute J - STADLER N - HOFER MOxidative stress in microorganbisms - I Microbial vs higher cells - Damage and defenses in relation to cell aging and death In Folia microbiologica Vol 44 no 6 (1999) p 587-999

11 JAMNIK P - RASPOR P Journal of biochemical and molecular toxicology 2005 Vol 19 Iss 4 pp 195-203

12 MIHALIKOVA K - GRESAKOVA L - BOLDIZAROVA K - FAIX S - LENG L - KISIDAYOVA S Folia microbiologica 2005 Vol 50 Iss 4 pp 353-356

13 KOČIacute R - DRAacuteBKOVAacute M - MAacuteROVAacute I Chemickeacute listy 2005 Vol 99 Iss 14 pp 297-298

14 ANDRADE RV - DA SILVA SP - TORRES FAG - POCAS-FONSECA MJ - SILVA-PEREIRA I - MARANHAO AQ - CAMPOS EG - MORAES LMP - JESUIacuteNO RSA - PEREIRA M - SOARES CMA - WALTER MEMT - CARVALHO MJA - ALMEIDA MF - BRIacuteGIDO MM - FELIPE MSS Revista iberoamericana de micologia 2005 Vol 22 Iss 4 pp 203-212

15 POLJŠAK B - GAZDAG Z - JENKO-BRINOVEC Š - FUJS Š - PESTI M - BEacuteLAGYI J - PLESNIČAR S - RASPOR P Journal of applied toxicology 2005 Vol 25 Iss 6 pp 535-548

Citaacutecie v monografiaacutech 4

STYK B - RUSS G - POLAacuteKOVAacute K Antigenic glycopolypeptides HA1 and HA2 of influenza virus haemagglutinin III Reactivity with human convalescent sera In Acta virologica Vol 23 no 1 (1979) p 1-8

1 VAREČKOVAacute E - KOSTOLANSKYacute F - MUCHA V InTrends in monoclonal antibody researched Simmons Marie A Nova Science pub INCNY 2005 Vol 1-59454-550-2 Iss pp 123-142

STYK B - RUSS G - POLAacuteKOVAacute K Antigenic glycopolypeptides HA1 and HA2 of influenza virus haemagglutinin IV Immunogenic properties of separated haemagglutinin glycopolypeptides In Acta virologica Vol 23 no 1 (1979) p 9-20

2 VAREČKOVAacute E - KOSTOLANSKYacute F - MUCHA V In Trends in monoclonal antibody researched Simmons Marie A Nova Science pub INCNY 2005 Vol 1-59454-550-2 Iss pp 123-142

162

RUSS G - STYK B - POLAacuteKOVAacute K Antigenic glycopolypeptides HA1 and HA2 of influenza virus haemagglutinin II Reactivity with rabbit sera against intact virus and purified undissociated haemagglutinin In Acta virologica Vol 22 no 5 (1978) p 371-382

3 VAREČKOVAacute E - KOSTOLANSKYacute F - MUCHA V InTrends in monoclonal antibody research ED Simmons Marie A Nova Science pub INCNY 2005 Vol 1-59454-550-2 Iss pp 123-142

POLAacuteKOVAacute K - RUSS G - STYK B Antigenic glycopolypeptides HA1 and HA2 of influenza virus haemagglutinin I Gel filtration in 6 M guanidine hydrochloride In Acta virologica Vol 22 no 5 (1978) p 362-370


163

Priacuteloha č 4

Uacutedaje o pedagogickej činnosti pracoviska

Prednaacutešateľ Semestraacutelny predmet ndash naacutezov prednaacutešky

Hod tyacutežd

Hod semest

Katedravysokaacute škola

Babušiacutekovaacute O Vyacuteznam imunofenotypizaacutecie pri detskyacutech malignitaacutech 2 Subkatedra detskej onkoloacutegie

