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RECOMBINACIÓN DE ADN DECAMBIO DE CLASE DE
INMUGLOBULINA: INDUCCIÓN,
ORIENTACIÓN Y MÁS
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ANTICUERPOS
Mediadores de lainmnidad
• Ne!rali"an dire$a!%&enos ' de
• Re#l!an e)e#!oinmnol%&i#os m#ellares $ara ein)e##iones ' #*
• I&M• I&D• I&G• I&A• I&E
CLASES Se iden!i+#an:
Di)eren!es re&ionesen ss #adenas$esadas
E+#a#ia #on!ra$a!%&enos
IgM: Se#re!adas #omo
$en!meros o-e.meros
Al!a a(ide" #on!raan!/&enos
Median la a#!i(a#i%ndel #om$lemen!o
Gran !ama0o 1 NOES2ACIOE3TRA4ASCULAR
IgG,A e Emonomerica o
dimericas: Dis!ri5#i%n $or los
!e6idos 4ariedad )n#iones
e)e#!oras 5iol%&i#as
ANTICUERPOS EFI
I&G7 e I&G8
I&G9en
I&G e I&E e.
I&A7 e I&A9 $ala
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CSR
Las re&iones #ons!an!esson #odi+#adas $or
dis!in!os &r$os de e.onesC?
ANTICUER2OS
RESULTADO DE
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Cellas B de #lase#am5iada:• I&G;B : res$es!a
r$ida a los an!/&enos
COLA CITO2LASMATICALARGA DEL RECE2TOR BINDUCE UNA ACIÓN
Se or&ani"an en el ordenC, C, CF, C ' CH de la
#adena $esada
I&D se &enera a !ra(s des$li#in& al!erna!i(o de las
!rans#ri$#iones $rimariase #odi+#an I&M
rean
$roin)e##i
'
Resolucin ! generacin deregin S de "S#◦Transcri$cin de la l%nea germinal I&'S'C& : CRS ne#esi!a del IG? I?
in!er(inien!e ' #on!inJa a !ra(s del e.%n I?, la re&i%n S ' le&o el &r$o
CRS IG& (I&)(Reginin*er+inien*e)En I&
Regin SNe#esi!a A !ra(s
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En C&
Le&oa
Deso.i#i!osinas Aellas en!re el !ndem K@AGC
8@TCGA@K re$i!e en el nJ#leo dre&i%n S
Los SSBs $ro.imos en #adenas
o$es!as $eden )ormar DSBses#alonados
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Los DSBs es#alonados $edenamen!ar a $ar!ir de$ro#esamien!o de la re&ion S!erminan!e
RA C I A
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G R A In*egran*es:
- Rosa Torres-
#renda Tor- Ma*ias-alderrama
