of 111
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epidermis
dermis
Subcutaneousfat tissue
Dermatohistopathology
(clinicopathological correlation)Ji tork
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2/111
Stratum corneum
(horny layer)
Stratum granulosum(granular layer)
Stratum spinosum
(spinous layer)
Stratum basale
(basal layer)
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3/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
4/111
Langerhans cell ?
Melanocyte
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
5/111
Langerhans cell
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
6/111
Melanocyte
Fibroblast
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7/111
melanin stain
Pityriasis versicolor Normal skin
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8/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
9/111
Fibroblast
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10/111
Elastic fibres
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
11/111
Eccrine sweat gland Adipose tissue
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
12/111
Eccrine sweat glandsecretory part
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
13/111
Eccrine sweat glandduct of Eccrine sweat gland
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14/111
Duct of Eccrine sweat gland
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15/111Fat tissue
Dermis
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
16/111
Apocrine sweat gland
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
17/111
Sebaceous gland
holocrine secretion
(Pilosebaceal unit)
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
18/111
Vein
Lymfatic vessel
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
19/111
Nerve and vessels
Pil b l i
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
20/111
Pars
bulbaris
isthmus
infundibulum
Papilla
Hair follicle:
inner root
sheath
outer rootsheath
basement
membrane
fibrous
sheath
matrix
Pilosebaceal unit
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21/111
Arrector muscle - m. arrector pili
Sebaceous gland
Hair shaft (telogen)
Pilosebaceal unit
Hair follicle
H i h f l
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22/111
Hair shaft - - anagen
Hair shaft - telogen
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23/111
Hair shaft - telogen
Hair shaft - - anagen
Arrector muscle
Hair bulge
hair stem cells
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
24/111
Vater-Paccini
Lamellated corpuscleSpecialized nerve receptor
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
25/111
Meissner corpuscle
specialized nerve receptor
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
26/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
27/111
hyperkeratosis
acanthosis
fibrotisation
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
28/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
29/111
Lichen sclerosus et atrophicus
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
30/111
vVacuolar degeneration
parakeratosis
papilomatosis
acanthosis
Coarse keratohyaline granules
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
31/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
32/111
Verruca vulgarisVulgar wart
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
33/111
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34/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
35/111
Verruca plantaris
plantar wart
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
36/111
Ku oko - clavus
Plantar wart verruca plantaris
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
37/111
Plantar wart verruca plantaris
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
38/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
39/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
40/111
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41/111
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42/111
Exocytosis
Spongiosis
Intercellular bridges
(desmosomes)
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43/111
Eczema:
-Exocytosis
-Spongiosis
-Exsudate
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
44/111
Dyshidrotic vesicles
Acute eczema
weeping
Acute dyshidrotic eczema
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
45/111
y
Spongiosis, exocytosis, exsudate (crust)chronic eczema
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
46/111
p g , y , ( )
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
47/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
48/111
multilocular intraepidermal vesicle
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
49/111
Intracellular oedema
balooning
Multinucleated cells
blister
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
50/111
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51/111
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52/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
53/111
acantholysis
Pemphigus vulgaris direct Nikolsky sign
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54/111
Pemphigus vulgaris direct Nikolsky sign
Pemphigus vulgaris indirect Nikolsky sign
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
55/111
Pemphigus vulgaris indirect Nikolsky sign
Pemphigus vulgaris
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56/111
Pemphigus vulgaris
direct immunofluorescence
Intercellular positivity
IgG
C3 complement
Dermatitis herpetiformis Duhring
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57/111
Dermatitis herpetiformis Duhring
microabscess
with neutrophils
Dermatitis herpetiformis Duhring
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
58/111
direct immunofluorescence
grainy IgA
in papillae
Linear IgA dermatosis
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
59/111
a g a
direct immunofluorescence
linear IgA at basement membrane
Auspitz signPsoriasis vulgaris
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
60/111
Psoriasis vulgaris
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Microabscess with neutrophils (Munro)
Spongiform pustule (Kogoj)
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PsoriasisMicroabscess with neutrophils (Munro)
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
63/111
Psoriasis pustulosa
Psoriasis pustulosa
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
64/111
Impetiginisation of eczema
( d i f ti )
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65/111
(secondary infection)
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
66/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
67/111
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68/111
Seborrhoeic keratosis (senile wart, verruca senilis)pigmented type
(dif.dg. melanoma)
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69/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
70/111
Bowen disease (m. Bowen)
Squamous cell carcinoma in situ
psoriasiform
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71/111
Basal cell carcinoma
superficial, multicentric type
Basal cell carcinoma
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
72/111
Basal cell carcinoma
nodular type
sal cell carcinoma
vasive sclerosing (sclerodermiform)
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
73/111
vasive sclerosing (sclerodermiform)
type
Basal cell carcinoma
Sclerosing (sclerodermiform) type
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74/111
Sclerosing (sclerodermiform) type
Basal cell carcinoma ulcus terebrans type
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75/111
asa ce ca c o a u cus te eb a s type
Basal cell carcinoma ulcus
rodens
type
Melanocytic nevus - junctional
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76/111
Flat - macule
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
77/111
Melanocytic nevus - compound
Maculo-papular
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
78/111
Melanocytic nevus
intradermal
Papules,nodules
Superficial spreading
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
79/111
melanoma (SSM)
60%
S fi i l di l (SSM)
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
80/111
Secondary regression
Superficial spreading melanoma (SSM)
60%
Superficial spreading melanoma (SSM)
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
81/111
Secondary regression
Superficial spreading melanoma (SSM)
60%
S d d lSecondary regression
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Secondary nodular
superficial spreading melanoma
(SN SSM)
satelite amelanotic
metastases
exulceration
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
83/111
Amelanotic nodular melanoma
Melanoma
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
84/111
Melanoma
Cellular and nuclear atypia
Atypical mitosis
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
85/111
Fat tissue
Breslow 1,0 mm (stage IA) 5-year survival = 95-98%
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86/111
10-year survival = to 95%Breslow > 4 mm (IIB no ulceration) - 5-year survival = 63%
(IIB with ulceration) - 5-year survival = 45%
Stage T N M 5-year survivalTab. 29.2.2./2 Staging of melanomu TNM classification (tumor, noduli lymphatici, metastasis) ( AJCC 2002)
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87/111
0 Tis N 0 M 0 100
I A T 1 a N 0 M 0 >95
I B T 1b
T 2a
N 0
N 0
M 0
M 0
89-91
II A T 2b
T 3a
N 0
N 0
M 0
M 0
77-79
II B T 3bT 4a N 0N 0 M 0M 0 63-67
II C T 4b N 0 M 0 45
III A T 1a 4a N 1a 2a M 0 63-69
III B T 1a
4aT 1b 4b
N 1b,2b,2cN 1a,2a,2c
M 0M 0
46-5330-50
III C PT1b 4b
jakkoliv T
N 1b,2b, 2c
N 3
M 0
M 0
24-29
IVjakkoliv T jakkoliv N jakkoliv M
7-19
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7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
89/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
90/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
91/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
92/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
93/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
94/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
95/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
96/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
97/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
98/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
99/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
100/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
101/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
102/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
103/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
104/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
105/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
106/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
107/111
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
108/111
pidatpityriasis versicolorklinika
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
109/111
ku oko klinika
ekzm puch vymnit
psoriasishistologiefoto mikroskopickho sklka
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
110/111
Auspitz signPsoriasis vulgaris
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
111/111