Slovenskaacute zdravotniacutecka univerzita

Bartošovaacute ZESF kurz Molekulaacuterna bioloacutegia a genetika v mediciacutene prednaacuteška Molekulaacuterne zaacuteklady karcinogeneacutezy

1 Katedra molekulaacuternej bioloacutegie PriF UK

Chalupa ICytogenetika III ročniacutek 4 Katedra genetikyPriF UK

Cytotaxonoacutemia živočiacutechov 1 13 Katedra fyzioloacutegie rastliacutenPriF UK

Chovanec MIntroduction to Molecular Biology - Recombination and double strand break repair

2 Katedra biocheacutemiePriF UK

Ondrušovaacute MEpidemioloacutegia naacutedorov močoveacuteho mechuacutera a urotelovyacutech naacutedorov hornyacutech močovyacutech ciest

1 Katedra uroloacutegie IPVZ a Urologickej klinikyLF UK Praha ČR

Piršel M

Introduction to Molecular Biology - DNA Repair


Oprava DNA rakovina a starnutie 2 Katedra biocheacutemie a mikrobioloacutegieFChPT STU

Mechanizmy opravy DNA a naacutedoroveacute ochorenie


Polaacutekovaacute K Molekulaacuterna imunoloacutegia 2 24 Katedra molekulaacuternej bioloacutegie Katedra viroloacutegiePriF UK

Sedlaacutek J Využitie fluorescenčnyacutech techniacutek v onkoloacutegii 1 Katedra molekulaacuternej bioloacutegie

PriF UK

Zajac V

Patoloacutegia dedičnyacutech naacutedorovyacutech ochoreniacute 2 Katedra patologickej

anatoacutemieLekaacuterska fakulta UK

Laboratoacuterne vyšetrovacie metoacutedy v zdravotniacutectve 2 Katedra patologickej


164

CvičeniaSemestraacutelny predmet ndash naacutezov prednaacutešky

Hodiny tyacuteždeň

Hodinysemester


Baraacuteth P

Dizertačnaacute praacuteca ndash 1L 40 480 Katedra genetikyPriF UK

Dizertačnaacute praacuteca ndash 2Z 40 480 Katedra genetikyPriF UK

Diplomovaacute praacuteca ndash 5L 14 182 Katedra molekulaacuternej bioloacutegie PriF UK

Bartošovaacute ZDizertačnaacute praacuteca ndash 1L 40 480 Katedra genetikyPriF UK


Biacutezik J

Cvičenie diplomantov I ndash 5Z 16 208 Katedra biocheacutemiePriF UK


Preddiplomovaacute prax- 4L 40 120 Katedra biocheacutemiePriF UK

Preddiplomovaacute prax- 4 40 120 Katedra biocheacutemiePriF UK

Čipaacutek Ľ Konzultaacutecie diplomovej praacutece - 5L 15 195 Katedra biocheacutemie a mikrobioloacutegie FChPT STU

Fridrichovaacute I Dizertačnaacute praacuteca ndash 1Z 40 480 Katedra genetiky PriF UK

Horvaacutethovaacute E

Cvičenie k diplomovej praacuteci -4L 6 72 Katedra genetikyPriF UK

Preddiplomovaacute prax -4L 3tyacutež 120 Katedra genetikyPriF UK

Špec seminaacuter k diplomovej praacuteci -5Z 2 24 Katedra genetikyPriF UK

Diplomovaacute praacuteca - 5Z 14 168 Katedra genetikyPriF UK

Chalupa I

Cytotaxonoacutemia živočiacutechov - 3Z 2 26 Katedra fyzioloacutegie rastliacutenPriF UK

Cvičenia k diplomovej praacuteci - 4Z 1 13 Katedra genetikyPriF UK


Diplomovaacute praacuteca -4Z 2 26 Katedra genetikyPriF UK

Chovanec M

Preddiplomovaacute prax- 3Z 8 104 Katedra genetikyPriF UK

Preddiplomovaacute prax ndash 3L (konzultaacutecie) 20 Katedra genetikyPriFUK

Cvičenia k diplomovej praacuteci -4Z (konzultaacutecie) 2 26 Katedra genetikyPriFUK

165



Hodinysemester


Chovanec M

Cvičenia k diplomovej praacuteci -4L (konzultaacutecie) 8 104 Katedra genetikyPriF UK

Diplomovaacute praacuteca ndash 5Z 8 104 Katedra genetikyPriF UK


Kučerovaacute LDizertačnaacute praacuteca ndash 1Z 40 480 LF UK Bratislava

Bakalaacuterska praacuteca ndash 3Z 8 96Katedra molekulaacuternej bioloacutegie PriF UK

Pastoraacutekovaacute A Bakalaacuterska praacuteca ndash 3Z 8 96Katedra molekulaacuternej bioloacutegie PriF UK

Piršel M

Diplomovaacute praacuteca ndash 4L 10 120Katedra molekulaacuternej bioloacutegie PriF UK

Preddiplomovaacute prax ndash 4L 3 tyacutežd 120Katedra molekulaacuternej bioloacutegie PriF UK

Diplomovaacute praacuteca ndash 5Z 28 336Katedra molekulaacuternej bioloacutegie PriF UK

Rauko P

Konzultaacutecie diplomovej praacutece - 5L 5 65 Katedra genetikyPriF UK


Dizertačnaacute praacuteca ndash 1Z 40 480 LF UK Bratislava

Sedlaacutek JSemestraacutelny projekt II- 4L 5 65 Uacutestav biocheacutemie vyacuteživy a ochrany

zdraviaFChPT STU

Semestraacutelny projekt III- 5Z 5 65 Uacutestav biocheacutemie vyacuteživy a ochrany zdraviaFChPT STU

Zajac V




Cvičenia k diplomovej praacuteci -4Z 3 39Katedra molekulaacuternej bioloacutegie PriF UK


166

Priacuteloha č 5

Uacutedaje o medzinaacuterodnej vedeckej spolupraacuteci

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Počet dniacute


Počet dniacute

Kuvajt Novotnyacute L 365Rakuacutesko Hlavatyacute J 365Taliansko Frecer V 365USA Bies J 365USA Markus J 365USA Kuacutedela P 365USA Tomka M 230Šveacutedsko Vigašovaacute D 115Fiacutensko Biziacutek J 61Rakuacutesko Košťanovaacute-

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Počet dniacute


Počet dniacute


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Daacutensko Ebbesen P 2Počet prijatiacute spolu 2 8

167

(C ) Uacutečasť pracovniacutekov pracoviska na konferenciaacutech v zahraničiacute (nezahrnutyacutech v A)Krajina Naacutezov konferencie Meno pracovniacuteka Počet dniacute

ČR 36th EEMSFarkašovaacute TGaacutebelovaacute AGurskaacute S

555

ČR

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ČR Bunečnaacute signalizace Boďo J 1ČR CECHTUMA 2006 Sedlaacutek J 3

ČR V Hradeckyacute deň molekulaacuternej genetiky a cytogenetiky Chalupa I 1

Fiacutensko EuroBioForum Polaacutekovaacute K 4Francuacutezsko 4th International Conference on HLA-G Polaacutekovaacute K 3

Francuacutezsko 16th European Congress of Clinical Microbiology and Infectious Diseases

Zajac VČiernikovaacute S

66

Francuacutezsko 49th EMRC Standing Committee Meeting Polaacutekovaacute K 4

Greacutecko Measuring Antigen-Specific Immune Responsis ndash MASIR 2006

Sedlaacutek JJakubiacutekovaacute J

44

Greacutecko IV European Social Forum Markovaacute E 4

GreacuteckoFEBS Advanced Lecture Course ndash Free Radical Summer School 2006 Biomarkers of Oxidative Stress amp Responses

Dudaacutešovaacute ZMaršaacutelkovaacute L

77

Holandsko DNA Repair from Molecular Mechanism to Human Disease Piršel M 7

Maďarsko EACR-19

Boďo JJakubiacutekovaacute JCholujovaacute DBiziacutek J Železniacutekovaacute T

44444

Nemecko PALM MicroBeam workshop Bujalkovaacute MMatuacuteškovaacute M

22

Noacutersko 15th Protein Kinase Meeting ndash Spatial and Temporal Regulation of Signalling Kollaacuterovič G 4

Rakuacutesko DNA Repair Chovanec M 1

Rakuacutesko Molecular and physiological effects of bioactive food compounds

Horvaacutethovaacute EŠramkova M

44

Rakuacutesko 48th EMRC Standing Committee Meeting Polaacutekovaacute K 4Rusko V Ruskaacute raacutediologickaacute konferencia Markovaacute E 5

Taliansko ESH-EHA third annual diagnostic work-up of hematological malignancies Železniacutekovaacute T 4

Vysvetlivky

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168

Obsah osnovy Spraacutevy o činnosti organizaacutecie SAV za rok 2006

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II Vedeckaacute činnosť 6

III Vedeckaacute vyacutechova a pedagogickaacute činnosť 15

IV Medzinaacuterodnaacute vedeckaacute spolupraacuteca 18

V Spolupraacuteca s vysokyacutemi školami inyacutemi domaacutecimi vyacuteskumnyacutemi

inštituacuteciami a s hospodaacuterskou sfeacuterou pri riešeniacute vyacuteskumnyacutech uacuteloh

28

VI Aktivity pre Naacuterodnuacute radu SR vlaacutedu SR uacutestredneacute orgaacuteny štaacutetnej

spraacutevy SR a ineacute subjekty

30

VII Vedecko-organizačneacute a popularizačneacute aktivity ceny a

vyznamenania

30

VIII Činnosť knižnično-informačneacuteho pracoviska 46

IX Aktivity v orgaacutenoch SAV 47

X Hospodaacuterenie organizaacutecie 48

XI Nadaacutecie a fondy pri organizaacutecii 49

XII Ineacute vyacuteznamneacute činnosti 50

XIII Vyznamenania ocenenia a ceny udeleneacute pracovniacutekom organizaacutecie

v roku 2006 (mimo SAV)

50

XIV Poskytovanie informaacuteciiacute v suacutelade so zaacutekonom o slobode informaacuteciiacute 51

XV Probleacutemy a podnety pre činnosť SAV 51

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2 Projekty riešeneacute na pracovisku 55

3 Vedeckyacute vyacutestup ndash bibliografickeacute uacutedaje vyacutestupov 95

4 Uacutedaje o pedagogickej činnosti organizaacutecie 162

5 Uacutedaje o medzinaacuterodnej vedeckej spolupraacuteci 165

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LF UK Bratislava




PriF UK Bratislava




PriF UK Bratislava



PriF UK Bratislava




PriF UK Bratislava




LF UK Bratislava

15





8 1 14 0













1

16





Čipaacutek L (IIA)












17




rok 2006


A


B



A B


- - - -


- 2 - 0


- 2 - 20 000


- - - -





18









19








20










21











FEBS členovia









22









23












24







Valovičovaacute Z





25












26











27











28










29















30




-








31














32










33












34










35









36










37













38













39
















40

















prevencia

41















42















43




















44




























45




















Dar 9 periodiacutek


46










47




rozpočet r 2006

Čerpaniek 31122006

celkom

z toho




8 356 8 310 8 310 0



4684 4 684 4 684 2 305


259 459 259 200


1 947 1 947 1 947 0



Plneniek 31122006


2 820 2 655

48










49













50

51
















Členovia VR






52


53

Priacuteloha č 1



54


55



56

Priacuteloha č 2









57











58










59





Publikaacutecie







60










61










62






Publikaacutecie



63






Publikaacutecie




64



Publikaacutecie







65








66







67








Publikaacutecie


68








69











70












71









72










73











74










75











76










77









78








79










80










81








82













83












84

















85












86








87










88










89










90









91











92










93












94












95









96

Priacuteloha č3













97













98











99












100











101










102













103















104











105










106










107










108











109











110











111









112










113













114










115









116











117












118













119















120












121





impakt faktor 0731









122

















123



















124















125

















40773-40781



126

















127

















128


















129





















130

















131

















132














133
















134

















135

















136
















137

















138

















139

















140









Iss 2 pp 157-168








141


















142




















143

















144














145















146















147

















148



















149















150













151
















152




















153
















154

















155













497-500







156







p 156








157

















158















159













160


899
















161















162





163

Priacuteloha č 4



Hod tyacutežd

Hod semest












Piršel M








PriF UK

Zajac V





164



Hodinysemester


Baraacuteth P






Biacutezik J












Chalupa I





Chovanec M




165



Hodinysemester


Chovanec M







Piršel M




Rauko P





zdraviaFChPT STU


Zajac V






166

Priacuteloha č 5



Krajina Druh dohody


Počet dniacute


Počet dniacute


Počet dniacute


Poliakovaacute D31




Krajina Druh dohody


Počet dniacute


Počet dniacute


Počet dniacute



167



555

ČR


Gurskaacute S 3






66




44




77


Maďarsko EACR-19


44444


22





44



Vysvetlivky


168




wwwexonsavbask






K

K do 35 rokov

Kved prac

M Ž M Ž

F P







10 2 8 10 10

Vysvetlivky


3



Rodovaacute

skladba


v stupňoch

DrSc CSc

PhD

prof doc I IIa IIb

Muži 5 20 1 2 5 16 6

Ženy 5 29 6 10 16



lt 30 30-35 35-40 40-45 45-50 50-55 55-60 60-65 gt65

Muži 9 8 1 3 5 6 3 3 8Ženy 26 15 3 6 7 11 5 2 8







4














5




rok 2006 v tis

A


B



projektu

A B



3 2 3 017 270





- - - -



3 - 600 -




6







7





8





9












54





0




104







a v cudzom jazyku

b v slovenčine

0



10




60

5 Ohlasy












11









12











13












14





celkovyacute počet



M Ž M Ž M Ž






0

Externaacute 1 0 0 0 1 3 0 0 0 0



Mesiac rok obhajoby







LF UK Bratislava

MUDr MichalMego



LF UK Bratislava



LF UK Bratislava




LF UK Bratislava




LF UK Bratislava




LF UK Bratislava




PriF UK Bratislava




PriF UK Bratislava



PriF UK Bratislava




PriF UK Bratislava




LF UK Bratislava

15





8 1 14 0













1

16





Čipaacutek L (IIA)












17




rok 2006


A


B



A B


- - - -


- 2 - 0


- 2 - 20 000


- - - -





18









19








20










21











FEBS členovia









22









23












24







Valovičovaacute Z





25












26











27











28










29















30




-








31














32










33












34










35









36










37













38













39
















40

















prevencia

41















42















43




















44




























45




















Dar 9 periodiacutek


46










47




rozpočet r 2006

Čerpaniek 31122006

celkom

z toho




8 356 8 310 8 310 0



4684 4 684 4 684 2 305


259 459 259 200


1 947 1 947 1 947 0



Plneniek 31122006


2 820 2 655

48










49













50

51
















Členovia VR






52


53

Priacuteloha č 1



54


55



56

Priacuteloha č 2









57











58










59





Publikaacutecie







60










61










62






Publikaacutecie



63






Publikaacutecie




64



Publikaacutecie







65








66







67








Publikaacutecie


68








69











70












71









72










73











74










75











76










77









78








79










80










81








82













83












84

















85












86








87










88










89










90









91











92










93












94












95









96

Priacuteloha č3













97













98











99












100











101










102













103















104











105










106










107










108











109











110











111









112










113













114










115









116











117












118













119















120












121





impakt faktor 0731









122

















123



















124















125

















40773-40781



126

















127

















128


















129





















130

















131

















132














133
















134

















135

















136
















137

















138

















139

















140









Iss 2 pp 157-168








141


















142




















143

















144














145















146















147

















148



















149















150













151
















152




















153
















154

















155













497-500







156







p 156








157

















158















159













160


899
















161















162





163

Priacuteloha č 4



Hod tyacutežd

Hod semest












Piršel M








PriF UK

Zajac V





164



Hodinysemester


Baraacuteth P






Biacutezik J












Chalupa I





Chovanec M




165



Hodinysemester


Chovanec M







Piršel M




Rauko P





zdraviaFChPT STU


Zajac V






166

Priacuteloha č 5



Krajina Druh dohody


Počet dniacute


Počet dniacute


Počet dniacute


Poliakovaacute D31




Krajina Druh dohody


Počet dniacute


Počet dniacute


Počet dniacute



167



555

ČR


Gurskaacute S 3






66




44




77


Maďarsko EACR-19


44444


22





44



Vysvetlivky


168



Rodovaacute

skladba


v stupňoch

DrSc CSc

PhD

prof doc I IIa IIb

Muži 5 20 1 2 5 16 6

Ženy 5 29 6 10 16



lt 30 30-35 35-40 40-45 45-50 50-55 55-60 60-65 gt65

Muži 9 8 1 3 5 6 3 3 8Ženy 26 15 3 6 7 11 5 2 8







4














5




rok 2006 v tis

A


B



projektu

A B



3 2 3 017 270





- - - -



3 - 600 -




6







7





8





9












54





0




104







a v cudzom jazyku

b v slovenčine

0



10




60

5 Ohlasy












11









12











13












14





celkovyacute počet



M Ž M Ž M Ž






0

Externaacute 1 0 0 0 1 3 0 0 0 0



Mesiac rok obhajoby







LF UK Bratislava

MUDr MichalMego



LF UK Bratislava



LF UK Bratislava




LF UK Bratislava




LF UK Bratislava




LF UK Bratislava




PriF UK Bratislava




PriF UK Bratislava



PriF UK Bratislava




PriF UK Bratislava




LF UK Bratislava

15





8 1 14 0













1

16





Čipaacutek L (IIA)












17




rok 2006


A


B



A B


- - - -


- 2 - 0


- 2 - 20 000


- - - -





18









19








20










21











FEBS členovia









22









23












24







Valovičovaacute Z





25












26











27











28










29















30




-








31














32










33












34










35









36










37













38













39
















40

















prevencia

41















42















43




















44




























45




















Dar 9 periodiacutek


46










47




rozpočet r 2006

Čerpaniek 31122006

celkom

z toho




8 356 8 310 8 310 0



4684 4 684 4 684 2 305


259 459 259 200


1 947 1 947 1 947 0



Plneniek 31122006


2 820 2 655

48










49













50

51
















Členovia VR






52


53

Priacuteloha č 1



54


55



56

Priacuteloha č 2









57











58










59





Publikaacutecie







60










61










62






Publikaacutecie



63






Publikaacutecie




64



Publikaacutecie







65








66







67








Publikaacutecie


68








69











70












71









72










73











74










75











76










77









78








79










80










81








82













83












84

















85












86








87










88










89










90









91











92










93












94












95









96

Priacuteloha č3













97













98











99












100











101










102













103















104











105










106










107










108











109











110











111









112










113













114










115









116











117












118













119















120












121





impakt faktor 0731









122

















123



















124















125

















40773-40781



126

















127

















128


















129





















130

















131

















132














133
















134

















135

















136
















137

















138

















139

















140









Iss 2 pp 157-168








141


















142




















143

















144














145















146















147

















148



















149















150













151
















152




















153
















154

















155













497-500







156







p 156








157

















158















159













160


899
















161















162





163

Priacuteloha č 4



Hod tyacutežd

Hod semest












Piršel M








PriF UK

Zajac V





164



Hodinysemester


Baraacuteth P






Biacutezik J












Chalupa I





Chovanec M




165



Hodinysemester


Chovanec M







Piršel M




Rauko P





zdraviaFChPT STU


Zajac V






166

Priacuteloha č 5



Krajina Druh dohody


Počet dniacute


Počet dniacute


Počet dniacute


Poliakovaacute D31




Krajina Druh dohody


Počet dniacute


Počet dniacute


Počet dniacute



167



555

ČR


Gurskaacute S 3






66




44




77


Maďarsko EACR-19


44444


22





44



Vysvetlivky


168














5




rok 2006 v tis

A


B



projektu

A B



3 2 3 017 270





- - - -



3 - 600 -




6







7





8





9












54





0




104







a v cudzom jazyku

b v slovenčine

0



10




60

5 Ohlasy












11









12











13












14





celkovyacute počet



M Ž M Ž M Ž






0

Externaacute 1 0 0 0 1 3 0 0 0 0



Mesiac rok obhajoby







LF UK Bratislava

MUDr MichalMego



LF UK Bratislava



LF UK Bratislava




LF UK Bratislava




LF UK Bratislava




LF UK Bratislava




PriF UK Bratislava




PriF UK Bratislava



PriF UK Bratislava




PriF UK Bratislava




LF UK Bratislava

15





8 1 14 0













1

16





Čipaacutek L (IIA)












17




rok 2006


A


B



A B


- - - -


- 2 - 0


- 2 - 20 000


- - - -





18









19








20










21











FEBS členovia









22









23












24







Valovičovaacute Z





25












26











27











28










29















30




-








31














32










33












34










35









36










37













38













39
















40

















prevencia

41















42















43




















44




























45




















Dar 9 periodiacutek


46










47




rozpočet r 2006

Čerpaniek 31122006

celkom

z toho




8 356 8 310 8 310 0



4684 4 684 4 684 2 305


259 459 259 200


1 947 1 947 1 947 0



Plneniek 31122006


2 820 2 655

48










49













50

51
















Členovia VR






52


53

Priacuteloha č 1



54


55



56

Priacuteloha č 2









57











58










59





Publikaacutecie







60










61










62






Publikaacutecie



63






Publikaacutecie




64



Publikaacutecie







65








66







67








Publikaacutecie


68








69











70












71









72










73











74










75











76










77









78








79










80










81








82













83












84

















85












86








87










88










89










90









91











92










93












94












95









96

Priacuteloha č3













97













98











99












100











101










102













103















104











105










106










107










108











109











110











111









112










113













114










115









116











117












118













119















120












121





impakt faktor 0731









122

















123



















124















125

















40773-40781



126

















127

















128


















129





















130

















131

















132














133
















134

















135

















136
















137

















138

















139

















140









Iss 2 pp 157-168








141


















142




















143

















144














145















146















147

















148



















149















150













151
















152




















153
















154

















155













497-500







156







p 156








157

















158















159













160


899
















161















162





163

Priacuteloha č 4



Hod tyacutežd

Hod semest












Piršel M








PriF UK

Zajac V





164



Hodinysemester


Baraacuteth P






Biacutezik J












Chalupa I





Chovanec M




165



Hodinysemester


Chovanec M







Piršel M




Rauko P





zdraviaFChPT STU


Zajac V






166

Priacuteloha č 5



Krajina Druh dohody


Počet dniacute


Počet dniacute


Počet dniacute


Poliakovaacute D31




Krajina Druh dohody


Počet dniacute


Počet dniacute


Počet dniacute



167



555

ČR


Gurskaacute S 3






66




44




77


Maďarsko EACR-19


44444


22





44



Vysvetlivky


168

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ÚSTAV EXPERIMENTÁLNEJ ONKOLÓGIE UEO SAV 2006.pdf · 2007. 10. 23. · cenu SAV získal nominant...

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